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All Journal Jurnal Ilmiah Farmasi JFIOnline Jurnal Mandala Pharmacon Indonesia Jurnal Farmasi dan Sains Indonesia (JFSI)
Sarimanah, Jamilah
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience

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HYPOGLYCEMIC EFFECT TEST OF ETHANOLIC EXTRACT OF BALIGO SEEDS (BENINCASA HISPIDA (THUMB.) COGN.) ON WHITE MALE RATS WISTAR STRAIN WITH ALLOXAN INDUCTION Maryati, Dina; Sarimanah, Jamilah; Herdwiani, Wiwin; Zamzani, Irfan
Jurnal Farmasi Indonesia Vol 11, No 2 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v11i2.668

Abstract

Baligo is native of tropical regions in Indonesia known as a large gourd or pumpkin. Baligo among others contain carbohydrates, glycosides, alkaloids, phytosterols, gums and mucilago, saponins, proteins and free amino acids, and flavonoids. Chemical constituents in seed baligo which is thought to have anti-diabetic activity of flavonoids and saponins. This study aims to determine the hypoglycemic effect of ethanolic extract of baligo seeds (Benincasa hispida (Thumb.) Cogn.) and find out what the larger dose of ethanolic extract of baligo seeds (Benincasa hispida (Thumb.) Cogn.) the greater hypoglycemic effect on white male rats strain wistar with alloxan induction. This study used a method in which alloxan induced rats were divided into five treatment groups that each group consisted of five rats. Group I as a negative control (CMC 0.5%), Group II as a positive control (glibenclamide) at a dose of 0.09 mg/200 g BB rats, and Group III, IV, V given doses of ethanol extract of seeds baligo 4.10 mg/200 g BB rast, 8.21 mg/200 g BB rats, 16.42 mg/200 g BB rats. All groups alloxan induced on day 0 (after fasting 16 hours) intraperitoneally. Examination of blood sugar levels performed on days 4 and 8 after administration of the test preparation. Statistical analysis showed that the greater the dose of ethanolic extract of baligo seeds (4.10 mg/200 g BB rats, 8.21 mg/200 g BBrats, 16.42 mg/200 g BB rats) was not the greater hypoglycemic effect on white male rats wistar strain with alloxan induced 
ANALISIS BAHAN KIMIA OBAT ASAM MEFENAMAT DALAM JAMU PEREDA NYERI YANG BEREDAR DI NGAWI DAN ONLINE SHOP SECARA KLT DAN SPEKTROFOTOMETRI UV-VIS Harjanti, Reslely; Pratiwi, Intan; Sarimanah, Jamilah
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p7-16

Abstract

One of the medicinal chemicals (BKO) that is abused in herbs preparations for pain reliever is mefenamic acid. Mefenamic acid is a class of non-steroidal anti-inflammatory drug (NSAID). The addition of mefenamic acid in herbs medicine aims to increase the effect of pain relief, but can caused harmful effects, including digestive tract disorders, hemolytic anemia, and seizures. The purpose of this study is to determine the presence of mefenamic acid in pain reliever herbs circulating in Ngawi and online shop.The samples in this study were several brands of pain reliever herbs from 4 herbal medicine shops (A,B,C, and D). This research is using purposive sampling method based on inclusion criteria. Samples was analyzed qualitatively by thin layer chromatography (TLC) method using cyclohexane:chloroform: methanol:glacial acetic acid (60:30:5:5) as mobile phase and silica GF254 as stationary phase. Quantitive analysis using spectrophotometry UV-Vis method. The results showed that 10 of 16 samples of herbal pain reliever were positive for mefenamic acid with levels ranging from 1.28% -7.30%. The UV-Vis spectrophotometric analysis method suitable for the analysis of mefenamic acid in herbal medicine for pain reliever based on validation results that meet the requirements includes linearity with r value 0.99956, accuracy 8 ppm was 100.32%, 10 ppm was 100.84%, 12 ppm was 100.61%, precision 1.33%, LOD 0.8914299023 ppm, and LOQ 2.701302734 ppm.
Tingkat Kepuasan Pasien terhadap Pelayanan Kefarmasian Di Apotek X Periode Februari Tahun 2024 Putri, Annisa Dwi Marita; Harsono, Samuel Budi; Sarimanah, Jamilah
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.561

