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The Effect of Family History of Seizures as A Risk Factor for The Inci-dence of Recurrent Febrile Seizures and Types of Febrile Seizures in Children at Waled Cirebon Hospital Permana, Irman; Meyrisa, Nissa Suci; Brajadenta, Gara Samara
Eduvest - Journal of Universal Studies Vol. 5 No. 4 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i4.25530

Abstract

Febrile seizures (FS) are common in children aged 6 months to 5 years, with familial seizure history implicated as a risk factor. However, regional data gaps persist, particularly in Indonesia. The research aims to analyze the influence of family seizure history on FS recurrence and types at Waled Hospital, Cirebon. A retrospective cohort study of 66 pediatric FS patients (2022) used chi-square tests and Prevalence Ratio (PR) analysis. Children with familial seizure history had significantly higher recurrent FS rates (62.1%, PR = 2.297, *p* = 0.009) but no association with seizure type (65.5% simple FS, PR = 0.797, *p* = 0.639). Familial history is a critical predictor of FS recurrence but not seizure complexity, underscoring the need for targeted monitoring and genetic-environmental interaction studies in high-risk children. This study contributes localized insights to global FS research and informs clinical prevention strategies.
KORELASI ANTARA NILAI HBA1C DAN KADAR KOLESTEROL LDL PADA PENDERITA DIABETES MELITUS TIPE 2 DI RSUD WALED KABUPATEN CIREBON Ahyaeni, Fenni Nurian; Luthfi, Muhammad; Brajadenta, Gara Samara; Noviani, Isti; Loebis, Irwan Meidi; Emman, Irene Max
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 11 No 1 (2025): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/tumed.v11i1.10298

Abstract

Latar Belakang: Diabetes Melitus (DM) Tipe 2 merupakan penyakit gangguan metabolik yang ditandai dengan kenaikan gula darah. Diagnosis DM dapat dilakukan dengan pemeriksaan kadar glukosa darah secara enzimatik dengan HbA1c. Low density lipoprotein (LDL) merupakan jenis kolesterol berbahaya dan paling banyak terdapat di dalam darah. Peningkatan kadar kolesterol LDL menjadi penyebab utama terjadinya gangguan yang menimbulkan penyakit jantuk koroner (PJK). Pasien DM dengan PJK dikarenakan adanya peningkatan kadar kolesterol LDL. Tujuan: Penelitian ini dilakukan untuk mengetahui korelasi antara nilai HbA1C dan kadar kolesterol LDL pada penderita DM tipe 2. Metode: Penelitian ini menggunakan metode cross sectional dengan sampel 53 responden. Peneliti menggunakan data sekunder dengan analisa univariat dan bivariat. Hasil: Peneliti mendapatkan nilai HbA1C rata-rata penderita DM tipe 2 adalah 20,93% dan hasil nilai LDL tertinggi adalah 255,90 mg/dl. Hasil perhitungan analisa didapatkan HbA1C >6,5 bermakna dengan nilai p = 0,000 <0,050 yang berarti terdapat hubungan yang bermakna antara HbA1C dan kadar kolesterol LDL dengan penderita DM tipe 2. Simpulan: Hasil analisis dalam penelitian tersebut membuktikan adanya korelasi positif antara nilai HbA1C dan kolesterol LDL pada penderita Diabetes Melitus tipe 2. Kata kunci: Low density lipoprotein (LDL), kolesterol, diabetes melitus ABSTRACT Background: Diabetes Mellitus (DM) Type 2 is a metabolic disorder disease characterized by an increase in blood sugar. The diagnosis of DM can be made by examining blood glucose levels enzymatically with HbA1c. Low density lipoprotein (LDL) is a dangerous type of cholesterol and is the most abundant in the blood. Increased levels of LDL cholesterol are the main cause of disorders that cause coronary heart disease (CHD). DM patients with CHD due to an increase in LDL cholesterol levels. Aim: This study was conducted to determine the correlation between HbA1C values ​​and LDL cholesterol levels in patients with type 2 diabetes. Methods: This study used a cross sectional method with a sample of 53 respondents. Researchers used secondary data with univariate and bivariate analysis. Results: Researchers found the average HbA1C value for patients with type 2 diabetes was 20.93% and the highest LDL value was 255.90 mg/dl. In the calculation results, it was found that HbA1C > 6.5 was significant with p value = 0.000<0.050, which means that there was a significant relationship between HbA1C and LDL cholesterol levels with type 2 DM patients. LDL cholesterol in patients with type 2 diabetes mellitus. Conclusion: From the results of the analysis in this study, it was proven that there was a positive relationship between HbA1C and LDL cholesterol levels with type 2 DM patients
Association of rs9939609 FTO Gene Polymorphism as a Risk Factor of Obesity in Adults Pratamawati, Tiar Masykuroh; Sadji, Angel Angriani Elma Budai; Brajadenta, Gara Samara; Nauphar, Donny
GHMJ (Global Health Management Journal) Vol. 7 No. 1 (2024)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-71967

