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All Journal Paediatrica Indonesiana Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal JURNAL PENELITIAN PERAWAT PROFESIONAL Jurnal Ilmu Medis Indonesia
Leni Ervina, Leni
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Faktor Risiko Infeksi pada Ibu terhadap Kejadian Sepsis pada Bayi Baru Lahir Ervina, Leni; Haq, Faisal; Gigaramadan, Sema; Eka, Yusnita; Tiara, Nanda
Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Vol 15 No 1 (2025): Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal: Januari 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Kendal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32583/pskm.v15i1.3197

Abstract

Sepsis pada bayi baru lahir terjadi sekitar 1,3 juta kasus di seluruh dunia dan merupakan penyebab utama ketiga kematian neonatal setiap tahun. Tujuan penelitian ini untuk menganalisis faktor ibu yang berhubungan dengan kejadian sepsis pada bayi. Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross-sectional. Penelitian dilakukan di RSUD Abdul Moeloek Provinsi Lampung periode bulan Januari-Juni 2024. Populasi dalam penelitian ini adalah semua rekam medik ibu yang melahirkan. Teknik sampel yang digunakan adalah simple random sampling, dengan jumlah sampel sebanyak 47 orang. Instrumen yang digunakan adalah rekam medis. Variabel independen meliputi usia ibu, paritas, ketuban pecah dini, metode persalinan, usia gestasi, suhu, laju endap darah dan kadar leukosit. Sedangkan variabel dengan dependennya adalah kejadian sepsis pada bayi baru lahir. Pengumpulan data dilakukan dengan menyalin masing-masing variabel pada lembar catatan. Pengolahan data meliputi editing, coding, tabulating dan cleaning. Analisis data mencakup analisis univariat (persentase) dan bivariat (uji Chi-Square). Analisis mendapatkan bahwa sebagian besar ibu adalah bayi yang tidak sepsis (55,3%), usia ibu tidak berisiko (72,3%), primipara (68,1%), tidak KPD (68,1%), persalinan pervaginam (53,2%), usia gestasi very preterm (44,7%), suhu tinggi (72,3%), laju endap darah normal (85,1%) dan leukosit rendah (55,3%). Tidak ada hubungan antara usia ibu, paritas, ketuban pecah dini, metode persalinan, usia gestasi, suhu dan laju endap darah. Ada hubungan leukosit dengan sepsis pada bayi di rumah sakit Abdul Moeleok Provinsi Lampung.
Laboratory and Clinical Manifestation Correlation of Neonatal Sepsis in Abdul Moeloek Hospital Ervina, Leni; Berawi, Khairunnisa; Busman, Hendri; Irawan, Bambang; Azizah, Nailul; Yolanda, Jennifer Ester
Jurnal Ilmu Medis Indonesia Vol. 4 No. 2 (2025): Maret
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/jimi.v4i2.4250

Abstract

Purpose: The prognosis of neonatal sepsis critically depends on early detection; however, its nonspecific clinical signs and variable laboratory findings often complicate the timely diagnosis. This study aimed to assess the correlation between clinical manifestations and laboratory results in neonatal sepsis cases, focusing on patients at Abdul Moeloek Hospital. Methodology/approach: A cross-sectional approach was used to analyze the medical records of neonates diagnosed with sepsis between January and June 2024. All neonates admitted to the neonatal unit with suspected sepsis during this period were included in the study. Results/findings: The majority of patients were male (65.1%) and 1 week old (58.7%). Hyperthermia (44.4%) was the most common symptom, followed by a normal heart rate (68.3%) and respiratory rate (81%). Most patients had normal hemoglobin (55.6%) and leukocyte levels (71.4%), low platelet counts (50.8%), and negative culture results (74.6%). Statistically significant correlations were found between heart rate (OR=0.4) and respiratory rate (OR=0.3) and laboratory findings (p<0.05), although the strength was weak to moderate. No significant correlation was observed with body temperature (p=0.412). Conclusions: Heart and respiratory rates were significantly associated with sepsis-related laboratory results, whereas body temperature was not. Most affected neonates were male, one week old, and presented with hyperthermia but otherwise normal vital signs and blood cell counts. Limitations: The limited sample size and study duration suggest the need for further research. Contribution: These findings provide insights into improving the early detection and management of neonatal sepsis, particularly in pediatric care settings in Indonesia.
Bacterial patterns and antibiotic sensitivity among neonatal sepsis patients in Dr. H. Abdul Moeloek Hospital, Lampung Ervina, Leni; Busman, Hendri; Berawi, Khairunnisa; Irawan, Bambang; Azizah, Nailul; Yolanda, Jennifer Ester
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.297-306

