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All Journal Paediatrica Indonesiana Jurnal Ilmu Medis Indonesia
Azizah, Nailul
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Laboratory and Clinical Manifestation Correlation of Neonatal Sepsis in Abdul Moeloek Hospital Ervina, Leni; Berawi, Khairunnisa; Busman, Hendri; Irawan, Bambang; Azizah, Nailul; Yolanda, Jennifer Ester
Jurnal Ilmu Medis Indonesia Vol. 4 No. 2 (2025): Maret
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/jimi.v4i2.4250

Abstract

Purpose: The prognosis of neonatal sepsis critically depends on early detection; however, its nonspecific clinical signs and variable laboratory findings often complicate the timely diagnosis. This study aimed to assess the correlation between clinical manifestations and laboratory results in neonatal sepsis cases, focusing on patients at Abdul Moeloek Hospital. Methodology/approach: A cross-sectional approach was used to analyze the medical records of neonates diagnosed with sepsis between January and June 2024. All neonates admitted to the neonatal unit with suspected sepsis during this period were included in the study. Results/findings: The majority of patients were male (65.1%) and 1 week old (58.7%). Hyperthermia (44.4%) was the most common symptom, followed by a normal heart rate (68.3%) and respiratory rate (81%). Most patients had normal hemoglobin (55.6%) and leukocyte levels (71.4%), low platelet counts (50.8%), and negative culture results (74.6%). Statistically significant correlations were found between heart rate (OR=0.4) and respiratory rate (OR=0.3) and laboratory findings (p<0.05), although the strength was weak to moderate. No significant correlation was observed with body temperature (p=0.412). Conclusions: Heart and respiratory rates were significantly associated with sepsis-related laboratory results, whereas body temperature was not. Most affected neonates were male, one week old, and presented with hyperthermia but otherwise normal vital signs and blood cell counts. Limitations: The limited sample size and study duration suggest the need for further research. Contribution: These findings provide insights into improving the early detection and management of neonatal sepsis, particularly in pediatric care settings in Indonesia.
Bacterial patterns and antibiotic sensitivity among neonatal sepsis patients in Dr. H. Abdul Moeloek Hospital, Lampung Ervina, Leni; Busman, Hendri; Berawi, Khairunnisa; Irawan, Bambang; Azizah, Nailul; Yolanda, Jennifer Ester
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.297-306

Abstract

Background Neonatal infections cause more than 550,000 deaths each year worldwide. Sepsis is a serious neonatal infection, defined as a severe form of infection that causes organ dysfunction. The incidence of neonatal sepsis in Dr. H. Abdul Moeloek Hospital, Lampung increased by 25% from 2017 to 2018 and by 30% from 2018 to 2019. Inappropriate use of antibiotics as therapy can lead to bacterial resistance to the medication. Understanding the most common bacterial patterns and using the guidance of antibiotic sensitivity tests can help health workers determine the empirical antibiotics needed to achieve optimal management, especially in neonatal sepsis patients. Objective To identify bacteria and their antibiotic sensitivity patterns in neonatal sepsis patients at Dr. H. Abdul Moeloek Hospital, Lampung between January and June 2024. Method  Descriptive study was conducted using medical record data from neonates suspected of having sepsis in Dr. H. Abdul Moeloek Hospital Lampung between January and June 2024. Blood culture data and antibiotic sensitivity testing was obtained from medical records. Results Of 65 blood culture of neonates suspected of having sepsis, 31 results were positive (47.6%). The most common microorganisms found were Klebsiella pneumoniae (23%), Burkholderia cepacia (19%), Acinetobacter baumannii (10%), Pseudomonas aeruginosa (10%), Enterococcus faecium (10%) Staphylococcus aureus (10%), Staphylococcus epidermidis (6%), Enterococcus faecalis (6%), Escherichia coli (3%), and Enterobacter cloacae (3%). Based on the sensitivity data calculated using weighted averages, ciprofloxacin (64.7%) and tigecycline (61.1%) showed highest sensitivity across more than five bacterial species. In contrast, ampicillin/sulbactam (96.0%), gentamicin (94.2%), and ceftriaxone (87.7%) had the highest resistance rates. Conclusion The most common bacteria causing neonatal sepsis were Klebsiella pneumoniae and Burkholderia cepacia. Among more than five bacterial species, the highest overall sensitivity was observed to ciprofloxacin and tigecycline, while the highest resistance rates were observed to ampicillin/sulbactam, gentamicin, and ceftriaxone.
Co-Authors Hendri Busman Khairun Nisa Leni Ervina, Leni RR. Ella Evrita Hestiandari Sembiring, Rinawati Yolanda, Jennifer Ester