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All Journal Medical Journal of Indonesia Indonesian Journal of Urology Narra J Brawijaya Journal of Urology
Nurhadi, Pradana
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Indonesian Journal of Urology

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CORRELATION BETWEEN PCAR WITH IPSS SCORE, QMAX, AND POST VOIDING RESIDUAL URINE AND ITS CUT-OFF VALUE IN DETERMINING BOO IN PATIENTS WITH BPH LUTS Nurhadi, Pradana; Hakim, Lukman; Djojodimedjo, Tarmono; Hardjowijoto, Sunaryo
Indonesian Journal of Urology Vol 24 No 1 (2017)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v24i1.263

Abstract

Objective: This study was conducted to determine the correlation between Presume Circle Area Ratio (PCAR) and IPSS score, Qmax, and post voiding residual urine (PVR) and to find PCAR cut-off value in determining the presence Bladder Outlet Obstruction (BOO) in Benign prostatic hyperplasia (BPH) Lower Urinary Tract Symptoms (LUTS). Materials & Methods: This study was observational analytic study with 30 BPH LUTS patients as subjects during the period September 2015 to January 2016. The determined variables were PCAR, IPSS score, Qmax, post voiding residual urine (PVR) and analyzed using the SPSS program v21. Results: There were 30 patients who met the inclusion and exclusion criteria with the mean age of 67.47 years. In the correlation test, there was insignificant correlation between PCAR with IPSS (r=0.138, p=0.467), a significant correlation between PCAR with Qmax (r=0.468, p=0.009), PCAR with PVR (r=0.399, p=0.029), PCAR with BOO (r=0.491, p=0.006) PCAR cutoff value is 0.65 with sensitivity of 69% and specificity of 71%. Conclusion: PCAR has a significant correlation with PVR, Qmax and BOO but no significant with IPSS score. PCAR value >0.65 indicating BOO in BPH LUTS. PCAR can be used as an alternative non-invasive examination in determining the existence of BOO.
THE ROLE OF DOCETAXEL AS FIRST-LINE CHEMOTHERAPY ON PSA LEVEL AND QOL IN CRPC PATIENTS Seputra, Kurnia Penta; Nurhadi, Pradana; Satria, Hikmat
Indonesian Journal of Urology Vol 31 No 2 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i2.853

Abstract

Objective: Prostate cancer is the second most common cancer in men and the fifth leading cause of death worldwide. 10-20% of cases can progress to a more aggressive stage called castration-resistant prostate cancer (CRPC) with a higher death rate. Clinical guidelines recommend docetaxel as first-line chemotherapy and evaluated using the PSA test. This study aims to investigate the effect of docetaxel chemotherapy on PSA levels in CRPC. Material & Methods: A retrospective study was conducted from January 2016 until August 2022 according to the medical records database Saiful Anwar Hospital. There were 16 patients who met the inclusion criteria, including male patients with a diagnosis of CRPC who received castration therapy and found an increase in PSA 3 times of nadir or found 2 or more bone metastatic lesions or soft tissue lesions > 2 cm, received 6 series of docetaxel chemotherapy, and have a PSA data was performed before and after chemotherapy. Statistical analysis was performed using a differential T-test. Results: The results, obtained were significantly different (p<0.05) on the average PSA (log) pre-post chemotherapy, visual analog scale (VAS), and quality of life, and not significantly different on BMI pre-post chemotherapy. Conclusion: 6 cycles of docetaxel chemotherapy resulted in a decrease in PSA levels of CRPC significantly. It showed an excellent response to docetaxel chemotherapy in managing CRPC patients. Limitations of this study were specifically the retrospective cohort study model and the ability to reduce PSA levels in assessing the prognosis of CRPC. Keywords: Castration-resistant prostate cancer, chemotherapy, docetaxel, prostate-specific antigen.
CONSERVATIVE MANAGEMENT PELVIC FRACTURE URETHRAL INJURY (PFUI) IN A GIRL: A CASE REPORT Sulistyanti, Rachma Fitri; Satyagraha, Paksi; Nurhadi, Pradana; Daryanto, Besut
Indonesian Journal of Urology Vol 30 No 3 (2023)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v30i3.905

