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All Journal The Indonesian Biomedical Journal JBN (Jurnal Bedah Nasional)
Suryawisesa, Ida Bagus Made
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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The Accuracy of FNAB as Diagnostic Tool For Thyroid Cancer Compared to Anatomical Pathology Results as Gold Standard at Sanjiwani Hospital, Gianyar Yasa, I Nyoman Wawan Tirtha; Maheswari, Luh Putu Dewanda; Suryawisesa, Ida Bagus Made; Irawan, Hendry; Sudarsa, I Wayan; Bharata, Made Dwi Yoga; Widarsa, I Ketut Tangking
JBN (Jurnal Bedah Nasional) Vol 8 No 2 (2024): JBN (Jurnal Bedah Nasional)
Publisher : Program Studi Ilmu Bedah, Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JBN.2023.v08.i02.p02

Abstract

Aim: The aim of this study was to assess the accuracy of fine needle aspiration biopsy (FNAB) as a diagnostic tool for thyroid cancer in Sanjiwani Hospital, Gianyar. Methods: This study used a diagnostic test method with a retrospective cross-sectional design. A total of 138 cases of thyroid nodules that received FNAB and anatomical pathology examinations were selected consecutively. The level of accuracy was determined from the number of sensitivity, specificity, positive predictive value and negative predictive value. Results: The results of this study showed a low sensitivity 11.53%, but high specificity 100%, positive predictive value 100%, and negative predictive value 82.96% of FNAB. The accuracy of FNAB as diagnostic tools of thyroid cancer was 83,3% compared with anatomical pathology results as gold standard. Conclusion: FNAB is less accurate to diagnose thyroid cancer, but FNAB examination is accurate in differentiate benign and cancer lesion in thyroid nodule.
Validity of Wagner, SINBAB, PEDIS, and WIFI Scoring Systems to Assess Risk of Amputation in Patients with Diabetic Foot Ulcers Gunawan, I Made Kasmadi; Budiarta, Ida Bagus; Mahadewa, Tjokorda Gde Bagus; Suryawisesa, Ida Bagus Made; Wibawa, I Gusti Agung Bagus Krisna; Ariyanta, Kadek Deddy
JBN (Jurnal Bedah Nasional) Vol 8 No 2 (2024): JBN (Jurnal Bedah Nasional)
Publisher : Program Studi Ilmu Bedah, Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JBN.2024.v08.i02.p04

Abstract

Aim: This study aims to determine validity of the Wagner, SINBAD, PEDIS, and WIFI scoring systems in assessing the risk of amputation in patients with diabetic foot ulcers at Prof. dr. I.G.N.G. Ngoerah General Hospital, Denpasar. Methods: This research is an observational study of diagnostic tests with a cross-sectional design. The sample in this study was selected by consecutive sampling from 1 January 2022 to 31 December 2022 with total of 72 respondents.Results: Wagner score test obtained sensitivity 77.2%, specificity 80.0%, PPV 93.6%, NPV 48%, accuracy 77.7%, and RR 1.8. PEDIS score test results obtained sensitivity 82.5%, specificity 86.7%, PPV 95.9%, NPV 56.5%, accuracy 83.3%, and RR 2.2. The results of the SINBAD test score obtained sensitivity 78.9%, specificity 66.7%, PPV 90.0%, NPV 45.5%, accuracy 76.3%, and RR 1.6. WIFI score test obtained sensitivity 89.5%, specificity 66.7%, PPV 91.1%, NPV 62.5%, accuracy 84.7%, and RR 2.4. Conclusion: The WIFI score has better sensitivity and accuracy compared to score Wagner, SINBAD, and PEDIS so it is recommended to use the WIFI score to assess the risk of amputation in diabetic foot ulcer patients.
Expression of CD8+ and Foxp3+ T Lymphocyte as Predictor for Response to Neoadjuvant Chemotherapy in Stage III Breast Cancer Yasa, I Nyoman Wawan Tirtha; Sudarsa, I Wayan; Niryana, I Wayan; Sriwidyani, Ni Putu; Jawi, I Made; Yasa, I Wayan Putu Sutirta; Manuaba, Ida Bagus Tjakra Wibawa; Suryawisesa, Ida Bagus Made
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3680

Abstract

BACKGROUND: Neoadjuvant chemotherapy (NAC) in breast cancer is usually utilized to eradicate micro-metastasis, induce apoptosis in tumor cells, and reduce the primary tumor size, enabling surgical intervention. Recent studies have shown that tumor-infiltrating lymphocytes (TILs), especially cytotoxic CD8+ T cells and immunosuppressive Foxp3+ regulatory T cells, influence tumor response to treatment. However, their role as predictive markers for NAC response remains unclear. Therefore, this study was performed to investigate whether high expression of CD8+ and low expression of Foxp3+ T lymphocytes are associated with better response to NAC in stage III breast cancer patients.METHODS: Total of 60 biopsy samples from stage III breast cancer patients were included, comprising 30 subjects in the response group (+) and 30 subjects in the non-response group (−). The expression levels of CD8+ and Foxp3+ T lymphocytes in tumor tissue were assessed semi-quantitatively by immunohistochemistry (IHC), using a scoring system based on the proportion and intensity of positively stained cells (Black’s grading criteria).RESULTS: Stage III breast cancer with high expression of CD8+ T lymphocytes was significantly associated with a better response to NAC (p=0.004; OR=6.882). Meanwhile, low expression of Foxp3+ T lymphocytes was not significantly associated with chemotherapy response (p=0.067; OR=3.250). A higher tumor grade was also associated with an improved response to treatment. The probability of achieving a positive response to NAC in subjects presenting with high CD8+ expression, low Foxp3+ expression, and high tumor grade was estimated at 96.98%.CONCLUSION: The combination of high expression of CD8+ T lymphocyte, low expression of Foxp3+ T lymphocyte and high tumor grade might be useful to predict good response to NAC in stage III breast cancer.KEYWORDS: CD8+ T lymphocyte, Foxp3+ T lymphocyte, neoadjuvant chemotherapy, breast cancer
Co-Authors Ariyanta, Kadek Deddy Bharata, Made Dwi Yoga Budiarta, Ida Bagus Hendry Irawan I Made Jawi I Made Kasmadi Gunawan, I Made Kasmadi I W. Sudarsa I Wayan Niryana I Wayan Putu Sutirta Yasa K Tangking Widarsa Maheswari, Luh Putu Dewanda Manuaba, Ida Bagus Tjakra Wibawa Ni Putu Sriwidyani Tjokorda Gde Bagus Mahadewa Wibawa, I Gusti Agung Bagus Krisna Yasa, I Nyoman Wawan Tirtha