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All Journal Journal of Biomedicine and Translational Research Jurnal Analis Kesehatan Jurnal Kesehatan Tambusai Jurnal EduHealth Jurnal Sehat Indonesia (JUSINDO)
Nuroh Najmi
Departemen Oral Biologi, Fakultas Kedokteran Gigi Universitas Padjadjaran Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Gambaran Hiperurisemia pada Pria dan Wanita Obesitas Usia Produktif Otih Yuningsih; Adelia Febriyossa; Apriani Apriani; Nuroh Najmi; Agus Rohmat Hidayat
Jurnal Sehat Indonesia (JUSINDO) Vol. 4 No. 01 (2022): Jurnal Sehat Indonesia (JUSINDO)
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.367 KB) | DOI: 10.59141/jsi.v4i01.41

Abstract

Hiperurisemia adalah keadaan terjadinya peningkatan kadar asam urat di atas normal. Bila keseimbangan asam urat di dalam darah terganggu maka dapat menyebabkan hiperurisemia salah satunya disebabkan oleh obesitas. Obesitas merupakan suatu keadaan tertimbunnya lemak dalam tubuh sebagai akibat berlebihnya asupan kalori dimana dapat memicu gangguan metabolisme yang menyebabkan asam urat dalam serum menjadi tinggi. Penelitian ini bertujuan untuk melihat gambaran hiperurisemia pada pria dan wanita obesitas di usia produktif 25-45 tahun. Penelitian ini penelitian dilakukan di Laboratorium Klinik Prodia Pluit pada bulan September – Oktober 2019. Sampel ditentukan dengan teknik purposive sampling. Sampel penelitian diperoleh sebanyak 80 orang. Hasil penelitian menunjukkan kadar hiperurisemia berdasarkan jenis kelamin yaitu pria lebih banyak mengalami hiperurisemia sebanyak 24 orang (53%) dan wanita 15 orang (43%). Kadar hiperurisemia berdasarkan usia menunjukkan usia 31-35 tahun paling banyak menderita hiperurisemia sebanyak 17 orang (55%). Kadar hiperurisemia berdasarkan pendidikan didapatkan kelompok pendidikan lulusan SMU yang paling banyak menderita hiperurisemia sebanyak 7 orang (88%) dan pemeriksaan kadar hiperurisemia berdasarkan riwayat genetika sebanyak 11 orang (69%). Dapat disimpulkan bahwa pada pria dan wanita yang mengalami obesitas di usia produktif memiliki kadar asam urat dalam batas normal.
Perbedaan Pemeriksaan Hitung Jumlah Trombosit Metode Impedans dan Optik pada Pasien Mikrositosis Anis Setyowati; Nuroh Najmi; Apriani Apriani
Jurnal Sehat Indonesia (JUSINDO) Vol. 4 No. 02 (2022): Jurnal Sehat Indonesia (JUSINDO)
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (159.489 KB) | DOI: 10.59141/jsi.v4i02.44

Abstract

Ada dua metode untuk menghitung trombosit secara otomatis, yaitu metode impedansi dan metode optik, dan prinsipnya berbeda. Prinsip kerja dari metode impedansi adalah resistansi atau hambatan baterai tergantung pada pengaruh volume baterai terhadap arus tinggi, semakin besar baterai, semakin besar resistansi dan sebaliknya. Prinsip metode optik adalah hamburan cahaya yang terjadi ketika sel mengalir melalui celah dan berkas difokuskan ke area penginderaan di aperture/orifice. Penelitian ini bertujuan untuk mengetahui perbedaan jumlah trombosit yang diperiksa dengan metode impedansi dan optik pada pasien dengan mikrositosis di laboratorium klinik utama Bio Medika. Penelitian dilakukan mulai September 2019 hingga Oktober 2019. Sampel yang digunakan dalam penelitian ini adalah 122 pasien dari laboratorium klinik utama Bio Medika. Data yang diperoleh diuji normalitasnya kemudian diolah menggunakan uji statistik Wilcoxon. Dari hasil uji beda diperoleh p-value sebesar 0,000 (<0,05) yang berarti terdapat perbedaan nilai pemeriksaan impedansi dan optical platelet count pada pasien mikrositosis di laboratorium klinik utama Bio Medika. Jumlah trombosit metode impedansi lebih tinggi daripada metode optik. Kesimpulan Metode optik untuk jumlah trombosit pada pasien dengan mikrositosis
Effect of Myristica fragrans on PGC1α and Synaptophysin Expression in Male Wistar Rats Hippocampus Veronica, Fifi; Goenawan, Hanna; Bahjah, Firda Hanan; Najmi, Nuroh; Lesmana, Ronny
Journal of Biomedicine and Translational Research Vol 10, No 1 (2024): April 2024
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v10i1.19959

