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All Journal Pharmacology and Clinical Pharmacy Research
Rosdianto, Aziiz M.
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Medicine & Pharmacology

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Prospect Study of Anti-inflammatory Activity by Identification of Muntingia calabura Leaf Infusion Permana, Shenny S.S; Yusuf, Muchamad R.A; Putri, Aufa A.D; Sukmayani, Jasmine Y.; Sudrajat, Ratu Z.A.P; Khairinisa, Miski A.; Wahyuni, Indah S.; Rohmawaty, Enny; Bashari, Muhammad H.; Lesmana, Ronny; Rosdianto, Aziiz M.
Pharmacology and Clinical Pharmacy Research Vol 9, No 1 (2024)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v9i1.49774

Abstract

Many diseases occur due to inflammation that is not handled properly. One of the feature of inflammation is swelling or edema. Inflammation can be handled with traditional medicine, such as Muntingia calabura L. (M. calabura L.) Pharmacologically, this plant extract is reported to have antipyretic, analgesic, anti-inflammatory, antioxidant, and antibacterial. Metabolite compound contained in M. calabura L. has the potential as an anti-inflammatory agent. The objective of this study is to ascertain the secondary metabolites contained in M. calabura L. leaves infusion. This experimental research method includes the simplicia making and infusion of M. calabura L. leaves by cold infusion and phytochemical screening. This study also showed that the infusion of M. calabura L. leaves contained flavonoids, alkaloids, and triterpenoids. Overall, the findings indicate potential as an anti-inflammatory agent that requires further investigation, specifically in preclinical testing. 
The Effect of Ashitaba (Angelica keiskei (Miq.) Koidz.)) Sap on the Total Cholesterol Levels of Cisplatin-Induced Wistar Rats Wahyuni, Ika; Aulifa, Diah L.; Rosdianto, Aziiz M.; Levita, Jutti
Pharmacology and Clinical Pharmacy Research Vol 8, No 3 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i3.51827

Abstract

Cisplatin is a platinum-based anticancer drug that, in long-term use, causes nephrotoxicity due to oxidative stress and increases total cholesterol and triglycerides in animal models. Angelica keiskei (Miq.) Koidz., (A. keiskei) or Japanese celery ashitaba, has been reported for its antioxidant and nephroprotective activity. This study aims to determine the activity of A. keiskei sap on total cholesterol levels of cisplatin-induced Wistar rats. The sap of A. keiskeiwas freeze-dried until a yield of 3.62% w/v was obtained. The fat content in A. keiskei sap powder was obtained at 7.36%. A total of 60 g of A. keiskei sap powder was macerated with 96% ethanol solvent (1:10) for 5 x 24 h until the ethanol extract of A. keiskei sap (ASEE) of 82.08% w/w was obtained. The pharmacology activity was conducted on male Wistar rats, which were divided into 5 groups, namely normal (treated with CMC Na 0.3%), negative (nephrotoxicity induced with cisplatin 5 mg/kg BW), positive (nephrotoxicity induced with cisplatin 5 mg/kg BW and treated with quercetin 20 mg/kg BW), and two test groups which were nephrotoxicity induced with cisplatin 5 mg/kg body weight and treated with ASEE 1000 mg/kg BW, and ASEE 1500 mg/ kg BW. It was found that neither dose of ASEE altered the total cholesterol levels in cisplatin-induced male Wistar rats and could maintain the cholesterol levels in the normal range.
Co-Authors Aulifa, Diah L. Bashari, Muhammad H. Enny Rohmawaty Ika WAHYUNI Jutti Levita Khairinisa, Miski A. Permana, Shenny S.S Putri, Aufa A.D Ronny Lesmana Sudrajat, Ratu Z.A.P Sukmayani, Jasmine Y. Wahyuni, Indah S. Yusuf, Muchamad R.A