Article Per Year (5 Year)
p-Index From 2021 - 2026
0.659
P-Index
This Author published in this journals
All Journal Narra J JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Biomedicine and Clinical Sciences
Mawarti, Yuli
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
The profile of bacteria isolated from urine culture of adults with urinary tract infection in Yogyakarta 2007-2022 Aman, Abu Tholib; Nuryastuti, Titik; Aman, Alia Hanifa; Linda, Vitia Ajeng Nur; Mawarti, Yuli
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 3 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i3.15890

Abstract

Local data regarding antimicrobial susceptibility patterns of bacteria from urine culture is limited in Indonesia, particularly in Yogyakarta. This study was conducted to provide epidemiology data of bacteria and their resistance profile, including the profile of bacteria that producing extended-spectrum beta-lactamase (ESBL) and carbapenemase in the urine of patients with urinary tract infection (UTI) in Yogyakarta. A descriptive retrospective study was conducted by assessing laboratory records of urine culture from adult patients at the Microbiology Laboratory, Department of Microbiology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta between 2007 and 2022. Of the 842 urine cultures, 464 (55.11%) isolates were recovered. Among thisolates, 50 (10.78%) were fungi, 67 (14.44%) were Gram-positive bacteria, and 347 (74.78%) were Gram-negative bacteria. Enterococcus sp. (41 (61.19%)) was the most bacteria found in the Gram-positive bacteria group, while Escherichia coli (38.90%) were the most bacteria found in the Gram-negative bacteria group. This study also identified Gram-negative bacteria producing ESBL enzymes (58.70%) and carbapenemases (27.94%). Gram-negative bacteria are the most common bacteria found in urine cultures of adult UTI patients in Yogyakarta, and the resistance profile of these bacteria is concerning.
Efficacy of rotavirus vaccines in Indonesia: A review of genotype distribution and impact Aman, Abu T.; Patriani, Afifah; Mawarti, Yuli
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1681

Abstract

Rotavirus remains the leading cause of diarrhea among children under five years of age, with an incidence of 31.1–90.9% in Indonesia. Initially, a rotavirus vaccination program was introduced in several provinces of Indonesia in 2022, which would be conducted nationally. This review provides information on the rotavirus genotype distribution in Indonesia, efficacy and effectiveness data of the rotavirus vaccine, and an update on the status of rotavirus vaccine implementation worldwide. The results show a varied distribution of G and P genotypes from 1978 to 2018, with G1–G3, G9, P[4], P[6], and P[8] as the prevalent genotypes, followed by a small proportion of G4, P[9], P[10], and P[11]. Three rotavirus vaccines, which are prequalified by the World Health Organization (WHO) and available in Indonesia, showed an efficacy of 17.6–76.9% in high-mortality countries. The Indonesian government procured ROTAVAC with a G9P[11] genotype for the national immunization program, which showed 31.3–69.1% protective efficacy against severe gastroenteritis caused by other strains. This review suggested that the decision to choose the rotavirus vaccine for the national program should take into account the country’s prevalent circulating genotype and the vaccine’s efficacy against severe diarrhea. The use of a pentavalent rotavirus vaccine with high efficacy in high-mortality countries can be regarded as the prime choice for the program. Another alternative is the rotavirus vaccine, which showed efficacy data in multiple high-mortality countries. In addition, regular surveillance of the rotavirus genotypes and the clinical manifestations of diarrhea are necessary to design vaccination strategies in Indonesia.
Correlation between ciprofloxacin and levofloxacin susceptibility in beta-lactam- and carbapenem-resistant Escherichia coli isolated from UTI patients in Yogyakarta Aman, Abu Tholib; Nuryastuti, Titik; Rizmattu, Kezhiki Diaz Martha; Riyelly, Zelfia; Mahanani, Nabeilla Shouma; Putri, Natasya Salsabila; Kuncorojati, R. Alif; Aman, Alia Hanifa; Mawarti, Yuli
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 2, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss2.art7

Abstract

Background: Escherichia coli (E. coli) is a major cause of urinary tract infection (UTI). The emerging resistance of E. coli against beta-lactams and or carbapenem lead to the increased use of fluoroquinolone (ciprofloxacin or levofloxacin) in clinical practice. Data of E. coli susceptibility, particularly regarding the extended-spectrum beta lactamase (ESBL) expression and carbapenem or fluoroquinolone resistance can be important for clinical treatment.Objectives: This study aimed to describe the susceptibility profile of ESBL producing E. coli isolates, as well as their resistance against carbapenem and fluoroquinolone. In addition, the use of ciprofloxacin in predicting levofloxacin against the E. coli isolates was analyzed.Methods: A retrospective analytic study was conducted on 135 laboratory records of E. coli isolated from urine culture of adult patients at FMPHN UGM (2007-2022). Proportion of ESBL phenotype, as well as carbapenem, ciprofloxacin and levofloxacin resistance were calculated and augmented by kappa score and plots matrix analysis.Results: The ESBL producer E. coli as well as their resistances to carbapenem and ciprofloxacin were observed in 71(53.78%) of the 132 isolates, 23(17.04%), and 82(60.74%) of the 135 isolates respectively. Among 108 E. coli isolates which tested against both ciprofloxacin and levofloxacin, phenotypic ESBL resistances to carbapenem, ciprofloxacin and levofloxacin were identified in 56(52.33%), 21(19.44%), 80(74.07%), and 60(55.55%) respectively. The kappa score (κ=0.6222) and plots matrix showed the moderate agreement of ciprofloxacin to predict levofloxacin susceptibility against E. coli isolates.Conclusion: The E. coli resistances against beta-lactams, carbapenem, ciprofloxacin and levofloxacin were alarming. In addition, both ciprofloxacin and levofloxacin are needed to be regularly tested because ciprofloxacin susceptibility results cannot accurately predict levofloxacin susceptibility.
Co-Authors Abu Tholib Aman Aman, Abu T. Aman, Alia Hanifa Kuncorojati, R. Alif Linda, Vitia Ajeng Nur Mahanani, Nabeilla Shouma Patriani, Afifah Putri, Natasya Salsabila Riyelly, Zelfia Rizmattu, Kezhiki Diaz Martha Titik Nuryastuti