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All Journal The Indonesian Biomedical Journal JBN (Jurnal Bedah Nasional)
Yasa, I Nyoman Wawan Tirtha
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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The Accuracy of FNAB as Diagnostic Tool For Thyroid Cancer Compared to Anatomical Pathology Results as Gold Standard at Sanjiwani Hospital, Gianyar Yasa, I Nyoman Wawan Tirtha; Maheswari, Luh Putu Dewanda; Suryawisesa, Ida Bagus Made; Irawan, Hendry; Sudarsa, I Wayan; Bharata, Made Dwi Yoga; Widarsa, I Ketut Tangking
JBN (Jurnal Bedah Nasional) Vol 8 No 2 (2024): JBN (Jurnal Bedah Nasional)
Publisher : Program Studi Ilmu Bedah, Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JBN.2023.v08.i02.p02

Abstract

Aim: The aim of this study was to assess the accuracy of fine needle aspiration biopsy (FNAB) as a diagnostic tool for thyroid cancer in Sanjiwani Hospital, Gianyar. Methods: This study used a diagnostic test method with a retrospective cross-sectional design. A total of 138 cases of thyroid nodules that received FNAB and anatomical pathology examinations were selected consecutively. The level of accuracy was determined from the number of sensitivity, specificity, positive predictive value and negative predictive value. Results: The results of this study showed a low sensitivity 11.53%, but high specificity 100%, positive predictive value 100%, and negative predictive value 82.96% of FNAB. The accuracy of FNAB as diagnostic tools of thyroid cancer was 83,3% compared with anatomical pathology results as gold standard. Conclusion: FNAB is less accurate to diagnose thyroid cancer, but FNAB examination is accurate in differentiate benign and cancer lesion in thyroid nodule.
Expression of CD8+ and Foxp3+ T Lymphocyte as Predictor for Response to Neoadjuvant Chemotherapy in Stage III Breast Cancer Yasa, I Nyoman Wawan Tirtha; Sudarsa, I Wayan; Niryana, I Wayan; Sriwidyani, Ni Putu; Jawi, I Made; Yasa, I Wayan Putu Sutirta; Manuaba, Ida Bagus Tjakra Wibawa; Suryawisesa, Ida Bagus Made
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3680

Abstract

BACKGROUND: Neoadjuvant chemotherapy (NAC) in breast cancer is usually utilized to eradicate micro-metastasis, induce apoptosis in tumor cells, and reduce the primary tumor size, enabling surgical intervention. Recent studies have shown that tumor-infiltrating lymphocytes (TILs), especially cytotoxic CD8+ T cells and immunosuppressive Foxp3+ regulatory T cells, influence tumor response to treatment. However, their role as predictive markers for NAC response remains unclear. Therefore, this study was performed to investigate whether high expression of CD8+ and low expression of Foxp3+ T lymphocytes are associated with better response to NAC in stage III breast cancer patients.METHODS: Total of 60 biopsy samples from stage III breast cancer patients were included, comprising 30 subjects in the response group (+) and 30 subjects in the non-response group (−). The expression levels of CD8+ and Foxp3+ T lymphocytes in tumor tissue were assessed semi-quantitatively by immunohistochemistry (IHC), using a scoring system based on the proportion and intensity of positively stained cells (Black’s grading criteria).RESULTS: Stage III breast cancer with high expression of CD8+ T lymphocytes was significantly associated with a better response to NAC (p=0.004; OR=6.882). Meanwhile, low expression of Foxp3+ T lymphocytes was not significantly associated with chemotherapy response (p=0.067; OR=3.250). A higher tumor grade was also associated with an improved response to treatment. The probability of achieving a positive response to NAC in subjects presenting with high CD8+ expression, low Foxp3+ expression, and high tumor grade was estimated at 96.98%.CONCLUSION: The combination of high expression of CD8+ T lymphocyte, low expression of Foxp3+ T lymphocyte and high tumor grade might be useful to predict good response to NAC in stage III breast cancer.KEYWORDS: CD8+ T lymphocyte, Foxp3+ T lymphocyte, neoadjuvant chemotherapy, breast cancer
Co-Authors Bharata, Made Dwi Yoga Hendry Irawan I Made Jawi I W. Sudarsa I Wayan Niryana I Wayan Putu Sutirta Yasa K Tangking Widarsa Maheswari, Luh Putu Dewanda Manuaba, Ida Bagus Tjakra Wibawa Ni Putu Sriwidyani Suryawisesa, Ida Bagus Made