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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Ina Kidney
Lusito, Lusito
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Vitamin D Insufficiency with Elevated ADMA and hs-CRP: A Single-center Study of Chronic Kidney Disease Patients Undergoing Hemodialysis Lusito, Lusito; Lestariningsih, Lestariningsih; Partiningrum, Dwi Lestari; Chasani, Shofa; Arwanto, Arwedi; Nurani, Ayudyah; Makarim, Fadhli Rizal
Indonesian Journal of Kidney and Hypertension Vol 1 No 2 (2024): Volume 1 No. 2, August 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i2.134

Abstract

Background: Vitamin D deficiency is a common issue among patients with chronic kidney disease (CKD) due to its ability to convert vitamin D into the active form of calcitriol, which is crucial for controlling cell inflammation. Low vitamin D levels are associated with increased inflammation and higher levels of biomarkers such as c-reactive protein and asymmetric dimethylarginine as an endogenous inhibitor of nitric oxide synthase. Those two combined become a specific marker for cardiovascular diseases, which become one of the common causes of CKD mortality. Objective: This study examines the correlation between vitamin D insufficiency, elevated high-sensitivity c-reactive protein, and asymmetric dimethylarginine in CKD patients receiving hemodialysis. Methods: This study used a cross-sectional design of CKD patients receiving hemodialysis in Dr. Kariadi Central General Hospital, Semarang, Indonesia, in November 2021. Thirty-six patients were randomly enrolled after meeting inclusion and exclusion criteria. Primary outcomes of Vitamin D, hs-CRP, and ADMA were measured from patients’ blood after hemodialysis. A statistical analysis of Pearson's correlation was used for primary outcomes. Results: No significant difference was found in the patient's baseline characteristics. A significant correlation between vitamin D and ADMA has been found; however, no correlation between vitamin D and hs-CRP has been found Conclusion: Vitamin D deficiency is correlated with elevated ADMA, indicative of endothelial dysfunction.
Factors affecting quality of life in patients undergoing hemodialysis in Semarang, Indonesia Lusito, Lusito; Utami, Kamilia Dwi; Yuliyanti, Suryani; Nurmalita, Ar-Rahmah; Amaliyah, Laily Rezky
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2025): June 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i1.39560

Abstract

The quality of life in patients with chronic kidney disease (CKD) reflects how well an individual's needs are met across three physical, psychological, and social dimensions. Measuring a patient's quality of life (QoL) helps evaluate the effectiveness of CKD therapies. This study compares patients' clinical conditions categorised by their quality of life while undergoing hemodialysis therapy for chronic kidney failure. This study compares the clinical conditions of CKD patients undergoing hemodialysis based on their QoL, using a cross-sectional design involving 82 patients from Sultan Agung Islamic Hospital, Semarang. QoL was assessed with the WHOQOL-BREF questionnaire, and demographic data were collected through interviews. Clinical data was sourced from electronic medical records. Logistic regression analysis identified influencing variables on QoL. The sample was predominantly female (62.2%), with most patients over 45 years old, meeting minimum education standards (61%), and 67.1% unemployed. Most identified as Muslim and married, with 98.8% reporting strong family support. While bivariate analysis showed no significant impact of demographic or clinical variables on QoL, multivariate analysis indicated a significant relationship with haemoglobin levels. While other factors like family support and knowledge contribute to well-being, further research with larger, more varied samples is needed to better understand the quality-of-life influences for CKD patients on hemodialysis.
Co-Authors Amaliyah, Laily Rezky Arwanto, Arwedi Dwi Lestari Partiningrum Lestariningsih Lestariningsih Makarim, Fadhli Rizal Nurani, Ayudyah Nurmalita, Ar-Rahmah Shofa Chasani Suryani Yuliyanti, Suryani Utami, Kamilia Dwi