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All Journal Medica Hospitalia Media Farmasi Indonesia Jurnal Kedokteran Meditek
Hardimarta, Fransisca Pramesshinta
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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The Increased Superoxide Dismuatase (SOD) In Mice Infected by Plasmodium Berghei ANKA Treated with Nanoparticle Extract of Beetroot (Beta Vulgaris L) Hardimarta, Fransisca Pramesshinta; Suromo, Lisyani Budipradigda; Djamiatun, Kis
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 2 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i2.1119

Abstract

BACKGROUND: Malaria infection causes increased free radicals which leads to severity and decreases antioxidant activity, thus increasing the risk of severe malaria complications. Beetroot extract has active compounds that function as anti-inflammatory and antioxidants. Nanoparticles are a technology that can be used to improve drug delivery efficiency in smaller doses. AIMS:  to prove the effectiveness of beetroot extract nanoparticles on SOD levels in mice infected with malaria and treated with artemisinin METHOD: An experimental study using a post-test-only randomized control group design. The research sample used 30 male Balb/c mice divided into 6 groups. Group 1 was the healthy group, group 2 was the infected group without treatment, group 3 was the infected group with artemisinin treatment, group 4 was the infected group with artemisinin treatment and 50 mg/kgBW/day beetroot extract nanoparticles, group 5 was the infected group with artemisinin treatment and 100 mg/kg BW/day beetroot extract nanoparticles, and group 6 was the infected group with artemisinin treatment and 200 mg/kg BW/day beetroot extract nanoparticles. Beetroot extract and artemisinin supplementation were given after parasitemia index > 1% and given for 4 days. On the 5th day after therapy, serum SOD levels were measured using ELISA. RESULT: The measurement of SOD levels in the artemisinin group supplemented with nanoparticle extracts of beetroot at doses 100-200 mg/KgBW were 21,48-21,59 ng/ml. Kruskal Wallis and Mann Whitney test showed that they are significantly higher serum SOD levels compared to the infected mice group (p<0.05). CONCLUSION: Supplementation of beetroot extract nanoparticles has an antioxidant effect by increasing SOD levels in mice infected with malaria and receiving artemisinin therapy.
PERBAIKAN GAMBARAN LESI ATEROSKLEROTIK DENGAN PEMBERIAN EKSTRAK BETA VULGARIS PADA TIKUS MODEL DIET ATHEROGENIK Hardimarta, Fransisca Pramesshinta; Ikawati, Kartika; Yuniarti, Christina Ary
Media Farmasi Indonesia Vol. 15 No. 1 (2020): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (418.432 KB) | DOI: 10.53359/mfi.v15i1.140

Abstract

Atherosclerosis is characterized by the accumulation of fat in the arteries so it forms plaque that causes thickening of the intima and blockage of the arteries. Beet roots are rich of phytochemical compounds that have antioxidant activity. Design of research is a laboratory experimental study with a Post Test Only Randomized Control Group Design. The population of this study was male Wistar rats with age 2-3 months and body weight 125-200 grams. The study sample was randomly selected and consists of 7 groups and 5 rats for each group. The average number of foam cells in the baseline group is 17.6; negative control group is 65.8; positive control is 54.6; group I is 38.8; group II is 27.4; group III is 46.4; and group IV is 42.4. The average thickness of the aortic intima tunica in the baseline group is 136.8 µ; negative control group is 251.4 µ; positive control is 211.8 µ; group I is 202.8 µ; group II is 184 µ; group III is 242.8 µ; and group IV is 210.6 µ. Statistical test results showed that there were significant differences in supplementation of beet root extracts against aortic thickness and the number of foam cells in rats fed atherogenic diets.
Susceptibility of Gastroesophageal Reflux Disease Symptoms in Medical Students: A Formative Study Sutanto, Eviana Budiartanti; Sutanto, Luciana Budiati; Hardimarta, Fransisca Pramesshinta; Ernestia , Henrita; To , Lidwina Indra Aprilia Christiana; Tjitradinata , Cynthia; Sebong , Perigrinus Hermin
Jurnal Kedokteran Meditek Vol 31 No 5 (2025): SEPTEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i5.3758

Abstract

Introduction: Gastroesophageal Reflux Disease (GERD) is a common chronic health problem associated with decreased quality of life and high morbidity. Many factors, including lifestyle, eating habits, medication, and mental stress, can trigger gastroesophageal reflux disease. A medical student who experiences high pressure during their training may have a GERD issue. Hence, this study aims to investigate the correlation between risk factors and the development of GERD in medical students. Methods: We used data from a cross-sectional study conducted at Soegijapranata Catholic University, Semarang, among medical students. Participants were recruited with inclusion criteria, namely all students aged over 18 years who were willing to fill out a questionnaire voluntarily, and were not undergoing treatment for gastric ulcers or mental disorders. Two questionnaires are used: a questionnaire developed to obtain demographic characteristics and a GERDQ questionnaire. A significant relationship is considered to occur if the p-value <0.05. Result: A total of 122 students were included. Among them, 23 students, consisting of 16 (13.11%) women and 7 (5.73%) men, suffered from GERD. It was found that nine people (7.4%) consumed NSAIDs, with a p-value of 0.014. Conclusion: The prevalence of GERD among medical students is relatively high, showing a significant link between the use of NSAIDs and GERD. Practical studies are needed to tackle the issue of uncontrolled NSAID use and to promote lifestyle modifications.
Co-Authors Ernestia , Henrita Ikawati, Kartika Kis Djamiatun Luciana Budiati Sutanto Sebong , Perigrinus Hermin Suromo, Lisyani Budipradigda Sutanto, Eviana Budiartanti Tjitradinata , Cynthia To , Lidwina Indra Aprilia Christiana yuniarti, christina ary