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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Acta Pharmaciae Indonesia : Acta Pharm Indo JFIOnline Jurnal Insan Farmasi Indonesia Proceeding ISETH (International Summit on Science, Technology, and Humanity) Jurnal Pengabdian Masyarakat Bangsa
Zamzani, Irfan
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HYPOGLYCEMIC EFFECT TEST OF ETHANOLIC EXTRACT OF BALIGO SEEDS (BENINCASA HISPIDA (THUMB.) COGN.) ON WHITE MALE RATS WISTAR STRAIN WITH ALLOXAN INDUCTION Maryati, Dina; Sarimanah, Jamilah; Herdwiani, Wiwin; Zamzani, Irfan
Jurnal Farmasi Indonesia Vol 11, No 2 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v11i2.668

Abstract

Baligo is native of tropical regions in Indonesia known as a large gourd or pumpkin. Baligo among others contain carbohydrates, glycosides, alkaloids, phytosterols, gums and mucilago, saponins, proteins and free amino acids, and flavonoids. Chemical constituents in seed baligo which is thought to have anti-diabetic activity of flavonoids and saponins. This study aims to determine the hypoglycemic effect of ethanolic extract of baligo seeds (Benincasa hispida (Thumb.) Cogn.) and find out what the larger dose of ethanolic extract of baligo seeds (Benincasa hispida (Thumb.) Cogn.) the greater hypoglycemic effect on white male rats strain wistar with alloxan induction. This study used a method in which alloxan induced rats were divided into five treatment groups that each group consisted of five rats. Group I as a negative control (CMC 0.5%), Group II as a positive control (glibenclamide) at a dose of 0.09 mg/200 g BB rats, and Group III, IV, V given doses of ethanol extract of seeds baligo 4.10 mg/200 g BB rast, 8.21 mg/200 g BB rats, 16.42 mg/200 g BB rats. All groups alloxan induced on day 0 (after fasting 16 hours) intraperitoneally. Examination of blood sugar levels performed on days 4 and 8 after administration of the test preparation. Statistical analysis showed that the greater the dose of ethanolic extract of baligo seeds (4.10 mg/200 g BB rats, 8.21 mg/200 g BBrats, 16.42 mg/200 g BB rats) was not the greater hypoglycemic effect on white male rats wistar strain with alloxan induced 
Antibacterial activity of Cassia alata stems ethanol extract against Staphylococcus aureus Mar'ie, Ahmad Mahdi; Zamzani, Irfan; Nashihah, Siti
Acta Pharmaciae Indonesia Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.5462

Abstract

Background: Cassia alata leaves, also known as petai cina or gelinggang in Indonesia, are commonly used to treat skin ailments. Objective: The purpose of this study is to test whether stem of C. alata has antibacterial activity against Staphylococcus aureus. Methods: C. alata stems were extracted using an ultrasound-assisted extraction method. For antibacterial activity, disc diffusion was used with extract concentrations of 25%, 50%, 75%, and 100%. Results: The inhibition zones of the ethanol extract of C. alata stems at 25%, 50%, and 75% concentrations were 17.6 mm, 21 mm, and 22.6 mm, respectively, with the highest inhibition zone at 100% concentration at 25 mm. Conclusion: The ethanolic extract of C. alata stems has a strong inhibitory effect on Staphylococcus aureus.
Antibacterial activity of ethanol extract of limpasu (Baccaurea lanceolata) pericarpium with the ultrasound assisted extraction method against Propionibacterium acne Ulpah, Rusmili; Nashihah, Siti; Zamzani, Irfan
Acta Pharmaciae Indonesia Vol 11 No 1 (2023): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2023.11.1.6393

