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All Journal Jurnal Ilmu Kefarmasian Indonesia Darmabakti Cendekia: Journal of Community Service and Engagements Current Research on Biosciences and Biotechnology MEDICINUS Journal of Tropical Pharmacy and Chemistry
Amirah Adlia
Institut Teknologi Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Community Empowerment Through Sulfur Soap Preparation for Dermatitis Prevention Amirah Adlia; Sakinah Aljuffrie; Annis Catur Adi; Deandra Ardya Regitasari; Vidya Anggarini Rahmasari; Heni Rachmawati
Darmabakti Cendekia: Journal of Community Service and Engagements Vol. 1 No. 2 (2019): December 2019
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (666.667 KB) | DOI: 10.20473/dc.V1.I2.2019.45-49

Abstract

Background: As a country with a tropical climate, Indonesia has the risk to have many disease problems, such as skin disorder or dermatitis. Dermatitis is an either acute, sub-acute, or chronic inflammatory skin disease. One of therapies is using sulfur compound. Purpose: The objective of this program was to improve public awareness of Tulungagung Regency on the importance of health care, to train people preparing soap containing sulfur, and to help the people to empower the economic community through home industry initiation. Methods: This program was done by motivation generating, counseling, advocacy, and education. The activities were performed through counseling about skin diseases, causes, the prevention and treatment of the disease with sulfur soap, demonstration and providing training to the community about sulfur soap. Results: The training on handmade soap preparation was conducted at the Village Hall of Mojosari, Kauman, Tulungagung, on July 28-29th 2019 and was attended by 20 female participants. The socialization programme was carried out by providing technical guidance, visual exposure of materials, packaging training through small groups. Conclusion:  This training program of soap containing sulfur preparation attracted public attention to gain the science, knowledge, and skill increase business motivation, knowledge, and community skills as well as motivation generation to apply a simple technology of soap containing sulfur manufacturing.
COUNSELING ABOUT THE PROCESS OF REMOVING THESMELL OF CATFISH OIL TO BE PROCESSED INTO JELLYCANDY IN TULUNGAGUNG: PENYULUHAN TENTANG PROSES PENGHILANGAN BAU MINYAK LELE UNTUK DIOLAH MENJADI PERMEN JELLY DI TULUNGAGUNG Heni Rachmawati; Ali Iqbal Tawakal; Damar Rasti Adhika; Annis Catur Adi; Wizara Salisa; Anna Smdyah Putri; Amirah Adlia
Darmabakti Cendekia: Journal of Community Service and Engagements Vol. 5 No. 1 (2023): JUNE 2023
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/dc.V5.I1.2023.1-7

