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Influence of Knowledge, Attitude, and Behavior on Hospital Workers' Vitamin D Febriarto*, Dimas; Makarim, Fadhli Rizal; Rizaldy, Rheza
JIM: Jurnal Ilmiah Mahasiswa Pendidikan Sejarah Vol 8, No 3 (2023): Juni, socio-economics, community law, cultural history and social issues
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jimps.v8i3.26362

This study aims to determine the role of knowledge, attitudes, and behaviors in relation to vitamin D levels among hospital workers who have limited sunlight exposure and those who are exposed to sunlight. This cross-sectional study were conducted on 54 participants randomly selected from hospital outdoor worker, clinic worker, and operating room worker. The participants completed a validated Vitamin D knowledge, attitude, and behaviour questionnaire. Blood samples were collected to measure 25(OH)D using ELISA method. Mann-whitney test was used to assess Vitamin D level between groups, while influence of knowledge, attitude, and behaviour on vitamin D levels were assessed using Chi-square test.

Vitamin D Insufficiency with Elevated ADMA and hs-CRP: A Single-center Study of Chronic Kidney Disease Patients Undergoing Hemodialysis Lusito, Lusito; Lestariningsih, Lestariningsih; Partiningrum, Dwi Lestari; Chasani, Shofa; Arwanto, Arwedi; Nurani, Ayudyah; Makarim, Fadhli Rizal
Indonesian Journal of Kidney and Hypertension Vol 1 No 2 (2024): Volume 1 No. 2, August 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i2.134

Background: Vitamin D deficiency is a common issue among patients with chronic kidney disease (CKD) due to its ability to convert vitamin D into the active form of calcitriol, which is crucial for controlling cell inflammation. Low vitamin D levels are associated with increased inflammation and higher levels of biomarkers such as c-reactive protein and asymmetric dimethylarginine as an endogenous inhibitor of nitric oxide synthase. Those two combined become a specific marker for cardiovascular diseases, which become one of the common causes of CKD mortality. Objective: This study examines the correlation between vitamin D insufficiency, elevated high-sensitivity c-reactive protein, and asymmetric dimethylarginine in CKD patients receiving hemodialysis. Methods: This study used a cross-sectional design of CKD patients receiving hemodialysis in Dr. Kariadi Central General Hospital, Semarang, Indonesia, in November 2021. Thirty-six patients were randomly enrolled after meeting inclusion and exclusion criteria. Primary outcomes of Vitamin D, hs-CRP, and ADMA were measured from patients’ blood after hemodialysis. A statistical analysis of Pearson's correlation was used for primary outcomes. Results: No significant difference was found in the patient's baseline characteristics. A significant correlation between vitamin D and ADMA has been found; however, no correlation between vitamin D and hs-CRP has been found Conclusion: Vitamin D deficiency is correlated with elevated ADMA, indicative of endothelial dysfunction.

Polymeric Chitosan Gel Modulates Inflammatory Responses to Prevent Peritoneal Adhesion in Rats Makarim, Fadhli Rizal; Ekasaputra, Vito Mahendra; Arnandha, Defan Adlill; Sahardin, Renaldy; Khayin, Iqbal Yusuf
International Journal of Cell and Biomedical Science Vol 1 No 3 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i3.25

Peritoneal adhesions are a pathological response to injury that connects adjacent structures that cause by inflammatory response such as IL-1 and IL-6. The current strategies to minimize or prevent peritoneal adhesions are very limited. Chitosan was found have antiinflammatory effect. However, chitosan hydropphobic properties give poor solubility in physiological solvent such as peritoneal fluid. Our study aims to investigate the effect of polymeric chitosan gel in the prevention of peritoneal adhesion through modulating IL-1 and IL-6 after laparotomy. Ten rats were divided into a control group and treated group. Laparotomy model was done with proper procedure. Illeum were scratch using cytobrush to mimic peritoneal adhesions. In the treated group, the defect was covered with Mediclore®. After 14 days, IL-1 and IL-6 were analyzed using ELISA from peritoneal fluid serum and macroscopic observation of adhesion were made. All animals in control group showed high grade of adhesin while treated group showed a filmy peritoneal adhesion. Group treated with Mediclore® showed a lower IL-1 levels compared to control group. Treated group showed a better control at inflammation by scoring lower IL-6 levels compared to control group. In conclusion, polymeric chitosan gel prevents peritoneal adhesions through modulation of inflammatory cytokines after laparotomy in rats. Keywords: chitosan, IL-1, IL-6, peritoneal adhesions, laparotomy