Abstract

ABSTRACT Objective: This case report aims to describe a different approach of PFUI by conservative management that resulted in good outcome. Case(s) Presentation: A 7-year-old girl patient was brought to the emergency department after falling from public transportation diagnosed with suspicious urethral rupture, perineal rupture grade III, vertical-shear type pelvic-ring injury, laceration wound on the right lower leg, abrasion on the medial side left lower leg and urinary retention. The patient underwent percutaneous cystostomy, pelvic bandage, a perineal debridement and repair, a cystography, percutaneous vesicolithotripsy, cystostomy and synechiae incision. One year after the first admission it was planned for urethroplasty due to completely obliterated from antegrade and retrograde panendoscopy. Discussion: 8 months later urethroplasty was aborted because of an open bladder neck, a fistula at the anterior connected to the distal of the bladder neck with size of 3 mm. The patient was performed a silicon cystostomy catheter insertion for 6 weeks. At the time of evaluation, the fistula was closed, it was proven by Qmax uroflowmetry was 18ml/s with average flow: 9.8 ml/s, voiding volume: 90ml, flow time: 9s, voiding time: 9s, hesistance:1.5, and PVR:5.35 cc. Conclusion: In this case, it showed that conservative management could improve PFUI with satisfactory result, proved by good result of uroflowmetry. However, periodic evaluations must be carried out to follow the progress of the disease and the possibility of future complications including sexual function. Keywords: PFUI, girl, urethral rupture
PENILE TORSION OF A TWO-YEAR-OLD BOY: A CASE REPORT Putra, Fikri Alam Riza; Daryanto, Besut; Nurhadi, Pradana
Indonesian Journal of Urology Vol 31 No 1 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i1.921

Abstract

Objective: This case report presented Penile Torsion in pediatrics. Case(s) Presentation: A two-year-old boy with a chief complaint of rotated penile to the right side since birth. There were 45º in clockwise torsion, slight chordee, and uncircumcised. Patient underwent penile reconstruction surgery, including penile degloving, urethral mobilization, and plication. After seven days follow-up, parents were satisfied with straight penile erection and no torsion at all. After 3 months follow-up, parents reported satisfaction with the surgical outcome such as cosmetic appearance, straight erection, and normal stream urine. Discussion: Surgical techniques ranging from simple penile degloving with foreskin repositioning to more complex surgical procedure involving corporeal tissue. Surgery by using degloving of penile skin and realignment could be suitable for penile torsion <90°. For the cases of >90°, other techniques should be considered such as corporopexy procedure, rotation flap of dorsal dartos, or diagonal suturing of corporeal folds away from and parallel to the neurovascular bundle. Conclusion: Penile reconstruction surgery using penile degloving, urethral mobilization, and plication for penile torsion showed satisfaction result including cosmetic appearance, penile erection, and normal urine flow. Keywords: Chordee, penile reconstruction, penile torsion.
SUCCESSFUL TRANSURETHRAL RESECTION OF ANTERIOR URETHRAL VALVE IN CHILDREN : A CASE REPORT Akbar, Fariz Kemal; Seputra, Kurnia Penta; Nurhadi, Pradana
Indonesian Journal of Urology Vol 31 No 1 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i1.933

Abstract

Objective: This case report will present transurethral resection of double anterior urethral valves in tertiary hospital. Case(s) Presentation: A three-year-old boy who complained of a poor stream of urine and discomfort during micturition. From the radiological examination, the main finding was found on ultrasound (USG), with thickening of the bladder wall without upper tract abnormality. On panendoscopy, we found double anterior urethral valves at bulbar part and trabeculation in bladder. Discussion: The resection of the valves was performed and achieved an excellent result included normal stream of urine and there was no discomfort during micturition. Conclusion: Anterior Urethral Valve is a rare case that can be caused a lower urinary tract obstruction. A good understanding of AUV’s radiological and endoscopic anatomy is required to differentiate it from other diseases, essential to prevent further injury, and also to decide for appropriate management. Keywords: Anterior Urethral Valve, Congenital Anomaly, Urinary Obstruction
PRELIMINARY RESULTS OF DELAYED PRIMARY BLADDER EXSTROPHY RECONSTRUCTION IN FEMALE PATIENT: A CASE REPORT Setiawan, Ilham Rachmat; Daryanto, Besut; Nurhadi, Pradana
Indonesian Journal of Urology Vol 31 No 2 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i2.948

