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All Journal Jurnal Farmasi dan Sains Indonesia (JFSI) AS-SHIHA: JURNAL KESEHATAN
Anggraeni, vivi
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Pengaruh Pemberian Antipsikotik terhadap Sindrom Metabolik pada Pasien Skizofrenia di Rumah Sakit X Jakarta Periode Juli 2023 – Desember 2023 Anggraeni, Vivi; Futihat, Chilyati Eky; Arianti, Anisa Rachmita; Perwitasari, Melania
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p81-94

Abstract

Schizophrenia is a severe mental disorder requiring long-term treatment with antipsychotics. Although effective in managing psychotic symptoms, antipsychotics such as Haloperidol (first-generation) and Clozapine (second-generation) carry risks of inducing metabolic syndrome, particularly hypertension and obesity. This study aims to compare the effects of Haloperidol and Clozapine use on the incidence of metabolic syndrome, specifically hypertension and obesity, in schizophrenia patients based on the 2021 PERKENI criteria. This analytical non-experimental study used a cross-sectional design with retrospective data from medical records of inpatient schizophrenia patients at X Regional Special Hospital Jakarta from July–December 2023. A total of 95 patients were selected by purposive sampling. Data were analyzed using the Mann-Whitney test. The majority of patients were male (56 patients, 58.95%) and aged 31–50 years (44 patients, 46.32%). Haloperidol was used by 50 patients (52.63%), while Clozapine was used by 45 patients (47.37%). The medication was administered orally as a single agent, 1–3 times daily, with doses ranging from 0.5 mg to 100 mg and an average treatment duration of 30 days. Total drug administrations were recorded 133 times due to some patients receiving more than one dosage form (tablet and single compound). Metabolic syndrome was observed in 40 patients (42.11%). Haloperidol significantly increased blood pressure compared to Clozapine (p = 0.036), but no significant difference was found in body mass index (p = 0.885). Haloperidol poses a higher risk of inducing hypertension than Clozapine. Routine blood pressure monitoring is essential during therapy.
Peran Orang Tua dalam Upaya Pemeliharaan Kesehatan Gigi terhadap Kejadian Karies Gigi pada Anak Usia 6-9 Tahun di SDN 169 Pekanbaru Isnaniar; Norlita, Wiwik; Anggraeni, Vivi
As-Shiha: Jurnal Kesehatan Vol. 3 No. 2 (2023): As-Shiha: Jurnal Kesehatan
Publisher : Fakultas MIPA dan Kesehatan, Universitas Muhammadiyah Riau

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Abstract

Dental caries is a decayed area inside the tooth that occurs due to a process that gradually dissolves enamel (the hard outer tooth surface) and continues to develop to the inside of the tooth. One of the causes of dental caries is the role of parents in efforts to maintain dental health. Study results say that parental psychosocial factors that have been shown to negatively impact children's oral health include maternal depression, low coherence, pampering parenting and stressed parents. Parents' concern for children's dental health can be seen through their attitude and attention to children's dental health. The purpose of the study was to determine "the relationship between the role of parents in efforts to maintain dental health on the incidence of dental caries in children aged 6-9 years at SDN 169 Pekanbaru". The type of research used was cross sectional with accidental sampling techniques totaling 38 respondents. Data collection tools using questionnaires and data analysis used univariate and bivariate analysis. The results showed that parents who played a good role in children at SDN 169 Pekanbaru as many as 21 respondents (55.3%), and children who had caries as many as 22 respondents (57.9%). The test results using chi-square produced a significant value of 0.917. Significant test values of 0.917 > 0.05 show that there is no influence between the role of parents in efforts to maintain dental health on the incidence of dental caries in children aged 6-9 years at SDN 169 Pekanbaru.
Co-Authors Arianti, Anisa Rachmita Futihat, Chilyati Eky Isnaniar Melania Perwitasari, Melania Wiwik Norlita