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All Journal Jurnal Pendidikan Biologi Undiksha Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Medula Indonesian Journal of Urology Bioeksperimen: Jurnal Penelitian Biologi Jurnal Penelitian Pertanian Terapan Paediatrica Indonesiana Jurnal Biologi Tropis Manuju : Malahayati Nursing Journal Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Kesehatan Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Jurnal Ilmu Medis Indonesia AMMA : Jurnal Pengabdian Masyarakat Bioma : Jurnal Biologi dan Pembelajaran Biologi IJIS Edu : Indonesian Journal of Integrated Science Education
Hendri Busman
Jurusan Biologi Fakultas Matematika dan Ilmu Pengetahuan Universitas Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Comparison Between Amaryl and Nut Grass (Cyperus rotindus L.) Rhizome Extract on Blood Sugar Levels of Male Mice (Mus musculus L.) Induced by Alloxan Besty Prastiwy, Ayu Ayssca; Busman, Hendri; Nurcahyani, Nuning
Jurnal Penelitian Pertanian Terapan Vol 16, No 1 (2016)
Publisher : Politeknik Negeri Lampung.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (412.023 KB) | DOI: 10.25181/jppt.v16i1.69

Abstract

Nut grass rhizome contains several chemical compounds including aetheric oil, flavonoid, saponine, and antidiabetic agents, where as amaryl is a chemical medicine used to treat diabetes.  A study about the comparison between amaryl and nut grass rhizome extract on blood sugar levels of male mice has been conducted.  The study aimed to determine the effect of nut grass rhizome extract compared to amaryl in decreasing the blood sugar levels of male mice.  The mice were divided into four groups of treatment, each group consists of six mice.  The mice were intraperitoneally induced by alloxan to induce diabetes with the dosage of 0,15 mg/40 gr BB, using 0,9% of  NaCl as solvent, before being given the medicine.  Later, the mice were given amaryl and the nut grass rhizome extract, they were group 1 as control :  amaryl 0,4 mg/40 gr BW in 0,4 ml/100 ml of aqua bidest, group 2:  nut grass rhizome extract 4,5 mg/40 gr BB in 0,4 ml/100 ml of aqua bidest, group 3:  nut grass rhizome extract 45 mg/40 gr BB in 0,4 ml/100 ml of aqua bidest, group 4:  nut grass rhizome extract 135 mg/40 gr BB in 0,4 ml/100 ml of aqua bidest.  The result showed that the mice given nut grass rhizome extract with the dosage of 135 mg/40 g BW had significantly decreased blood sugar level compared to amaryl.  This was the effect of flavoniod compound in the nut grass rhizome extract which was rich in antioxidants so it could decrease the blood sugar levels of the diabetic mice.Key words:  amaryl, nut grass rhizome extract, intraperitoneal, flavonoid, anti oxidants, diabetes.
Ekstrak Ethanol Daun Sirsak (Annona Muricata) Berpotensi Memiliki Efek Kemoterapi pada Kanker Payudara Tikus Putih Kasban, Muhartono Sudarmo; Windarti, Indri; Busman, Hendri; S, Hendri Tarigan; DJ, Bayu Putra
Jurnal Kedokteran Brawijaya Vol 28, No 2 (2014)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (558.289 KB) | DOI: 10.21776/ub.jkb.2014.028.02.7

Abstract

Kanker payudara merupakan jenis kanker yang terbanyak di derita wanita dan memerlukan kemoterapi berbiaya tinggi dengan efek samping yang banyak. Daun sirsak (Annona muricata) mengandung senyawa asetogenin bersifat sitotoksik terhadap sel kanker. Penelitian ini bertujuan untuk mengetahui efek kemoterapi daun sirsak pada kanker payudara tikus. Penelitian ini merupakan penelitian eksperimental yang dilakukan di Laboratorium Patologi Anatomi FK Unila pada bulan Mei-September 2013 dengan menggunakan 25 ekor tikus betina  Sprague Dawley yang dibagi dalam 5 kelompok, yaitu Kelompok I, kontrol negatif; kelompok II, diberikan 75mg/kg BB DMBA, kelompok III diberikan 75mg/kg BB DMBA+ekstrak daun sirsak 100mg/kgBB, kelompok III, 75mg/kg BB DMBA + ekstrak daun sirsak 200mg/kgBB, 75mg/kg BB DMBA+ekstrak daun sirsak III 400mg/kgBB. Ekstrak daun sirsak diberikan selama 4 minggu. Dilakukan pemeriksaan histopatologi untuk menilai apoptosis yang terjadi setelah pemberian daun sirsak. Hasil dianalisis menggunakan uji Kruskall Wallis dan uji Man Whitney. Pemberian ekstrak etanol daun sirsak dapat memicu kejadian apoptosis pada KIII, KIV, KV sebesar 2,5%, 3,44%, dan 3,56% lebih tinggi dari kejadian apoptosis kelompok kontrol positif sebesar 1,80% (p<0,05). Dapat disimpulkan ekstrak etanol daun sirsak berpotensi memiliki efek kemoterapi pada kanker payudara tikus putih yang diinduksi DMBA.Kata Kunci: Ekstrak daun sirsak, efek kemoterapi, DMBA, kanker payudara
Peningkatan Ketebalan Miokardium Mencit (Mus musculus L.) Akibat Paparan Medan Listrik Tegangan Tinggi Busman, Hendri; Muhartono, Muhartono
Majalah Kedokteran Bandung Vol 45, No 3 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1324.403 KB)

