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All Journal Jurnal Dinamika Pengabdian (JDP) Science and Technology Indonesia PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Abdi: Media Pengabdian Kepada Masyarakat Jurnal Masyarakat Madani Indonesia Camellia
Diyah, Nuzul Wahyuning
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Other

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PELATIHAN PEMBUATAN PRODUK SUSU PROBIOTIK-SARI BUAH BAGI KELOMPOK WANITA TANI DUSUN WONOREJO KOTA BATU Diyah, Nuzul Wahyuning
Jurnal ABDI: Media Pengabdian Kepada Masyarakat Vol 6, No 1 (2020)
Publisher : Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/ja.v6n1.p13-7

Abstract

The cow milk collected in KUD Batu has reached 16-17 tons per day. The most product is fresh dairy milk and only small amount of processed products. The target community had no experiences in processing cow milk using probiotic microbes yet. The objectives was transfering of science and technology about the production of probiotic milk combined with fruit juice. This program was specifically directed to increase the empowerment of Kelompok Wanita Tani "Wonoasri" in Wonorejo-Batu, in developing probiotic dairy products combined with fruit juice to increase the diversification of products with higher economic value. The method included workshop and technical assistance, which were carried out in a serie of steps: 1) exploring the knowledge of target by surveys and pre test, 2) lecturing and discussion, 3) demonstrating how to prepare and characterize the probiotic milk products, 4) training of product preparation, 5) product characterization and packaging assistance, 6) evaluation. The results were the target community gained increase in knowledge and experience, and they could produce fruity probiotic milk. In addition, they would increase their understanding and enthusiasm to appreciate the potency of their territory in order to improve the nation's competitiveness. Key words : probiotic milk-fruit juice, workshop, kelompok wanita tani, wonorejo
Molecular Docking of Flavonoids from Extract of Roselle (Hibiscus sabdariffa L.) Calyx on PBP2a as the Basis for Antibacterial Activity Against Methicillin Resistant Staphylococcus aureus Ramadhani, Firmansyah Ardian; Prastika, Marsha Fendria; Fikriyah, Nuril; Isnaeni; Diyah, Nuzul Wahyuning
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.487-493

Abstract

The increasing bacterial resistances to antibiotics are serious threat to world health. In Indonesia, there are resistant bacteria such as Methicillin Resistant Staphylococcus aureus (MRSA). In order to overcome the problem, the compounds contained in the Hibiscus sabdariffa L. are potential to be developed as new antibacterial against MRSA. To confirm the antibacterial activity, the extract of roselle calyx was tested against MRSA. The twelve compounds contained in the extract was docked into binding site of PBP2a using Autodock 4.2.6. The results showed MIC 2.5% of roselle extract. Two flavonoid compounds comply the Lipinski’s rules and the docking results showed all compounds had higher binding affinity than reference ligand ceftobiprole. The quantitative structure-physicochemical property relationship (QSPR) found that steric property (CMR) and energy (Etotal) of ligand contributed to the binding affinity against PBP2a. It concluded kaempferol-rutinoside was the most potential compound from H. sabdariffa that could be selected as lead compound to be develop as antibacterial agents.
In silico Study on Physicochemical, Pharmacokinetic and Toxicity Profiles of Available Antiviral Drugs and The Drug-Target Interaction with Protease of SARS-CoV-2 Diyah, Nuzul Wahyuning; Ghifari, Aileen Syifa; Hidayati, Shabrina Wahyu; Ekowati, Juni
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 1 No 2 (2022): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v1i2.16714

Abstract

Introduction: In emergency conditions such as the COVID-19 pandemic, many drugs treating SARS-CoV-2 are currently being developed through the concept of repurposing the existing drugs. This study aims to evaluate the physicochemical, pharmacokinetic and toxicity (ADMET) profiles of 15 drugs that have been used clinically for other viral diseases, and inspect their activity as antivirals against SARS-CoV-2. Methods: The physicochemical properties were obtained by using the ChemDraw and the ADMET were predicted using pkCSM on line tools. The selected drugs based on Lipinski's Rules were docked into main protease of SARS-CoV-2 (PDB. 6LU7) using Molegro program. Results: Six drugs complied with Lipinski's Rules and showed good ADMET profile except for their hepatotoxicity, but favipiravir and oseltamivir were predicted to be non-hepatotoxic. Oseltamivir also showed high binding affinity with free energy score below -100 kcal/mol. Conclusions: Oseltamivir is a potential antivirus for COVID-19 based on physicochemical, ADMET profile, and in silico activity against protease of SARS-CoV-2. 
Antimicrobial Activity and Molecular Docking of Benzoyl-N,N’-dialkylurea against Target Proteins in Microbial Cells Diyah, Nuzul Wahyuning; Warsito, Gita Miranda; Isnaeni; Hidayati, Shabrina Wahyu
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 2 No 2 (2023): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v2i2.20903