Abstract

ABSTRAK Latar belakang: Intensitas kegiatan industri penepungan ikan lele menghasilkan berbagai produk samping dalam jumlah besar, yaitu tulang/duri, minyak, dan kulit. Hasil-hasil samping tersebut jika tidak diolah akan menjadi limbah organik yang mengganggu lingkungan. Oleh karena itu, pada kegiatan pengabdian masyarakat ITB 2022 yang dilakukan bersama PT Rumah Inovasi Natura bertujuan untuk memanfaatkan salah satu limbah tersebut, yaitu minyak ikan. Minyak ikan lele sebagaimana minyak ikan lainnya, mempunyai aroma yang sangat tidak sedap sehingga tidak disukai, padahal kandungan senyawa aktifnya sangat bagus untuk pertumbuhan dan perkembangan kecerdasan. Tujuan: Tujuan kegiatan pengabdian masyarakat ini adalah melakukan penjernihan minyak ikan lele menggunakan bentonit agar dihasilkan minyak yang lebih jernih dan tidak berbau. Selanjutnya, minyak tersebut diolah menjadi permen yuppy sehingga lebih disukai oleh anak-anak. Metode: Kegiatan pengabdian tersebut dikemas dalam berbagai bentuk kegiatan: penyuluhan dan pelatihan kepada masyarakat di kabupaten Tulung Agung, meliputi masyarakat dari kelompok PKK, IKM (industri kecil menengah), murid SMKN 1, serta murid PAUD. Khusus untuk murid PAUD, mereka diberikan permen yuppy minyak ikan dan nasihat pentingnya makan minyak ikan untuk kepintaran. Hasil: Hasil kegiatan pengabdian masyarakat mendapatkan respon yang sangat baik dari berbagai kalangan masyarakat yang diikutsertakan pada program ini. Kesimpulan: Kegiatan pengabdian ini menghasilkan produk pangan yang berpotensi digunakan sebagai sarana suplementasi minyak ikan lele yang mengandung berbagai bioaktif yang baik untuk membantu meningkatkan perkembangan kecerdasan anak. Kata kunci: Minyak Ikan Lele, Permen, Bentonit, Tulung Agung, Kecerdasan Mental ABSTRACT Background: The intensity of the activity of catfish flour industry produces various by-products in large quantity, namely bones/thorns, oil, and skin. These by-products, if not treated, will become organic waste that disturbs the environment. Therefore, the ITB 2022 community service activity carried out with PT Rumah Inovasi Natura aims to utilize one of these wastes, namely fish oil. Catfish oil, like other fish oils, has a very unpleasant aroma that is not liked, even though the content of active compounds is very good for the growth and development of intelligence. Objective: The purpose of this community service is to purify catfish oil using bentonite so that the oil produced is clearer and odorless. Furthermore, the oil is processed into sweet candy so that it is preferred by children. Methods: The service activities are packaged in various forms of activities: counseling and training for the community in Tulung Agung district, including people from the PKK group, IKM (small and medium industries), SMKN 1 students, and PAUD students. Especially for PAUD students, they were given fish oil yuppy candy and advice on the importance of fish oil for intelligence. Results: The results of community service activities received a very good response from various groups of people who were included in this program. Conclusion: This service activity produces food products that can be used as a means of supplementing catfish oil which contains various good bioactives to help improve the development of children's intelligence. Keywords: Catfish Oil, Candy, Bentonite, Tulung Agung, Mental Intelligence
Sun protection factor and tyrosinase inhibitory activity of several plant secondary metabolites Raihana Mufliha Fatharani; Ula Aulia Fitrian; Sumail Sidik Ode Ishak; Amirah Adlia
Current Research on Bioscences and Biotechnology Vol. 5 No. 1 (2023)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2023.5.1/VCLQ3ADV

Abstract

Severe exposure to ultraviolet (UV) rays leads to skin damage, including hyperpigmentation, freckles, melanoma, age spots, and melasma, all of which are related to the skin pigment enzyme, tyrosinase. Prevention can be achieved by avoiding harsh UV rays and inhibiting tyrosinase catalytic activity. Many compounds have been developed for the treatment of such conditions; however, most come with unwanted side effects. The purpose of this study was to determine the sun protection factor (SPF) value and tyrosinase enzyme inhibitory activity of plant secondary metabolites with high antioxidant activity, namely rutin, catechin, niazirin, piperine, quercetin, and quercitrin, as potential alternatives. Both tests were carried out using UV-Vis spectrophotometry. SPF determination was performed by observing the absorbances across a wavelength range of 290 to 320 nm. The determination of anti-tyrosinase activity was conducted by measuring dopachrome at 490 nm after enzymatic reactions and calculating the IC50 value. In the SPF assay, benzophenone-3 was used as the standard, and piperine, rutin, quercetin, and quercitrin exhibited high protective abilities with SPF values above 30 at 500 µg/mL. In the tyrosinase inhibition assay, kojic acid as the standard showed a strong potential for inhibition with an IC50 of 33.65 µg/mL, while quercetin, rutin, and piperine exhibited weaker inhibitory potential with IC50 values of 178.44, 271.73, and 347.62 µg/mL, respectively. On the other hand, quercitrin and niazirin showed little to no tyrosinase inhibition activity. However, catechin demonstrated more catalytic activity towards the enzyme. In conclusion, quercetin, rutin, and piperine have the potential to be developed as active ingredients to protect the skin from UV-induced damage due to their satisfactory SPF values and tyrosinase inhibition activity.
Pengembangan Formula Nanoemulsi Minyak Cengkeh (Syzygium aromaticum L.) dan Ekstrak Siwak (Salvadora persica) serta Uji Aktivitasnya terhadap Bakteri dari Saliva Mencit Galur BALB/c Siti Fatimah Zahro; Safira Prisya Dewi; Amirah Adlia; Heni Rachmawati
MEDICINUS Vol. 37 No. 1 (2024): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/jp1ap691