Abstract

Pembangunan saluran transmisi listrik tegangan tinggi diduga dapat merugikan manusia atau makhluk hidup lain. Tujuan penelitian untuk mengetahui pengaruh paparan medan listrik tegangan tinggi pada ketebalan miokardium ventrikel kiri mencit jantan (Mus musculus L.). Penelitian dilaksanakan di Laboratorium Zoologi Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Lampung serta Laboratorium Patologi Balai Penyidikan dan Pengujian Veteriner Regional III Bandar Lampung, pada bulan Juni−November 2011.Penelitian menggunakan rancangan acak lengkap dengan 4 perlakuan, ulangan 6 kali, dan dibagi dalam empat kelompok. Kelompok kontrol (K) tidak diberi perlakuan, kelompok 1 (P1) diberi paparan 5 kV/m, kelompok 2 (P2) diberi paparan 6 kV/m, dan kelompok 3 (P3) diberi paparan 7 kV/m, masing-masing 8 jam/hari selama 37 hari. Data dianalisis menggunakan analysis of variance. Hasil penelitian didapatkan ketebalan miokardium ventrikel kiri mencit jantan pada K sebesar 1.329,83±173,29 μm; P1 sebesar 1.507,50±109,24 μm; P2 sebesar 1.536,70±103.42 μm; dan P3 sebesar 1.574.23±123,36 μm. Terdapat peningkatan ketebalan miokardium rata-rata dengan bertambahnya daya paparan medan listrik (p=0,019). Simpulan, terdapat hubungan antara paparan medan listrik tegangan tinggi dan perubahan ukuran ketebalan miokardium ventrikel kiri mencit jantan, semakin tinggi paparan medan listrik semakin tebal miokardium ventrikel kiri mencit jantan. [MKB. 2013;45(3):155–60] Increased Thickness Myocardium Mice (Mus musculus L.) Caused by Exposure to High Voltage Electric FieldDevelopment of high voltage power transmission line could be expected to harm humans or other living creatures. Research objective was to determine the effect of exposure tohigh-voltage electric field to the thickness of the left ventricular myocardium male mice (Mus musculus L.). The experiment was conducted at the Laboratory of Zoology Faculty of Mathematics and Natural Sciencesat the University of Lampung and Central Pathology Laboratory Regional Veterinary Investigation III Bandar Lampung, in June−November 2011. Research using completely randomized design with 4 treatments, replicated 6 times and divided into four groups.The control group (K) was not given treatment, group 1 (P1) given exposure to 5 kV/m, group 2 (P2) given exposure to 6 kV/m and group 3 (P3) given exposure to 7 kV/m for 8 hours/day, to 37 days. Data were analyzed using analysis of variance. The results obtained thickness of the left ventricular myocardium of male mice at K1,329.83±173.29 μm; P1 at 1,507.50±109.24 μm; P2 at 1,536.70±103.42 μm, and P3 at 1,574.23±123.36 μm. There was an increase in the average thickness of the myocardium with increasing exposure to power an electric field with a statistical test obtained (p=0.019). In conclusion, there is a significant relationship between exposure to high-voltage electric field to change the size of the thickness of the left ventricular myocardium male mice, the higher the electric field exposure thicker left ventricular myocardium male mice. [MKB. 2013;45(3):155–60] DOI: http://dx.doi.org/10.15395/mkb.v45n3.145
Uji Potensi Tepung Daun Kelor (Moringa oleifera) Sebagai Anthelmintik Terhadap Ascaridia galli pada Ayam Petelur (Gallus domesticus) Utami, Hanifa Fauzia; Rosa, Emantis; Pratami, Gina Dania; Busman, Hendri
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 8, No 3 (2023): October 2023
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v8i3.6475

