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All Journal International Journal of Evaluation and Research in Education (IJERE) Prosiding Seminar Biologi Jurnal Pendidikan Sains Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Islam and Muslim Societies Indonesian Journal of Urology Jurnal Bioterdidik: Wahana Ekspresi Ilmiah Bioedukasi: Jurnal Pendidikan Biologi Jurnal Pendidikan Biologi Indonesia Biology, Medicine, & Natural Product Chemistry Jurnal Florea UNEJ e-Proceeding Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan BIOEDUKASI Diklabio: Jurnal Pendidikan dan Pembelajaran Biologi Proceeding Biology Education Conference Berkala Penelitian Hayati Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Ta'dib Jurnal Ilmu Hayat
Umie Lestari
Universitas Negeri Malang
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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PENINGKATAN KUALITAS PEMBELAJARAN FISIOLOGI HEWAN DENGAN PENGEMBANGAN BAHAN AJAR BERKARAKTER BERBASIS HASIL PENELITIAN Wahono, Beno; Lestari, umie; Gofur, Abdul
Bioedukasi Jurnal Pendidikan Biologi Vol 4, No 2 (2013): Nopember 2013
Publisher : UNIVERSITAS MUHAMMADIYAH METRO

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Abstract

This study aims to improve the quality of learning by developing character-based teaching materials research animal physiology courses. This research method is the development of module manufacturing as a source of learning based on the research that has been done, including a description, picture research and implementation process that include sites expected character, whether written or unwritten is adapted from Dick and Carey learning system to make some adjustments. The results obtained are based on the calculation and conversion of valuation module by module expert instructional materialsby 71, 66%. Based on the results of the conversion, the preparation of the module other wise well qualified and do not need to be revised. The results of the assessment calculation and conversion modules by physiologists by 85%. Based on the results of  the conversion, the module qualification other wise excellent preparation and do not need to be revised. Conclusion are obtained the results by the developing of characterized teaching materials based on the results of experiment is feasible and can be used to support lectures to enhance the quality of teaching Animal Physiology courses in college.Kata kunci: Kualitas pembelajaran fisiologi hewan, bahan ajar berkarakter 
PENGEMBANGAN BAHAN AJAR BERBASIS PENELITIAN KARAKTERISASI PROTEIN MEMBRAN SPERMA PADA MATAKULIAH BIOTEKNOLOGI Oktaviana, Ika; B Sumitro, Sutiman; Lestari, Umie
Jurnal Florea Vol 2, No 2 (2015)
Publisher : Jurnal Florea

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Abstract

The purpose of the research and development is to produce teaching materials such as textbookssupporting course in Biotechnology research based on the characterization of the sperm membraneproteins for students who take a course in Biotechnology. This research is a research and development, where the results of research become the teaching materials developed supporting Biotechnologycourse. Development models have prepared using ADDIE Model. Sources of data in this researchinclude laboratory research and validation of the results sheet of Biotechnology material experts,instructional design experts, the media, and the trials in students. The analysis is used descriptiveanalysis and quantitative descriptive exploratory. The results of the research have developed becometeaching materials like text books supporting courses and have been validated by the Biotechnology,the biotechnology material experts, instructional design experts, the media, the individual testing, andgroup trials. Based on the results of the validation material have obtained value of 89.56%, the resultsof the design validation and media experts to get the value of 93.75%, it means that the teachingmaterials has been developed which suitable to be used as a teaching material support biotechnologycourse. While the experiments performed to get a data the percentage of students that are equal to88.98% and included in the category of “very good”, but still need to be revised based on advices andcomments from students.Keywords: Teaching material, Characterization of Membrane Proteins, Biotechnology. 
PENGEMBANGAN BAHAN AJAR MATA KULIAH FISIOLOGI REPRODUKSI DI JURUSAN BIOLOGI UNIVERSITAS NEGERI MALANG Irmawati, Farizha; Lestari, Umie; Suwono, Hadi
Jurnal Florea Vol 2, No 2 (2015)
Publisher : Jurnal Florea

