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Analisis Kadar Kalsium Saliva dan Hubungannya dengan Pembentukan Karang Gigi Kuswandani, Faisal
Indonesian Journal of Pharmaceutical Science and Technology Vol 3, No 1 (2016)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Kalsium dan fosfat di dalam saliva penting dalam proses remineralisasi email dan berperan juga dalam pembentukan karang gigi. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar kalsium saliva dengan pembentukan karang gigi. Sampel dilarutkan dalam larutan lanthanum (III) klorida konsentrasi tinggi yang berfungsi untukÂ mengikat ion-ion pengganggu. Kadar kalsium di dalam saliva dianalisis dengan Spektroskopi Serapan Atom Nyala. Hasil penelitian menunjukkan bahwa kadar kalsium saliva adalah 56,84 ppm sampai 121,91 ppm. Sampel dari kelompok studi memiliki kadar kalsium rata-rata 95,34 dan sampel dari kelompok pembanding memiliki kadar kalsium rata-rata 78,13 ppm. Dari hasil penelitian dapat disimpulkan bahwa sampel dari kelompok studi memiliki kadar kalsium lebih besar dari pada sampel dari kelompok pembanding, yang berarti bahwa semakin besar kadar kalsium dalam saliva akan semakin mudah seseorang terkena karang gigi.Â Kata kunci: Kalsium, karang gigi, saliva, spektroskopi serapan atom nyala

Antimicrobial Efficacy of Myrmecodia pendens Extract and Fraction Combination against Enterococcus faecalis ATCC 29212 Kuswandani, Faisal; Satari, Mieke H; Maskoen, Ani M
Journal of Dentistry Indonesia Vol. 26, No. 3
Publisher : UI Scholars Hub

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Enterococcus faecalis can withstand harsh environmental conditions in the root canal and cause a secondary infection. Myrmecodia pendens is an herbal medicine rich in polyphenol compounds that have antibacterial, antioxidant, and anticancer properties. Objectives: To analyze the effects of M. pendens fraction combination on the sensitivity of E. faecalis. Methods: The minimum inhibitory concentration (MIC) was determined using a serial microdilution method, and the minimum bactericidal concentration (MBC) was determined by adding the test sample to sterile Mueler Hinton agar medium. Results: The MIC of combination 1 (hexane-ethyl acetate, HE) was 0.049 mg/mL, whereas those of combinations 2 (hexane-water, HA) and 3 (ethyl acetate-water, EA) were 0.098 and 0.390 mg/ mL, respectively. The MIC of NaOCl was 0.390 mg/mL, and that of methanol extract was 0.390 mg/mL. The MBC of combination 1 (HE) was 12.50 mg/mL, whereas that of combinations 2 (HA) and 3 (EA) was 50 mg/mL. The MBC of NaOCl was 25 mg/mL and that of methanol extract was 50 mg/mL against E. faecalis. This study showed that fraction combinations increase the antibacterial effect of M. pendens against E. faecalis ATCC 29212. Conclusion: The HE fraction combination showed the best effect against E. faecalis and can be developed as an alternative endodontic irrigant

Analisis Kadar Kalsium Saliva dan Hubungannya dengan Pembentukan Karang Gigi Faisal Kuswandani
Indonesian Journal of Pharmaceutical Science and Technology Vol 3, No 1 (2016)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Kalsium dan fosfat di dalam saliva penting dalam proses remineralisasi email dan berperan juga dalam pembentukan karang gigi. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar kalsium saliva dengan pembentukan karang gigi. Sampel dilarutkan dalam larutan lanthanum (III) klorida konsentrasi tinggi yang berfungsi untuk mengikat ion-ion pengganggu. Kadar kalsium di dalam saliva dianalisis dengan Spektroskopi Serapan Atom Nyala. Hasil penelitian menunjukkan bahwa kadar kalsium saliva adalah 56,84 ppm sampai 121,91 ppm. Sampel dari kelompok studi memiliki kadar kalsium rata-rata 95,34 dan sampel dari kelompok pembanding memiliki kadar kalsium rata-rata 78,13 ppm. Dari hasil penelitian dapat disimpulkan bahwa sampel dari kelompok studi memiliki kadar kalsium lebih besar dari pada sampel dari kelompok pembanding, yang berarti bahwa semakin besar kadar kalsium dalam saliva akan semakin mudah seseorang terkena karang gigi. Kata kunci: Kalsium, karang gigi, saliva, spektroskopi serapan atom nyala