Abstract

This research aims to evaluate the antimicrobial activity of benzoyl dialkylurea derivatives to meet the global need for new antibiotic lead compounds. Four compounds were tested in vitro against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans by broth dilution method using ciprofloxacin and nystatin as standards. Docking simulations were performed to target essential proteins including DNA gyrase, FabH, RNA polymerase in bacterial cells and DHFR in C. albicans. BDMU, BEU1, BEU2, BEU3 exhibited antibacterial activity while BEU1 and BEU2 showed weak antifungal activity against C. albicans. The BDMU, BEU2, BEU3 considered promising growth inhibition against P. aeruginosa. In silico molecular docking on DNA gyrase from P. aeruginosa (PDB. 6M1S) was proposed as a model for mechanism of action in bacterial cells. The monobenzoyl of dialkylurea containing urea functionality with chloro-substituent at position-2 and 4 on aromatic rings were potential as lead compound to generate new antibacterial agent.
The Physicochemical properties and in silico binding interaction with gyrase B of antibacterial compounds from aquous extract of Hibiscus sabdariffa L. Diyah, Nuzul Wahyuning; Andini, Khairunnisa; Isnaeni
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 3 No 1 (2024): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v3i1.22874

Abstract

Hibiscus sabdariffa L. (Hs) is recognized to have various pharmacological activities such as antibacterial, antiedema, anti-fungal, antihypertensive, anti-inflammatory, and antiviral. The aquous extract of Hs’ calyx which is rich in polyphenols and flavonoids displayed antibacterial activity against several bacteria so that the compounds are important to be developed further as antibacterial agents. This study aims to find out which compounds contained in the extract have the antibacterial potency based on in silico interaction with gyrase B. Physicochemical descriptors of ten compounds were evaluated before molecular docking study, and the docking simulation was executed with Autodocktools 1.5.6. The selected compounds based on Lipinski’s Rules and their lower DG0 were subjected to prediction of pharmacokinetic and toxicity (ADMET) using pKCSM online tool. The results gave five test compounds showed the higher binding affinity on gyrase B compared to quercetin which served as inhibitor of the enzyme. The glycosides displayed better scores due to the existence of more hydroxyl groups. The potential aglycones were myricetin and delphinidin. According to the ADMET parameters, the two compounds have the best profile where they were neither hepatotoxic nor carcinogenic and also safer due to the higher LD50. In conclusion, the myricetin and delphinidin generated better binding interaction than the ligand inhibitor of gyrase B which indicated that they have higher potential as antibacterial agents.
PENDIDIKAN POLA HIDUP SEHAT PASCA PANDEMI COVID-19 SEBAGAI UPAYA MENJAGA KESEHATAN SISWA SMP DI MAGETAN Isadiartuti, Dewi; Sari, Retno; Diyah, Nuzul Wahyuning; Lestari, Maria Lucia Ardhani Dwi; Rudyanto, Marcellino; Kusumawati, Idha; Setyawan, Dwi; Rohana, Melissa; Dewanthy, Kyrana Sekar; Fauzia, Alfi Nur; Siammita, Dhea Anansya
Jurnal Dinamika Pengabdian Vol. 10 No. 1 (2024): JURNAL DINAMIKA PENGABDIAN VOL. 10 NO. 1 OKTOBER 2024
Publisher : Departemen Budidaya Pertanian Fakultas Pertanian UNHAS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jdp.v10i1.32996