Abstract

Mulut merupakan habitat bagi sekitar 700 spesies bakteri yang dapat memicu gangguan jika kebersihan mulut tidak terjaga. Salah satu upaya menjaga kebersihan mulut adalah dengan menggunakan mouthwash atau obat kumur. Saat ini masih banyak beredar obat kumur di pasaran yang mengandung alkohol, padahal penggunaan alkohol dalam obat kumur dapat menimbulkan beberapa efek samping setelah pemakaian. Di sisi lain, terdapat bahan alam yang memiliki aktivitas antibakteri terhadap bakteri mulut seperti Salvadora persica dan Syzygium aromaticum. Minyak cengkeh merupakan minyak atsiri yang kurang stabil, sehingga pada penelitian ini dikembangkan formula nanoemulsi minyak cengkeh dengan penambahan ekstrak siwak. Formula akhir nanoemulsi diuji aktivitas antibakterinya terhadap bakteri dari saliva mencit galur BALB/c melalui penentuan konsentrasi hambat minimum (KHM). Pada formula akhir, diperoleh nanoemulsi dengan ukuran 22,4 nm dengan indeks polidispersitas 0,385, zeta potensial -2,1 mV,dan pH 7,15. Hasil uji aktivitas antibakteri menunjukkan bahwa nanoemulsi yang ditambahkan dan tidak ditambahkan ekstrak siwak memiliki KHM terhadap bakteri saliva mencit sebesar 6,25 mg/ml. Hal ini disebabkan karena KHM dari minyak cengkeh adalah 6,25 mg/mL, sedangkan dari ekstrak siwak adalah 12,5 mg/ml sehingga jumlah ekstrak dalam formula tidak dapat menurunkan KHM nanoemulsi. Hasil uji stabilitas menunjukkan bahwa nanoemulsi stabil terhadap 2 siklus beku-cair dan masih dapat diterima pada penyimpanan selama 4 minggu dalam suhu 4°C. Oleh karena itu, dapat dikatakan bahwa formula yang dikembangkan memiliki aktivitas antibakteri terhadap bakteri saliva mencit BALB/c dan memiliki stabilitas yang cukup baik selama 4 minggu dengan suhu penyimpanan 4°C.
Antithrombotic and Antioxidant Activities of Binahong [Anredera cordifolia (Ten.) Steenis] Leaf Ethanol Extract and Its Nanoemulsion Preparation in Swiss Webster Mice Maria Immaculata Iwo; Amirah Adlia; Silviyanita Isna Septila; Yennie Agnes Pratama; Dicki Bakhtiar Purkon
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 2 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i2.516