Abstract

Dalam menjalankan usaha peternakan unggas, para peternak tak lepas dari hambatan dan masalah yang harus dihadapi, salah satunya adalah penyakit yang menyerang unggas. Ascaridia galli merupakan nematoda parasitik yang sering ditemukan pada unggas. Penanggulangan cacing oleh peternak dapat dilakukan dengan pemberian anthelmintik dari bahan-bahan kimiawi atau anthelmintik sintetik. Namun, penggunaan anthelmintik sintetik dalam jangka panjang dapat mengakibatkan resistensi terhadap cacing dan meninggalkan residu pada daging serta telur. Oleh karena itu, disarankan menggunakan bahan alami. Tujuan penelitian ini yaitu mengetahui potensi tepung daun kelor dan efektivitasnya sebagai anthelmintik terhadap A. galli. Perlakuan pemberian tepung daun kelor dilakukan dengan cara dicampurkan pada pakan dengan 4 dosis berbeda selama 14 hari. Data jumlah telur cacing dalam Egg Per Gram (EPG) kemudian dianalisis secara statistik menggunakan uji ANOVA dan didapatkan perbedaan yang signifikan, maka selanjutnya dilakukan uji Duncan. Hasil penelitian menunjukkan bahwa tepung daun kelor berpotensi sebagai anthelmintik terhadap cacing A. galli karena mampu mereduksi nilai EPG sebelum perlakuan. Dosis efektif pemberian tepung daun kelor yakni terdapat pada dosis 20% dari 120 kg pakan namun belum mampu mencapai standar efektivitas (≥ 95 %).  
Pengaruh Ekstrak Etanol Daun Rhizophora apiculata terhadap Kolesterol Total dan Trigliserida Rattus norvegicus Galur Sprague dawley yang Diinduksi Diet Tinggi Lemak Mustofa, Syazili; Adli, Farhan Kamali; Wardani, Dyah Wulan Sumekar Rengganis; Busman, Hendri
Jurnal Kesehatan Vol 13 No 3 (2022): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v13i3.3178

Abstract

Dyslipidemia is a lipid metabolism disorder in the form of an increase and decrease in the lipid fraction which is one of the high-risk factors for coronary heart disease and other non-communicable diseases. Rhizophora apiculata contains secondary metabolites in the form of flavonoid, tannin, alkaloid, saponin, and terpenoid which are thought to have the effect of preventing an increase in total cholesterol and triglyceride. This research is an experimental study with a posttest-only control group design carried out for 30 days using 30 experimental animals of Rattus norvegicus Sprague Dawley. There were 6 treatment groups, KN which was only given standard feed, K+ which was given quail egg yolk induction, simvastatin 10 mg/day, and K- which was given quail egg yolk induction. On the other hand, P1, P2, and P3 were given quail egg yolk induction, respectively. and leaf extract of Rhizophora apiculata with doses of 56mg/KgBW,m28mg/KgBW, and 14mg/KgBW. Then the rats were terminated using ketamine xylazine and blood was taken through the heart to be examined for total cholesterol and triglyceride using spectrophotometry. The results of the normality Shapiro-Wilk and Levene test p-value>0.05. In the One-way Anova test, cholesterol levels were 0.006 and triglyceride 0,002 (p-value
Review Artikel : Aktifitas Hepatoprotektor Pada Tanaman Herbal Hanifah, Farah; Busman, Hendri
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1087