Pharmacy staffing and workload in RSGM Unpad using Workload Indicators of Staffing Needs (WISN) method Faisal Kuswandani; Dwintha Lestari; Felisha F. Balaﬁf
Indonesian Journal of Clinical Pharmacy Vol 10, No 3 (2021)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2021.10.3.198

Introduction : One of the challenges in the health facility is the balance between the number of staff and workloads to achieve quality, effectiveness and efficiency. Developing countries that have limited resources and budgets finds out difficult to achieve it. This study aims to analyze the workload at Pharmacy RSGM Unpad using the Workload Indicators of Staffing Needs (WISN) from the World Health Organization (WHO). Methodology: The study employed descriptive cross-sectional design and the Workload Indicator of Staffing Needs (WISN) methodology. Conducted in May 2020. We utilized observations, discussion and interviews to obtain information from staff; document review from hospital's records in 2019. Results : Available work time in a year were 97440 minutes. As a result, the staffing needed the Inpatient-outpatient department in Pharmacy RSGM Unpad were 4 people and in the logistic-purchasing department in Pharmacy RSGM Unpad were 2 people. The WISN ratio was obtained at 1.17 (> 1) which means the workload and number of staff at Pharmacy RSGM Unpad were not appropriate (overstaff). Conclusion : Based on the analysis using the WISN method, the number of staff in the Pharmacy RSGM Unpad is overstaff the existing workload. The Pharmacy RSGM Unpad can redistribute staff and develop pharmaceutical satellites to increase effectiveness and efficiency.

Oral Candida Albicans Colonization In Denture Wearer: A Literature Review Febriane Balafif, Felisha; Rafisa, Anggun; Kuswandani, Faisal; Najmi, Nuroh
Jurnal EduHealth Vol. 15 No. 03 (2024): Jurnal EduHealt (September), Year 2024
Publisher : Sean Institute

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Denture stomatitis is the most prevalent multifactorial, chronic inflammatory oral condition amongs denture wearers. One of the primary roles of dentures in denture stomatitis is their potential to cause irritation and inflammation of the oral tissues. This continuous irritation creates an environment where fungal infections, notably C. albicans. The traumatic factors such as mechanical trauma caused by loose prosthesis can increase the risk of tissue penetration and colonization of Candida species. This literature review aimed to explore the colonization of C. albicans in the denture wearer. The article was conducted of two databases and were limited to the period from 2019 to 2024 with a combination of the following keywords: “oral Candida albicans” "colonization" "denture wearer". The results obtained A total of 243 articles were initially identified through the designated keywords in PubMed and Google scholar. After meticulous removal of duplicate articles and application of the inclusion and exclusion criteria, 7 articles met the study’s eligibility criteria. C. albicans was the predominant species recovered from oral caviproty of both denture wearers and non-denture wearers. C. albicans can not only adhere to the oral mucosa but also can colonize the surface of the acrylic denture when it is poorly maintained. The presence of prosthetic appliances changes the microenvironment of the oral cavity through the facilitation of Candida colonization and proliferation. The biofilm on the denture can enhance its adhesion adding to its virulence. Wearing of a denture has been found to enhance adhesion of C. albicans.

