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Sanjib Bahadur, Sanjib
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Medicine & Pharmacology

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Effect of solubilization technique on dissolution Das, Sujoy; Bahadur, Sanjib; Choudhury, Ananta; Saha, Suman
Journal of Applied Pharmaceutical Research Vol 2 No 1 (2014)
Publisher : Creative Pharma Assent

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Abstract

More than 40 percent of newly discovered drugs have little or  no water solubility thus the present research aimed at the study of improvement of solublisation on dissolution by addition of different solublising agents and modification of methods. Irbesartan is the drug of choice. Effect of Solubility on dissolution was studied with some solubilizing agents like ?-Cyclodextrins, PEG-6000, Polysorbate-80, Cremophore and Resins (Doshion). It was seen that Irbesartan give 90 percent release in 1hr with polysorbate-80 where cremophore containing tablets showed 97 % release in 1 hr in case of solid dispersion technique and in case of complexation technique respectively. Thus the present study concluded that, dissolution rate of poorly soluble drug can be increases by using solubilizing agent as well as using different techniques.  
Review on natural gums and mucilage and their application as excipient Bahadur, Sanjib; Sahu, Uttam; Sahu, Dipesh; Sahu, Ghanshyam; Roy, Amit
Journal of Applied Pharmaceutical Research Vol 5 No 4 (2017)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/2348-0335.2017.0010

Abstract

Natural mucilage’s are included in novel drug delivered (NDDS) to multitask functions and in any cases directly or indirectly control the increase and rate of drug release. Substantial research efforts have been directed towards develop safe and efficient natural based mucilage particulate drug delivery systems., natural gums and mucilages and their isolation, purification, standardization and characterization characteristics along with their applications are covered. Recent trend towards the use of plant based and natural products demands the replacement of synthetic additives with natural ones. Today, the whole world is increasingly interested in natural drugs and excipients. These natural mucilages have advantages over synthetic ones since they are chemically inert, nontoxic, less expensive, and widely available.
Formulation and evaluation of enteric coated microcapsules of diclofenac sodium for modified release by combination of wet granulation and thermal change method Roy, Amit; Saha, Suman; Choudhury, Ananta; Bahadur, Sanjib; Baghel, Pragya; Chanda, Ranabir
Journal of Applied Pharmaceutical Research Vol 2 No 4 (2014)
Publisher : Creative Pharma Assent

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Abstract

The purpose of the present work was to develop optimized novel enteric microcapsules containing diclofenac sodium, a non steroidal anti inflammatory drug (NSAID) used for rheumatoid arthritis, for improved delivery and to diminish its adverse effect after oral administration. The microcapsule was prepared by using different polymers and the enteric coating was provided by using an innovative technique combining wet granulation method and thermal change method. This work also investigated different levels of enteric polymers like cellulose acetate phthalate (CAP) (X1) and ethyl cellulose (EC) (X2) and the stirring speed during coating ethyl cellulose (X3), by using 23 full factorial design. The dependent variables assessed were % yield (Y1), Q8 (% drug released after 8 hour) (Y2), n (Diffusion coefficient) (Y3), DEE (Drug entrapment efficiency) (Y4). The main effect and interaction terms were quantitatively evaluated using a mathematical model. The prepared microcapsules were evaluated for percentage drug dissolved, scanning electron microscopy, drug excipient interaction, angle of repose, particle size. Mean dissolution time (MDT) was used to compare dissolution patterns obtained. The results showed that X1 and X2 significantly affected the release properties. 
Standardization of herbal medicines – an overview Bhairam, Monika; Roy, Amit; Bahadur, Sanjib; Banafar, Alisha; Turkane, Dhanushram
Journal of Applied Pharmaceutical Research Vol 1 No 1 (2013)
Publisher : Creative Pharma Assent

