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Surtiningsih
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Journal : Jurnal Penelitian Pendidikan IPA (JPPIPA)

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Optimizing Ketamine-Propofol Collaboration to Prevent SpO₂ Decrease in TIVA Patients at RSU Emanuel Banjarnegara Handayani, Rahmaya Nova; Novaliyanto, Sakhfa Syesar; Surtiningsih
Jurnal Penelitian Pendidikan IPA Vol 11 No 4 (2025): April
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i4.10982

Abstract

Total Intravenous Anesthesia (TIVA) is a widely used anesthetic technique that relies entirely on intravenous agents. However, one of its challenges is the potential reduction in oxygen saturation (SpO₂) during induction. Ketamine and propofol are commonly used anesthetic agents and their combination is hypothesized to optimize hemodynamic stability and prevent SpO₂ decline. Objectives: This study aims to evaluate the effectiveness of ketamine-propofol collaboration in maintaining oxygen saturation during TIVA induction at RSU Emanuel Banjarnegara. Methods: This study was a quasi-experimental study with 50 TIVA patients who met the inclusion criteria. Result: The study found that patients receiving the ketamine-propofol combination exhibited a more stable SpO₂ level compared to those receiving propofol alone. The mean decrease in SpO₂ was significantly lower in the combination group (p < 0.05), indicating the protective effect of ketamine in preventing hypoxia. The combo group also maintained hemodynamic indicators including blood pressure and heart rate better. Conclusion: The simultaneous injection of Ketamine and Propofol is beneficial in preventing a drop in SpO₂ 1 minute after induction of anesthesia compared to the combination of Propofol alone.
Co-Authors Ayu Prameswari, Diyah Diyah Ayu Prameswari Fauziah Hanum NA Fauziah Hanum Nur Adriyani Feti Kumala Dewi Istikomah, Evita Nurul linda yanti Linda Yanti Novaliyanto, Sakhfa Syesar Rahmaya Nova Handayani Retno Syafitri Riska Purwaning Tyas Vian Putria Isma