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Abstract

The purpose of the research and development is to produce teaching materials such as textbooks supporting course in Reproduction Physiology research based on the toxicity analysis for students whotake a course in Reproduction Physiology. This research is a research and development, where theresults of research become the teaching materials developed supporting Reproduction Physiologycourse. Development models have prepared using ADDIE Model. Sources of data in this researchinclude laboratory research and validation of the results sheet of Biotechnology material experts,instructional design experts, the media, and the trials in students. The analysis is used quantitative andqualitative.The results of the research have developed become teaching materials like text bookssupporting courses and have been validated by the Reproduction Physiology, the ReproductionPhysiology material experts, instructional design experts, the media, the individual testing, and grouptrials. Based on the results of the validation material have obtained value of 95%, the results of thedesign validation and media experts to get the value of 93.75%, it means that the teaching materials hasbeen developed which suitable to be used as a teaching material support biotechnology course. Whilethe experiments performed to get a data the percentage of students that are equal to 88,25 % andincluded in the category of “very good”, but still need to be revised based on advices and commentsfrom students.Keywords: Development, Instructional Material, ADDIE
Profile protein autism analysis based bioinformatics as public dissemination materials in Malang about the potensial causes autism Listawati, Rizki Mei; Lestari, Umie; Amin, Mohammad
Jurnal Pendidikan Biologi Indonesia Vol 2, No 3 (2016): NOVEMBER
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1142.517 KB) | DOI: 10.22219/jpbi.v2i3.3876

Abstract

Kehidupan saat ini menawarkan berbagai kemudahan. Namun, seiring dengan hal tersebut ada banyak permasalahan yang memicu stress. Selain itu, terdapat banyak unsur kimia dan logam berat yang jika saling berinteraksi dapat menimbulkan berbagai macam penyakit mulai dari flu hingga kanker, termasuk autis. Penelitian ini bertujuan untuk menganalisis potensi profil protein dalam darah yang menyebabkan autis berdasarkan bioinformatik. Kemudian, disosialisasikan kepada masyarakat khususnya orang tua anak autis di Kota Malang sehingga dapat memberikan wawasan tentang autis. Penelitian ini juga dapat dikembangkan sebagai dasar penelitian laboratorium. Jenis penelitian ini adalah deskriptif kualitatif, menggunakan tiga database yaitu National Center for Biotechnology Information (NCBI), Uniprot, dan Protein Data Bank (PDB) serta menggunakan software Pymol. Hasil penelitian ini menunjukkan bahwa: 1) Protein dalam darah yang berpotensi menyebabkan autis berdasarkan artikel yaitu mTOR, Glutathione S Transferase P, Chemokine Monocyte Chemotactic Protein-1 (MCP-1), Interferon-∂-Inducible Protein-16 (IFI-16), dan serotonin; 2) Protein-protein tersebut setelah dianalisis dengan menggunakan tiga database (NCBI, Uniprot, dan PDB) menunjukkan bahwa protein Glutathione S Transferase P  lebih berpotensi terhadap autis. Hal ini karena protein tersebut berfungsi untuk mencegah neurodegeneration; 3) Penelitian tentang penyebab autis sangat dibutuhkan oleh orang tua anak autis (masyarakat), sehingga dapat diminimalisir akses masuknya pemicu tersebut.
Potensi Genistein Terhadap Histopatologi Tubulus Seminiferus Testis Mencit (Mus musculus) Novi Primiani, Cicilia; Lestari , Umie
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 17, No 2 (2012): June 2012
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (40.122 KB) | DOI: 10.24002/biota.v17i2.130