Abstract

The liver plays a vital role in the human body, serving as a site for the metabolism of fats, carbohydrates, and proteins, as well as detoxification of toxic compounds, bile salt formation, and vascular function. Liver damage can be caused by various factors, including drugs, infections, alcohol, autoimmune disorders, or hepatitis. Substances that induce liver damage are known as hepatotoxins, commonly including NSAIDs like paracetamol and carbon tetrachloride (CCl4). Chronic hepatitis is a significant global issue, including in Indonesia, with hepatitis B and hepatitis C viruses being the most common causes. Herbal medicine is increasingly being used for health benefits worldwide, contributing significantly to human health in preventive, curative, and rehabilitative aspects. Indonesia, rich in biodiversity, presents numerous opportunities for plants with potential hepatoprotective properties. Various herbal plants containing flavonoid compounds have been found to possess anti- inflammatory and antioxidant properties. These bioactive compounds, particularly flavonoid derivatives, act as potential antioxidant prophylactic agents, crucial in protecting against liver lesions induced by CCl4. Reactive oxygen species (ROS) are believed to be responsible for the pathogenesis of various liver diseases, and studies have shown the efficacy of herbal extracts in reducing ROS levels and lipid peroxidation in ethanol-induced liver damage. Several herbal plants exhibit hepatoprotective activities, including turmeric, bee pollen honey, cinnamon, eclipta alba, Tinospora cordifolia, Mimosa pudica, and Cassia fistula L. These plants have shown effects such as antioxidant, anti-inflammatory, and antiviral properties, contributing to the protection and regeneration of liver cells, inhibition of viral replication, and modulation of immune responses. In conclusion, numerous herbal plants exhibit hepatoprotective activities through various mechanisms, including antioxidant, anti-inflammatory, antiviral, and immunomodulatory effects. Further research and exploration of these plants' therapeutic potential could lead to the development of effective treatments for liver diseases.
Phosphatidylserine Exposure in Thalassemia Β Patients Sangging, Putu Ristyaning Ayu; Sutyarso, Sutyarso; Busman, Hendri
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1162

Abstract

Thalassemia is a genetic disorder that involves the formation of abnormal hemoglobin. Thalassemia is divided into two main categories namely alpha and beta thalassemia depending on the hemoglobin chain affected. Although some categories of thalassemia are mild and cause only mild anemia and iron deficiency problems in patients, other, more severe forms of thalassemia can result in death. Thalassemia sufferers can get treatment according to the severity of the condition. The degree of ineffective erythropoiesis is known to be associated with clinical severity in individuals with thalassemia. However, the association of ineffective erythropoiesis biomarker levels with different thalassemia genotypes is limited. Studies have explored levels of red blood cells exposed to phosphatidylserine and ineffective erythropoiesis biomarkers in patients with different genotypes. Based on the results of the review, beta thalassemia patients have the highest GDF-15 levels, followed by patients with non-deletal alpha thalassemia. Patients with non-delesional alpha thalassemia showed elevated hemoglobin levels and decreased GDF-15 levels after splenectomy. Patients with beta thalassemia and non-delesional alpha thalassemia had the highest levels of red blood cell exposure to PS and ineffective erythropoiesis biomarkers, which correlated with the clinical severity of thalassemia. Differences in erythropoiesis rates are not effective in thalassemia, which emphasizes the need for different treatment approaches in patients with different thalassemia genotypes.
Pengaruh Tinta Cumi-Cumi (Loligo sp.) Terhadap Kualitas dan Kuantitas Spermatozoa Mencit (Mus musculus L.) yang Diinduksi D-Galaktosa Safitri, Dewi Restika Ayu; Sutyarso, Sutyarso; Busman, Hendri; Nurcahyani, Nuning
Jurnal Pendidikan Biologi Undiksha Vol. 10 No. 3 (2023)
Publisher : Undiksha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/jjpb.v10i3.69718

Abstract

Increased levels of free radicals in the body are thought to trigger oxidative stress and cause aging. Biologists state that aging is one of the causes of infertility in men. Squid ink is known to have high antioxidant activity so that it can be used as an alternative treatment. Therefore, this study was conducted with the aim of knowing the effect of inking squid on the quality and quantity of male individual spermatozoa, which included sperm count, motility, and viability of the spermatozoa of mice experiencing oxidative stress due to D-Galactose induction. This research was conducted experimentally in December 2022 – March 2023 where 24 male mice were divided into 4 groups, namely K, K- (D-Gal 150 mg/kgBB), P1 (D-Gal 150 mg/kgBB + squid ink 40 mL/kgBB), and P2 (D-Gal 150 mg/kgBB + squid ink 100 mL/kgBB). The results showed that squid ink was able to increase the quality and quantity (sperm count, motility, and viability) of mice spermatozoa which had previously decreased due to D-Galactose induction, where the best results for each parameter were shown by P2.
Size Shortening of Body Parts of Fetus Mice (Mus musculus L.) After Giving Bitter Melon Fruit Extract (Momordica charantia L.) Andriani, Silvia; Nurcahyani, Nuning; Busman, Hendri; Sutyarso; Kurniawaty, Evi; Sahroni, Mizan; Puspa, Egita Windrianatama
Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Vol. 10 No. 2 (2023)
Publisher : Department of Biology Faculty of Mathematics and Natural Sciences Universitas Lampung in collaboration with The Indonesian Association of Biology (PBI) Lampung Branch.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jbekh.v10i2.298

