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All Journal STOMATOGNATIC- Jurnal Kedokteran Gigi ODONTO Dental Journal Odonto dental journal
Dewi, Leni Rokhma
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Health Professions Medicine & Pharmacology

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Daya Hambat Ekstrak Buah Okra (Abelmoschus esculentus L.) terhadap Pertumbuhan Candida albicans Iflachiana, Usykuri Naila; Dewi, Leni Rokhma; Prihanti, Ayu Mashartini
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 21 No 1 (2024)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v21i1.47338

Abstract

Oral candidiasis is a fungal infection of the superficial epithelium of the oral cavity caused by an overgrowth of Candida species. Effective therapy for oral candidiasis is nystatin. However, this drug has a variety of side effects. Therefore, natural therapeutic agent with minimal side effects is needed to be safe in long-term use. Okra fruit contains active ingredients that can be used as an antifungal agent. Aims to prove the ability of okra fruit extract and analyze the optimal concentration of okra fruit extract in inhibitting the growth of C. albicans. The antifungal activity test was carried out using the disk diffusion method. The research sample was divided into six groups, namely K (+) (nystatin), K (-) (DMSO 10%), and okra fruit extract with concentrations of 100%, 75%, 50%, and 25% obtained through the maceration process. Each research group was taken with a micropipette and then dripped on a paper disk. Paper disks were placed and distributed evenly on the surface of Saboroud Dextrose Agar (SDA) media that had been inoculated with C. albicans then incubated for 48 hours. The results showed the formation of a clear area around the paper disk that has been dropped with concentrations of 100%, 75%, and 50% of okra fruit extract. Okra fruit extract had an inhibitory effect on the growth of C. albicans and 100% concentration of okra fruit extract had the optimal ability to inhibit the growth of C. albicans.
Bay Leaf Extract Aggravated Fungal Infections in The Rat Model of Oral Candidiasis. Sulistyani, Erna; Triwahyuni, Iin Eliana; Dewi, Leni Rokhma; Futaihana, Hasna' Garaniva; Andriani, Hilma; Agustin, Merry Ayu Ayu; Khairunnisa, Luthfitah Zahra
Odonto : Dental Journal Vol 12, No 2 (2025): August 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.2.136-142

Abstract

Background: The prevalence of oral candidiasis has been increasing in recent years due to various factors, such as diseases that weaken the immune system, medication, xerostomia, and chemotherapy. The types of antifungal drugs are still very limited, and those that can be given systemically have significant side effects. Numerous in-vitro studies have demonstrated that bay leaves have antifungal properties. This study aimed to evaluate the effect of bay leaf extract in vivo on the oral candidiasis rat model.Method: The rat model for oral candidiasis was created by adding Tetracycline HCl 500 mg/L to the rats' drinking water. Then, the rats were injected with methylprednisolone one day before and after inoculating 0.3 ml of Candida albicans (9.4 x 107 cells/ml) into the oral cavity of the rats. The bay leaf extract was given to two groups of the oral candidiasis rat model by intragastric tube at 250 mg/kgBW/day (P1) and 500 mg/kgBW/day (P2)  doses for 5 days.  Oral candidiasis infection was evaluated on the last day by counting the number of colonies from swabs of the oral mucosa cultured on SDA-C. Result: After 5 days of treatment, the number of fungal colonies of group P2 was surprisingly higher than P1, positive and negative control. Conclusion: This study revealed that bay leaf extract aggravated oral candidiasis in vivo. The flavonoids in bay leaves may inhibit the production of pro-inflammatory cytokines, which could diminish the rats' immune response.
Bay Leaf Extract Aggravated Fungal Infections in The Rat Model of Oral Candidiasis. Sulistyani, Erna; Triwahyuni, Iin Eliana; Dewi, Leni Rokhma; Futaihana, Hasna' Garaniva; Andriani, Hilma; Agustin, Merry Ayu Ayu; Khairunnisa, Luthfitah Zahra
Odonto : Dental Journal Vol 12, No 2 (2025): August 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.2.136-142

Abstract

Background: The prevalence of oral candidiasis has been increasing in recent years due to various factors, such as diseases that weaken the immune system, medication, xerostomia, and chemotherapy. The types of antifungal drugs are still very limited, and those that can be given systemically have significant side effects. Numerous in-vitro studies have demonstrated that bay leaves have antifungal properties. This study aimed to evaluate the effect of bay leaf extract in vivo on the oral candidiasis rat model.Method: The rat model for oral candidiasis was created by adding Tetracycline HCl 500 mg/L to the rats' drinking water. Then, the rats were injected with methylprednisolone one day before and after inoculating 0.3 ml of Candida albicans (9.4 x 107 cells/ml) into the oral cavity of the rats. The bay leaf extract was given to two groups of the oral candidiasis rat model by intragastric tube at 250 mg/kgBW/day (P1) and 500 mg/kgBW/day (P2)  doses for 5 days.  Oral candidiasis infection was evaluated on the last day by counting the number of colonies from swabs of the oral mucosa cultured on SDA-C. Result: After 5 days of treatment, the number of fungal colonies of group P2 was surprisingly higher than P1, positive and negative control. Conclusion: This study revealed that bay leaf extract aggravated oral candidiasis in vivo. The flavonoids in bay leaves may inhibit the production of pro-inflammatory cytokines, which could diminish the rats' immune response.
Co-Authors Agustin, Merry Ayu Ayu Andriani, Hilma Erna Sulistyani Futaihana, Hasna' Garaniva Iflachiana, Usykuri Naila Iin Eliana Triwahyuni Khairunnisa, Luthfitah Zahra Prihanti, Ayu Mashartini