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All Journal HAYATI Journal of Biosciences Microbiology Indonesia Pharmaciana: Jurnal Kefarmasian Jurnal Matematika & Sains Journal of Mathematical and Fundamental Sciences Jurnal Sains dan Teknologi Farmasi Jurnal Media Gizi Indonesia (MGI) INDONESIAN JOURNAL OF PHARMACY Jurnal Komputer Terapan Jurnal Sisfokom (Sistem Informasi dan Komputer) FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Respirasi (JR) Darmabakti Cendekia: Journal of Community Service and Engagements Jurnal Layanan Masyarakat (Journal of Public Service) Narra J Jurnal Puruhita MEDICINUS Journal of Community Engagement in Health
HENI RACHMAWATI
School of Pharmacy, Institute of Technology Bandung. Jl. Ganesha, 10, Bandung 40132
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Influence of Artocarpus communis Leave Extract on the Physical Characteristic of Pellet Heni Rachmawati; Tjandrawati Mozef; Shafiqah Adam
Jurnal Matematika & Sains Vol 15, No 3 (2010)
Publisher : Institut Teknologi Bandung

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Abstract

Artocarpus communis (Forst.) is popularly known in English as breadfruit tree because of the bread-like texture of its edible fruits. The leaves are potential for fever and liver disorders and it also possesses significant anti-platelet and anti-inflammatory activities. The aim of this study is to formulate ethyl acetate extract of Artocarpus communis leaves into a solid dosage form. Pelletization was developed to formulate the extract. The formula was prepared using various ratios of extract (5, 10, 15 and 20 %) with PVP as a binder and Avicel pH101 as a filler. The influence of extract concentration was studied on the pellet characteristics. Pellet was prepared by extrusion-spheronization technique. In order to produce pellet with optimum diameter (500-900 µm), the moisture of the extrudates must be around 40%, with spheronizer speed of 800-900 rpm for 1.5 minutes. In particular for flow property, all pellets containing more than 5% of Artocarpus communis leaf extract were better (> 8 g/s) over blank pellets (< 4 g/s). In conclusion, the presence of extract in the pellet formulas improved the physical characteristic of pellet. The self binding property of the extract is suggested as a key parameter for this improvement.
Development of fast disintegrating tablet formula of ketoprofen-β-cyclodextrin inclusion complexes Rachmawati, Heni; Marbun, Estherina Juliana; Pamudji, Jessie S.
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (261.281 KB) | DOI: 10.14499/indonesianjpharm0iss0pp229-237

Abstract

Ketoprofen  is  one  of  non  steroidal  anti  inflammatory  drugs  (NSAID)  used for  rheumatoid  arthritis.  However,  unpleasant  taste of  ketoprofen  leads  to difficulty  in  the  formulation,  in  particular  for  oral  route.  Therefore,  in  present study, a technique to mask the unacceptable taste of ketoprofen was developed. Then,  a  fast  disintegrating  tablet  on  this  inclusion  complex  was  established  for rapid  release  and  faster  analgesic  effect  of  ketoprofen.  Taste  masking  was prepared  by  complex  inclusion  with  β-cyclodextrin.  The  ratio  of  ketoprofen  and β-cyclodextrin  was  varied.  The  fast  disintegrating  tablet  was  formulated  with direct compression using various ratios of mannitoland lactose as tablet diluent, the main factor influencing the successful of fast disintegrating tablet. Evaluation of  final  product  was  performed  according  to  compendial  standard  and  specific requirements  for  fast  disintegrating  tablet.  The  best  ratio  from  ketoprofen  and β-cyclodextrin  was  2:3  with  concentration  of  ketoprofen  in  inclusion  complex was  40.32%.  The  tablet  met  standard  requirement  was resulted  with  the composition  of  ketoprofen-cyclodextrin  equivalent  to  50  mg  of  pure  ketoprofen and mannitol and lactose (ratio 1:1) as tablet diluent. Fast disintegrating tablet of  modified  ketoprofen  in  inclusion  complex  was  fulfilled  standard  specification for ketoprofen tablet with better acceptance.Key words:ketoprofen, inclusion complex, fast disintegratingtablet, beta cyclodextrin.
Formulasi Mikroenkapsulasi Protein dalam Poli(D,L-Laktida) dengan Teknik Penguapan Pelarut Fitriani, Lili; Rachmawati, Heni; Suciati, Tri
Jurnal Sains dan Teknologi Farmasi Vol 15 No 1 (2010)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Poly (D,L-lactide acid) has been used as scaffold and controlled release device for protein such as growth factor in tissue engineering. In this study, PDLLA microparticles were made and papain was used as model protein. Protein was encapsulated in microparticles using water-oil-water (W1/O/W2) and solid-oil-water (S/O/W) emulsification-solvent evaporation. Types of encapsulation methods and ratios of papain-PEG 20000 were observed in this study to provide the highest encapsulation efficiency. The entrapment efficiency made by W1/O/W2 method was 6,38%±0,025,&nbsp; whilst S/O/W using ratios of papain-PEG 20000 1:1 ; 1:4 ; and 1:5 were 6,24%±0,91 ; 30,15%±1,66 and 60,67%±4,93, respectively. To conclude, S/O/W is the best method to encapsulate protein with highest entrapment efficiency.
HEPATOPROTECTIVE ACTIVITY OF SAPONIN FRACTION OF OYONG SEED FLESH AND ITS COMBINATION AGAINST CCl4-INDUCED CHRONIC LIVER DAMAGE IN MALE WISTAR RAT Rachmawati, Heni; Y. Hartiadi, R. Leonny; Fidrianny, Irda; Adnyana, I Ketut
Indonesian Journal of Pharmacy Vol 24 No 3, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (940.23 KB) | DOI: 10.14499/indonesianjpharm0iss0pp177-185