Abstract

Background: The cause of obesity is an imbalance between the number of calories taken and the amount burned. Obesity is a complex disease. The FTO rs9939609 gene polymorphism is one of the genetic factors that contribute to obesity in addition to environmental factors. Numerous researches have suggested a connection between the prevalence of obesity and the FTO rs9939609 gene polymorphism Aims: The purpose of this study is to ascertain how the FTO rs9939609 gene polymorphism relates to the prevalence of adult obesity. Methods: At the Biomolecular and Genetics Laboratory of the UGJ Faculty of Medicine, an analytical observational study using a case-control design was carried out with 84 participants, 42 subjects in case group, and 42 subjects in control groups. Data were collected utilizing DNA from blood collection, PCR-RFLP for genotyping, and 2.5% electrophoretic gel for visualization. Chi-square was used for data analysis. Results: Findings showed that there is no link between the FTO rs9939609 polymorphism and the prevalence of obesity (p>0.05, OR=0.710). Conclusion: In the Indonesian population, the FTO rs9939609 gene polymorphism is not associated with an increased risk of obesity.
ANALISIS TINGGI BADAN BERDASARKAN TINGGI POTENSI GENETIK PADA MAHASISWA FK UGJ Permana, Irman; Sofyan, Pinka Kirana; Brajadenta, Gara Samara; Surjono, Deni Wirhana; Syakhruddin, Imam
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 10 No 3 (2024): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/tumed.v10i3.9625

Abstract

Latar Belakang: Tinggi badan berkaitan erat dengan hasil interaksi faktor genetik dan status gizi. Tinggi badan diwariskan atau diturunkan secara terus menerus dari generasi ke generasi. Dikutip dari Ikatan Dokter Anak Indonesia, salah satu cara yang dapat memprediksi tinggi badan anak saat dewasa adalah melalui perhitungan rumus Tinggi Potensi Genetik yang dapat digunakan untuk memperkirakan tinggi akhir anak menggunakan data tinggi badan kedua orang tua. Tujuan: Menganalisis tinggi badan berdasarkan Tinggi Potensi Genetik. Metode: Penelitian observasional analitik dengan desain penelitian cross sectional. Data penelitian diambil dari 53 orang Mahasiswa FK UGJ angkatan tahun 2020-2022 yang dilakukan menggunakan metode stratified random sampling. Data dianalisis menggunakan analisis univariat. Hasil: Hasil studi ini didapatkan sebagian besar memiliki kesesuaian Tinggi Potensi Genetik. Responden yang memiliki kesesuaian dengan Tinggi Potensi Genetik berjumlah 46 orang (86,8%). Sementara itu, responden yang tinggi badannya tidak sesuai dengan Tinggi Potensi Genetik berjumlah 7 orang (13,2%). Kesimpulan: Terdapat kesesuaian antara tinggi badan dan Tinggi Potensi Genetik Kata Kunci : Tinggi badan, Genetik, Tinggi Potensi Genetik ABSTRACT Background: Height is closely related to the interaction of genetic factors and nutritional status. Height is inherited or passed down continuously from generation to generation. Reporting from the Indonesian Pediatrician Association, one way to predict a child's height as an adult is through calculating the Genetic Potential Height formula which can be used to estimate a child's final height using data on the height of both parents. Methods: Analytical observational study with a cross-sectional research design. Research data was taken from 53 UGJ Faculty of Medicine students from the 2020- 2022 classes using the stratified random sampling method. The data were analyzed using univariate analysis Results: The results this study showed that most of them had a high suitability of genetic potential. Respondents who are compatible with High Genetic Potential are 46 people (86.8%). Meanwhile, the number of respondents whose height did not match the genetic potential height was 7 people (13.2%). Conclusion: There is a concordance between height and genetic potential height