Abstract

Pelayanan kefarmasian tidak lepas dari kualitas pelayanan apotek itu sendiri. Hal ini sangat berkaitan erat dengan kepuasan pasien, dimana kepuasan pasien merupakan cerminan kualitas pelayanan kesehatan yang mereka terima. Tujuan dari penelitian ini adalah untuk mengetahui tingkat kepuasan pasien terhadap pelayanan di Apotek X berdasarkan kehandalan, ketanggapan, jaminan, empati dan bukti fisik secara parsial dan keseluruhan. Metode yang digunakan pada penelitian ini adalah metode SERVQUAL (Service Quality) dengan dimensi Tangible (bukti nyata), Reliability (kehandalan), Responsiveness (ketanggapan), Assurance (jaminan), Empathy (keramahan). Sampel dalam penelitian ini adalah pasien atau keluarga pasien yang menerima pelayanan kefarmasian dan termasuk dalam kriteria inklusi dan teknik pengambilan sampel yang dilakukan yaitu purposive sampling. Analisis data menggunakan metode analisis gap (kesenjangan) yang dihasilkan dari skor harapan dan skor kenyataan pelayanan kefarmasian di Apotek X yang telah diukur dengan skala likert. Hasil dari penelitian ini pasien merasa puas pada dimensi tangible, responsiveness, dan empathy dengan nilai masing-masing gap 0,0533; 0,0150;0,0267. Hasil pada dimensi reliability dan assurance menyatakan bahwa pasien merasa tidak puas terhadap pelayanan kefarmasian dengan nilai masingmasing gap adalah -0,0367; -0,0033. Secara keseluruhan menunjukkan bahwa pasien merasa puas dengan nilai gap 0,011.
AKTIVITAS ANTIPIRETIK EKSTRAK ETANOL DAUN SAMPARE (Glochidion philippicum (Cav.) C.B.Rob.) PADA MENCIT PUTIH JANTAN (Mus musculus) YANG DIINDUKSI PEPTON Amala, Ima Choirul; Sarimanah, Jamilah; Wijayanti, Tri
Jurnal Ilmiah Farmasi Vol. 22 No. 1 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss1.art10

Abstract

Background: Sampare leaves (Glochidion philippicum (Cav.) C.B. Rob.) contain secondary metabolites, including flavonoids, tannins, steroids, alkaloids, and saponins, which exhibit antipyretic potential.Objective: This study aimed to evaluate the antipyretic efficacy of the ethanolic extract of sampare leaves in a peptone-induced fever mouse model.Method: The ethanolic extract of sampare leaves was prepared via maceration, and its secondary metabolites were qualitatively identified using standard test-tube reagents. For the in vivo study, twenty-five male Swiss mice (Mus musculus) were randomly divided into five groups. Group I (negative control) received a 0.5% CMC-Na suspension, and Group II (positive control) received paracetamol at a dose of 65 mg/kg body weight (BW). Groups III, IV, and V were administered the ethanolic extract at doses of 200, 400, and 800 mg/kg BW, respectively. Pyrexia was induced via subcutaneous injection of peptone (0.5 mL/g BW). Rectal temperatures were measured using a digital thermometer every 15 minutes for a duration of 180 minutes. Data were analyzed using the Shapiro-Wilk test, followed by repeated measures ANOVA and an appropriate post-hoc test.Results: The maceration process yielded 20.05% (w/w) of ethanolic extract. Phytochemical screening confirmed the presence of tannins, flavonoids, steroids, alkaloids, and saponins. Furthermore, the in vivo evaluation showed that the extract exhibited significant antipyretic activity. The 800 mg/kg BW dose demonstrated the highest antipyretic activity, which was significantly different from the negative control (p < 0.05) and comparable to the positive control (paracetamol). Conclusion: Sampare leaf ethanol extract had antipyretic activity, with an effective dose of 800 mg/kg body weight in mice.
Co-Authors Amala, Ima Choirul Harsono, Samuel Budi Maryati, Dina Pratiwi, Intan Putri, Annisa Dwi Marita Reslely Harjanti Tri Wijayanti Wiwin Herdwiani Zamzani, Irfan