Abstract

Saponin fraction of seed flesh of Oyong (Luffaacutangula [L.]Roxb) has been investigated to have a hepatoprotective activity in rats with fibrotic chronic liver damage. This research was conducted to evaluate whether saponin fraction of Oyongseed flesh has a hepatoprotective activity in CCl4-induced acute liver damage. Hepatoprotective activity was determined by measuring the activity of liver enzymes (SGOT, SGPT, LDH), total nitrite/nitrate level, liver index and liver histology. Saponin fraction of Oyong flesh seeds 10mg/kg BW and meniran extract 400mg/kg BW alone showed hepatoprotective activity. Administration of saponin fraction 10mg/kb BB decreased SGPT and LDH significantly over untreated group. Group given meniran extract at dose of 200mg/kg BW showed decreased on LDH, while at dose of 400mg/kg BW decreased SGPT, SGOT, and LDH significantly. Hystological observation revealed any improvement in liver morphology especially after treated with saponin fraction 10mg/kg BWand meniran extract at dose of 400mg/kg BW. However, all groups treated with combination of saponin and meniran did not show improvement both at biochemical parameter and liver histology. In conclusion, saponin extract with dose of 10mg/kg BW and meniran extract at dose of 400mg/kg BW showed hepatoprotector activity. In contrast, combination of both did not show any hepatoprotective effect and it was suspected that they have antagonist effects.Key words:hepatoprotective, CCl4-induced liver fibrosis, Luffaacutangula, Phyllanthusniruri
PENINGKATAN STABILITAS KURKUMIN MELALUI PEMBENTUKAN KOMPLEKS KURKUMIN--SIKLODEKSTRIN NANOPARTIKEL DALAM BENTUK GEL Ariani Edityaningrum, Citra; Rachmawati, Heni
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (530.476 KB) | DOI: 10.12928/pharmaciana.v5i1.2286

Abstract

Curcumin is a compound derived from turmeric. This compound is practically insoluble inwater and has poor stability. To improve the benefit of curcumin as a potential active compound in agel preparation, better stability are requested. Encapsulation was performed by freeze drying methodsand all evaluation data confirmed that curcumin included in the -cyclodextrin forming curcumin--cyclodextrin nanoparticle. The formula showed particle size of 156.8 ± 38.3 nm, polydispersity indexof 0.174 ± 0.026, and zeta potential of -17.3  0.2 mV. The gelling agents used for formulation of gelbase were HPMC, CMC-Na, carbopol 940, water-soluble chitosan, and viscolam. Viscolam showedbest stability of pH and viscosity after storage at 25 and 40 oC for 28 days. The inclusion complex andcurcumin were incorporated into gel. Both of the formulas showed good stability in pH and viscosityafter storage at 25 and 40oC for 28 days, and the inclusion complex gel showed improvement in thechemical stability which is approximately 2.12-fold (p&lt;0.01) and 1.41-fold (p&lt;0.05), after storage at25 and 40 oC, respectively.
PENGEMBANGAN SISTEM PEMBAWA ALBUMIN NANOPARTIKEL UNTUK SILIMARIN DAN KAJIAN SIFAT FISIK SERTA PROFIL PELEPASANNYA SECARA IN VITRO Ambarwati, Rini; Rachmawati, Heni
FITOFARMAKA | Jurnal Ilmiah Farmasi Vol 7, No 2 (2017): Vol.7, No.2, Desember 2017
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.755 KB)

