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All Journal World Nutrition Journal Babali Nursing Research Bali Medical and Wellness Journal
Harimawan, Agustinus I Wayan
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Meta analysis studies: effectiveness of omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on clinical outcomes in lung cancer patients Wijanadi, M. Candra; Weta, I Wayan; Harimawan, Agustinus I Wayan; Prabandari, A A S Mirah; Sirait, Josephine Claudia
World Nutrition Journal Vol. 8 No. S1 (2024): Selected conference proceedings of the Nutri Symposium 2024
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.S1.0022

Abstract

Lung cancer is a malignant cancer and the leading cause of cancer-related deaths worldwide. Appropriate nutritional care planning for lung cancer patients needs to be considered, one of which is by providing omega-3 polyunsaturated fatty acids (ω-3 PUFAs) in the patient's nutrition management plan. This study aims to determine the effectiveness of ω-3 PUFA supplementation on clinical outcomes in lung cancer.
Micronutrients intake as risk factor of stunting in toddlers aged 6-24 months in Kintamani District, Bali Prabandari, Anak Agung Sagung Mirah; Sirait, Josephine Claudia; Wijanadi, M.Candra; Harimawan, Agustinus I Wayan
World Nutrition Journal Vol. 8 No. S1 (2024): Selected conference proceedings of the Nutri Symposium 2024
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.S1.0028

Abstract

Reducing stunting is a priority program for the Indonesian government. Kintamani District is one of the areas in Bali Province with a stunting prevalence above the provincial average. Micronutrients play an essential role in growth and development, but their intake in children is often overlooked. This study aimed to investigate micronutrient intake as a risk factor for stunting in toddlers aged 6-24 months in the Kintamani district, Bali.
Medical nutrition therapy in patients with severe malnutrition, unresectable gastric cancer and percutaneous endoscopic gastrostomy (PEG) Sukawati, Cokorda Istri Mas Dalem; Harimawan, Agustinus I Wayan
World Nutrition Journal Vol. 8 No. S1 (2024): Selected conference proceedings of the Nutri Symposium 2024
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.S1.0040

Abstract

The yearly burden of stomach cancer is expected to rise to 1.8 million new cases and 1.3 million deaths by 2040. These indicate rises of almost 63% and 66%, respectively, from 2020. This case aim to describe medical nutrition therapy in patients with unresectable gastric cancer and percutaneous endoscopic gastrostomy (PEG).
Evaluating the Therapeutic Impact of L-Carnitine on Postoperative Left Ventricular Ejection Fraction in Patients Undergoing Coronary Artery Bypass Grafting: A Meta-Analysis Pangkahila, Evangelista Maria; Dewi, Made Yudha Asrithari; Harimawan, Agustinus I Wayan; Silitonga, Josua
Bali Medical and Wellness Journal Vol. 1 No. 3 (2024): Bali Medical and Wellness Journal
Publisher : PT BMW Journal Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71341/bmwj.v1i3.24

Abstract

Background: L-Carnitine (LC) plays a crucial role in transporting long-chain fatty acids into mitochondria for oxidation, which is particularly important for the heart and skeletal muscles. Additionally, it acts as an antioxidant and anti-inflammatory agent, helping to protect tissues from damage caused by reactive oxygen species (ROS). This study aims to evaluate the effect of LC on postoperative left ventricular ejection fraction (LVEF) in patients undergoing coronary artery bypass grafting (CABG). Methods: This systematic review adhered to PRISMA guidelines and searched Google Scholar, PubMed, and ScienceDirect for randomized controlled trials (RCTs) comparing L-Carnitine to placebo in CABG patients. We focused on outcomes related to left ventricular ejection fraction (LVEF) and serum creatine kinase-MB (CK-MB) levels. Data were analyzed using a random-effects model, with results reported as weighted mean differences (WMD) and 95% confidence intervals (CI), considering statistical significance at p < 0.05. Results: The analysis included five RCTs involving 365 CABG patients, with LC doses ranging from 2 to 6 g per day, administered from one month before to 180 days after surgery. The results showed that LC significantly improved LVEF (Weighted Mean Difference [WMD]: 3.22%, 95% Confidence Interval [CI]: 0.28 to 6.16, P = 0.0001). Additionally, LC treatment resulted in a reduction of serum creatine kinase-MB (WMD: -12.75, 95% CI: -22.46 to -3.05, P = 0.01). However, there was no significant difference in cardiopulmonary bypass time between the LC and control groups (WMD: 0.78%, 95% CI: 0.37 to 1.20, P = 0.51). Conclusion: L-Carnitine is effective in improving LVEF and reducing serum CK-MB levels in patients with heart disease undergoing CABG. This suggests it may contribute to a more favorable postoperative recovery.
The Role of Omega-3 Fatty Acids in Mitigating Metabolic Risk Factors Associated with Alzheimer's Disease: A Systematic Review and Meta-Analysis Harimawan, Agustinus I Wayan; Yusnianingsih, Cuay; Prabandari, Anak Agung Sagung Mirah
Bali Medical and Wellness Journal Vol. 2 No. 2 (2025): Bali Medical and Wellness Journal
Publisher : PT BMW Journal Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71341/bmwj.v2i2.42