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Abstract

In the few decades, there has been exponentional growth in the field of herbal medicines. Most of the traditional systems of medicine are effective due to lack of standardization. So there is a need to develop a standardization technique. Standardization of herbal formulation is essential in order to assess the quality, purity, safety and efficacy of the drug. There is increasing awareness and general acceptability of the use herbal drugs in today’s medical practice. The world population depends on herbal medicines and product for healthy living. This rise in the use of herbal product has also given rise to various forms of adulteration of the products, which leading to consumers’ and manufacturers’ disappointment and in some instances fatal consequences. The challenge is innumerable and enormous, to fulfill the need of global herbal market. The standardization of this formulations like the organoleptic characters, physical properties, the various physic-chemical properties such as moisture content, ash values, extractive values need to be carried out along with Thin layer chromatography and heavy metal content study should also carried out to ascertain the quality, purity and safety of this herbal formulation.
INVESTIGATION OF OXIDATIVE POTENTIAL OF MAHASUDARSHAN CHURNA USING GOAT LIVER AS IN-VITRO EXPERIMENTAL MODEL Pandit, Bibhas; Satapathy, Trilochan; Bahadur, Sanjib; Dewangan, Jyoti
Journal of Applied Pharmaceutical Research Vol 7 No 2 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2019.002

Abstract

The American Medical Research Community sounded a heavy metal warning against some herbo-mineral Ayurvedic formulations from Indian System of Medicine sold in United States of America. The products were rejected by Unites States Food and Drug Administration due to the presence of high level of lead, mercury and arsenic as impurities, marked as toxicity inducers. This work has been design to investigate whether the toxicity produced by Mahasudarshan churna is due to the results of lipid peroxidation, as oxidative degradation of phospholipids is one of the causes of drug-induced toxicity. The level of malondialdehyde, reduced glutathione and nitric oxide were estimated in control, drug-treated, drug-antioxidant treated and only antioxidant-treated group at two hours and six hours of incubation time in goat liver homogenates. Ascorbic acid was used to compare the oxidative potentials of Mahasudarshan churna. The level of malondialdehyde was found to be decreased in the drug-treated, drug-antioxidant treated and only antioxidant treated group where as the level of reduced glutathione and nitric oxide increased when compared to control. Above all the Drug-antioxidant treated group showed maximum anti-oxidant properties when compared to other groups. The study was designed to investigate the lipid peroxidation induction capacity of Mahasudarshan churna as consequences of its toxicity and found that lipid peroxidation is not the contributing factor.
FORMULATION, OPTIMIZATION AND EVALUATION OF QUICK DISPERSIBLE TABLETS OF SUMATRIPTAN Baghel, Pragya; Roy, Amit; Chandrakar, Shashikant; Bahadur, Sanjib; Bhairam, Monika
Journal of Applied Pharmaceutical Research Vol 7 No 3 (2019)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2019.004

Abstract

The main objective of this study was to prepare Quick Dispersible Tablets of drug Sumatriptan Succinate, which can rapidly disintegrate in the saliva using three different Superdisintegrants that is, Sodium Starch Glycolate, Crospovidone, and Croscarmallose Sodium with Taste Masking Polymer Beta-Cyclodextrin and Aspartame as a Sweetener. The taste masking of the drug was done by mixing it with the polymer beta-cyclodextrin using Solvent Evaporation method and then mixing optimized quantity of aspartame to it. The Quick Dispersible tablets were prepared by Direct Compression Technique using taste masked drug and other formulation excipients. The effect of various Superdisintegrants in three different concentrations has been studied. The prepared tablets were evaluated for wetting time, In-vitro Disintegration time, strength, and in-vitro Dissolution time. As per the results obtained, it was found that the formulation batch no. 4 was found to be the best formulation, as the data?s obtained by it was found to be in the required range of mouth dissolving tablets.
Standardization of herbal medicines – an overview Bhairam, Monika; Roy, Amit; Bahadur, Sanjib; Banafar, Alisha; Turkane, Dhanushram
Journal of Applied Pharmaceutical Research Vol. 1 No. 1 (2013)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.877 KB)

Abstract

In the few decades, there has been exponentional growth in the field of herbal medicines. Most of the traditional systems of medicine are effective due to lack of standardization. So there is a need to develop a standardization technique. Standardization of herbal formulation is essential in order to assess the quality, purity, safety and efficacy of the drug. There is increasing awareness and general acceptability of the use herbal drugs in today’s medical practice. The world population depends on herbal medicines and product for healthy living. This rise in the use of herbal product has also given rise to various forms of adulteration of the products, which leading to consumers’ and manufacturers’ disappointment and in some instances fatal consequences. The challenge is innumerable and enormous, to fulfill the need of global herbal market. The standardization of this formulations like the organoleptic characters, physical properties, the various physic-chemical properties such as moisture content, ash values, extractive values need to be carried out along with Thin layer chromatography and heavy metal content study should also carried out to ascertain the quality, purity and safety of this herbal formulation.
Effect of solubilization technique on dissolution Das, Sujoy; Bahadur, Sanjib; Choudhury, Ananta; Saha, Suman
Journal of Applied Pharmaceutical Research Vol. 2 No. 1 (2014)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (518.489 KB)

