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All Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Biomedicine and Clinical Sciences
Aman, Alia Hanifa
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The profile of bacteria isolated from urine culture of adults with urinary tract infection in Yogyakarta 2007-2022 Aman, Abu Tholib; Nuryastuti, Titik; Aman, Alia Hanifa; Linda, Vitia Ajeng Nur; Mawarti, Yuli
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 3 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i3.15890

Abstract

Local data regarding antimicrobial susceptibility patterns of bacteria from urine culture is limited in Indonesia, particularly in Yogyakarta. This study was conducted to provide epidemiology data of bacteria and their resistance profile, including the profile of bacteria that producing extended-spectrum beta-lactamase (ESBL) and carbapenemase in the urine of patients with urinary tract infection (UTI) in Yogyakarta. A descriptive retrospective study was conducted by assessing laboratory records of urine culture from adult patients at the Microbiology Laboratory, Department of Microbiology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta between 2007 and 2022. Of the 842 urine cultures, 464 (55.11%) isolates were recovered. Among thisolates, 50 (10.78%) were fungi, 67 (14.44%) were Gram-positive bacteria, and 347 (74.78%) were Gram-negative bacteria. Enterococcus sp. (41 (61.19%)) was the most bacteria found in the Gram-positive bacteria group, while Escherichia coli (38.90%) were the most bacteria found in the Gram-negative bacteria group. This study also identified Gram-negative bacteria producing ESBL enzymes (58.70%) and carbapenemases (27.94%). Gram-negative bacteria are the most common bacteria found in urine cultures of adult UTI patients in Yogyakarta, and the resistance profile of these bacteria is concerning.
Correlation between ciprofloxacin and levofloxacin susceptibility in beta-lactam- and carbapenem-resistant Escherichia coli isolated from UTI patients in Yogyakarta Aman, Abu Tholib; Nuryastuti, Titik; Rizmattu, Kezhiki Diaz Martha; Riyelly, Zelfia; Mahanani, Nabeilla Shouma; Putri, Natasya Salsabila; Kuncorojati, R. Alif; Aman, Alia Hanifa; Mawarti, Yuli
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 2, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss2.art7

Abstract

Background: Escherichia coli (E. coli) is a major cause of urinary tract infection (UTI). The emerging resistance of E. coli against beta-lactams and or carbapenem lead to the increased use of fluoroquinolone (ciprofloxacin or levofloxacin) in clinical practice. Data of E. coli susceptibility, particularly regarding the extended-spectrum beta lactamase (ESBL) expression and carbapenem or fluoroquinolone resistance can be important for clinical treatment.Objectives: This study aimed to describe the susceptibility profile of ESBL producing E. coli isolates, as well as their resistance against carbapenem and fluoroquinolone. In addition, the use of ciprofloxacin in predicting levofloxacin against the E. coli isolates was analyzed.Methods: A retrospective analytic study was conducted on 135 laboratory records of E. coli isolated from urine culture of adult patients at FMPHN UGM (2007-2022). Proportion of ESBL phenotype, as well as carbapenem, ciprofloxacin and levofloxacin resistance were calculated and augmented by kappa score and plots matrix analysis.Results: The ESBL producer E. coli as well as their resistances to carbapenem and ciprofloxacin were observed in 71(53.78%) of the 132 isolates, 23(17.04%), and 82(60.74%) of the 135 isolates respectively. Among 108 E. coli isolates which tested against both ciprofloxacin and levofloxacin, phenotypic ESBL resistances to carbapenem, ciprofloxacin and levofloxacin were identified in 56(52.33%), 21(19.44%), 80(74.07%), and 60(55.55%) respectively. The kappa score (κ=0.6222) and plots matrix showed the moderate agreement of ciprofloxacin to predict levofloxacin susceptibility against E. coli isolates.Conclusion: The E. coli resistances against beta-lactams, carbapenem, ciprofloxacin and levofloxacin were alarming. In addition, both ciprofloxacin and levofloxacin are needed to be regularly tested because ciprofloxacin susceptibility results cannot accurately predict levofloxacin susceptibility.
Co-Authors Abu Tholib Aman Kuncorojati, R. Alif Linda, Vitia Ajeng Nur Mahanani, Nabeilla Shouma Mawarti, Yuli Putri, Natasya Salsabila Riyelly, Zelfia Rizmattu, Kezhiki Diaz Martha Titik Nuryastuti