Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Medica Hospitalia
Suromo, Lisyani Budipradigda
Unknown Affiliation
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Hubungan Hemoglobin Terglikosilasi (HbA1c) Dengan Risiko Kardiovaskular Pada Pasien Diabetes Mellitus Widyatmojo, Hadian; Suromo, Lisyani Budipradigda
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (259.243 KB) | DOI: 10.36408/mhjcm.v7i2.500

Abstract

Latar belakang : Diabetes Mellitus (DM) dengan kondisi hiperglikemik kronik dapat mengakibatkan gangguan sistem kardiovaskular dan peningkatan mortalitas. Hemoglobin terglikosilasi (HbA1c) merupakan salah satu parameter untuk pengendalian DM. Tujuan penelitian untuk membuktikan adanya hubungan antara kadar HbA1c serum dengan risiko kardiovaskular pada pasien DM. Metode : Penelitian belah lintang dilakukan pada 42 penderita DM yang dirawat di RSUP Dr. Kariadi Semarang periode Agustus - September 2017. Diagnosis DM didapatkan melalui rekam medis. Dilakukan pemeriksaan HbA1c dan dinilai faktor risiko yang terdapat pada rekam medis menggunakan skor interheart (IHR). Analisa statistik menggunakan uji korelasi Spearman. Hasil : Terdapat hubungan antara HbA1c dengan skor IHR dengan nilai r=0,887, p=0,001. Pasien dengan kategori risiko kardiovaskular tinggi memiliki nilai HbA1c dengan rerata 10,12 ± 2,29, skor kategori sedang 6,62 ± 1,67 dan skor kategori rendah 5,75 ± 0,78. Simpulan :Terdapat hubungan positif kuat antara HbA1c dengan risiko kardiovaskular pada pasien DM. Perlu dilakukan penelitian prospektif dengan sampel yang lebih besar. Kata kunci DM, HbA1c, Skor risiko Interheart
The Increased Superoxide Dismuatase (SOD) In Mice Infected by Plasmodium Berghei ANKA Treated with Nanoparticle Extract of Beetroot (Beta Vulgaris L) Hardimarta, Fransisca Pramesshinta; Suromo, Lisyani Budipradigda; Djamiatun, Kis
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 2 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i2.1119

Abstract

BACKGROUND: Malaria infection causes increased free radicals which leads to severity and decreases antioxidant activity, thus increasing the risk of severe malaria complications. Beetroot extract has active compounds that function as anti-inflammatory and antioxidants. Nanoparticles are a technology that can be used to improve drug delivery efficiency in smaller doses. AIMS:  to prove the effectiveness of beetroot extract nanoparticles on SOD levels in mice infected with malaria and treated with artemisinin METHOD: An experimental study using a post-test-only randomized control group design. The research sample used 30 male Balb/c mice divided into 6 groups. Group 1 was the healthy group, group 2 was the infected group without treatment, group 3 was the infected group with artemisinin treatment, group 4 was the infected group with artemisinin treatment and 50 mg/kgBW/day beetroot extract nanoparticles, group 5 was the infected group with artemisinin treatment and 100 mg/kg BW/day beetroot extract nanoparticles, and group 6 was the infected group with artemisinin treatment and 200 mg/kg BW/day beetroot extract nanoparticles. Beetroot extract and artemisinin supplementation were given after parasitemia index > 1% and given for 4 days. On the 5th day after therapy, serum SOD levels were measured using ELISA. RESULT: The measurement of SOD levels in the artemisinin group supplemented with nanoparticle extracts of beetroot at doses 100-200 mg/KgBW were 21,48-21,59 ng/ml. Kruskal Wallis and Mann Whitney test showed that they are significantly higher serum SOD levels compared to the infected mice group (p<0.05). CONCLUSION: Supplementation of beetroot extract nanoparticles has an antioxidant effect by increasing SOD levels in mice infected with malaria and receiving artemisinin therapy.
Co-Authors Hardimarta, Fransisca Pramesshinta Kis Djamiatun Widyatmojo, Hadian