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Antimicrobial Activity and Molecular Docking of Benzoyl-N,N’-dialkylurea against Target Proteins in Microbial Cells Diyah, Nuzul Wahyuning; Warsito, Gita Miranda; Isnaeni; Hidayati, Shabrina Wahyu
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 2 No 2 (2023): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v2i2.20903

This research aims to evaluate the antimicrobial activity of benzoyl dialkylurea derivatives to meet the global need for new antibiotic lead compounds. Four compounds were tested in vitro against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans by broth dilution method using ciprofloxacin and nystatin as standards. Docking simulations were performed to target essential proteins including DNA gyrase, FabH, RNA polymerase in bacterial cells and DHFR in C. albicans. BDMU, BEU1, BEU2, BEU3 exhibited antibacterial activity while BEU1 and BEU2 showed weak antifungal activity against C. albicans. The BDMU, BEU2, BEU3 considered promising growth inhibition against P. aeruginosa. In silico molecular docking on DNA gyrase from P. aeruginosa (PDB. 6M1S) was proposed as a model for mechanism of action in bacterial cells. The monobenzoyl of dialkylurea containing urea functionality with chloro-substituent at position-2 and 4 on aromatic rings were potential as lead compound to generate new antibacterial agent.

Application of Edible Film from Mung Bean Starch with the Addition of Glycerol Plasticizer on Broccoli Setiani, Ugi Asih; Sedyadi, Endaruji; Rahmayanti, Maya; Warsito, Gita Miranda
ALCHEMY:Journal of Chemistry Vol 13, No 1 (2025): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v13i1.31683

The research on making edible film from mung bean starch with glycerol plasticizer as broccoli packaging aims to determine the characteristics of the edible film from mung bean starch with glycerol addition and its effect on broccoli weight loss. This study involved three stages, which include producing mung bean starch, making and characterizing the edible film, and applying the edible film on broccoli. The glycerol concentrations added were 25.2%, 31.5%, and 37.8% of the starch weight used. The edible film characteristics tested were thickness, tensile strength, elongation, Young's modulus, water vapor transmission rate (WVTR), and ash content. The application test on broccoli lasted 9 days. Results showed that thickness, tensile strength, and ash content met edible film standards, while elongation, Young's modulus, and WVTR did not meet applicable standards. Broccoli coated with the edible film had lower weight loss compared to the control.

Identifying the Weak Foundation of Public Health Resilience forNational Disaster Policy in Indonesia’s Mid-term DevelopmentAgenda 2015–2019: A Policy Content Analysis Warsito, Gita Miranda; Budiharsana, Meiwita; Burns, Sharyn
Kesmas Vol. 15, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Indonesia is one of the most susceptible nations toward natural disasters in the world. Since 1992, approximately 37 tsunami incidents have occurred inIndonesia, with at least 1,244 cases of natural disasters during 2018. Despite the overwhelming impact of disasters on Indonesia, Public Health Resilience,as an approach to disaster countermeasures, has been poorly elaborated in Indonesia’s development agenda (National Mid-term Development Plan (NMDP),or Rencana Pembangunan Jangka Menengah Nasional (RPJMN), 2015 - 2019). By utilizing the method of policy content analysis, this study aimed to analyzethe policy background of Public Health Resilience against disasters in the NMDP 2015 - 2019 and National Disaster Management Authority (NDMA)’s, orBadan Nasional Penanggulangan Bencana (BNPB),Strategic Plan 2015 - 2019. The results showed that the NMDP 2015 - 2019 and NDMA‘s Strategic Plan2015 - 2019 lack the scientific background for Public Health Resilience building in Indonesia. Enhancing the scientific background in these plans will enhancefocus on evidence-based Public Health Resilience establishment.

Antimicrobial Activity and Molecular Docking of Benzoyl-N,N’-dialkylurea against Target Proteins in Microbial Cells Diyah, Nuzul Wahyuning; Warsito, Gita Miranda; Isnaeni; Hidayati, Shabrina Wahyu
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 2 No 2 (2023): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v2i2.20903

This research aims to evaluate the antimicrobial activity of benzoyl dialkylurea derivatives to meet the global need for new antibiotic lead compounds. Four compounds were tested in vitro against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans by broth dilution method using ciprofloxacin and nystatin as standards. Docking simulations were performed to target essential proteins including DNA gyrase, FabH, RNA polymerase in bacterial cells and DHFR in C. albicans. BDMU, BEU1, BEU2, BEU3 exhibited antibacterial activity while BEU1 and BEU2 showed weak antifungal activity against C. albicans. The BDMU, BEU2, BEU3 considered promising growth inhibition against P. aeruginosa. In silico molecular docking on DNA gyrase from P. aeruginosa (PDB. 6M1S) was proposed as a model for mechanism of action in bacterial cells. The monobenzoyl of dialkylurea containing urea functionality with chloro-substituent at position-2 and 4 on aromatic rings were potential as lead compound to generate new antibacterial agent.

Edible Film Application of Mung Bean Starch with the Addition Glycerol as a Button Mushrooms Packer Firdausi, Karima Mumtaz; Sedyadi, Endaruji; Rahmayanti, Maya; Warsito, Gita Miranda
ALCHEMY:Journal of Chemistry Vol 13, No 2 (2025): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v13i2.31684

The research on the production of edible films from mung bean starch with the addition of glycerol as packaging for button mushrooms aims to analyze the effect of varying glycerol concentrations on the physical and mechanical properties of the edible film, as well as the shelf life of button mushrooms in terms of weight loss. The stages of this research include the production of mung bean starch, the creation of edible films, characterization of the starch and edible films, and their application to button mushrooms using weight loss tests. The edible films were made with glycerol concentrations of 6.3%, 12.6%, and 18.9% of the total starch weight used. The results showed that the edible films at each glycerol variation exhibited a reduction in weight loss that was generally lower compared to the weight loss of the control button mushrooms.

Academic community perception of smoke-free zone implementation on campus: situation analysis at UIN Sunan Kalijaga Yogyakarta Warsito, Gita Miranda; Fatimah, Siti; Raharja, Nia Maharani; Khusnuryani, Arifah
Journal of Community Empowerment for Health Vol 8, No 3 (2025)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.108566

The Indonesian government regulates the use of tobacco products by establishing Smoke-Free Zones (SFZs), including through the Sleman Regent Regulation No. 42/2012, which mandates educational institutions to implement SFZ policies. State Islamic University (UIN) Sunan Kalijaga, located in Sleman Regency, Yogyakarta, is expected to comply with this regulation, especially given its Strategic Plan to establish a Health Faculty and its broader commitment to creating a healthy campus. However, smoking remains prevalent on campus. This study aimed to analyze the perceptions, attitudes, and behaviors of the university’s academic community toward the SFZ policy as a basis for policy development. Data were collected from 1,228 respondents, consisting of 1,164 students and 64 staff (including lecturers), using a self-administered questionnaire. The survey was distributed in January 2024 and promoted through official channels and peer networks to increase the response rate. The data were analyzed using a descriptive approach, with results presented in frequencies and percentages. Findings show that, in general, respondents expressed positive support for the adoption of a campus-wide smoke-free or comprehensive tobacco-free policy.

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