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All Journal Majalah Kedokteran The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Wiyanto, Marwito
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Medicine & Pharmacology

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Effect of autologous stromal vascular fraction (SVF) for diabetes mellitus type-2 Remelia, Melinda; Novriandina, Shanaz; Karina; Panjaitan, Ani O.; Andriana, Jumaini; Sitohang, John; Batubara, Frisca; Wiyanto, Marwito; Sitompul, Yunita R.M.B
Majalah Kedokteran UKI Vol. 38 No. 1 (2022): JANUARI - APRIL
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mk.v38i1.4188

Abstract

Autologous Stromal Vascular Fraction (SVF) is one of the alternative therapy for type 2 diabetes that might potentially regenerate pancreatic beta cells. HbA1c levels ≤7% is an efficacious indicator for type 2 diabetes mellitus treatment. The aim of this study is to analyze the effect of autologous SVF therapy on decreasing HbA1c levels of type 2 diabetes patients at Hayandra Clinic in 2016. This study uses observational analytics by obtaining 30 patients' medical records after autologous SVF therapy and analyzing by using paired t-test. The results showed a decrease in HbA1c levels in 24 patients (83.4%), increased HbA1c levels in 4 patients (13.3%), and two patients (3.3%) who had no changes in HbA1c levels after one month got autologous SVF therapy. Based on HbA1c levels as an efficacious indicator, there was an increase in the percentage of type 2 diabetes patients with controlled HbA1c levels from 37% to 47%. The percentage of type 2 diabetes patients with uncontrolled HbA1c levels decreased from 63% to 53%. There was a correlation between autologous SVF therapy and the decrease of HbA1c levels in type 2 diabetes patients (p=0,003). Keywords: Type 2 diabetes; HbA1c levels; Stromal Vascular Fraction
The Effect of an Annona muricata Leaves Extract on Circulating Soluble Adhesion Molecules in Colon Carcinogenesis Model Indrawati, Lili; Kusmardi, Kusmardi; Wiyanto, Marwito
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/241202330-34

Abstract

Background: Annona muricata leaves are used as traditional tea drink that is currently being studied on the developing effort of treating some types of cancers because they are known as anti-cancer. Motivated by that usage, this study aims to analyse the potential of A. muricata leaves extract to be an anti-colon cancer by investigating the extract capability in reducing blood intercellular cell-adhesion molecule-1 (ICAM-1) and vascular cell-adhesion molecule-1 (VCAM-1).Method: The research was conducted in Faculty of Medicine Universitas Indonesia with an ex­perimental design. A. muricata leaves extract was tested in vivo. In vivo test was conducted to Swiss Webster mice induced with 10 mg/kg azoxymethane (AOM) and dextran sodium sulfate 1% (DSS). Statistical analysis used was SPSS.Results: EIFAM reduce the serum level of ICAM-1 and VCAM-1. EIFAM significantly reduce serum level of VCAM compare to ESFAM.Conclusion: Ethanol insoluble fraction of Annona muricata leaves water extract of is potential to be an anti-colon cancer proven by the extract capability to reduce ICAM-1 and VCAM-1.
Co-Authors Andriana, Jumaini Batubara, Frisca Karina Kusmardi Kusmardi Lili Indrawati Novriandina, Shanaz Panjaitan, Ani O. Remelia, Melinda Sitohang, John Sitompul, Yunita R.M.B