Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Indonesian Journal of Kidney and Hypertension JOURNAL LA MEDIHEALTICO
Nurani, Ayudyah
Unknown Affiliation
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Vitamin D Insufficiency with Elevated ADMA and hs-CRP: A Single-center Study of Chronic Kidney Disease Patients Undergoing Hemodialysis Lusito, Lusito; Lestariningsih, Lestariningsih; Partiningrum, Dwi Lestari; Chasani, Shofa; Arwanto, Arwedi; Nurani, Ayudyah; Makarim, Fadhli Rizal
Indonesian Journal of Kidney and Hypertension Vol 1 No 2 (2024): Volume 1 No. 2, August 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i2.134

Abstract

Background: Vitamin D deficiency is a common issue among patients with chronic kidney disease (CKD) due to its ability to convert vitamin D into the active form of calcitriol, which is crucial for controlling cell inflammation. Low vitamin D levels are associated with increased inflammation and higher levels of biomarkers such as c-reactive protein and asymmetric dimethylarginine as an endogenous inhibitor of nitric oxide synthase. Those two combined become a specific marker for cardiovascular diseases, which become one of the common causes of CKD mortality. Objective: This study examines the correlation between vitamin D insufficiency, elevated high-sensitivity c-reactive protein, and asymmetric dimethylarginine in CKD patients receiving hemodialysis. Methods: This study used a cross-sectional design of CKD patients receiving hemodialysis in Dr. Kariadi Central General Hospital, Semarang, Indonesia, in November 2021. Thirty-six patients were randomly enrolled after meeting inclusion and exclusion criteria. Primary outcomes of Vitamin D, hs-CRP, and ADMA were measured from patients’ blood after hemodialysis. A statistical analysis of Pearson's correlation was used for primary outcomes. Results: No significant difference was found in the patient's baseline characteristics. A significant correlation between vitamin D and ADMA has been found; however, no correlation between vitamin D and hs-CRP has been found Conclusion: Vitamin D deficiency is correlated with elevated ADMA, indicative of endothelial dysfunction.
Plasma Exchange is a Therapeutic Procedure used in the Management of Rapidly Progressive Glomerulonephritis (RPGN): A Case Report Chekmat, Muh. Dina Tursina; Pratiningrum, Dwi Lestari; Lestariningsih, Lestariningsih; Arwanto, Arwedi; Chasani, Shofa; Nurani, Ayudyah; Setiawan, Budi; Miranti, Ika Pawitra
Journal La Medihealtico Vol. 7 No. 2 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i2.3147

Abstract

Rapidly Progressive Glomerulonephritis (RPGN) is a clinical syndrome characterized by a rapid decline in kidney function and the presence of crescents on kidney biopsy, requiring immediate treatment to prevent disease progression. A 34-year-old man was admitted to the hospital with generalized body swelling that began in the eyelids one week prior. He had a history of fever before admission, which subsided upon hospitalization. Additional complaints included shortness of breath, cough, and runny nose. Past medical history included hypertension and hiperuresemia. In recent days, he experienced oliguria. Physical examination revealed pitting edema in the lower extremities. Laboratory tests showed anemia, hypoalbuminemia, and rapid decline in kidney function. Urinalysis revealed protein +3, leukocytes sediment 80.1/µL, erythrocytes sediment 468/µL, and Esbach 0.5 g/L. Complement C3 53 mg/dL, C4 13.8 mg/dL, ANA, and anti-dsDNA were negative, with no available data for anti-GBM, ANCA and kidney biopsy Segmental Mesangial Hypercellular Glomerulus and focal segmental sclerosis. Chest X-ray showed cardiomegaly, bronchopneumonia, and left pleural effusion. Abdominal ultrasound revealed bilateral parenchymal renal disease. The patient was treated with high dose steroids, antibiotics, antihypertensives, symptomatic medications, two sessions of hemodialysis, and four sessions of plasma exchange (PLEX). The combination therapy of high dose steroids and followed by hemodialysis and plasma exchange, resulted in significant reduction of edema and improvement in kidney function, demonstrating the effectiveness of an aggressive immunomodulatory regimen. In pauci-immune or idiopathic RPGN, the combination of high-dose steroids and plasma exchange along with dialysis provides a rapid clinical response, increases the chance of remission, and preserves kidney function.
Co-Authors Arwanto, Arwedi Budi Setiawan Chekmat, Muh. Dina Tursina Dwi Lestari Partiningrum Ika Pawitra Miranti Lestariningsih Lestariningsih Lusito, Lusito Makarim, Fadhli Rizal Pratiningrum, Dwi Lestari Shofa Chasani