Abstract

Pembelajaran tatap muka secara offline bagi pelajar sudah dimulai kembali setelah pandemi Covid-19 melanda Indonesia. Sejak pandemi ditetapkan WHO tanggal 11 Maret 2020, telah menyebabkan 5.956.561 orang terkonfirmasi positif dan sebanyak 153.599 orang meninggal dunia (per 21 Maret 2022) di Indonesia. Kembalinya proses belajar mengajar ke kondisi normal perlu diantisipasi dengan kesadaran dan tanggung jawab siswa terhadap protokol kesehatan yang dianjurkan pemerintah. Tujuan kegiatan ini adalah untuk meningkatkan pemahaman dan kesadaran siswa SMPN tentang pola hidup sehat dalam upaya menjaga kesehatan pasca pandemi Covid-19. Dalam program ini siswa didorong untuk menerapkan pola hidup sehat diantaranya dengan senantiasa menjaga kebersihan tangan dan menjaga daya tahan tubuh. Pengabdian masyarakat dilakukan dalam bentuk webinar dengan platform zoom diikuti oleh 59 siswa dari SMPN 1 Magetan dan diberikan dalam bentuk pre-test dan post-test, ceramah, diskusi dan pembuatan e-poster. Hasil kuesioner yang diberikan kepada peserta sebelum kegiatan diketahui 100% siswa telah mendapatkan vaksinasi dosis dua, 100 % siswa setuju proses pembelajaran pasca pandemi dilakukan secara luring, 100% siswa setuju mengikuti protokol kesehatan selama mengikuti kegiatan pembelajaran di sekolah, 73,58% siswa selalu menggunakan masker, 35,85% siswa mencuci tangan sebelum masuk sekolah, 41,51% siswa menjaga jarak dengan temannya, dan 1,89% siswa menderita penyakit infeksi Covid-19 selama proses pembelajaran luring pasca pandemi. Hasil evaluasi kegiatan berupa pre-test dan post test serta pembuatan e-poster diketahui terdapat peningkatan pemahaman siswa terhadap materi yang disampaikan dan semua peserta menyatakan setuju materi pola hidup sehat yang disampaikan dapat diaplikasikan dalam mengikuti proses pembelajaran di sekolah. ABSTRACT Offline face-to-face learning for students has started again after the Covid-19 pandemic hit Indonesia. Since the pandemic was declared by WHO on March 11 2020, it has resulted in 5,956,561 people being confirmed positive and 153,599 people dying (as of March 21 2022) in Indonesia. The return of the teaching and learning process to normal conditions needs to be anticipated with students' awareness and responsibility for the health protocols recommended by the government. The aim of this activity is to increase understanding and awareness of junior high school students about healthy lifestyles in an effort to maintain health after the Covid-19 pandemic. In this program, students are encouraged to adopt a healthy lifestyle, including always keeping their hands clean and maintaining their immune system. Community service was carried out in the form of a webinar with a zoom platform attended by 59 students from SMPN 1 Magetan and given in the form of pre-test and post-tests, lectures, discussions and making e-posters. The results of the questionnaire given to participants before the activity showed that 100% of students had received the second dose of vaccination, 100% of students agreed that the post-pandemic learning process would be carried out offline, 100% of students agreed to follow health protocols while participating in learning activities at school, 73.58% of students always wearing masks, 35.85% of students washing their hands before entering school, 41.51% of students keeping their distance from their friends, and 1.89% of students suffering from Covid-19 infection during the post-pandemic offline learning process. The results of the evaluation of activities in the form of pre-test and post-tests and making e-posters showed that there was an increase in students' understanding of the material presented and all participants agreed that the healthy lifestyle material presented could be applied in following the learning process at school. Keywords: Healthy lifestyle, Covid-19, post-pandemic, student education, maintaining health.
Pemanfaatan Suplemen Makanan Secara Tepat Guna untuk Menjaga dan Meningkatkan Daya Tahan Tubuh Diyah, Nuzul Wahyuning; Poerwono, Hadi; Nofianti, Kholis Amalia; Poernomo, Achmad Toto; Hidayati, Shabrina Wahyu; Isnaeni, Isnaeni
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 3 No 2 (2024): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v3i2.24882

Abstract

Komponen makanan telah dikenal memberikan fungsi perlindungan terhadap benda asing yang mengakibatkan masalah kesehatan bagi masyarakat. Mikronutrien seperti vitamin dan mineral sangat penting bagi tubuh manusia dan kebutuhan hariannya harus dipenuhi melalui sumber makanan. Jika kebutuhan harian tidak terpenuhi karena beberapa kondisi, maka diperlukan tambahan suplemen makanan. Beberapa vitamin dan mineral berfungsi sebagai imunomodulator dan melindungi respons imun inang, sehingga mencegah penurunan daya tahan tubuh akibat serangan patogen. Berdasarkan acuan berbagai penelitian, artikel ini membahas fungsi suplemen vitamin dan mineral sebagai imunomodulator dalam meningkatkan daya tahan tubuh melalui sistem imun dan mekanisme kerja yang memperantarai fungsi ini. Kekurangan vitamin dan mineral dapat menyebabkan penurunan kinerja sistem imun, yang menjadi penyebab utama keadaan patologis dan imunologis yang tidak menguntungkan. Dari berbagai hasil penelitian secara in vitro dan in vivo dapat disimpulkan bahwa mikronutrien utama yang berperan dalam respons imun, yaitu: vitamin A, C, D, E, B6, B12, folat, dan mineral seng, zat besi, tembaga, dan selenium, dapat meningkatkan daya tahan tubuh terhadap infeksi.  Kekurangan asupan harian mikronutrien dari makanan dapat diatasi dengan memanfaatkan suplemen makanan.
Edukasi dan Pelatihan Pemanfaatan Tanaman Obat Keluarga di Desa Dlingo Bantul sebagai Upaya Pencapaian Tujuan SDGs di Bidang Kesehatan: Education and Training on the Use of Family Medicinal Plants in Dlingo Village, Bantul, as an Initiative to Support the Achievement of Health-Related SDGs Sukardiman, Sukardiman; Kusumawati, Idha; Handayani, Rosita; Sudjarwo, Sudjarwo; Munandar, Tristiana Erawati; Yusuf, Helmy; Diyah, Nuzul Wahyuning; Poerwono, Hadi; Purwanto, Bambang Tri
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 7 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i7.10042