Abstract

Pemanfaatan sarana kontrasepsi pria dengan memanfaatkan bahan alami berasal dari tanaman sudah banyak dilakukan. Tetapi pemanfaatan biji kedelai sebagai salah satu tanaman suku Leguminoceae belum pernah dilakukan. Biji kedelai mengandung senyawa genistein, sebagai salah satu senyawa derivat isoflavon mempuyai struktur kimia mirip dengan 17β-estradiol bersifat seperti hormon steroid estrogen, mampu menyebabkan kerusakan pada sistem reproduksi jantan. Penelitian bertujuan menguji pengaruh genistein terhadap histopatologi tubulus seminiferus testis mencit jantan (Mus musculus). Penelitian dilakukan menggunakan pendekatan eksperimental, yang rancangannya mengikuti rancangan acak lengkap. Variabel bebas adalah dosis genistein 0 mg/g, 0,0035 mg/g, 0,0042 mg/g, dan 0,0049 mg/g. Variabel terikat adalah sel-sel germinal tubulus seminiferus testis. Data rerata jumlah sel-sel germinal dianalisis menggunakan Analisis Varians Satu Arah (One Way ANOVA) dengan tingkat signifikansi 95% (α 5%) dilakukan uji Post Hoc dengan Least Significant Difference (LSD) α 5%. Perubahan pada jaringan testis dianalisis secara deskriptif. Hasil penelitian menunjukkan bahwa ada pengaruh pemberian genistein terhadap rerata jumlah sel-sel germinal dan menyebabkan penghambatan proliferasi sel-sel germinal dalam tubulus seminiferus testis.
POTENSI GENISTEIN PADA SISTEM REPRODUKSI MENCIT JANTAN (MUS MUSCULUS) Primiani, Cicilia Novi; Lestari, Umie; Amin, Mohamad
Prosiding Seminar Biologi Vol 8, No 1 (2011): Seminar Nasional VIII Pendidikan Biologi
Publisher : Prodi Pendidikan Biologi FKIP UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (412.028 KB)

Abstract

ABSTRAK Usaha untuk mendapatkan sarana kontrasepsi pria sebenarnya telah banyak dilakukan dengan memanfaatkan bahan alami yang berasal dari tanaman. Salah satunya adalah tanaman famili Leguminoceae yang mengandung senyawa genistein. Genistein sebagai salah satu senyawa derivat isoflavon mempuyai struktur kimia mirip dengan 17?-estradiol yang bersifat seperti hormon steroid estrogen, yang mampu menyebabkan kerusakan pada sistem reproduksi jantan sebagai salah satu indikator digunakannya genistein sebagai senyawa antifertilitas. Penelitian ini bertujuan untuk mengetahui pengaruh genistein terhadap sistem reproduksi mencit jantan (Mus musculus). Penelitian ini menggunakan pendekatan kuantitatif eksperimental, yang rancangannya mengikuti Rancangan Acak Kelompok. Variabel bebas adalah dosis genistein 0 mg/g, 0,0035 mg/g, 0,0042 mg/g, dan 0,0049 mg/g. Variabel terikatnya adalah sel-sel germinal dalam tubulus seminiferus testis, morfologi spermatozoa, viabilitas spermatozoa, dan kadar hormon testosteron. Data sel-sel germinal dalam tubulus seminiferus testis kadar hormon testosteron dianalisis menggunakan Analisis Varians Satu Jalan (One Way ANOVA) dengan tingkat signifikansi 5%. Selanjutnya dilakukan uji Post Hoc dengan Least Significant Difference (LSD) 5%. Data morfologi dan viabilitas spermatozoa dinyatakan dalam prosentase. Hasil penelitian menunjukkan bahwa ada pengaruh genistein pada sistem reproduksi mencit jantan (Mus musculus). Genistein yang diberikan dengan dosis 0,0035 mg/g; 0,0042 mg/g; dan 0,0049 mg/g berpengaruh terhadap jumlah sel germinal, morfologi dan viabilitas spermatozoa. Kadar hormon testosteron berbeda nyata pada dosis 0,0049 mg/g. Kata kunci : genistein, sistem reproduksi jantan
The Potential of Chrysin of Oroxylum indicum L. to Induce Carbonic Anhydrase (CA) to Improve Cattle Fertility Amin, Mohamad; Fahmi, Muhammad Najib; Ridho, Muhammad Andi Ali; Fitri, Nurul; Lestari, Umie; Maulina, Dina; Amin, Ihya Fakhrurizal
Biology, Medicine, & Natural Product Chemistry Vol 9, No 1 (2020)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2020.91.27-32

