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All Journal Journal of Community Empowerment for Health Camellia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Warsito, Gita Miranda
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Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Antimicrobial Activity and Molecular Docking of Benzoyl-N,N’-dialkylurea against Target Proteins in Microbial Cells Diyah, Nuzul Wahyuning; Warsito, Gita Miranda; Isnaeni; Hidayati, Shabrina Wahyu
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 2 No 2 (2023): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v2i2.20903

Abstract

This research aims to evaluate the antimicrobial activity of benzoyl dialkylurea derivatives to meet the global need for new antibiotic lead compounds. Four compounds were tested in vitro against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans by broth dilution method using ciprofloxacin and nystatin as standards. Docking simulations were performed to target essential proteins including DNA gyrase, FabH, RNA polymerase in bacterial cells and DHFR in C. albicans. BDMU, BEU1, BEU2, BEU3 exhibited antibacterial activity while BEU1 and BEU2 showed weak antifungal activity against C. albicans. The BDMU, BEU2, BEU3 considered promising growth inhibition against P. aeruginosa. In silico molecular docking on DNA gyrase from P. aeruginosa (PDB. 6M1S) was proposed as a model for mechanism of action in bacterial cells. The monobenzoyl of dialkylurea containing urea functionality with chloro-substituent at position-2 and 4 on aromatic rings were potential as lead compound to generate new antibacterial agent.
Identifying the Weak Foundation of Public Health Resilience forNational Disaster Policy in Indonesia’s Mid-term DevelopmentAgenda 2015–2019: A Policy Content Analysis Warsito, Gita Miranda; Budiharsana, Meiwita; Burns, Sharyn
Kesmas Vol. 15, No. 2
Publisher : UI Scholars Hub

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Abstract

Indonesia is one of the most susceptible nations toward natural disasters in the world. Since 1992, approximately 37 tsunami incidents have occurred inIndonesia, with at least 1,244 cases of natural disasters during 2018. Despite the overwhelming impact of disasters on Indonesia, Public Health Resilience,as an approach to disaster countermeasures, has been poorly elaborated in Indonesia’s development agenda (National Mid-term Development Plan (NMDP),or Rencana Pembangunan Jangka Menengah Nasional (RPJMN), 2015 - 2019). By utilizing the method of policy content analysis, this study aimed to analyzethe policy background of Public Health Resilience against disasters in the NMDP 2015 - 2019 and National Disaster Management Authority (NDMA)’s, orBadan Nasional Penanggulangan Bencana (BNPB),Strategic Plan 2015 - 2019. The results showed that the NMDP 2015 - 2019 and NDMA‘s Strategic Plan2015 - 2019 lack the scientific background for Public Health Resilience building in Indonesia. Enhancing the scientific background in these plans will enhancefocus on evidence-based Public Health Resilience establishment.
Antimicrobial Activity and Molecular Docking of Benzoyl-N,N’-dialkylurea against Target Proteins in Microbial Cells Diyah, Nuzul Wahyuning; Warsito, Gita Miranda; Isnaeni; Hidayati, Shabrina Wahyu
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 2 No 2 (2023): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v2i2.20903

Abstract

This research aims to evaluate the antimicrobial activity of benzoyl dialkylurea derivatives to meet the global need for new antibiotic lead compounds. Four compounds were tested in vitro against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans by broth dilution method using ciprofloxacin and nystatin as standards. Docking simulations were performed to target essential proteins including DNA gyrase, FabH, RNA polymerase in bacterial cells and DHFR in C. albicans. BDMU, BEU1, BEU2, BEU3 exhibited antibacterial activity while BEU1 and BEU2 showed weak antifungal activity against C. albicans. The BDMU, BEU2, BEU3 considered promising growth inhibition against P. aeruginosa. In silico molecular docking on DNA gyrase from P. aeruginosa (PDB. 6M1S) was proposed as a model for mechanism of action in bacterial cells. The monobenzoyl of dialkylurea containing urea functionality with chloro-substituent at position-2 and 4 on aromatic rings were potential as lead compound to generate new antibacterial agent.
Academic community perception of smoke-free zone implementation on campus: situation analysis at UIN Sunan Kalijaga Yogyakarta Warsito, Gita Miranda; Fatimah, Siti; Raharja, Nia Maharani; Khusnuryani, Arifah
Journal of Community Empowerment for Health Vol 8, No 3 (2025)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.108566

Abstract

The Indonesian government regulates the use of tobacco products by establishing Smoke-Free Zones (SFZs), including through the Sleman Regent Regulation No. 42/2012, which mandates educational institutions to implement SFZ policies. State Islamic University (UIN) Sunan Kalijaga, located in Sleman Regency, Yogyakarta, is expected to comply with this regulation, especially given its Strategic Plan to establish a Health Faculty and its broader commitment to creating a healthy campus. However, smoking remains prevalent on campus. This study aimed to analyze the perceptions, attitudes, and behaviors of the university’s academic community toward the SFZ policy as a basis for policy development. Data were collected from 1,228 respondents, consisting of 1,164 students and 64 staff (including lecturers), using a self-administered questionnaire. The survey was distributed in January 2024 and promoted through official channels and peer networks to increase the response rate. The data were analyzed using a descriptive approach, with results presented in frequencies and percentages. Findings show that, in general, respondents expressed positive support for the adoption of a campus-wide smoke-free or comprehensive tobacco-free policy.
Co-Authors Arifah Khusnuryani, Arifah Budiharsana, Meiwita Burns, Sharyn Diyah, Nuzul Wahyuning Hidayati, Shabrina Wahyu Isnaeni Nia Maharani Raharja Siti Fatimah