Abstract

Objective: Reporting a rare case and provide a view of bladder extrophy management. Case(s) Presentation: A 12-year-old female complained of an open abdominal wall below the umbilicus accompanied by continuous incontinence of urine since birth. The MRI showed diastasis symphisis 5.1 cm and a soft tissue defect in the suprapubic region, suspicious of bladder exstrophy. Bladder mucose biopsy showed squamous metaplasia. The patient underwent pelvic osteotomy, bladder wall closure, bladder neck reconstruction, abdominal closure with double keystone flap with proceed mesh, and external fixation. A cystostomy catheter was placed until one week after surgery, and the patient was able to hold the urge to urinate and started to move around while sitting. Two months after the reconstruction, the primary closure and keystone removal on skin defect were carried. The patient was already able to walk and continence the urine. Discussion: Bladder extrophy is a rare condition. Currently delayed reconstruction on bladder growth is the subject of debate and speculation. The patient’s condition in this presented case improved, this is in accordance with the literature that states that delayed reconstruction can still be considered in special conditions that do not allow early reconstruction. Conclusion: Delayed bladder reconstruction and bladder neck reconstruction can improve the anatomy of the bladder and quality of life on certain cases. Keywords: Bladder exstrophy, bladder reconstruction, female bladder exstrophy.
ASSESSING CARDIOVASCULAR SAFETY OF TESTOSTERONE REPLACEMENT THERAPY FOR MALE HYPOGONADISM: A SYSTEMATIC REVIEW AND META-ANALYSIS Rachman, Manarul Iman Alfafa; Vilado, Irene Yasmina; Satriawan , Ilham; Lalchanzani , Jawaharlal Akbar; Faida, Nova Auliyatul; Permata , Angeline Asti Shiela; Nurhadi, Pradana; Daryanto, Besut
Indonesian Journal of Urology Vol 31 No 3 (2024)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v31i3.988

Abstract

Objective: This study aims to comprehensively assess TRT's cardiovascular safety in males with hypogonadism, providing valuable insights for treatment decisions. Material & Methods: Adhering to PRISMA guidelines, we registered our PROSPERO protocol and analyzed relevant English-language randomized clinical trials published from 2008 to 2023. Results: Among 1187 initial papers, 7 studies met inclusion criteria, with 6 in quantitative analysis and all 7 in qualitative assessment. Our findings indicate that TRT does not significantly increase the risk of cardiovascular events compared to placebo. Specifically, the analysis of major adverse cardiac events (MACE) yielded an OR of 0.90 (95% CI: 0.74, 1.10; I² = 26%; p = 0.25), while the evaluation of all cardiovascular adverse events revealed an OR of 1.37 (95% CI: 0.73, 2.55; I² = 75%; p = 0.001). Conclusion: This study offers reassurance for clinical decision-making by suggesting that TRT is not significantly associated with an elevated cardiovascular risk in hypogonadal men, addressing the ongoing debates on this issue. Keywords: Cardiovascular safety, hypogonadism, testosterone replacement therapy.
CLINICAL PROFILE OF PATIENTS WITH HYPOSPADIAS IN SAIFUL ANWAR GENERAL HOSPITAL, MALANG Henrizal, Fenni; Daryanto, Besut; Nurhadi, Pradana
Indonesian Journal of Urology Vol 32 No 2 (2025)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v32i2.1051

Abstract

Objective: This study aims to present the clinical profile of hypospadias patients in the Urology Department of Saiful Anwar Hospital. Material & Methods: This retrospective study analysed the characteristics of delayed hypospadias cases at Saiful Anwar General Hospital in Malang. The study utilized a descriptive design with a quantitative approach, conducted from January 2019 to February 2024. All patients with hypospadias who visited were included in this study. Data were presented in percentage format to illustrate the distribution of cases. Results: Among the 250 patients, 242 (97%) were classified as having a delayed diagnosis. Of all the cases, 141 (56%) were located in Malang. Proximal hypospadias was the most prevalent anomaly, affecting 131 (52%) of the patients. Additionally, there were 88 cases (35% of the total) of mid-shaft hypospadias and 31 cases (13% of the total) of distal hypospadias. Out of the total, 39 patients (16%) had undescended testis (UDT), while 53 patients (22%) had bifid scrotum as an additional condition. Of the 46 patients, 18.4% experienced preterm labor, and approximately 78% of the newborns, specifically 194 of them, had a birth weight over 2500 grams. The healthcare provider participated in 226 out of 232 births, accounting for 97% of the total. The condition was primarily diagnosed by obstetricians, who identified 42% of cases, while midwives identified 58% of the cases. Conclusion: Most hypospadias patients presenting at Saiful Anwar Hospital are diagnosed late, with proximal hypospadias being the most prevalent type. Accompanying conditions include bifid scrotum, occurring in 22%, and undescended testes, present in 16% of cases. This finding presents a potential opportunity to enhance the standard of care. Keywords: Hypospadias, UDT, bifid scrotum.
PEDIATRIC URINARY STONE PROFILE IN SAIFUL ANWAR HOSPITAL Balafif, Muhammad Firas; Daryanto, Besut; Nurhadi, Pradana
Indonesian Journal of Urology Vol 32 No 2 (2025)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v32i2.1054