Abstract

Background: Nutmeg is an indigenous plant from Indonesia that has been used extensively in herbal treatment. Nutmeg seed extract (NuSE) contains the active compound macelignan, which exhibits pharmacological activities. A previous study stated that NuSE is PPARγ or peroxisome proliferator-activated receptor gamma agonist that potentially enhances synaptic signal modulation. PPARγ activation can activate PGC1α or peroxisome proliferator-activated receptor gamma coactivator-1 alpha as the primary regulator of mitochondrial biogenesis. Mitochondria are involved in synaptic transmission. Increased modulation of signals at synapses can increase neuroplasticity, potentially improving the brain's cognitive function, as seen by the amount of Synaptophysin in the synaptic vesicle membrane for evaluating synaptogenesis.Objective: This research demonstrates how nutmeg seed extract (NuSE) affects PGC1α and synaptophysin expression compared with DHA or docosahexanoieac acid, which has been evidenced to promote neurite growth.Methods: Twenty-four Wistar male rats aged eight weeks were divided into four groups (control, PGA group, NuSE group, and DHA group). The treatment group was administered for 12 weeks using a gavage. After that, the rats were sacrificed, and the hippocampus neurons were collected. The PGC1α and Synaptophysin mRNA expression was measured using semiquantitative reversed PCR, visualized with electrophoresis, and then quantified with ImageJ.Results: This study showed that NuSE increased synaptophysin and PGC1α mRNA expressions compared to the control group with significance statistic (p=0.017, p<0,05) in synaptophysin expression but did not increase PGC1α expression significantly (p=0.364, p>0,05).Conclusion: In conclusion, nutmeg seed extract (NuSE) impacts synaptogenesis in synaptophysin expression to modulate synaptic transmission.
Pemeriksaan Cea dan M2PK Sebagai Tes Skrining Pada Kanker Kolorektal Murti, Evivana Pranika; Najmi, Nuroh; Apriani, Apriani; Setyawati, Rina
Jurnal Analis Kesehatan Vol. 10 No. 1 (2021): JURNAL ANALIS KESEHATAN
Publisher : Department of Health Analyst, Politeknik Kesehatan, Kementerian Kesehatan Tanjungkarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jak.v10i1.2720

Abstract

Kanker memiliki ciri mempertahankan sinyal proliferatif, menghindari penekan pertumbuhan, terjadi invasi dan metastasis, menginduksi angiogenesis, memungkinkan replikatif yang immortal, dan melawan kematian sel. Kanker kolorektal (CRC) merupakan hubungan kompleks dari sel tumor, sel non-neoplastik, dan sejumlah besar mikroorganisme. Deteksi dini pada awal lesi dapat menurunkan mordibitas dan mortilitas keganasan, sehingga penting dilakukan skrining. Pemeriksaan CEA dan M2PK dapat dilakukan sebagai tes skrining yang dilakukan di laboratorium. Beberapa Laboratorium sering kali hanya melakukan 1 pemeriksaan saja seperti CEA tanpa M2PK. Penelitian ini bertujuan untuk mengetahui perbedaan antara pemeriksaan CEA dan M2PK sebagai tes skrining kanker kolorektal. Penelitian ini dilakukan menggunakan metode komparatif. Penelitian dilakukan pada bulan Maret-Mei 2020 di Laboratorium Multilab Rawamangun. Sampel penelitian berasal dari 30 orang subjek yang dipilih berdasarkan kriteria harus melakukan pemeriksaan CEA dan M2PK secara bersamaan. Hasil uji statistik menggunakan uji Mann-Whitney diperoleh hasil p value 0,000. Hasil analisa tersebut menujukkan adanya perbedaan yang signifikan antara pemeriksaan CEA dan M2PK sebagai diagnosis kanker kolorektal. Pemeriksaan CEA dan M2PK dapat digunakan sebagai tes skrining awal pada pemeriksaan kanker kolorektal.
Oral Candida Albicans Colonization In Denture Wearer: A Literature Review Febriane Balafif, Felisha; Rafisa, Anggun; Kuswandani, Faisal; Najmi, Nuroh
Jurnal EduHealth Vol. 15 No. 03 (2024): Jurnal EduHealt (September), Year 2024
Publisher : Sean Institute