Abstract

Silimarin merupakan senyawa flavonolignan yang berasal dari tumbuhan Silybum marianum (Asteraceae). Silimarin memiliki efek farmakologi sebagai antikanker dan hepatoprotektor, tetapi senyawa ini memiliki kelarutan yang rendah dalam air. Tujuan penelitian ini adalah mengembangkan formulasi silimarin dalam sistem pembawa nano dengan teknik desolvasi. Pembawa yang digunakan adalah serum albumin (bovine serum albumin/BSA). Kombinasi silimarin dalam BSA diharapkan dapat meningkatkan efikasi silimarin sebagai anti kanker karena permeabilitas BSA yang lebih baik pada sel kanker. Evaluasi standar terhadap nanopartikel silimarin-BSA meliputi ukuran dan distribusi ukuran partikel, zeta potensial, morfologi nanopartikel, kristalinitas, sifat termal, spektroskopi inframerah, efisiensi penjeratan serta profil pelepasan silimarin dari BSA nanopartikel pada 2 media   berbeda (HCl 0,1 N & PBS pH 7,4). Nanopartikel BSA- silimarin memiliki ukuran partikel 174,23 ± 13,94 nm; distribusi ukuran partikel 0,185 ±0,052; efisiensi penjeratan 90,54 ± 0,098 %; loading capacity 30,18 ± 0,036 % dan zeta potensial -1,62 mV. Hasil analisis menggunakan DSC (differential scanning calorimetry), XRD (X-ray diffraction) dan spektroskopi inframerah menunjukan bahwa nanopartikel silimarin berhasil terenkapsulasi di dalam nanopartikel BSA, dan BSA-silimarin memiliki bentuk amorf. Setelah 1 jam uji pelepasan, terdapat sebanyak 21,89% silimarin terlepas dalam HCl 0,1 N dan 54,84% silimarin terlepas dalam PBS pH 7,4 sehingga dapat disimpulkan bahwa silimarin-BSA memiliki kelarutan yang baik dalam air. Oleh karena itu,  perlu  dilakukan  pengujian  lebih  lanjut  untuk  mengkaji  akt ivitas  serta  perilaku silimarin-BSA in vivo untuk mengkonfirmasi data in vitro.
Peran Digital Marketing dan Packaging dalam Meningkatkan Produktifitas UMKM di Desa Muntung, Kecamatan Candiroto, Kabupaten Temanggung Suraya, Fatona; Maharani, Dita Galuh; Rachmawati, Heni; Putri, Dea Mayang Yulia; Sari, Ririn Andika
Jurnal Puruhita Vol 3 No 2 (2021): August 2021
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/puruhita.v3i2.53100

Abstract

Digital marketing adalah salah satu cara pemasaran yang saat ini sedang diminati oleh para pelaku usaha, melalui digital marketing ini pelaku usaha bisa memasarkan produk hasil buatannya. Pelaku UMKM di Desa Muntung memproduksi snack atau makanan yang berbahan baku dari tepung terigu. Produk kembang jambu ini merupakan salah satu produk unggulan dan diminati oleh warga masyarakat di sekutar Desa Muntung. Pemasaran kembang jambu masih menggunakan pemasaran manual, seperti dititipkan di warung-warung terdekat, atau bahkan para pembeli datang langsung ke lokasi produksi kembang jambu tersebut. Hal inilah yang menjadikan Kelompok KKN Unnes yang berjumlah 13 orang untuk membantu para pelaku UMKM dalam teknik pemasarannya. Ada 2 UMKM yang sudah berjalan lancar di Desa Muntung ini, namun masih disayangkan jika teknik pemasaran dan pengemasan masih tradisional. teknik pemasaran melalui digital marketing adalah salah satu upaya untuk meningkatkan produksi karena melalui digital marketing khalayak umum akan lebih tau produk-produk yang dijual terlebih jika memang produknya merupakan produk yang berkualitas. Sementara itu, dari hasil wawancara awal dengan pelaku usaha mikro produk makanan, baik produsen maupun retailer mengakui bahwa kemasan produk mempengaruhi citra produk. Namun pemahaman mereka tentang kemasan produk masih sangat minim. Menurut mereka kemasan hanya sekedar wadah dan pembungkus makanan agar tidak rusak. Permasalahan lain yaitu mereka tidak mempunyai kemampuan dana untuk mengemas produknya dengan baik. Dengan situasi persaingan semakin tajam, desain sebuah kemasan merupakan suatu nilai tambah, dapat berfungsi sebagai media promosi dan untuk menjaring konsumen.
PENINGKATAN STABILITAS KURKUMIN MELALUI PEMBENTUKAN KOMPLEKS KURKUMIN--SIKLODEKSTRIN NANOPARTIKEL DALAM BENTUK GEL Citra Ariani Edityaningrum; Heni Rachmawati
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (530.476 KB) | DOI: 10.12928/pharmaciana.v5i1.2286