Abstract

Bitter melon (Momordica charantia L.) is a plant that has traditional medicinal properties. In bitter melon fruit, there are several toxic compounds, namely momordicoside K and L, which are thought to have cytotoxic properties. This study aims to determine the teratogenic effect of bitter melon fruit extract given to pregnant females on the length of the fetus' cranium and sternum. Bitter melon fruit extraction was carried out using the maceration method using 95% ethanol. By using a completely randomized design 20 male mice and 20 female mice were divided into 4 groups. Each group consisting of 5 pregnant female mice was given bitter melon extract orally starting from day 6 to day 17 of pregnancy once a day in the morning with a treatment dose of aquabidest as a control [A], [B] 22.5 mg/30 gr BW, [C] 30 mg/30 gr BW, and [D] 37.5 mg/30 gr BW. Next, the female mice were dissected, the fetus was removed and the length of the cranium and the length of the sternum were measured. The results showed that in general, the administration of bitter melon fruit extract caused a decrease in the average length of the cranium and sternum. The results of the further analysis with the Least Significant Difference (LSD) at the 5% level showed that administering doses of [B], [C], and [D] had a significant effect on reducing the length of the cranium and sternum. The most effective dose to reduce the length of the cranium and sternum of fetal mice is 37.5 mg/30 g BW
Penggunaan Aerated Compost Tea Dari Bahan Kompos Seresah Untuk Nutrisi Dan Perlindungan Tanaman Farisi, Salman; Irawan, Bambang; Suratman; Busman, Hendri
AMMA : Jurnal Pengabdian Masyarakat Vol. 3 No. 7 : Agustus (2024): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

One product of composting technology that also growing rapidly is the manufacture of compost tea (CT). CT is an oxygenated compost water extract obtained through aeration in the liquid phase. The process of making CT with this method is called Aerated Compost Tea (ACT). ACT is a compost water extract containing dissolved nutrients and growth hormones. In addition to functioning as a source of nutrients, ACT can also improve the soil ecosystem for the growth of decomposing microbes that can support soil fertility, improve soil physical and biological properties, improve microbial activity, and can also increase plant resistance to pathogens. ACT provides dissolved nutrients that are more quickly absorbed by plants and at the same time provides biopesticides to prevent or inhibit infection by pathogens that cause plant diseases. This Community Service activity is the development of science and technology from the results of research that has been carried out. The results of Community Service show quite good results, namely there is an increase of about 33.35% from the initial understanding. This is quite interesting because the initial understanding of ACT was low, at level of 60.54. The explanation given by the Community Service team, able to be understood by the target audience well so that their understanding increased to 78.02.
Co-Authors Adli, Farhan Kamali Alqoriani A, Ostarica Ananta, Yoga Andriani, Silvia Angelia, Tisa Arofah, Nur Lailatul Ayu Ayssca Besty Prastiwy, Ayu Ayssca Azizah, Nailul Bayu Putra DJ Dyah Wulan Sumekar Rengganis Wardani Endah Setyaningrum, Endah Endang Nurcahyani Ernawiati, Eti Farisi, Salman Gina Dania Pratami, Gina Dania Ginting, Bisart Giska Tri Putri Hadibrata, Exsa Hanifah, Farah Hendri Tarigan S Indri Windarti Indriyani Indriyani Indriyani Intanri Kurniati Iswandi Darwis Jausal, Anisa Nuraisa Justisia, Adilla Karina, Salwa Al Khairun Nisa Kurniawaty, Evi Kurniawaty, Evi Kurniawaty Leni Ervina, Leni Muhammad Ilyas Muhartono Muhartono Muhartono Sudarmo Kasban Mumtazah, Dzul Fithria NA, Ahmad Mufid Nuning Nurcahyani Nursidiq, Iqbal Muhammad Rafi Puspa, Egita Windrianatama Putri, Lolyta Mutiara Rahmanisa, Soraya Rahmanisa Ramdini, Dwi Aulia Rosa, Emantis RR. Ella Evrita Hestiandari Safitri, Dewi Restika Ayu Sahroni, Mizan Sangging, Putu Ristyaning Ayu Sarasati, Filia Sembiring, Rinawati Septiani, Linda suratman Susanto, Gregorius Nugroho Susianti Susianti, Susianti Sutyarso Sutyarso Sutyarso Syakir, Muhammad Addin Syarif, Muhammad Reza Syazili Mustofa Tengku Riza Zarzani N Utami, Hanifa Fauzia Yolanda, Jennifer Ester Yulianty Yuningrum, Hesti