Abstract

Background: Acne, a prevalent skin condition, can arise from factors such as an unhealthy lifestyle, dietary habits, hormonal imbalances, and bacterial infections. Propionibacterium acnes is a notable bacterium responsible for acne. In South Borneo, the pericarpium of the limpasu plant (Baccaurea lanceolata) is traditionally used to treat acne. Objective: This study aims to scientifically validate the empirical antibacterial effects of limpasu pericarpium against Propionibacterium acnes, as reported by the communities in South Borneo. Methods: The ultrasound-assisted extraction (UAE) method was utilized to extract compounds from limpasu pericarpium. The antibacterial activity of the limpasu pericarpium extract was evaluated using the disc diffusion method at concentrations of 20%, 40%, 60%, 80%, and 100% w/v. Clindamycin served as the positive control, and 1% DMSO was the negative control. Results: The lowest concentration (20%) fell within the strong activity category, producing a clear zone diameter of 18.76 mm. Higher concentrations (40%, 60%, 80%, and 100%) demonstrated more potent antibacterial effects, with inhibition zones of 23.23 mm, 26.06 mm, 26.93 mm, and 27.33 mm, respectively. Notably, 60% to 100% concentrations exhibited greater inhibitory effects than the positive control, clindamycin, which had an inhibition zone of 25.23 mm. Conclusion: The study confirms the antibacterial properties of limpasu pericarpium against Propionibacterium acnes, supporting the traditional claims of its efficacy by the South Borneo communities.
AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL 96% DAUN BANGKAL (Nauclea subdita) TERHADAP BAKTERI Staphylococcus aureus Monica, Cahya; Zamzani, Irfan; Siti Nashihah
Jurnal Insan Farmasi Indonesia Vol 7 No 2 (2024): JIFI : Special edition
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v7i2.2129

Abstract

Bangkal (Nauclea subdita) is a typical plant in the southern part of the island of Borneo. In everyday life, bangkal leaves are used to treat wounds, ulcers, toothache, fever and diarrhea. The purpose of this study was to measure and determine the antibacterial activity of the ethanol extract of bangkal leaves against Staphylococcus aureus using the Ultrasonic Assisted Extraction (UAE) method. Bangkal leaves were extracted by UAE using 96% ethanol. The antibacterial inhibition test was carried out using the Kirby-Bauer disc diffusion method. Testing of antibacterial inhibition zones of Bangkal leaf extract against Staphylococcus aureus bacteria had an effect or significantly different with concentrations of 40%, 60%, 80%, 100% respectively and produced antibacterial activity with inhibition zones of 12.7±0.06 respectively. mm, 13.9±0.00 mm, 15±0.00 mm, 16±0.00mm. The results of the antibacterial activity examination showed that the ethanolic extract of bangkal leaves could inhibit the growth of Staphylococcus aureus at a concentration of 40% with an inhibition zone diameter of 12.7 mm and the highest concentration at 100% with an inhibition zone diameter of 16.00 mm. This indicates that the extract of bangkal leaves has antibacterial activity against Staphylococcus aureus which has an inhibition zone with a moderate to strong category.
Sosialisasi Obesitas dan Pencegahannya dengan Infused Water pada Usia Remaja di SMK Islam Sabilal Muhtadin Banjarmasin Latifah, Nor; Sa’adah, Hayatus; Zamzani, Irfan
Jurnal Pengabdian Masyarakat Bangsa Vol. 1 No. 12 (2024): Februari
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v1i12.742

Abstract

Indonesia menghadapi transisi epidemiologi, yaitu terjadinya perubahan beban penyakit dari penyakit menular ke penyakit tidak menular (PTM). Penyakit menular menjadi penyebab kematian dan kecacatan terbesar di Indonesia disebabkan oleh gaya hidup yang tidak sehat. Gaya hidup yang tidak sehat, atau yang juga dikenal dengan istilah faktor risiko perilaku PTM, memberikan dampak bagi kesehatan salah satunya adalah terjadinya obesitas. Obesitas pada remaja ditandai dengan berat badan yang relatif berlebihan bila dibandingkan dengan usia atau tinggi badan. Adapun beberapa tujuan dari penelitian ini adalah untuk mengetahui apa yang dimaksud obesitas, kemudian untuk mengetahui apa penyebab dari obesitas, dan untuk mengetahui apa yang dimaksud dengan infused water. Metode yang digunakan dalam psikoedukasi ini adalah dengan metode eksperimen dengan desain pre-test post-test control group design. Dalam kegiatan ini pre-test dan post-test didesain dalam bentuk angket atau kuesioner. Kesimpulannya dengan melihat hasil pre-test dan pos-test yang dilakukan bahwa siswa SMK Islam Sabilal Muhtadin Banjarmasin memahami makna obesitas, kemudian siswa mengetahui penyebab obesitas diantaranya yaitu pola makan yang tidak tepat, pola aktivitas fisik yang kurang dan faktor lain seperti genetik. Serta siswa telah memahami yang dimaksud dengan infused water sebagai cara penanggulangan obesitas.
Edukasi Penyakit Gastritis Sejak Dini: Cegah Sakit Ciptakan Fokus Belajar di Lingkungan SMP Negeri 6 Banjarbaru Sa'adah, Hayatus; Latifah, Nor; Zamzani, Irfan; Ahdyani, Risa; Dewi, Retna Eka; Padjrin, Muhammad Awaluddin; Makki, Makki; Mahmudah, Mahmudah; Azzahra, Maulida
Jurnal Pengabdian Masyarakat Bangsa Vol. 2 No. 6 (2024): Agustus
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v2i6.1244

