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All Journal MNJ (Malang Neurology Journal) Journal of Pain, Vertigo and Headache
Mondiani, Yeni Quinta
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Neuroscience

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PATTERN OF ANTI EPILEPTIC DRUG ADVERSE EFFECT IN TERTIARY REFERRAL HOSPITAL Damayanti, Ria; Husna, Machlusil; Mondiani, Yeni Quinta; Kurniawan, Shahdevi Nandar
MNJ (Malang Neurology Journal) Vol. 6 No. 2 (2020): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

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Abstract

Background: Epilepsy is a major chronic neurological problem in the world. The goal of epilepsy therapy is seizure-free and without side effects. The emergence of side effects in patients with epilepsy will be its limitations that can cause the failure of epilepsy therapy. Therefore, it is necessary to do a simple descriptive study, which illustrates the pattern of side effects of anti-epileptic drugs that occur in people with epilepsy, so that later clinicians are more alert and can take preventative measures.Objective: Knowing the pattern of side effects of antiepileptic drugs at the Neurology Outpatient Clinic dr. Saiful Anwar hospital.Methods: This research is an observational descriptive study. Samples were taken by filling the questionnaire at the Neurology Outpatient Clinic dr. Saiful Anwar hospital. Demographic data in this study will be presented in the frequency distribution table. Chi Square test is used to determine the relationship of demographic data, also the pattern of therapy with the side effects that arise.Results: 93 epilepsy patients were involved in the study. More than 40% of patients experience side effects. The most common side effects appear in idiopathic epilepsy (30.1%). Based on the duration of epilepsy, the most side effects appear in epilepsy duration> 10 years (17.2%). However, from the results of the influence test using chi square, there was no significant difference between the duration of epilepsy with the appearance of side effects, even the type of epilepsy (p-value> 0.05). 28 patients who experience side effects, appear after the duration of use of AED 1 - 5 years. It was found that the duration of AED uses affected the emergence of side effects (p-value <0.05).Conclusion: Side effects occur in patients taking anti-epileptic drugs, and are related to the duration of drug use. This data can be used to increase the awareness of clinicians related to the emergence of side effects in patients who consume AED.
POST HERPETIC NEURALGIA AND OPHTAMOPLEGIA IN PATIENT WITH MULTIPLE SCLEROSIS : A CASE REPORT Widodo Mardi Santoso; Yeni Quinta Mondiani; Machlusil Husna; Rodhiyan Rachmatiar
Journal of Pain, Headache and Vertigo Vol. 1 No. 1 (2020): March
Publisher : Journal of Pain, Headache and Vertigo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (209.476 KB) | DOI: 10.21776/ub.jphv.2020.001.01.3

Abstract

Zoster Herpes which is also known as ‘shingles’ may cause infection on neuro system through the reactivation of the virus. This infection causes skin eruption along the affected dermatomal distribution and it is called post herpetics neuralgia. This condition occurs on approximately 9-15% patients of zoster herpes who receive no treatment. Elderly women have a higher risk of the condition. Complete oftamoplegia is also related with zoster herpes. It was reported that there were 16 cases in the past one year with a relatively good prognosis (total recovery within 18 months) with an analysis starting from inflammation of trigeminus nervus to cavernosus sinus, cranialis nervus microinfark caused by vasculitis, meningeal inflammation, and demyelinisation (of autopsy). On the other hand, there are theories showing a correlation between zoster herpes infection and multiple sclerosis. Based on the epidemiologic study which has been conducted, that zoster herpes is influencing multiple sclerosis. This virus might induce autoimmune cascade and proinflammatory via particle like Toll – like receptor 4 (TLR-4).
POST HERPETIC NEURALGIA AND OPHTAMOPLEGIA IN PATIENT WITH MULTIPLE SCLEROSIS : A CASE REPORT Widodo Mardi Santoso; Yeni Quinta Mondiani; Machlusil Husna; Rodhiyan Rachmatiar
Journal of Pain, Headache and Vertigo Vol. 1 No. 1 (2020): March
Publisher : Journal of Pain, Headache and Vertigo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jphv.2020.001.01.3

Abstract

Zoster Herpes which is also known as ‘shingles’ may cause infection on neuro system through the reactivation of the virus. This infection causes skin eruption along the affected dermatomal distribution and it is called post herpetics neuralgia. This condition occurs on approximately 9-15% patients of zoster herpes who receive no treatment. Elderly women have a higher risk of the condition. Complete oftamoplegia is also related with zoster herpes. It was reported that there were 16 cases in the past one year with a relatively good prognosis (total recovery within 18 months) with an analysis starting from inflammation of trigeminus nervus to cavernosus sinus, cranialis nervus microinfark caused by vasculitis, meningeal inflammation, and demyelinisation (of autopsy). On the other hand, there are theories showing a correlation between zoster herpes infection and multiple sclerosis. Based on the epidemiologic study which has been conducted, that zoster herpes is influencing multiple sclerosis. This virus might induce autoimmune cascade and proinflammatory via particle like Toll – like receptor 4 (TLR-4).
NON-SPECIFIC HEADACHE AS THE MAIN MANIFESTATION OF TUBERCULOUS MENINGITIS: A RARE CASE REPORT Mondiani, Yeni Quinta; Iryawati, Dinda; Munir, Badrul
MNJ (Malang Neurology Journal) Vol. 11 No. 2 (2025): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.02.15

