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All Journal Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Cardiovascular and Cardiometabolic Journal (CCJ) Cermin Dunia Kedokteran
Suwanto, Denny
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Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Peran Hiperhomosisteinemia dalam Atherosklerosis Suwanto, Denny
Cermin Dunia Kedokteran Vol 44, No 9 (2017): Kardiologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (500.016 KB) | DOI: 10.55175/cdk.v44i9.728

Abstract

Hiperhomosistenemia adalah peningkatan kadar homosistein dalam darah di atas 15 μmol/L. Di dalam siklus daur homosistein terdapat beberapa enzim yang memerlukan vitamin B12 dan asam folat sebagai kofaktor. Hiperhomosisteinemia dapat disebabkan defek genetik bawaan seperti defisiensi enzim Metilentetrahidrofolat reduktase, Metionin sintase, dan Sistationin β sintase, atau oleh faktor didapat seperti gagal ginjal, kanker, psoriasis, diabetes, paparan asap rokok, alkohol, kopi, usia tua, menopause, serta obat-obatan. Berbagai studi menunjukkan hiperhomosisteinemia berhubungan dengan disfungsi endotel, aktivasi platelet, dan pembentukan thrombus yang dapat berujung pada aterosklerosis dan penyakit jantung koroner.Hyperhomocysteinemia is defined as plasma homocystein level above 15 μmol/L. Several enzymes involved in homocysteine metabolism require vitamin B and folic acid as cofactor. Hyperhomocysteinemia could be caused by inherited genetic disease such as deficiency of Methylentetrahydrofolate reductase and Methionin synthase, or by acquired factors such as kidney failure, cancer, psoriasis, diabetes, smoking, alcohol, caffeine, elderly, menopause, and drugs. Prospective studies has shown that hyperhomocysteinaemia is associated with endothelial injury and dysfunction, promoting platelet activation and thrombus formation, which could result in atherosclerosis and coronary artery disease.
Hiperkoagulabilitas pada Kehamilan dengan COVID-19 Marpaung, Richardo; Chandra, Evelyne; Suwanto, Denny
Cermin Dunia Kedokteran Vol 47, No 11 (2020): Infeksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (181.561 KB) | DOI: 10.55175/cdk.v47i11.1203

Abstract

Pandemi coronavirus disease 2019 (COVID-19) akibat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) menginfeksi lebih dari 7 juta jiwa di seluruh dunia dengan angka kematian lebih dari 400.000 jiwa. Koagulopati adalah salah satu sekuele paling berat dari COVID-19. Hipotesis terkait koagulopati ini melibatkan peningkatan signifikan respon inflamasi yang mengakibatkan trombo-inflamasi melalui mekanisme seperti badai sitokin, aktivasi komplemen, dan endotelitis. Dalam kehamilan, terdapat beberapa perubahan fisiologis yang memengaruhi koagulasi dan sistem fibrinolisis mengakibatkan kondisi hiperkoagulabilitas dan meningkatkan risiko kejadian tromboemboli. Tulisan ini memaparkan mekanisme hiperkoagulasi dalam COVID-19 dan kehamilan, manifestasi klinis, pemeriksaan laboratorium yang diperlukan, serta rekomendasi terapi.Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects more than 7 million people worldwide with a death toll of more than 400,000. Coagulopathy is one of the most severe sequelae of COVID-19. This coagulopathy-related hypothesis involves a significant increase in the inflammatory response that causes thrombo-inflammation , through several mechanism such as cytokine storms, complement activation, and endothelitis. In pregnancy, several physiological changes affect coagulation and fibrinolysis system which results in hypercoagulability and increases the risk of thromboembolic events. This article describes the mechanism of hypercoagulation in COVID-19 and pregnancy, clinical manifestations, necessary laboratory tests, and recommendations for therapy. 
Deteksi Dini untuk Mencegah Kematian Mendadak Akibat Aritmia Chandra, Evelyne; Suwanto, Denny
Cermin Dunia Kedokteran Vol 48, No 6 (2021): Kardiologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.435 KB) | DOI: 10.55175/cdk.v48i6.1429

Abstract

Penyakit kardiovaskuler merupakan penyebab 30% kematian di dunia ( 17 juta jiwa) dan 25% nya ( 4 juta jiwa) merupakan kematian jantung mendadak. Kematian jantung mendadak menggambarkan kematian alami yang tidak diduga dengan penyebab jantung dalam periode singkat, umumnya ≤1 jam sejak timbulnya gejala, pada seseorang yang tidak memiliki keluhan sebelumnya. Salah satu etiologi kematian jantung mendadak adalah aritmia jantung, yang umumnya dapat dicegah dengan implantable cardioverter defibrillator (ICD). Skrining dan asesmen risiko dapat mencegah kematian jantung mendadak pada berbagai populasi individu dengan atau tanpa penyakit jantung. Artikel ini membahas deteksi dini potensi kematian jantung mendadak untuk pencegahan primer.Cardiovascular diseases are responsible for 30% of global mortality rate annually, approximately 25% of which caused by sudden cardiac deaths. Sudden cardiac death is defined as unpredictable death, with cardiovascular cause as the presumed etiology, within 1 hour from the onset of symptoms in previously asymptomatic individual. Arrhythmia is one of the most prevalent cause, potentially preventable with implantable cardioverter defibrillator (ICD). Sudden cardiac death may be preventable by risk screening and severity assessment. This article sought to elaborate early detection as a part of primary prevention continuum in sudden cardiac death.
Precordial Catch Syndrome: Unveiling a Benign Yet Noteworthy Cause of Chest Pain in the Young Koswara, Jonathan; Chen, Jery; Yap, Irianto; Suwanto, Denny
Cardiovascular and Cardiometabolic Journal (CCJ) Vol. 5 No. 2 (2024): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v5i02.2024.103-110