Chemical And Physical Evaluation Of Herbal Artificial Saliva Formulations-Scoping Review kuswandani, Faisal; Febriane Balafif, Felisha; Najmi, Nuroh; Rafisa, Anggun
Jurnal EduHealth Vol. 15 No. 02 (2024): Jurnal eduHealt, Edition April - June , 2024
Publisher : Sean Institute

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Saliva plays an important role in physiological function. Alteration in saliva production results in serious health problems that affect patient oral health-related quality of life (OHRQiL). the purpose of the research was to investigate the chemical and physical evaluation of natural artificial saliva formulations. Methods, the data synthesis protocol for a rapid review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocol (PRISMA-P). Electronic databases were searched on articles published in 2004- 2024. evaluating Chemical and physical properties of herbal artificial saliva formulations in preclinical study. Results, Identification from the Science Direct and PubMed databases obtained 332 scientific articles and 3 articles met inclusion criteria. Basella alba Linn. (Ceylon Spinach mucilage) shows non-Newtonian characteristic fluid, similar to normal human saliva. It has antioxidative activity, adhesion inhibition, and non-toxic. Propolis extract and Aloe vera extract showed minimal effect on viscoelastic properties but were still in the range of normal human saliva. Dioscorea batatas (Yam tuber mucilage) viscosity shows non-Newtonian characteristic fluid and antibacterial activity by influenced the enzymatic activity of lysozyme and peroxidase. Conclusion, Chemical and physiological evaluation shows that herbal plant extract has the potential to be used as an artificial saliva constituent. It had a viscosity in the range of normal human saliva with several advantages in terms of pharmacological activity.

Metabolic Disorders And Periodontal Disease: A Scoping Review Of Recent Studies Rafisa, Anggun; Febriane Balafif, Felisha; Najmi, Nuroh; Kuswandani, Faisal
Jurnal EduHealth Vol. 15 No. 02 (2024): Jurnal eduHealt, Edition April - June , 2024
Publisher : Sean Institute

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The bidirectional relationship between periodontal disease and metabolic disorders is of particular concern, as these conditions may exacerbate each other through shared inflammatory pathways and metabolic disturbances. This scoping review aims to comprehensively explore the current body of literature on the interconnection between metabolic disorders and periodontal disease. A comprehensive literature search was conducted across databases, such as PubMed and Scopus. This review included studies that focusing on the relationship between metabolic disorders and periodontal disease, as well as articles written in English and published between 2019 and 2024. Non-peer-reviewed articles, articles that were not available in full text, and animal studies were excluded. A total 186 studies met the inclusion and exclusion criteria and were included in the review. Only 2.2% of the studies employed an experimental design, while a substantial majority (77.4%) utilized observational methodologies The majority of the research (72.0%) focused on adults, with a relatively small proportion (16.1%) dedicated to children and adolescents. Research focusing on specific populations, such as women with obesity or gestational diabetes, was limited (7.5%). This review identified a significant gap in intervention studies specifically targeting metabolic disorders to improve periodontal outcomes. Furthermore, it underscores the need for more focused research on vulnerable populations such as children, adolescents, and pregnant women.

SIRT1 As A Novel Therapeutic Target For Periodontitis: A Rapid Review kuswandani, Faisal; Febriane Balafif, Felisha; Najmi, Nuroh; Rafisa, Anggun
Jurnal EduHealth Vol. 15 No. 04 (2024): Jurnal EduHealt (inpres), Year 2024
Publisher : Sean Institute

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SIRT1 plays a pivotal role in regulating a multitude of biological processes, including cellular metabolism, aging, DNA repair, inflammation, and oxidative stress. evidence suggesting a potential association between SIRT1 activity and periodontal health including periodontitis. This article aims to explore the immunobiological functions of SIRT1 in the initiation and progression of periodontitis. This comprehensive review utilized the PubMed and Cochrane Library databases to collate studies from December 2024 to December 2024. Arround 53 studies were screened and 5 studies were deemed suitable for analyses. Evidence based revealed that, SIRT1 levels elevated after periodontal treatment and its involvement in anti-inflammatory pathways suggest its beneficial role in managing periodontitis. Conclussion, clinical studies shows that SIRT1's potential as a biomarker and therapeutic target. Elevated SIRT1 levels after periodontal treatment and its involvement in anti-inflammatory pathways suggest its beneficial role in managing periodontitis. However, Prospective studies are necessary to deepen our understanding of their role in the pathophysiology of periodontitis and their potential clinical applications.

