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Chandrakar, Shashikant
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Medicine & Pharmacology

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FORMULATION, OPTIMIZATION AND EVALUATION OF QUICK DISPERSIBLE TABLETS OF SUMATRIPTAN Baghel, Pragya; Roy, Amit; Chandrakar, Shashikant; Bahadur, Sanjib; Bhairam, Monika
Journal of Applied Pharmaceutical Research Vol 7 No 3 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2019.004

Abstract

The main objective of this study was to prepare Quick Dispersible Tablets of drug Sumatriptan Succinate, which can rapidly disintegrate in the saliva using three different Superdisintegrants that is, Sodium Starch Glycolate, Crospovidone, and Croscarmallose Sodium with Taste Masking Polymer Beta-Cyclodextrin and Aspartame as a Sweetener. The taste masking of the drug was done by mixing it with the polymer beta-cyclodextrin using Solvent Evaporation method and then mixing optimized quantity of aspartame to it. The Quick Dispersible tablets were prepared by Direct Compression Technique using taste masked drug and other formulation excipients. The effect of various Superdisintegrants in three different concentrations has been studied. The prepared tablets were evaluated for wetting time, In-vitro Disintegration time, strength, and in-vitro Dissolution time. As per the results obtained, it was found that the formulation batch no. 4 was found to be the best formulation, as the data?s obtained by it was found to be in the required range of mouth dissolving tablets.
Formulation, optimization and evaluation of quick dispersible tablets of sumatriptan Baghel, Pragya; Roy, Amit; Chandrakar, Shashikant; Bahadur, Sanjib; Bhairam, Monika
Journal of Applied Pharmaceutical Research Vol. 7 No. 3 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (516.132 KB) | DOI: 10.18231/j.joapr.2019.004

Abstract

The main objective of this study was to prepare quick dispersible tablets of drug sumatriptan succinate, which can rapidly disintegrate in the saliva using three different superdisintegrants that is, sodium starch glycolate, crospovidone, and croscarmallose sodium with taste masking polymer beta-cyclodextrin and aspartame as a sweetener. The taste masking of the drug was done by mixing it with the polymer beta-cyclodextrin using solvent evaporation method and then mixing optimized quantity of aspartame to it. The quick dispersible tablets were prepared by direct compression technique using taste masked drug and other formulation excipients. The effect of various super disintegrants in three different concentrations has been studied. The prepared tablets were evaluated for wetting time, in-vitro disintegration time, strength, and in-vitro dissolution time. As per the results obtained, it was found that the formulation batch no. 4 was found to be the best formulation, as the data’s obtained by it was found to be in the required range of mouth dissolving tablets.
Formulation and evaluation of ointment containing hydroalcoholic extract derived from the bark of Moringa oleifera for wound healing activity in rat model Sahu, Himanshu; Satapathy, Trilochan; Chandrakar, Shashikant; Gupta, Puahpa Prasad; Sahu, Poonam; Sahu, Akhilesh
Journal of Applied Pharmaceutical Research Vol. 12 No. 4 (2024)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69857/joapr.v12i4.556

Abstract

Background: This study aimed to assess the effectiveness of a hydroalcoholic extract derived from the bark of Moringa oleifera in facilitating the healing process of second-degree burns wounds. Moreover, a comprehensive assessment was carried out on standardized M. oleifera bark to ascertain its physiochemical characteristics, botanical compound layout, and antioxidant activity, all of which play a crucial role in its capacity to facilitate the healing process of burns. Methods: For 14 days, the efficacy of ointments containing a hydroalcoholic extract of M. oleifera bark at concentrations of 5% and 10% was evaluated for treating second-degree burns in rats. Additionally, histological analysis was conducted on skin tissue samples. Results: The M. oleifera bark extract exhibited TPC (52.56 mg/gm of dried extract) and TFC (84.33 mg/gm of dried extract) value along with antioxidant activity (IC50 value of 0.98 µg/ml) for radical scavenging, in the presence of several phytochemicals. The most favorable outcomes were achieved using a 10% ointment composition, demonstrating a wound closure and tissue repair rate of 83.04 ± 0.89%, along with a noteworthy decrease in tissue oxidative stress indicators. Histological investigations have verified the wound-healing properties of M. oleifera bark extract. Conclusion: Due to its significant antioxidant properties and its capacity to create a moist environment for wounds, M. oleifera has the potential to serve as a natural treatment for burns. Additional clinical trials are recommended to validate the efficacy of M. oleifera bark extract as a therapeutic agent for wound healing.
Co-Authors Amit Roy, Amit Gupta, Puahpa Prasad Monika Bhairam, Monika Pragya Baghel, Pragya Sahu, Akhilesh Sahu, Himanshu Sahu, Poonam Sanjib Bahadur, Sanjib Trilochan Satapathy, Trilochan