Intracavernous Stem Cell Injection for Erectile Dysfunction: Safety and Efficacy Review Lubis, Ahmad Sulaiman; Makarim, Fadhli Rizal; Aldiosta, Pradipta Hadyan
International Journal of Cell and Biomedical Science Vol 2 No 4 (2023)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v2i4.28

Background: Erectile dysfunction is a common condition in men characterized by the inability to maintain an erectile state. Current treatment using phosphodiesterase-5 inhibitors treatment may leave significant side effects and effectivity problems in some patients. The use of stem cell transplantation in erectile dysfunction has been emerging as a replacement therapy for erectile dysfunction. The effectiveness of stem cell therapy for the treatment of erectile dysfunction has been investigated in several animal studies and one clinical trial in humans. The intracavernous injection is one of the methods to deliver stem cell treatment for erectile dysfunction besides intravenous and intraperitoneal. It was believed to improve erectile function by promoting cavernosal tissue regeneration, vascularization, and smooth muscle relaxation. However, the intracavernous injection of stem cells for erectile dysfunction treatment in clinical settings requires further investigation since its long-term efficacy and safety concerns regarding swelling, priapism, and fibrous plaque. Objective: This review aims to summarize the available evidence on the safety and efficacy of intracavernous stem cell injection for erectile dysfunction treatment in clinical studies only from PubMed. Conclusion: In conclusion, while the available evidence suggests that intracavernous stem cell injection is considered safe and effective for the treatment of erectile dysfunction, further large-scale clinical studies are needed to determine its long-term safety, efficacy, and optimal dosing regimens.

Vitamin D Levels and its Influence on Maternal Blood Glucose, Blood Pressure, and Fetal Weight Reza, Hanif; Soraya, Yulice; Makarim, Fadhli Rizal; Alfarizi, Rizki
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 5 No. 2 (2025): COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/comserva.v5i2.3230

Vitamin D is essential for various physiological functions. Vitamin D deficiency is a global concern, including vitamin D deficiency during pregnancy. Maternal vitamin D deficiency is associated with an increased risk of adverse gestational outcomes. The objective of this cross-sectional study is to examine the impact of maternal Vitamin D levels on blood sugar, blood weight, and fetal weight. The study used quantitative method. Twenty-six women with gestational age 12-16 weeks as participants of this study were recruited from two Primary health care in Semarang, Indonesia between September - October 2023 were analyzed for serum 25-hydroxy Vit. D (25(OH)D). The samples then were evaluated for blood glucose, blood pressure and fetal weight using ultrasonography. The results of the Pearson's correlation rank test for Vitamin D with estimated fetal weight, blood glucose, systolic blood pressure, and gestational ages as covariate showed P>0.05, It implies that there is no relationship between Vit. D and other variables. Our study showed level of Vitamin D has no influence on of blood glucose level, incidence of hypertension, and low fetal weight.

Vitamin D Levels and its Influence on Maternal Blood Glucose, Blood Pressure, and Fetal Weight Reza, Hanif; Soraya, Yulice; Makarim, Fadhli Rizal; Alfarizi, Rizki
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 5 No. 2 (2025): COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/comserva.v5i2.3230

Vitamin D is essential for various physiological functions. Vitamin D deficiency is a global concern, including vitamin D deficiency during pregnancy. Maternal vitamin D deficiency is associated with an increased risk of adverse gestational outcomes. The objective of this cross-sectional study is to examine the impact of maternal Vitamin D levels on blood sugar, blood weight, and fetal weight. The study used quantitative method. Twenty-six women with gestational age 12-16 weeks as participants of this study were recruited from two Primary health care in Semarang, Indonesia between September - October 2023 were analyzed for serum 25-hydroxy Vit. D (25(OH)D). The samples then were evaluated for blood glucose, blood pressure and fetal weight using ultrasonography. The results of the Pearson's correlation rank test for Vitamin D with estimated fetal weight, blood glucose, systolic blood pressure, and gestational ages as covariate showed P>0.05, It implies that there is no relationship between Vit. D and other variables. Our study showed level of Vitamin D has no influence on of blood glucose level, incidence of hypertension, and low fetal weight.

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