Abstract

Background: Alzheimer’s disease (AD) is linked to metabolic conditions like obesity and hypertension, which share inflammation and oxidative stress as common factors. Omega-3 fatty acids (EPA and DHA) may have neuroprotective and anti-inflammatory benefits. Objective: This study aims to review the effectiveness of omega-3 supplements in reducing metabolic risk factors and slowing cognitive decline in people with AD. Methods: Following PRISMA guidelines, a comprehensive search was conducted in PubMed, ScienceDirect, and Google Scholar for randomized controlled trials (RCTs) published until July 2025. Eligible studies included older adults (≥65 years) with AD or mild cognitive impairment (MCI) and assessed the impact of omega-3 supplements on cognitive and/or metabolic outcomes. The risk of bias was evaluated using the Cochrane ROB-2 tool. Data were analyzed with Review Manager 5.4 using fixed-effects models for continuous outcomes. Results: Five RCTs with a total of 490 participants were included. Meta-analysis of four trials (326 participants) revealed that omega-3 supplementation significantly improved Mini-Mental State Examination (MMSE) scores compared to placebo (mean difference: 0.21; 95% CI: 0.02–0.41; P = 0.03; I² = 0%). No significant effects were found for ADAS-Cog scores (mean difference: 0.11; 95% CI: –0.40 to 0.62; P = 0.68; I² = 46%) or IADL scores (mean difference: 0.48; 95% CI: –0.17 to 1.13; P = 0.15; I² = 36%). Conclusion: Omega-3 fatty acids may offer modest cognitive benefits in AD, though heterogeneity among studies limits general conclusions. Future well-designed RCTs should consider metabolic profiles and standardized dosing to identify populations most likely to benefit from omega-3 supplementation.
Glucomannan from Porang (Amorphophallus muelleri) Improves Short-Chain Fatty Acid in Wistar Rat with High-Fat and High-Fructose Diet Harimawan, Agustinus I Wayan
Babali Nursing Research Vol. 5 No. 2 (2024): April
Publisher : Babali Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37363/bnr.2024.52369

Abstract

Introduction: Short-chain fatty acids (SCFAs) improve lipid profile and prevent coronary artery disease. Searching for nutrition based on local foods that might raise the body's SCFA levels is imperative. Porang (Amorphophallus muelleri) is a plant with a high concentration of glucomannan that is investigated to have a healthy benefit. This study aimed to investigate the effect of glucomannan from Porang (A.muelleri) on SCFA in Wistar rats with a high-fat, high-fructose diet.Methods: This was an experimental study with a randomized and post-test-only control group design. Thirty male Wistar rats were divided into five groups: a normal control group, a negative control group given a high-fat, high-fructose diet, and treatment groups given Porang glucomannan 25mg, 50mg, or 100mg/200gBW. Twenty-eight days after the intervention, the SCFA level was measured using gas chromatography–masstry (GC/MS). Data were analyzed in SPSS.Results: The treatment group with Porang glucomannan 50 mg/200gBW has the highest mean SCFA level (3.98±0.83 nmol/ml) compared to normal control (1.56±0.24), negative control (2.18±0.45), treatment group 25mg/200gBW (1.81±0.26), and treatment group 100mg/200gBW (2.58±0.38). Kruskal Wallis test showed significant differences among groups (p<0.001). Post hoc test revealed that SCFA in the treatment group 50 mg was significantly higher than the normal control and negative control group.Conclusion: Glucomannan from Porang (A.muelleri) at 50 mg/200gBW doses improves short-chain fatty acid in Wistar rats with high-fat and high-fructose diets.
Systematic Review: Effectiveness of Probiotic Giving as Additional Therapy in Atopic Dermatitis Patient Pangkahila, Evangelista Maria; Dewi, Made Yudha Asrithari; Harimawan, Agustinus I Wayan
Bali Medical and Wellness Journal Vol. 1 No. 2 (2024): Bali Medical and Wellness Journal
Publisher : PT BMW Journal Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71341/bmwj.v1i2.21

Abstract

Background: Atopic dermatitis (AD), also known as eczema, is a chronic inflammatory skin condition affecting the epidermis and dermis. It is triggered by a combination of environmental and genetic factors, leading to symptoms such as polymorphic rashes and intense itching. Objective: This systematic review aims to evaluate the effectiveness of oral probiotic supplementation as an adjunct therapy for individuals with atopic dermatitis. Methods: The literature was reviewed by searching two electronic databases, Google Scholar and PubMed, resulting in the inclusion of eight studies that collectively involved 347 AD patients. Results: The findings indicate that probiotic supplementation can significantly reduce the severity and incidence of atopic dermatitis. This effect is attributed to the inhibition of Th2 cell activity and a reduction in pro-inflammatory cytokines, including TNF-α and IgE, which are known contributors to the pathophysiology of AD. Conclusion: Probiotics present a promising alternative for the prevention and management of atopic dermatitis, potentially enhancing patient outcomes.
Co-Authors Dewi, Made Yudha Asrithari I Wayan Weta Josua Silitonga, Josua Pangkahila, Evangelista Maria Prabandari, A A S Mirah Prabandari, Anak Agung Sagung Mirah Sirait, Josephine Claudia Sukawati, Cokorda Istri Mas Dalem Wijanadi, M. Candra Wijanadi, M.Candra Yusnianingsih, Cuay