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All Journal Pharmaceutical Journal of Indonesia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang
Rani Wardani Hakim
Departemen Ilmu Farmasi Kedokteran, FK Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Potency of Ficus deltoidei Jack Bioactive as An Antidiabetic Treament: In Silico Study Wahyurini, Dyahati; Clarinta Putri, Rizky; Wardani Hakim, Rani; Wibowo, Heri
Pharmaceutical Journal of Indonesia Vol. 9 No. 2 (2024)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2024.009.02.2

Abstract

Background: Type 2 Diabetes Mellitus (T2DM) is a metabolic disease with an increasing prevalence. T2DM is related to chronic low-grade inflammation or meta-inflammation conditions. Nowadays, treatment begins to target the molecules or proteins involved in T2DM. Peroxisome Proliferator Activator Receptor gamma (PPAR-γ) is one of the proteins involved in T2DM. The Herbal is a potential solution to finding molecular medicine with bioactive compounds. Extract from Tabat Barito (Ficus deltoidea Jack) has proven as antidiabetic. It has many bioactive compounds and can be analyzed using software and molecular docking. This research aims to analyze the biological and pharmacological bioactive compounds of Ficus deltoidea Jack as an antidiabetic. Methods: The bioactive compounds of Ficus deltoidea Jack were determined from the literature. PASS (Prediction of Activity Spectra for Substances) was used to analyze the bioactive compounds. SwissADME was used to know the pharmacology properties Molecular docking was used to find the interaction between bioactive compounds and PPAR-γ. Results: Ficus deltoidea Jack has many bioactive compounds. Lupeol, Vitexin, and Isovitexin were chosen to advance analysis using PASS and SwissADME. All of them had antidiabetic activity. SwissADME was used to identify the pharmacology properties. The result, every bioactive compound has its specific characteristics. Molecular docking showed that Vitexin is the best, with ΔGibbs - 6.59kcal/mol and Inhibition constant (Ki) 14.77 µM. Conclusions: Ficus deltoidea Jack consists of many bioactive compounds. Vitexin and Isovitexin are potential as an antidiabetic. From the docking results, the strongest interaction is Vitexin.
The Potency of Ficus deltoidei Jack Bioactive as An Antidiabetic Treament: In Silico Study Wahyurini, Dyahati; Clarinta Putri, Rizky; Wardani Hakim, Rani; Wibowo, Heri
Pharmaceutical Journal of Indonesia Vol. 9 No. 2 (2024)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2024.009.02.2

Abstract

Background: Type 2 Diabetes Mellitus (T2DM) is a metabolic disease with an increasing prevalence. T2DM is related to chronic low-grade inflammation or meta-inflammation conditions. Nowadays, treatment begins to target the molecules or proteins involved in T2DM. Peroxisome Proliferator Activator Receptor gamma (PPAR-γ) is one of the proteins involved in T2DM. The Herbal is a potential solution to finding molecular medicine with bioactive compounds. Extract from Tabat Barito (Ficus deltoidea Jack) has proven as antidiabetic. It has many bioactive compounds and can be analyzed using software and molecular docking. This research aims to analyze the biological and pharmacological bioactive compounds of Ficus deltoidea Jack as an antidiabetic. Methods: The bioactive compounds of Ficus deltoidea Jack were determined from the literature. PASS (Prediction of Activity Spectra for Substances) was used to analyze the bioactive compounds. SwissADME was used to know the pharmacology properties Molecular docking was used to find the interaction between bioactive compounds and PPAR-γ. Results: Ficus deltoidea Jack has many bioactive compounds. Lupeol, Vitexin, and Isovitexin were chosen to advance analysis using PASS and SwissADME. All of them had antidiabetic activity. SwissADME was used to identify the pharmacology properties. The result, every bioactive compound has its specific characteristics. Molecular docking showed that Vitexin is the best, with ΔGibbs - 6.59kcal/mol and Inhibition constant (Ki) 14.77 µM. Conclusions: Ficus deltoidea Jack consists of many bioactive compounds. Vitexin and Isovitexin are potential as an antidiabetic. From the docking results, the strongest interaction is Vitexin.
Potensi Ekstrak Daun Ficus deltoidea Jack sebagai Anti Kanker Payudara Putri, Rizky Clarinta; Kusmardi, Kusmardi; Hakim, Rani Wardani
Majalah Kedokteran Indonesia Vol 74 No 1 (2024): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.74.1-2024-1232

Abstract

Female breast cancer is the most common diagnosed cancer worldwide in 2020, with an estimated 2.3 million new cases or 11.7% from total 18,1 million cases, followed by lung, colorectal, prostate, and stomach cancers. In 2040, the breast cancer cases are predicted will be increased into 3 million cases per year or grow 40% from 2020 data. It is also estimated the number of deaths due to breast cancer will be one million death per year in 2040. In Indonesia, the number of new breast cancers reached 68,858 cases (16.6%) of a total of 396,914 new cases of cancer in 2020. ​ The incidence and mortality rates of breast cancer are 44 and 15.3 per 100,000 population, respectively in Indonesia. The most common breast cancer treatments used currently are surgery, chemotherapy, and radiation. These three treatments involve a rather invasive approach and often causes side effects. Serious side effects can reduce a patient's quality of life, lead to non-compliance to chemotherapy, and lead to drug resistance.​ Some cancer patients use alternative therapy such as complementary medicine including herbal medicine to treat the cancer. Patients try to discover and utilize natural-derived anti-cancer drugs because it believes has fewer side effects and more affordable. One of Indonesia plant which is therapeutically beneficial is Ficus deltoidea. Ficus deltoidea leaves had been used in traditional medicine to treat diabetes, inflammation, diarrhoea, cancer and infections. F. deltoidea leaves contained flavonoids, saponins, tannins, steroids and terpenes which known for its anticancer effect.
Co-Authors Adisti Dwijayanti Clarinta Putri, Rizky Desak Gede B. Krisnamurti Erni H. Purwaningsih Heri Wibowo Kusmardi Kusmardi Putri, Rizky Clarinta Siti Farida Wahyurini, Dyahati