Abstract

Curcumin is a compound derived from turmeric. This compound is practically insoluble inwater and has poor stability. To improve the benefit of curcumin as a potential active compound in agel preparation, better stability are requested. Encapsulation was performed by freeze drying methodsand all evaluation data confirmed that curcumin included in the -cyclodextrin forming curcumin--cyclodextrin nanoparticle. The formula showed particle size of 156.8 ± 38.3 nm, polydispersity indexof 0.174 ± 0.026, and zeta potential of -17.3  0.2 mV. The gelling agents used for formulation of gelbase were HPMC, CMC-Na, carbopol 940, water-soluble chitosan, and viscolam. Viscolam showedbest stability of pH and viscosity after storage at 25 and 40 oC for 28 days. The inclusion complex andcurcumin were incorporated into gel. Both of the formulas showed good stability in pH and viscosityafter storage at 25 and 40oC for 28 days, and the inclusion complex gel showed improvement in thechemical stability which is approximately 2.12-fold (p<0.01) and 1.41-fold (p<0.05), after storage at25 and 40 oC, respectively.
FORMULASI DAN KARAKTERISASI SEDIAAN NANOEMULSI VITAMIN A [Formulation and Characterization of Vitamin A Nanoemulsion] Annis Catur Adi; Nelly Setiawaty; Atsarina Anindya; Heni Rachmawati
Media Gizi Indonesia Vol. 14 No. 1 (2019): JURNAL MEDIA GIZI INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (489.678 KB) | DOI: 10.20473/mgi.v14i1.1-13

Abstract

Vitamin A is an essential nutrient to support the function of vision, growth, and immune system. Vitamin A cannot be synthesized in the body hence must be obtained through foods or supplements. However, oral administration of vitamin A is often hindered by poor absorption due to its hydrophobic nature and by its easily degradable nature by light and oxygen, particularly at high temperature. This study aimed to prepare a self-assembly vitamin A nanoemulsion with a high loading capacity to improve vitamin A absorption accross intestinal mucosa and to slow down its degradation process. The nanoemulsion was composed by glyceryl monooleate, Cremophor RH-40, and PEG 400 (1:8:1), then titrated with aqueous phase. The nanoemulsion characterization included globule size evaluation, size distribution, zeta potential, globule morphology, entrapment efficiency, physical and chemical stabilities, and ex vivo penetration test on New Zealand albino rabbit intestines. The vitamin A nanoemulsion was found to form transparent and nano-sized emulsions even when loaded with 16.67% vitamin A. The formula also produced 58.1±2.0 nm spherical globules with -0.69 mV zeta potential. Entrapment efficiency of vitamin A in the nanoemulsion was higher than 95%. The nanoemulsion shows stable after storage for 10 days at room temperature, as well as able to increase penetration rate compared to free vitamin A. Taken together, our established vitamin A nanoemulsion has a good stability and was proved to increase vitamin A absorption through intestinal mucosa while simultaneously decreased the vitamin A degradation rate.
DEVELOPMENT AND CHARACTERIZATION OF POLYCLONAL ANTIBODY OF RECOMBINANT HUMAN INTERFERON Α2B IN NEW ZEALAND WHITE RABBIT Heni Rachmawati
Indonesian Journal of Pharmacy Vol 25 No 3, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (476.864 KB) | DOI: 10.14499/indonesianjpharm25iss3pp132