Abstract

Tujuan dari penyuluhan ini adalah untuk memberikan edukasi tentang definisi, penyebab, gejala dan terapi farmakologi atau non-farmakologi dari penyakit gastritis pada remaja sejak dini untuk pencegahan sehingga dapat meningkatkan fokus belajar. Metode yang digunakan adalah metode KIE (Konseling Informasi dan Edukasi) oleh Dosen dan Mahasiswa S1 Farmasi/Fakultas Farmasi Universitas Muhammadiyah Banjarmasin, dilaksanakan secara offline di SMPN 6 Banjarbaru. Berdasarkan hasil KIE kepada Siswa SMPN 6 Banjarbaru, mereka sudah mengetahui penyakit Gastritis dengan nama lain Maag, Sebagian besar pernah mengalami gastritis disebabkan karena tidak sarapan agar sampai ke sekolah tepat waktu. Dengan adanya KIE ini, siswa lebih memahami penyakit gastritis, pengobatan dan pencegahannya.
Antibacterial activity of Sappan (Caesalpinia sappan L.) wood methanol extract against Staphylococcus epidermidis Atunnisa, Waro; Zamzani, Irfan; Nashihah, Siti
Media Farmasi: Jurnal Ilmu Farmasi Vol. 20 No. 1: March 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i1.21900

Abstract

The entry and proliferation of microorganisms, such as bacteria, cause skin infections. One of the bacteria that causes skin infections is Staphylococcus epidermidis. Sappan (Caesalpinia sappan L.) wood has been known to have various pharmacology activities, one of which is antibacterial, so its activities need to be developed and improved. This study aimed to determine the activity of the methanol extract of Sappan (C. sappan L.) wood as an antibacterial against S. epidermidis. This research was conducted by extracting Sappan wood powder with 96% methanol as solvent using the Ultrasound-Assisted Extraction (UAE) method and testing for antibacterial activity with concentrations of 25%, 50%, 75% and 100% using the disc method. Results showed that the methanol extract of Sappan wood had an antibacterial activity; the highest inhibition zone at a concentration of 75% was 29.25 mm. Sappan wood was expected to be a promising alternative therapy for overcoming acne problems and can increase economic value for the wider community. 
Antibacterial Activity of Extract and Fraction of Baccaurea macrocarpa Leaf on Escherichia coli and Bacillus cereus Zamzani, Irfan; Triadisti, Nita
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.1426

Abstract

Purpose: The purpose of the present study is to investigate antibacterial activity of extract and fraction of Baccaurea macrocarpa leaf, and to identify secondary metabolite contents of the best activity.Methodology: Baccaurea macrocarpa leaf was extracted by using maceration method with the use of methanol solvent. The extract was then fractionated by adopting n-hexane and ethyl acetate by using liquid-liquid extraction. Antibacterial activity assay was performed by using inhibition zone assay particularly Disc Diffusion Susceptibility method from methanol extract and fraction extract of ethyl acetate and n-hexane. Phytochemical screening as the best activity was performed by using by adopting Thin Layer Chromatography (TLC). Result: Antibacterial activity was identified in the ethyl acetate extract of Baccaurea macrocarpa leaf. In addition, secondary metabolites with the best activity such as alkaloid, anthraquinone, flavonoid, and tannin were identifiable in the fraction extract of ethyl acetate of Baccaurea macrocarpa.
Co-Authors Ahdyani, Risa Atunnisa, Waro Azzahra, Maulida Dewi, Retna Eka Hayatus Sa’adah M. Awaluddin Padjrin Mahmudah Mahmudah Makki, Makki Mar'ie, Ahmad Mahdi Maryati, Dina Monica, Cahya Nashihah, Siti Nor Latifah Sarimanah, Jamilah Sa’adah, Hayatus Triadisti, Nita Ulpah, Rusmili Wiwin Herdwiani