Dietary Vitamin D in Periodontal Diseases: A Scoping Review of Interventions and Assessments Rafisa, Anggun; Balafif, Felisha Febriane; Najmi, Nuroh; Kuswandani, Faisal
Jurnal EduHealth Vol. 15 No. 04 (2024): Jurnal EduHealt (inpres), Year 2024
Publisher : Sean Institute

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Vitamin D has gained significant attention for its potential role in periodontal health. This scoping review investigates the evidence on dietary vitamin D interventions and assessments in periodontal diseases, examining their impact on periodontal outcomes and identifying research gaps. Using the PRISMA for Scoping Reviews protocols, data were sourced from PubMed and Scopus, including studies focused on dietary vitamin D interventions in periodontal diseases. Exclusions were non-peer-reviewed articles, reviews, animal studies, and inaccessible full-text articles. A total of 22 studies were included: 11 experimental and 11 observational. Among experimental studies, vitamin D supplementation (n=7) was the most common intervention. Observational studies employed various dietary assessment methods, including 24-hour dietary recall (n=2), food frequency questionnaires (FFQ) (n=3), dietary supplement intake (n=3), and combined methods (n=3). Experimental findings suggest that vitamin D supplementation may enhance periodontal health, particularly when paired with non-surgical treatments. Mixed findings from observational studies and limited research on surgical contexts underscore the complexity of establishing definitive conclusions. These findings emphasize the need for standardized methodologies and further investigation to better understand the role of vitamin D in periodontal health.

Plants for oral biofilms eradication: literature review Amatul Firdaustia PRATIWI; Hening Tjaturina PRAMESTI; Faisal KUSWANDANI
Journal of Syiah Kuala Dentistry Society Vol 6, No 2 (2021): December 2021
Publisher : Dentistry Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jds.v6i2.24193

ABSTRACT Oral Biofilm is a collection of microbial cell colonies related to periodontal diseases and caries. Biofilmbacteria were more resistant to antimicrobial agents than in the planktonic phase. The rapid progression of bacterialresistance to antimicrobial agents such as chlorhexidine has encouraged researchers to find alternative antimicrobialagents from natural plant products with low side effects. The purpose of this review was to summarize plants thatcontain bioactive compounds for biofilm eradication in terms of preventing caries and periodontal diseases. Themethod was used Systematic Review without Metha Analysis. Articles to be reviewed were searched from Pubmed,Cochrane, Science Direct, and Google Scholar databases using the PRISMA method and hand searching. The lastselected articles were analyzed using narrative analysis. There are 1,610 articles specified in the first stage and only18 articles left in the final extraction stage. Plants that contain bioactive compounds for oral biofilm eradicationinclude Piper betle (betel), Psidium sp., Mangifera sp., Mentha sp., Caesalpinia sappan (secang), Baccharis dracunculifolia,Laurus nobilis L. (dafnah), Croton nepetaefolius, Salvadora persica (miswak), Dryopteris crassirhizoma, Diospyros kakiThunb. (persimmon), Ginkgo biloba, Azadirachta indica (neem), Camellia sinensis, Lippia alba, Cymbopogon citratus(lemongrass), Citrus aurantifolius, Tamarindus indica (sour), Syzygium cumini (jamblang), Emblica officinalis (malacca),Acacia Arabica (prickly acacia), Terminalia chebula (myrobalan), Terminalia bellerica (bahera), Carica papaya, Ocimumbasilicum L. (basil), and Myrmercodia pendans. These plant bioactive compounds are belong to the group of alkaloids,terpenoids, and polyphenols which were tested in the form of single compounds or mixtures, especially againstStreptococcus mutans. In conclusion, 26 plant species have reported containing bioactive compounds tested in theform of single or mixed extracts to eradicate oral bacterial biofilm. KEYWORDS: Plants, eradication, natural products, oral biofilm

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