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All Journal Biology, Medicine, & Natural Product Chemistry Jurnal Forensik dan Medikolegal Indonesia
Amin, Ihya Fakhrurizal
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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The Potential of Chrysin of Oroxylum indicum L. to Induce Carbonic Anhydrase (CA) to Improve Cattle Fertility Amin, Mohamad; Fahmi, Muhammad Najib; Ridho, Muhammad Andi Ali; Fitri, Nurul; Lestari, Umie; Maulina, Dina; Amin, Ihya Fakhrurizal
Biology, Medicine, & Natural Product Chemistry Vol 9, No 1 (2020)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2020.91.27-32

Abstract

The Artificial Insemination (AI) aims to develop the potential of the cattle reproduction comprehensively. The success of AI results is highly dependent on the level of livestock fertility. Therefore, improv the quality and quantity of semen could be done by hormone induction. However, hormone prices are expensive. This problem could be overcome using alternative way with the natural compound containing chrysin which might has the same function. The purpose of the study was analyze the potential of chrysin compound from Bungli plant (Oroxylum indicum) as fertilizer of males through bioinformatics approach. Methods performed through data search by webserver with the following stages: (1) Pubchem, (2) Swiss (3) Target Prediction, (4) Uniprot, (5) Protein Data Bank and (6) docking software using PyRx, PyMOL and Discovery Studio. The results showed that the chrysin compound interact with carbonic anhydrase (CA) expressed from the testes of the cattle, through van der Waals and Pi-Alkyl bonds. Chrysin is effective as CA ligand inducers based on affinity bonds (-8.4 kcal/mole) and more negatively than flavonol as a control compound with binding affinity (-6.2 kcal/mol). This suggests that chrysin is an effective compound as a potential drug for improved livestock fertility.
Memperkirakan saat Kematian (Postmortem Interval) Menggunakan Temuan Mikrobiom pada Setiap Tahap-Tahap Penguraian (Decomposition) Putra, Afid Brilliana; Amin, Ihya Fakhrurizal; Fitriyasa, Rizky Dini; Najma, Najma; Safitry, Oktavinda
Jurnal Forensik dan Medikolegal Indonesia Vol 2 No 1 (2020): Jurnal Forensik dan Medikolegal Indonesia
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

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Abstract

Microorganisms play an important role in the process of corpse decomposition. The corpse's decomposition can indicate time since death or postmortem interval (PMI). Bacterial decomposition plays an important role in determining the time since death and has a significant impact on forensic investigations. Therefore, it is necessary to know the type of microbiome that appears at each stage of decomposition. Literature searching was conducted online and was carried out through 4 journal databases, including PubMed, EBSCOhost, ProQuest, and Cochrane. The literature is selected based on inclusion & exclusion criteria, then critically appraised using criteria from the University of Oxford's Center for Evidence-Based Medicine. Based on the results, obtained a systematic review, two prospective cohorts, and a cross-sectional study with good validity, importance and applicability. The study showed a relationship between time since death/PMI and colonization of certain bacteria, which may be related to alteration of oxygen levels. Facultative anaerobic bacteria appear in early stage of decomposition and shift into obligate anaerobic bacteria in the final stage of decomposition. The presence of certain types of microbiome can determine duration of decomposition and PMI objectively and quantitatively.
Co-Authors Dina Maulina Fahmi, Muhammad Najib Fitri, Nurul Fitriyasa, Rizky Dini Najma, Najma Oktavinda Safitry Putra, Afid Brilliana Ridho, Muhammad Andi Ali Sembiring, Rinawati Umie Lestari