Abstract

Introduction: Tuberculous meningitis (TBM) is the most severe form of extrapulmonary TB, posing a major public health challenge due to high morbidity and mortality. Non-specific symptoms and limited diagnostic access delay detection, worsening patient outcomes. Headache, as one of the non-specific symptoms of TB meningitis, often leads to misdiagnosis Case Report: Male, 31 years old, presented with a persistent headache as the primary symptom, without definite fever, neck stiffness, or altered mental status. Initial cerebrospinal fluid (CSF) analysis showed no significant abnormalities, delaying diagnosis. GeneXpert MTB/RIF later confirmed Mycobacterium tuberculosis, and the patient was diagnosed with tuberculous meningitis (TBM). Follow-up imaging revealed persistent meningeal enhancement, leading to an extended treatment duration. The patient showed clinical improvement after completing 12 months of anti-tuberculosis therapy. Discussion: The diagnosis of tuberculous meningitis (TBM) remains challenging due to its non-specific clinical presentation and overlap with other central nervous system (CNS) disorders. Delays in diagnosis often arise from non-specific headache (reported in over 50% of cases, typically presenting with a holocranial and throbbing pattern), unexplained fever, absence of classic meningeal signs, and inconclusive initial cerebrospinal fluid (CSF) findings. Early and accurate diagnosis relies on a comprehensive approach integrating CSF analysis, molecular diagnostics, and neuroimaging. Persistent imaging abnormalities may necessitate extended treatment beyond the standard duration in certain cases. Conclusion: Non-specific symptoms, such as headache, often lead to a delayed diagnosis of TBM, requiring CSF analysis, molecular testing, and neuroimaging. While a 12-month treatment course is standard, further research on advanced imaging and artificial intelligence is essential to improve TBM detection and management.
PIMPINELLA PRUATJAN MOLK. AS A POTENTIAL ANTI-DIABETIC NEUROPATHY WITH ANTIOXIDANT MECHANISMS: A REVIEW Dewi, Trisni Untari; Mondiani, Yeni Quinta; Rukmi, Kartika Widya; Munawaroh, Fauziyatul; Rusmajati, Jetty; Batubara, Irmanida
MNJ (Malang Neurology Journal) Vol. 12 No. 2 (2026): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2026.012.02.17

Abstract

Medicinal plant utilization in the clinical management of metabolic disorders, including Diabetes Mellitus (DM) and its associated complications, has gained considerable scientific attention in recent decades. Their perceived tolerability positions them as viable complementary or adjunct options to standard pharmacological regimens. Purwoceng (Pimpinella pruatjan Molk.) is a plant indigenous to Indonesia that demonstrates notably high concentrations of antioxidant constituents. Given that oxidative stress constitutes a fundamental driver in the pathophysiology of DM, it is implicated in the development of complications including diabetic peripheral neuropathy. Objective: To review existing evidence on the potential of purwoceng in reducing blood glucose levels and repairing nerve damage in diabetic neuropathy, including its mechanisms, active compounds, and toxicity profile. Methods: A literature review was conducted using keywords including Pimpinella pruatjan/Molk, Purwoceng, Antioxidant, Diabetes Mellitus, Diabetic Neuropathy, and secondary metabolites. Relevant studies were selected and critically reviewed. Results: Several studies identified secondary metabolites in purwoceng, including phenolics, flavonoids, tannins, coumarins, saponins, terpenes, and steroids. These compounds exhibit antioxidant and anti-inflammatory properties, suggesting potential benefits in reducing hyperglycemia and preventing or repairing nerve damage in diabetic neuropathy. Available evidence also indicates no significant acute toxicity in renal and hepatic organs. Conclusion: Purwoceng exhibits promising potential as an adjunctive therapeutic agent in the management of Diabetes Mellitus and its neuropathic complication, mediated principally through antioxidant and anti-inflammatory mechanisms, with a favorable preliminary safety profile. Rigorous clinical investigations are warranted to substantiate its efficacy and safety in human subjects.
Co-Authors Badrul Munir, Badrul Damayanti, Ria Dinda Iryawati Irmanida Batubara Machlusil Husna Machlusil Husna, Machlusil Munawaroh, Fauziyatul Rodhiyan Rachmatiar Rukmi, Kartika Widya Rusmajati, Jetty Shahdevi Nandar Kurniawan, Shahdevi Nandar Trisni Untari Dewi Widodo Mardi Santoso