Abstract

Background Neonatal infections cause more than 550,000 deaths each year worldwide. Sepsis is a serious neonatal infection, defined as a severe form of infection that causes organ dysfunction. The incidence of neonatal sepsis in Dr. H. Abdul Moeloek Hospital, Lampung increased by 25% from 2017 to 2018 and by 30% from 2018 to 2019. Inappropriate use of antibiotics as therapy can lead to bacterial resistance to the medication. Understanding the most common bacterial patterns and using the guidance of antibiotic sensitivity tests can help health workers determine the empirical antibiotics needed to achieve optimal management, especially in neonatal sepsis patients. Objective To identify bacteria and their antibiotic sensitivity patterns in neonatal sepsis patients at Dr. H. Abdul Moeloek Hospital, Lampung between January and June 2024. Method  Descriptive study was conducted using medical record data from neonates suspected of having sepsis in Dr. H. Abdul Moeloek Hospital Lampung between January and June 2024. Blood culture data and antibiotic sensitivity testing was obtained from medical records. Results Of 65 blood culture of neonates suspected of having sepsis, 31 results were positive (47.6%). The most common microorganisms found were Klebsiella pneumoniae (23%), Burkholderia cepacia (19%), Acinetobacter baumannii (10%), Pseudomonas aeruginosa (10%), Enterococcus faecium (10%) Staphylococcus aureus (10%), Staphylococcus epidermidis (6%), Enterococcus faecalis (6%), Escherichia coli (3%), and Enterobacter cloacae (3%). Based on the sensitivity data calculated using weighted averages, ciprofloxacin (64.7%) and tigecycline (61.1%) showed highest sensitivity across more than five bacterial species. In contrast, ampicillin/sulbactam (96.0%), gentamicin (94.2%), and ceftriaxone (87.7%) had the highest resistance rates. Conclusion The most common bacteria causing neonatal sepsis were Klebsiella pneumoniae and Burkholderia cepacia. Among more than five bacterial species, the highest overall sensitivity was observed to ciprofloxacin and tigecycline, while the highest resistance rates were observed to ampicillin/sulbactam, gentamicin, and ceftriaxone.
Korelasi Laboratorium dan Klinis dengan Sepsis Neonatal Ervina, Leni; Tirzaningrum1, Amalia; Naufal, Arif; Julianti, Dinul Aliya; Fernanda, Marcella Dena
Jurnal Penelitian Perawat Profesional Vol 6 No 6 (2024): Desember 2024, Jurnal Penelitian Perawat Profesional
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jppp.v6i6.4840

Abstract

Sepsis neonatorum merupakan kondisi yang berkontribusi signifikan terhadap morbiditas dan mortalitas pada neonatus. Diagnosis yang akurat dan tepat waktu penting untuk pengobatan yang efektif dan lebih baik. Keandalan diagnosis klinis memerlukan konfirmasi uji laboratorium. Penelitian ini bertujuan untuk mengevaluasi kesesuaian antara hasil laboratorium dan diagnosis klinis sepsis neonatorum. Metode penelitian menggunakan metode cross-sectional, data penelitian menggunakan rekam medis pasien sepsis neonatorum periode Januari-Juni 2024. Metode pengambilan sampel adalah total sampling. Sebagian besar pasien berusia 1 minggu (58,7%) dan laki-laki (65,1%). Sebagian besar pasien mengalami hipertermia (44,4%) dan denyut jantung normal (68,3%). Laju pernapasan pada sebagian besar pasien juga normal (81%). Kadar hemoglobin pada sebagian besar pasien berada dalam rentang normal (55,6%), kadar hematokrit yang hampir seimbang antara rendah (50,8%) dan normal (49,2%). Sebagian besar pasien memiliki kadar leukosit normal (71,4%) dan trombosit rendah (50,8%). Hasil kultur menunjukkan sebagian besar pasien negatif (74,6%). Analisis bivariat hasil laboratorium dan suhu dengan p-value 0,412. Hasil laboratorium dengan denyut jantung memiliki p-value 0,000 dan laju pernapasan dengan hasil laboratorium memperoleh p-value 0,004.
Co-Authors Azizah, Nailul Eka, Yusnita Fernanda, Marcella Dena Gigaramadan, Sema Haq, Faisal Hendri Busman Julianti, Dinul Aliya Khairun Nisa Naufal, Arif RR. Ella Evrita Hestiandari Sembiring, Rinawati Tiara, Nanda Tirzaningrum1, Amalia Yolanda, Jennifer Ester