Abstract

The Artificial Insemination (AI) aims to develop the potential of the cattle reproduction comprehensively. The success of AI results is highly dependent on the level of livestock fertility. Therefore, improv the quality and quantity of semen could be done by hormone induction. However, hormone prices are expensive. This problem could be overcome using alternative way with the natural compound containing chrysin which might has the same function. The purpose of the study was analyze the potential of chrysin compound from Bungli plant (Oroxylum indicum) as fertilizer of males through bioinformatics approach. Methods performed through data search by webserver with the following stages: (1) Pubchem, (2) Swiss (3) Target Prediction, (4) Uniprot, (5) Protein Data Bank and (6) docking software using PyRx, PyMOL and Discovery Studio. The results showed that the chrysin compound interact with carbonic anhydrase (CA) expressed from the testes of the cattle, through van der Waals and Pi-Alkyl bonds. Chrysin is effective as CA ligand inducers based on affinity bonds (-8.4 kcal/mole) and more negatively than flavonol as a control compound with binding affinity (-6.2 kcal/mol). This suggests that chrysin is an effective compound as a potential drug for improved livestock fertility.
PRODUKSI ANTIBODI POLIKLONAL HASIL INDUKSI ISOLAT PROTEIN NON KINASE DARI MEMBRAN SPERMATOZOA MANUSIA Lestari, Umie; Purnomo, Basuki B
Indonesian Journal of Urology Vol 15 No 2 (2008)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v15i2.350

Abstract

Objective: The aim of this research is to get the profile of human sperms membrane protein based on identification for molecular weight, concentration protein, phosphorylation activity, and ability to raise enough antibodies. Material and methods: There are three phases in this research, first, isolation protein of human sperms membrane with using lysis buffer containing Tween-20, second, determination of molecular weight, phosphorylation activity, and protein concentration, and third, antibody production. Molecular weight of protein membrane was detected by SDS-PAGE, confirmation of protein concentration measured Biuret method, kinase activity measured using spectrophometry at its optimum condition, and then production of antibody that corfirmed by ELISA technique. Results: Human sperms contain the protein with molecular weight of 201, 163, 116, 97, 72, 56, 48, 32, 27, 20, and 17kDa. The highest phosphorylation activity was found on protein with molecular weight of 20 kDa is 30.197x 10-3 unit, while the lowest phosphorylation activity is 28.976x10-3 unit was shown on protein with 116 kDa of molecular weight and then   this protein can induce production of antibody. Biuret method show the protein concentration from protein with molecular weight 116 kDa is 410 ug/mL. Conclusion: The protein that has molecular weight of 116 kDa can be used as immunocontraception agent because phosphorylation activity has lower, good concentration, and could induce the production of antibody.
Critical thinking skills: Profile and mastering concepts of undergraduate students Rizkia Suciati; Herawati Susilo; Umie Lestari; Abdul Gofur
International Journal of Evaluation and Research in Education (IJERE) Vol 11, No 3: September 2022
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijere.v11i3.22409

Abstract

As one of the 21st-century skills, critical thinking (CT) is required for working in an interdisciplinary setting. Educators are expected to provide learning activities that enhance students’ CT skills. Biology, particularly Cell Biology, is seen as challenging since the topics covered therein relate to those covered in the following semester. This research was conducted out as a preliminary study to improve the quality of the learning process, especially in the Cell Biology course. It aimed to identify students’ CT skills in mastering concepts about Cell Membranes. This study enlisted the participation of 105 students from two universities. This research used an instrument test essay using the rubric CT skills. The findings revealed that undergraduate students’ CT skills were classified as basic in mastering the concept of Cell Membrane.
Bioaktif Alami Dari Minyak Atsiri Akar Wangi Terhadap Pengaruh Kerusakan Lambung Mohamad Amin; Monalisa PJ Taihuttu; Umie Lestari
Jurnal Bioterdidik: Wahana Ekspresi Ilmiah Vol 7, No 4 (2019): Jurnal Bioterdidik
Publisher : Universitas Lampung