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Abstract

Denture stomatitis is the most prevalent multifactorial, chronic inflammatory oral condition amongs denture wearers. One of the primary roles of dentures in denture stomatitis is their potential to cause irritation and inflammation of the oral tissues. This continuous irritation creates an environment where fungal infections, notably C. albicans. The traumatic factors such as mechanical trauma caused by loose prosthesis can increase the risk of tissue penetration and colonization of Candida species. This literature review aimed to explore the colonization of C. albicans in the denture wearer. The article was conducted of two databases and were limited to the period from 2019 to 2024 with a combination of the following keywords: “oral Candida albicans” "colonization" "denture wearer". The results obtained A total of 243 articles were initially identified through the designated keywords in PubMed and Google scholar. After meticulous removal of duplicate articles and application of the inclusion and exclusion criteria, 7 articles met the study’s eligibility criteria. C. albicans was the predominant species recovered from oral caviproty of both denture wearers and non-denture wearers. C. albicans can not only adhere to the oral mucosa but also can colonize the surface of the acrylic denture when it is poorly maintained. The presence of prosthetic appliances changes the microenvironment of the oral cavity through the facilitation of Candida colonization and proliferation. The biofilm on the denture can enhance its adhesion adding to its virulence. Wearing of a denture has been found to enhance adhesion of C. albicans.
Chemical And Physical Evaluation Of Herbal Artificial Saliva Formulations-Scoping Review kuswandani, Faisal; Febriane Balafif, Felisha; Najmi, Nuroh; Rafisa, Anggun
Jurnal EduHealth Vol. 15 No. 02 (2024): Jurnal eduHealt, Edition April - June , 2024
Publisher : Sean Institute

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Abstract

Saliva plays an important role in physiological function. Alteration in saliva production results in serious health problems that affect patient oral health-related quality of life (OHRQiL). the purpose of the research was to investigate the chemical and physical evaluation of natural artificial saliva formulations. Methods, the data synthesis protocol for a rapid review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocol (PRISMA-P). Electronic databases were searched on articles published in 2004- 2024. evaluating Chemical and physical properties of herbal artificial saliva formulations in preclinical study. Results, Identification from the Science Direct and PubMed databases obtained 332 scientific articles and 3 articles met inclusion criteria. Basella alba Linn. (Ceylon Spinach mucilage) shows non-Newtonian characteristic fluid, similar to normal human saliva. It has antioxidative activity, adhesion inhibition, and non-toxic. Propolis extract and Aloe vera extract showed minimal effect on viscoelastic properties but were still in the range of normal human saliva. Dioscorea batatas (Yam tuber mucilage) viscosity shows non-Newtonian characteristic fluid and antibacterial activity by influenced the enzymatic activity of lysozyme and peroxidase. Conclusion, Chemical and physiological evaluation shows that herbal plant extract has the potential to be used as an artificial saliva constituent. It had a viscosity in the range of normal human saliva with several advantages in terms of pharmacological activity.
Metabolic Disorders And Periodontal Disease: A Scoping Review Of Recent Studies Rafisa, Anggun; Febriane Balafif, Felisha; Najmi, Nuroh; Kuswandani, Faisal
Jurnal EduHealth Vol. 15 No. 02 (2024): Jurnal eduHealt, Edition April - June , 2024
Publisher : Sean Institute

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Abstract

The bidirectional relationship between periodontal disease and metabolic disorders is of particular concern, as these conditions may exacerbate each other through shared inflammatory pathways and metabolic disturbances. This scoping review aims to comprehensively explore the current body of literature on the interconnection between metabolic disorders and periodontal disease. A comprehensive literature search was conducted across databases, such as PubMed and Scopus. This review included studies that focusing on the relationship between metabolic disorders and periodontal disease, as well as articles written in English and published between 2019 and 2024. Non-peer-reviewed articles, articles that were not available in full text, and animal studies were excluded. A total 186 studies met the inclusion and exclusion criteria and were included in the review. Only 2.2% of the studies employed an experimental design, while a substantial majority (77.4%) utilized observational methodologies The majority of the research (72.0%) focused on adults, with a relatively small proportion (16.1%) dedicated to children and adolescents. Research focusing on specific populations, such as women with obesity or gestational diabetes, was limited (7.5%). This review identified a significant gap in intervention studies specifically targeting metabolic disorders to improve periodontal outcomes. Furthermore, it underscores the need for more focused research on vulnerable populations such as children, adolescents, and pregnant women.
SIRT1 As A Novel Therapeutic Target For Periodontitis: A Rapid Review kuswandani, Faisal; Febriane Balafif, Felisha; Najmi, Nuroh; Rafisa, Anggun
Jurnal EduHealth Vol. 15 No. 04 (2024): Jurnal EduHealt (inpres), Year 2024
Publisher : Sean Institute