Abstract

We have developed recombinant wild type and mutant human interferon α2b (rhIFNα2b) from synthetic gene in Escherichia coli. To identify the successful product of the proteins, immunology-based assay was suggested due to specificity for characterization. This work was aimed to develop and characterize rhIFNα2b polyclonal antibody generated in White New Zealand rabbits. The rhIFNα2b was overproduced in Escherichia coli BL21 containing rhIFNα2b synthetic gene in pET32b.The protein was obtained as inclusion bodies, refolded, purified using nickel affinity chromatography, and characterized using polyacrylamide gel electrophoresis. The purified rhIFNα2b protein was injected into rabbits for 21 days. Absorption of E.coli antibody was done using total E. coli protein to remove antibody againts host cell.   The generation of antibody was monitored using dot blot and Western blot methods and quantified using Enzyme Linked Immunsorbant Assay (ELISA). To do so, rhIFNa2b was used as an antigen. The result showed that the rhIFNα2b was produced as a His-tag protein fusion of 33kDa in size. The results of dot blot and Western blot analyses strongly indicated that antibody against rhIFNα2b was generated and specifically recognized rhIFNα2b. ELISA showed that the titer of the polyclonal anti-rhIFNα2b was 1:10.000. In conclusion, polyclonal antibody spesifically against rhIFNα2b protein was successfully detected with high titer after 21 days after rabbit immunization.
Co-Authors Abdillah, Oktaviardi Bityasmawan Agustiyanti, Dian Fitria Alfan Danny Arbianto Ali Iqbal Tawakal Ali Iqbal Tawakal Amalia, Riezki Ambarwati, Rini Amirah Adlia Anna Smdyah Putri Anna Surgean Veterini Annis Catur Adi Arbianto, Alfan Danny Arini Setiawati Asrul Muhamad Fuad Asrul Muhamad Fuad, Asrul Muhamad Atsarina Anindya Azzania Fibriani Bambang Wahjuprajitno Citra Ariani Edityaningrum, Citra Damar Rasti Adhika Deandra Ardya Regitasari Deandra Ardya Regitasari DEBBIE SOFIE RETNONINGRUM Debbie Sofie Retnoningrum DEBBIE SOFIE RETNONINGRUM Dewi Esti Restiani Dian Fitria Agustiyanti Dwiyatna, Archie Arman Emyr Reisha Ishaura Estherina Juliana Marbun, Estherina Juliana Farapti Farapti Fathrizqita Aghnia Raudhany Fatona Suraya, Fatona Ferry Iskandar Hamzah Hamzah Herdiani Sulistyo Putri Hidayat, Erzi I Ketut Adnyana Irda Fidrianny Isaura, Emyr Reisha Iskandar, Fery Jessie S. Pamudji Kusnandar Anggadiredja Leonny Yulita Hartiadi Lili Fitriani Magdalena Yuni Kristanti Maharani, Dita Galuh Mahmud Aditya Rifqi Marlina Indriastuti Meirawan, Rizky Fajar Muhammad mahrus zain Nelly Setiawaty Nuthathai Sutthiwong Permatasari, Fitri A. Permatasari, Fitri Aulia Pricillia Sinambela Putri, Dea Mayang Yulia Rachmad Suhanda Rachmadani, Nisa Amanda Rachmat Mauludin Rahmah, Ainur Rahmana E. Kartasasmita Rahmana E. Kartasasmita Rasyidi, Mohammad Fahmi RATIH ASMANA NINGRUM Rehatta, Nancy Margarita Resmi, Juniar Kalpika Restiani, Dewi Esti Rika Hartati Rini Ambarwati S.Pd. M Kes I Ketut Sudiana . Sabar Pambudi Safira Prisya Dewi Sakinah Aljuffrie Salisa, Wizara Santika, Arum Sinda Sari, Ririn Andika Sarmanu, Sarmanu Satuman Satuman Shafiqah Adam Siti Fatimah Zahro Soetomo, Meilisa Keizia Sophi Damayanti Subijanto Marto Soedarmo Subijanto Marto Soedarmo Sukmadjaja Asyarie Sukmadjaja Asyarie Sukmadjaja Asyarie Sulistiawan, Soni Sunarso Syefrida Yulina, Syefrida Taharuddin, Audrey Angelina Putri Tarwadi Tarwadi Tarwadi, Tarwadi Tjandrawati Mozef Tri Suciati Vidya Anggarini Rahmasari Vidya Anggarini Rahmasari Wenda Novayani Wibowo, Indra Widijiati Widijiati Widjiati Widjiati, Widjiati Widodo Jatim P Widodo Jatim Pudjirahardjo Widodo, Ferri Wijayanti, Ni PAD. Wizara Salisa Wizara Salisa Wizara Salisa Yeyet C. Sumirtapura YEYET CAHYATI Yogie Handoko