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Abstract

This study aims to determine the natural bioactive compounds of vetiver essential oil for the treatment of gastric damage based on in silico screening. Natural secondary metabolites that have the potential to treat gastric damage are pyrozoline, which is contained in essential oils of vetiver. 3D chemical structures and SMILES ligands (Pirazolin) are taken from the compound database on the server. The target selection results using Pharmmapper (JOBID 17043231348). Swiss Target Prediction and Super Pret found that Pirazolin Compound interacts with the target protein Tyrosyl-DNA phosphodiesterase 1. This research proves that Pirazolin natural compounds that can be obtained from essential oils of vetiver have the potential as gastric inflammatory drugs similar to the chemical compounds commonly used as drugs namely Celecoxib. Penelitian ini bertujuan untuk mengetahui senyawa bioaktif alami dari minyak atsiri akar wangi  untuk pengobatan kerusakan lambung berdasarkan penyaringan in silico. Senyawa metabolit sekunder alami yang berpotensi untuk pengobatan kerusakan lambung adalah Pirozolin, yang terkandung pada minyak atsiri akar wangi. Struktur kimia 3D dan SMILES ligan (Pirazolin) diambil dari database senyawa pada server. Hasil seleksi target menggunakan Pharmmapper (JOBID 17043231348). Swiss Target Prediction dan Super Pret ditemukan bahwa Senyawa Pirazolin berinteraksi dengan protein  target Tyrosyl-DNA phosphodiesterase 1. Penelitian ini membuktikan bahwa senyawa alami Pirazolin yang bisa diperoleh dari minyak atsiri akar wangi memiliki potensi sebagai obat inflamasi lambung yang mirip dengan senyawa kimia yang biasa digunakan sebagai obat yaitu Celecoxib. Kata kunci: akar wangi, in silico, kerusakan lambung, minyak atsiri
Co-Authors Abdul Gofur Abdul Gofur Abdul Gofur Abdul Gofur Abu Husen Abu Husen Afifah Nur Aini Alif Yanuar Zukmadini Aloysius Duran Corebima Amin, Ihya Fakhrurizal Anton Setia Budi Ardiyas Robi Saputra Basuki B Purnomo, Basuki B Beno Wahono Beno Wahono, Beno Betty Lukiati Cicilia Novi Primiani Cicilia Novi Primiani Cicilia Novi Primiani Cicilia Novi Primiani, Cicilia Desy Putri Rahmawati Dewi Murni Dina Maulina Dina Maulina Dwi Anggorowati Rahayu Endang Suarsini Endik Deni Nugroho Fahmi, Muhammad Najib Farizha Irmawati Farizha Irmawati, Farizha Fitri, Nurul Hadi Suwono Haqqi Anajili Setyanto Haqqi Anajili Setyanto Herawati Susilo Ihya Fakhrurizal Amin Ika Oktaviana Ika Oktaviana, Ika Istamar Syamsuri Istamar Syamsyuri Izza Rohman Kurniawan Setia Putra Listawati, Rizki Mei Misgiati, Misgiati Mochammad Ali Mashur Moh. Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohamad Amin Mohammad Amin Mohammad Amin Mohammad Amin Mohammad Amin Monalisa PJ Taihuttu Muh. Nur Akbar Murni Sapta Sari Nafisatuzzamrudah Nafisatuzzamrudah Nanda Earlia Nandang Mufti Naning Wahyuni Nindya Ulfa Wardhani Nugrahaningsih Nugrahaningsih Nur Hayati Rahman Fadli Rahmawati D Rahmawati Darussyamsu Reni Istiningrum RENI ISTININGRUM Ridho, Muhammad Andi Ali Ristiana, Evi Ritia Rahmawati Ritia Rahmawati Rizka Elan Fadilah, Rizka Elan Rizki Mei Listawati Rizkia Suciati Rizkia Suciati Saparuddin Saparuddin Sembiring, Rinawati Siti Nur Arifah Siti Rahma Lestaluhu Sri Endah Indriwati Sri Rahayu Lestari Sulistyo Dwi Kartining Putro Sulistyo Dwi Kartining Putro Susriyati Mahanal Sutiman B Sumitro Sutiman B Sumitro, Sutiman Sutiman B. Sumitro Ulin Nuha Ulin Nuha Ulya Ruwaida Umi Fitriyati Urla Tri Wulanzani Urla Tri Wulanzani