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Abstract

SIRT1 plays a pivotal role in regulating a multitude of biological processes, including cellular metabolism, aging, DNA repair, inflammation, and oxidative stress. evidence suggesting a potential association between SIRT1 activity and periodontal health including periodontitis. This article aims to explore the immunobiological functions of SIRT1 in the initiation and progression of periodontitis. This comprehensive review utilized the PubMed and Cochrane Library databases to collate studies from December 2024 to December 2024. Arround 53 studies were screened and 5 studies were deemed suitable for analyses. Evidence based revealed that, SIRT1 levels elevated after periodontal treatment and its involvement in anti-inflammatory pathways suggest its beneficial role in managing periodontitis. Conclussion, clinical studies shows that SIRT1's potential as a biomarker and therapeutic target. Elevated SIRT1 levels after periodontal treatment and its involvement in anti-inflammatory pathways suggest its beneficial role in managing periodontitis. However, Prospective studies are necessary to deepen our understanding of their role in the pathophysiology of periodontitis and their potential clinical applications.
A Review Of IL-17 Relation With Microbiome In Metabolic Disorder Najmi, Nuroh; Kuswandani , Faisal; Rafisa, Anggun; Falisha Febriane Balafif
Jurnal EduHealth Vol. 15 No. 04 (2024): Jurnal EduHealt (inpres), Year 2024
Publisher : Sean Institute

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Abstract

The relationship between IL-17 and the microbiome remains an area requiring extensive research. IL-17, a pro-inflammatory cytokine, plays a crucial role in immune function, particularly in its interactions with the microbiome, especially within the intestinal digestive system. In metabolic diseases linked to inflammation, this connection underscores the importance of understanding cytokine activity and the microbiome's response within the body. In this literature review, three articles were retrieved from a single database, exploring the relationship between IL-17, metabolic diseases, and the microbiome.
Dietary Vitamin D in Periodontal Diseases: A Scoping Review of Interventions and Assessments Rafisa, Anggun; Balafif, Felisha Febriane; Najmi, Nuroh; Kuswandani, Faisal
Jurnal EduHealth Vol. 15 No. 04 (2024): Jurnal EduHealt (inpres), Year 2024
Publisher : Sean Institute

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Abstract

Vitamin D has gained significant attention for its potential role in periodontal health. This scoping review investigates the evidence on dietary vitamin D interventions and assessments in periodontal diseases, examining their impact on periodontal outcomes and identifying research gaps. Using the PRISMA for Scoping Reviews protocols, data were sourced from PubMed and Scopus, including studies focused on dietary vitamin D interventions in periodontal diseases. Exclusions were non-peer-reviewed articles, reviews, animal studies, and inaccessible full-text articles. A total of 22 studies were included: 11 experimental and 11 observational. Among experimental studies, vitamin D supplementation (n=7) was the most common intervention. Observational studies employed various dietary assessment methods, including 24-hour dietary recall (n=2), food frequency questionnaires (FFQ) (n=3), dietary supplement intake (n=3), and combined methods (n=3). Experimental findings suggest that vitamin D supplementation may enhance periodontal health, particularly when paired with non-surgical treatments. Mixed findings from observational studies and limited research on surgical contexts underscore the complexity of establishing definitive conclusions. These findings emphasize the need for standardized methodologies and further investigation to better understand the role of vitamin D in periodontal health.
Co-Authors Agus Rohmat Hidayat Anggun Rafisa Anis Setyowati APRIANI Apriani Apriani Bahjah, Firda Hanan Balafif, Felisa Febriane Balafif, Felisha Balafif, Felisha Febriane Faisal Kuswandani Falisha Febriane Balafif Febriane Balafif, Felisa Febriane Balafif, Felisha Fifi Veronica Hanna Goenawan Kuswandani , Faisal Murti, Evivana Pranika Otih Yuningsih Ronny Lesmana Setyawati, Rina