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Andayani, Sri Hastuti
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology

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Detection of ADAM33 Gene Variants Using Sanger Sequencing Suwardji, Kencono Viyati; Prayuni, Kinasih; Andayani, Sri Hastuti; Zulhamidah, Yenni; Sofwan, Achmad; Muflihah, Lilah; Yunus, Ronike; Junaefi, Junaefi; Judasah, Ijun
Majalah Sainstekes Vol. 10 No. 2 (2023): DESEMBER 2023
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/ms.v10i2.3962

Abstract

Asma adalah penyakit pernafasan yang ditandai oleh obstruksi saluran napas yang disebabkan oleh peradangan bronkus akut dan kronis. Gen disintegrin and metalloprotease 33 (ADAM33) merupakan gen terkait kerentanan terhadap asma dan diketahui memiliki lebih dari 300 polimorfisme. Studi meta-analisis melaporkan bahwa rs2280091, rs2787094, rs511898, rs2280089 dan rs2280090 memiliki asosiasi kuat dengan asma pada populasi Asia. Penelitian pendahuluan ini mengumpulkan 10 partisipan dengan penyakit asma dan 10 partisipan sehat untuk mengidentifikasi alel dan genotipe dari masing-masing polimorfisme menggunakan metode amplifikasi dan sekuensing Sanger. Hasil sekuensing menunjukkan bahwa 60% dari sampel yang diuji memiliki genotipe heterozigot untuk rs2280090 dan rs228091 baik pada sampel kasus maupun kontrol. Varian SNP rs2280096 menunjukkan bahwa frekuensi alel homozigot wildtype sebesar 60% baik pada sampel kasus maupun kontrol. Penelitian lanjutan perlu dilakukan untuk mengetahui apakah varian SNP tersebut memiliki aosisasi yang positif dengan penyakit asma.
Hubungan Status Gizi dengan Trombositopenia pada Anak Demam Berdarah Dengue di RSUD Kabupaten Bekasi Periode 2022-2023 Andayani, Sri Hastuti; Saputri, Titania Isro Mawar
Majalah Sainstekes Vol. 11 No. 2 (2024): DESEMBER 2024
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/ms.v11i2.4623

Abstract

Dengue hemorrhagic fever (DHF) is an infectious disease caused by the dengue virus and often occurs in tropical and subtropical climates. At the end of 2022, the most cases of DHF occurred on the island of Java and Bekasi City was ranked 3rd highest in Indonesia. Children have a higher risk factor for dengue infection. Several studies have shown a correlation between nutritional status and the incidence of DHF. Children with poor nutritional status are very susceptible to dengue virus infection due to low cellular immunity. Meanwhile, excessive nutritional status can affect the severity of DHF. One of the body's responses to DHF is thrombocytopenia which is related to the severity of DHF. DHF sufferers who experience a decrease in platelet levels to <100,000 cells/mm3 have a higher risk of developing grade III DHF and Dengue Shock Syndrome. This study used an analytical observational study with a cross-sectional approach conducted on pediatric DHF patients who were treated at the Bekasi Regency Hospital between January 2022-December 2023, and had complete medical records with data in the form of height, weight, diagnosis, and platelet levels from day 5 to day 7. There were 159 DHF patients and 59 children met the inclusion criteria, with more males than females, and the highest age was 17 years. Most of the study population had normal nutritional status. The highest degree of thrombocytopenia was in the moderate category. The results of the analysis of the relationship between nutritional status and thrombocytopenia levels obtained p> 0.05. This study concludes that there is no relationship between nutritional status and thrombocytopenia in children with DHF.
Co-Authors Judasah, Ijun Junaefi, Junaefi Kinasih Prayuni, Kinasih Muflihah, Lilah Saputri, Titania Isro Mawar Sofwan, Achmad Suwardji, Kencono Viyati Yenni Zulhamidah, Yenni Yunus, Ronike