Abstract

Global health issues have become increasingly urgent following the COVID-19 pandemic, which resulted in approximately 6.6 million deaths by 2022. This impact has prompted communities to revert to traditional medicines, aligning with the National Development Planning System (RPJPN) 2005-2025, which promotes a health paradigm through traditional remedies. Community service activities were carried out in partnership with the Ngudi Makmur Farmer Group (POKTAN) in Dlingo Village, Bantul Regency. The primary objective of this activity was to enhance residents’ knowledge in Dlingo Village regarding the benefits and processing of Family Medicinal Plants (TOGA). The methods employed included material development, counseling sessions, question-and-answer discussions, and direct practical training in the preparation of aromatherapy candles. Evaluation was undertaken using pretests and posttests, which demonstrated a significant increase in participants’ understanding. The average scores rose from 81.67 (pretest) to 132.5 (posttest), with a statistically significant difference (p <0.001). These findings indicate that the counseling was effective in improving knowledge about TOGA and its utilization in producing aromatherapy candles. Such activities not only enhance awareness but also reinforce community autonomy in managing traditional medicinal resources, in line with the health-related objectives of the Sustainable Development Goals (SDGs).
Pemberdayaan UMKM Melalui Pelatihan Pembuatan Produk Berbasis Probiotik Di Desa Candi, Sidoarjo Kusumawati, Idha; Hendradi, Esti; Isnaeni, Isnaeni; Diyah, Nuzul Wahyuning; Purwanti, Tutiek; Widyawaruyanti, Aty; Poernomo, Achmad Toto; Poerwono, Hadi; Paramita, Diajeng Putri; Ekasari, Wiwied
Jurnal Masyarakat Madani Indonesia Vol. 4 No. 3 (2025): Agustus
Publisher : Alesha Media Digital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59025/vmwny271

Abstract

Kegiatan pengabdian masyarakat ini bertujuan untuk memberdayakan UMKM di Desa Candi, Sidoarjo melalui pelatihan pembuatan produk berbasis probiotik-herbal. Program ini dilatarbelakangi oleh peran strategis UMKM dalam perekonomian Indonesia dan potensi pengembangan produk pangan fungsional probiotik-herbal. Metode pelaksanaan meliputi tahap persiapan, pelaksanaan pelatihan, dan evaluasi. Pelatihan diikuti oleh 48 peserta UMKM dan mencakup pemberian materi oleh narasumber ahli serta praktik langsung pembuatan yogurt-herbal. Hasil menunjukkan peningkatan signifikan dalam pengetahuan peserta, dengan kenaikan rata-rata 36,24 poin antara pre-test dan post-test. Evaluasi keseluruhan menunjukkan respon sangat positif, dengan mayoritas peserta menyatakan materi mudah dipahami (75,6% sangat setuju) dan pelatihan bermanfaat (65,9% sangat setuju). Program ini berhasil meningkatkan kapasitas UMKM dalam mengembangkan produk inovatif berbasis probiotik-herbal, membuka peluang diversifikasi produk dan pasar baru bagi UMKM setempat.
Co-Authors Achmad Toto Poernomo Andini, Khairunnisa Aty Widyawaruyanti Bambang Tri Purwanto Dewanthy, Kyrana Sekar Dewi Isadiartuti Dwi Setyawan Esti Hendradi Fauzia, Alfi Nur Fikriyah, Nuril Ghifari, Aileen Syifa Hadi Poerwono Handayani, Rosita Hidayati, Shabrina Wahyu Idha Kusumawati Isnaeni Isnaeni Isnaeni Juni Ekowati Kholis Amalia Nofianti Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Munandar, Tristiana Erawati Paramita, Diajeng Putri Prastika, Marsha Fendria Ramadhani, Firmansyah Ardian Retno Sari Rohana, Melissa Siammita, Dhea Anansya Sudjarwo Sudjarwo Sukardiman Tutiek Purwanti Warsito, Gita Miranda Wiwied Ekasari Yusuf, Helmy