Abstract

Objective: This study aims to provide an overview of the characteristics of age, gender, stone location, stone side, stone analysis, and management of pediatric urinary stone in the tertiary hospital. Material & Methods: This was a retrospective study done over a period of four years from January 2019 - December 2023 in our institution. The patient has undergone supporting examinations to confirm the diagnosis. Clinical data including the patient’s age, gender, stone location, stone side, stone analysis, and management were observed. Data were analyzed descriptively and using SPSS 17.0. Results: Total of 55 cases of upper and lower urinary tract stones were encountered in our study with a mean age of 11.2 years. The highest incidence was 15-18 years old (36.4%). The distribution by gender showed a higher prevalence in males (67.2%) compared female patients (32.8%). The kidney stone was the most frequent clinical presentation (36.3%). From the upper urinary tract stone, the left side becomes the predominant area (54.2%). The most common stone constituent was calcium oxalate (41.8%). The kidney stone was mostly treated with Percutaneous Nephrolithotomy (PCNL) (75.0%). Conclusion: Pediatric urinary tract stone patients in our institution are predominantly male, with a peak rate in 15- 18 years old, most commonly found in the kidney, predominantly on the left side, and the most common stone constituent was calcium oxalate. Th kidney stone is mostly treated with PCNL. Keywords: Bladder stone, pediatric urinary stone, cystolithotripsy.
THE RELATIONSHIP OF NEUTROPHIL-TO-LYMPHOCYTE RATIO (NLR) WITH LOCALIZED AND NON-LOCALIZED TESTICULAR GERM CELL TUMORS Seputra, Kurnia Penta; Nurhadi, Pradana; Husein, Rahmat
Indonesian Journal of Urology Vol 32 No 3 (2025)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v32i3.1019

Abstract

Objective: This study aim to reveal the relationship preoperative neutrophil-to-lymphocyte ratio (NLR) with testicular germ cell tumors (GCT). Material & Methods: A total of twenty-six patients diagnosed with TGCT from 2017 to 2022 in Saiful Anwar Hospital, Malang were included in this retrospective study. Patients were grouped as localized and non-localized. Hematological and biochemical blood measured the days before radical orchiectomy. Results: Eleven patients (42.3%) had seminomas and fifteen patients (57.7%) had non-seminomatous testicular cancer. Six patients (23.1%) had localized and twenty patients (76.9%) had non-localized testicular cancer. There was a statistically significant difference between mean NLR of the localized patients and non-localized patients (localized NLR: 1.7±0.84, non-localized: 3.65±0.97, p=0.000). The optimal cut-off value for localized and non-localized TGCT was 3.05 with sensitivity 83.33% and specificity 75%. That was statistically significant between cut-off value NLR with localized and non-localized TGCT (correlation coefficient 0.505, p=0.008). Conclusion: NLR appears to be a useful marker for TGCT. It is successful in predicting localized and non-localized disease in early preoperative period. Keywords: Neutrophil-to-lymphocyte ratio, testicular cancer, testicular germ cell tumors.
Co-Authors Akbar, Fariz Kemal Alfandy, Tommy N. Anderson, Vincent Enrico Balafif, Muhammad Firas Clark Rizqullah Suhermanto, Muhammad Dhani, Fauzan K. Dhani, Fauzan Kurniawan Faida, Nova Auliyatul Henrizal, Fenni Husein, Rahmat Kenty Wantri Anita, Kenty Wantri Kurnia Penta Seputra Kusworini Handono Lalchanzani , Jawaharlal Akbar Lukman Hakim Paksi Satyagraha Permata , Angeline Asti Shiela Prasetyo Nugroho Purnomo, Athaya F. Putra, Fikri Alam Riza Rachman, Manarul Iman Alfafa Rachmat Setiawan, Ilham Samudra, Fathan Satria Satria, Hikmat Satriawan , Ilham Setiawan, Ilham Rachmat Subrata, Gabriella Sulistyanti, Rachma Fitri Sunaryo Hardjowijoto Tarmono Djojodimedjo Taufiq Nur Budaya Vilado, Irene Yasmina