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All Journal Cermin Dunia Kedokteran Indonesian Journal of Case Reports
Marpaung, Richardo
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Health Professions Medicine & Pharmacology Neuroscience Public Health

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Hiperkoagulabilitas pada Kehamilan dengan COVID-19 Marpaung, Richardo; Chandra, Evelyne; Suwanto, Denny
Cermin Dunia Kedokteran Vol 47, No 11 (2020): Infeksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (181.561 KB) | DOI: 10.55175/cdk.v47i11.1203

Abstract

Pandemi coronavirus disease 2019 (COVID-19) akibat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) menginfeksi lebih dari 7 juta jiwa di seluruh dunia dengan angka kematian lebih dari 400.000 jiwa. Koagulopati adalah salah satu sekuele paling berat dari COVID-19. Hipotesis terkait koagulopati ini melibatkan peningkatan signifikan respon inflamasi yang mengakibatkan trombo-inflamasi melalui mekanisme seperti badai sitokin, aktivasi komplemen, dan endotelitis. Dalam kehamilan, terdapat beberapa perubahan fisiologis yang memengaruhi koagulasi dan sistem fibrinolisis mengakibatkan kondisi hiperkoagulabilitas dan meningkatkan risiko kejadian tromboemboli. Tulisan ini memaparkan mekanisme hiperkoagulasi dalam COVID-19 dan kehamilan, manifestasi klinis, pemeriksaan laboratorium yang diperlukan, serta rekomendasi terapi.Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects more than 7 million people worldwide with a death toll of more than 400,000. Coagulopathy is one of the most severe sequelae of COVID-19. This coagulopathy-related hypothesis involves a significant increase in the inflammatory response that causes thrombo-inflammation , through several mechanism such as cytokine storms, complement activation, and endothelitis. In pregnancy, several physiological changes affect coagulation and fibrinolysis system which results in hypercoagulability and increases the risk of thromboembolic events. This article describes the mechanism of hypercoagulation in COVID-19 and pregnancy, clinical manifestations, necessary laboratory tests, and recommendations for therapy. 
Hope After Cancer: Pregnancy Outcomes Following Fertility-Sparing Surgery – A Case Report Marpaung, Richardo; Armanza, Ferry; Yuseran, Hariadi; Waluyo, Setyo Teguh; Salan, Yosef Dwi Cahyadi
Indonesian Journal of Case Reports Vol. 3 No. 1 (2025): June 2025
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ijcr.v3i1.260

Abstract

Pregnancy after diagnosis of ovarian cancer is a rare event. Ovarian Cancer is associated with difficulty in achieving pregnancy. Little is known about the mechanism of this condition due to limited literature and studies. In this paper, the authors report a rare case of successful pregnancy in a patient with ovarian cancer. Patient initially diagnosed with cystadenocarcinoma mucinous of the ovary, two years prior to pregnancy, and later diagnosed with suspected ovarian cancer in the third trimester. The patient was then treated with optimal debulking surgery and cesarean section at 35 weeks of pregnancy. The patient delivered a healthy baby girl. Debulking surgery was carried out, and the patient was scheduled for chemotherapy. The findings from this case conclude that patients with ovarian cancer who receive conservative surgical treatment could have successful pregnancy outcomes. The quality of the patient’s life should be a priority, and follow-up for further treatment is essential.
Co-Authors Chandra, Evelyne Ferry Armanza, Ferry Salan, Yosef Dwi Cahyadi Suwanto, Denny Waluyo, Setyo Teguh Yuseran, Hariadi