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All Journal Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Jurnal Entomologi Indonesia
Prasasti, Gita Dwi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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KEJADIAN SKABIES BERDASARKAN PEMERIKSAAN DERMOSKOP, MIKROSKOP DAN SKORING DI PONDOK PESANTREN AL ITTIFAQIAH Miftahurrizqiyah, Miftahurrizqiyah; Prasasti, Gita Dwi; Anwar, Chairil; Handayani, Dwi; Dalilah, Dalilah; Aryani, Indah Astri; Ghifari, Ahmad
Syifa'Medika Vol 10, No 2 (2020): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v10i2.1972

Abstract

ABSTRAK Skabies merupakan penyakit kulit akibat arthopod, spesies Sarcoptes scabiei, dengan gejala klinis berupa rasa gatal dan lesi polimorfik berupa eritem, papul, nodul, atau pustula. Penyakit tular ini berhubungan dengan rendahnya higienitas perorangan dan kebiasaan bertukar barang. Faktor lain yang berperan yaitu rendahnya sosial ekonomi dan sanitasi lingkungan. Skabies memiliki prevalensi tinggi di negara tropis dan berkembang, salah satunya Indonesia. Pesantren merupakan tempat potensial bagi transmisi penyakit kulit, terutama skabies, karena memiliki lingkungan tempat tinggal yang padat. Penelitian ini bersifat deskriptif dengan desain potong lintang dan dilakukan pada bulan Oktober hingga Desember 2018. Data diambil dari semua santri yang menderita penyakit skabies. Prevalensi skabies sebesar 112 (4,4%) dengan jumlah subjek terbanyak berjenis kelamin perempuan 78 (69,6%). Lesi skabies positif secara dermokopis terdapat pada 53 subjek (47%), sedangkan positif secara mikroskopis sebanyak 19 subjek (17%). Skabies yang masih terdiagnosis mencerminkan rendahnya tingkat sanitasi dan higienitas para santri dalam mencegah penyakit kulit menular seperti skabies.   ABSTRACT Scabies is a skin disease due to arthopod, a species of Sarcoptes scabiei, with clinical symptoms of itching and polymorphic lesions in the form of erythema, papules, nodules, or pustules. This contagious disease is associated with low personal hygiene and habits of exchanging goods. Other factors that play a role are low socioeconomic and environmental sanitation. Scabies has a high prevalence in tropical and developing countries, one of which is Indonesia. Pesantren is a potential place for the transmission of skin diseases, especially scabies, because it has a dense residential environment. This research is a descriptive cross-sectional design and was conducted in October to December 2018. Data were taken from all students suffering scabies. The prevalence of scabies was 112 (4.4%) with the highest number of female subjects was 78 (69.6%). Dermocopically positive scabies lesions were found in 53 subjects (47%), while microscopically positive were 19 subjects (17%). Scabies that are still diagnosed reflect the low level of sanitation and hygiene of students in preventing infectious skin diseases such as scabies. Keywords : skin disease, scabies, pesantren.
Investigasi resistensi Anopheles sp. terhadap insektisida piretroid dan kemungkinan terjadinya mutasi gen voltage gated sodium channel (VGSC) Haryanto, Didid; Dalilah, Dalilah; Anwar, Chairil; Prasasti, Gita Dwi; Handayani, Dwi; Ghiffari, Ahmad
Jurnal Entomologi Indonesia Vol 15 No 3 (2018): November
Publisher : Perhimpunan Entomologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5994/jei.15.3.134

Abstract

Extensive and continuous use of pyrethroid insecticides to prevent the transmission of malaria can lead to mutations in the voltage gate sodium channel gene (VGSC) in mosquito vectors. This gene mutation associated with insensitivity pyrethroid is known as knockdown resistance (kdr). The emergence of resistance to pyrethroid insecticides in vector mosquitoes can be a barrier to the successful termination of malaria transmission. Therefore, detection of mutation is necessary to prevent the resistency from build up. The aim of the study was to determine the resistance status of pyrethroid insecticides and identify mutations in the VGSC gene codon 1014 marker for resistance to Anopheles sp. which is a malaria vector in South Sumatra Province. Samples were taken from three districts in South Sumatra: Muara Enim, OKU, and Lahat. The susceptibility enzymatic test of pyrethroid insecticide (permethrin 0.75%) was preliminarily carried out according to WHO 2016 standard on Anopheles vagus Dí¶nitz species. Identification of VGSC gene mutation was performed on all An. vagus that were previously tested for susceptibility and on An. barbirostris van der Wulp species using seminested-PCR and followed by sequencing. The result showed that samples from Muara Enim regency had resistance, whereas in Lahat and OKU regencies were still susceptible to permethrin. From the sequence analysis it is shown that there are no change in DNA kdr bases in VGSC gene insecticide target sites from all regencies. In conclusion, based on molecular studies, there were no pyrethroid insecticide resistance in South Sumatra Province.
Investigasi resistensi Anopheles sp. terhadap insektisida piretroid dan kemungkinan terjadinya mutasi gen voltage gated sodium channel (VGSC) Haryanto, Didid; Dalilah, Dalilah; Anwar, Chairil; Prasasti, Gita Dwi; Handayani, Dwi; Ghiffari, Ahmad
Jurnal Entomologi Indonesia Vol 15 No 3 (2018): November
Publisher : Perhimpunan Entomologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5994/jei.15.3.134

Abstract

Extensive and continuous use of pyrethroid insecticides to prevent the transmission of malaria can lead to mutations in the voltage gate sodium channel gene (VGSC) in mosquito vectors. This gene mutation associated with insensitivity pyrethroid is known as knockdown resistance (kdr). The emergence of resistance to pyrethroid insecticides in vector mosquitoes can be a barrier to the successful termination of malaria transmission. Therefore, detection of mutation is necessary to prevent the resistency from build up. The aim of the study was to determine the resistance status of pyrethroid insecticides and identify mutations in the VGSC gene codon 1014 marker for resistance to Anopheles sp. which is a malaria vector in South Sumatra Province. Samples were taken from three districts in South Sumatra: Muara Enim, OKU, and Lahat. The susceptibility enzymatic test of pyrethroid insecticide (permethrin 0.75%) was preliminarily carried out according to WHO 2016 standard on Anopheles vagus Dí¶nitz species. Identification of VGSC gene mutation was performed on all An. vagus that were previously tested for susceptibility and on An. barbirostris van der Wulp species using seminested-PCR and followed by sequencing. The result showed that samples from Muara Enim regency had resistance, whereas in Lahat and OKU regencies were still susceptible to permethrin. From the sequence analysis it is shown that there are no change in DNA kdr bases in VGSC gene insecticide target sites from all regencies. In conclusion, based on molecular studies, there were no pyrethroid insecticide resistance in South Sumatra Province.
Co-Authors Ahmad Ghiffari Aryani, Indah Astri Chairil Anwar Dalilah Dalilah Dwi Handayani Ghifari, Ahmad Haryanto, Didid Miftahurrizqiyah, Miftahurrizqiyah