Abstract

More than 40 percent of newly discovered drugs have little or no water solubility thus the present research aimed at the study of improvement of solublisation on dissolution by addition of different solublising agents and modification of methods. Irbesartan is the drug of choice. Effect of Solubility on dissolution was studied with some solubilizing agents like β-Cyclodextrins, PEG-6000, Polysorbate-80, Cremophore and Resins (Doshion). It was seen that Irbesartan give 90 percent release in 1hr with polysorbate-80 where cremophore containing tablets showed 97 % release in 1 hr in case of solid dispersion technique and in case of complexation technique respectively. Thus the present study concluded that, dissolution rate of poorly soluble drug can be increases by using solubilizing agent as well as using different techniques
Formulation and evaluation of enteric coated microcapsules of diclofenac sodium for modified release by combination of wet granulation and thermal change method Bahadur, Sanjib; Baghel, Pragya; Chanda, Ranabir; Roy, Amit; Saha, Suman; Choudhury, Ananta
Journal of Applied Pharmaceutical Research Vol. 2 No. 4 (2014)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (501.495 KB)

Abstract

The purpose of the present work was to develop optimized novel enteric microcapsules containing diclofenac sodium, a non steroidal anti inflammatory drug (NSAID) used for rheumatoid arthritis, for improved delivery and to diminish its adverse effect after oral administration. The microcapsule was prepared by using different polymers and the enteric coating was provided by using an innovative technique combining wet granulation method and thermal change method. This work also investigated different levels of enteric polymers like cellulose acetate phthalate (CAP) (X1) and ethyl cellulose (EC) (X2) and the stirring speed during coating ethyl cellulose (X3), by using 23 full factorial design. The dependent variables assessed were % yield (Y1), Q8 (% drug released after 8 hour) (Y2), n (Diffusion coefficient) (Y3), DEE (Drug entrapment efficiency) (Y4). The main effect and interaction terms were quantitatively evaluated using a mathematical model. The prepared microcapsules were evaluated for percentage drug dissolved, scanning electron microscopy, drug excipient interaction, angle of repose, particle size. Mean dissolution time (MDT) was used to compare dissolution patterns obtained. The results showed that X1 and X2 significantly affected the release properties.
Review on natural gums and mucilage and their application as excipient Bahadur, Sanjib; Sahu, Uttam Kumar; Sahu, Dipesh; Sahu, Ghanshyam; Roy, Amit
Journal of Applied Pharmaceutical Research Vol. 5 No. 4 (2017)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (732.392 KB) | DOI: 10.18231/2348-0335.2017.0010

Abstract

Natural mucilage’s are included in novel drug delivered (NDDS) to multitask functions and in any cases directly or indirectly control the increase and rate of drug release. Substantial research efforts have been directed towards develop safe and efficient natural based mucilage particulate drug delivery systems., natural gums and mucilages and their isolation, purification, standardization and characterization characteristics along with their applications are covered. Recent trend towards the use of plant based and natural products demands the replacement of synthetic additives with natural ones. Today, the whole world is increasingly interested in natural drugs and excipients. These natural mucilages have advantages over synthetic ones since they are chemically inert, nontoxic, less expensive, and widely available.
Co-Authors Alisha Banafar, Alisha Amit Roy, Amit Ananta Choudhury, Ananta Chandrakar, Shashikant Dewangan, Jyoti Dhanushram Turkane, Dhanushram Dipesh Sahu, Dipesh Ghanshyam Sahu, Ghanshyam Monika Bhairam, Monika Pandit, Bibhas Pragya Baghel, Pragya Ranabir Chanda, Ranabir Sahu, Uttam Kumar Sujoy Das, Sujoy Suman Saha, Suman Trilochan Satapathy, Trilochan Uttam Sahu, Uttam