Abstract

Platelet aggregation has the potential to form thrombi and result in cardiovascular system diseases such as myocardial infarction and ischemic stroke - one of the leading causes of death globally. Traditionally, people use binahong leaves as blood thinners. Therefore, this study aims to obtain scientific data on the efficacy of binahong leaf as antithrombotic. The efficacy test was carried out on male Swiss-Webster mice. The results showed that the ethanol extract of binahong leaves at doses of 50 (BLEE50) and 100 mg/kg bw (BLEE100) could increase bleeding time on H7 (7.61±1.79% and 3.72±1.76% vs 1.08±0.90%) and H14 (13.81±4.42% and 5.06±2.30% vs 1.66±1.09%) and coagulation time at H7 (5.01±1.36% and 4.18±1.67% vs 1.38±1.08%) and at H14 (7.92±1.97% and 7.19±1.96% vs 1.70±1.10%) significantly (p<0.05). The two doses of BLEE were formulated in the form of nanoemulsions with the Self Nano Emulsifying Drug Delivery System (NBLEE50 and NBLEE100) were also able to prolong bleeding time and coagulation time significantly (p<0.01) but only NBLEE50 prolonged bleeding time (p<0.05) significantly against BLEE50. In the test of the anti-platelet aggregation effect with ADP as an inducer, both doses of BLEE and the nanoemulsion preparation (NBLEE) could significantly (p<0.01) inhibit platelet aggregation with a percentage of inhibition >70% which was not different from the standard (acetylsalicylic acid). In the antioxidant effect test using the DPPH method, BLEE has an IC50 = 66.08?g/mL which is classified as a strong antioxidant. Both doses of BLEE and its NBLEE could significantly (p<0.01) inhibit lipid peroxidation in plasma and liver and NO radicals formation. BLEE50 can significantly (p<0.05) reduce mean platelet volume (6.05±0.24fL vs 6.55±0.34fL) and platelet distribution width (8.52±0.36% vs 9.25±0.42%). Based on those results, BLEE has the potential to be used as an antiplatelet aggregation and antioxidant.
Formulation and antimicrobial evaluation of mouthwash containing propolis and roselle extract Putu Diah Apri Anjalikha; Amirah Adlia; Dhyan Ayu Kusumaningtyas; Deasy Dyah Retno Wulan; I Ketut Adnyana
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 2 (2026): JIFI In Press
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i2.2024

Abstract

Poor oral hygiene can promote the transition of commensal microorganisms into opportunistic pathogens and contribute to the development of oral diseases. Antimicrobial mouthwashes may serve as preventive or adjunctive therapies in the early stages of oral infections. On the other hand, propolis and roselle (Hibiscus sabdariffa), both rich in phenolic compounds, possess well-documented antimicrobial activities and are promising candidates for natural mouthwash formulations. This study evaluated the antimicrobial activity of the combination of ethanolic extract of propolis (EEP) and aqueous extract of roselle (AER) against Staphylococcus aureus, Streptococcus mutans, and Candida albicans, and developed a combined-extract mouthwash formulation. The MIC values of EEP against S. aureus, S. mutans, and C. albicans were 1280, 640, and >20,480 μg/mL, respectively, whereas AER exhibited MIC values of 320, 1280, and 10,240 μg/mL. The MBC values of EEP were 1280 μg/mL for S. aureus and 2560 μg/mL for S. mutans, while AER showed MBC/MFC values of 1280, 10,240, and 10,240 μg/mL against S. aureus, S. mutans, and C. albicans, respectively. Checkerboard assays indicated additive interactions against S. aureus (FICI = 2) and S. mutans (FICI = 3). A mouthwash containing 2% EEP and 1% AER was successfully formulated, exhibiting a transparent light-brown appearance, menthol aroma, homogeneous characteristics, pH of 5.44 ± 0.03, and viscosity of 1.36 mPa·s. The undiluted formulation achieved complete microbial reduction within 2–10 min of contact. These findings suggest that the EEP–AER combination has potential as a natural antimicrobial mouthwash for oral health management.
Co-Authors Ali Iqbal Tawakal Anna Smdyah Putri Annis Catur Adi Damar Rasti Adhika Deandra Ardya Regitasari Deasy Dyah Retno Wulan Dhyan Ayu Kusumaningtyas Dicki Bakhtiar Purkon HENI RACHMAWATI I Ketut Adnyana Maria Immaculata Iwo Putu Diah Apri Anjalikha Raihana Mufliha Fatharani Safira Prisya Dewi Sakinah Aljuffrie Silviyanita Isna Septila Siti Fatimah Zahro Sumail Sidik Ode Ishak Ula Aulia Fitrian Vidya Anggarini Rahmasari Wizara Salisa Yennie Agnes Pratama