Abstract

Highlights: 1. An insight on how precordial catch syndrome could be a potential research base for further research because of its rarity. - Background: This syndrome is rarely discussed in the differential diagnosis of chest pain, as it deserves wider recognition. Pediatricians report that PCS accounts for 80% to 90% of chest discomfort in the absence of trauma, primarily in adolescent and young adults. The classic pain history can help identify precordial catch syndrome, often eliminating the need for further testing or referrals. The diagnosis of precordial catch can be challenging due to various inconclusive workups. However, once diagnosed, this condition can be managed conservatively. Objective: This review sought to describe the distinctive features of the syndrome and its management strategy. Method: Descriptive review method was used in this study to provide a comprehensive overview for this study. Results: The pain is sudden in onset, is severe, and is localized above the cardiac apex (fifth intercostal space within the left midclavicular line). General testing is required to exclude various conditions., but several tests like ECG and chest x-ray can be done to rule out other causes of chest pain. Though in pediatric considerations, classic pain history can help identify PCS, often eliminating the need for further testing or referrals. Conclusion: This syndrome deserves wider recognition because it is rarely discussed in the differential diagnosis of precordial pain. Pediatricians report that precordial catch accounts for 80% to 90% of chest pain once any chest trauma is excluded
Assessing Cardiovascular Fitness on Military Recruitment Koswara, Jonathan; Yap, Irianto; Chandra, Ricky Alexander; Suwanto, Denny
Cardiovascular and Cardiometabolic Journal (CCJ) Vol. 6 No. 1 (2025): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v6i1.2025.9-25

Abstract

Background: Military recruitment demands optimal health, with cardiovascular fitness being a key criterion. To assess candidates, military organizations worldwide employ standardized screening protocols. Initial evaluations typically involve history-taking and physical examinations based on guidelines from the American Heart Association and the European Society of Cardiology. Method: Electrocardiography (ECG) serves as an accessible and cost-effective screening tool. Abnormal findings in these initial tests necessitate further assessments to determine a candidate’s fitness for service. Depending on the severity and context, additional tests such as echocardiography or, in rare cases, coronary angiography may be conducted. However, cost constraints influence the extent of these evaluations in some countries. Aim: This article examines cardiovascular screening in military recruitment and the variations in assessment practices across different nations. -- Highlights: 1. This article addresses the importance of standardized yet flexible cardiovascular assessments essential for military screenings. While standardized protocols are essential for consistency, military screenings should also adapt to environmental factors, individual differences, and evolving fitness benchmarks to ensure accurate evaluations.
Efektivitas Ekstrak Kulit Kayu Manis (Cinnamomum Burmannii) Terhadap Penyembuhan dan Ekspresi Tnf-Α Pada Kulit Luka Bakar Sudirman, Andi Resvianty Asmiralda; Million, Hendy; Suwanto, Denny
JURNAL PENELITIAN PENDIDIKAN, PSIKOLOGI DAN KESEHATAN (J-P3K) Vol 6, No 2 (2025): J-P3K
Publisher : Yayasan Mata Pena Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51849/j-p3k.v6i2.768

Abstract

Penelitian ini bertujuan untuk mengevaluasi efektivitas ekstrak kulit kayu manis (Cinnamomum burmannii) dalam mempercepat penyembuhan luka bakar dan mengatur ekspresi TNF-α pada tikus putih galur Wistar jantan. Tikus dibagi menjadi beberapa kelompok perlakuan, termasuk kelompok kontrol negatif, kelompok kontrol positif, dan kelompok perlakuan dengan berbagai konsentrasi ekstrak kulit kayu manis. Luka bakar diinduksi pada tikus, dan ekstrak dioleskan secara topikal selama periode tertentu. Hasil penelitian menunjukkan bahwa penerapan ekstrak kulit kayu manis secara signifikan mempercepat penyembuhan luka bakar dibandingkan dengan kelompok kontrol negatif. Selain itu, ekstrak mengurangi ekspresi TNF-α, yang berperan dalam proses inflamasi. Kesimpulannya, ekstrak kulit kayu manis menunjukkan potensi sebagai agen terapeutik alami untuk penyembuhan luka bakar melalui sifat anti-inflamasi dan stimulasi regenerasi jaringan.
Co-Authors Chandra, Evelyne Chandra, Ricky Alexander Chen, Jery Koswara, Jonathan Marpaung, Richardo Million, Hendy Sudirman, Andi Resvianty Asmiralda Yap, Irianto