Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal Pharmacology and Clinical Pharmacy Research Indonesian Journal of Biological Pharmacy
Aulifa, Diah L.
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Studi In Silico Senyawa dalam Daun Sirih (Piper betle L.) sebagai Inhibitor Enzim Asetilkolinesterase (AChE) pada Penyakit Alzheimer Az-Zahra, Farhah; Afidika, Janifa; Diamantha, Sagung D. A.; Rahmani, Almeira E.; Fatimah, Syifa; Aulifa, Diah L.; Elaine, Angela A.; Sitinjak, Bernap D. P.
Indonesian Journal of Biological Pharmacy Vol 2, No 2 (2022): IJBP (Agustus)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v2i2.40462

Abstract

Alzheimer merupakan penyakit neurodegeneratif yang disebabkan oleh penurunan sintesis asetilkolin akibat pemecahan asetilkolin menjadi kolin dan asetat oleh enzim asetilkolinesterase (AChE). Senyawa dengan aktivitas inhibitor AChE diketahui merupakan kandidat obat yang menjanjikan untuk mengobati penyakit ini. Pada penelitian ini, dilakukan studi in-silico terhadap senyawa dalam Daun Sirih (Piper betle L.) sebagai anti-alzheimer menggunakan metode penambatan molekuler dan prediksi Lipinski’s dan PreADMET. Pengujian dilakukan menggunakan perangkat lunak meliputi, ChemDraw, BIOVIA Discovery Studio 2020, dan AutoDock Tools-1.5.6. serta situs SwissADME dan PreADMET. Dari hasil analisis, diketahui senyawa Piperin merupakan kandidat obat yang paling baik dengan nilai energi ikatan dan konstanta inhibisi berturut-turut sebesar -9.97 kkal/mol dan 0.049 um, dengan ikatan hidrogen yang terjadi pada residu asam amino PHE 295.
The Effect of Ashitaba (Angelica keiskei (Miq.) Koidz.)) Sap on the Total Cholesterol Levels of Cisplatin-Induced Wistar Rats Wahyuni, Ika; Aulifa, Diah L.; Rosdianto, Aziiz M.; Levita, Jutti
Pharmacology and Clinical Pharmacy Research Vol 8, No 3 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i3.51827

Abstract

Cisplatin is a platinum-based anticancer drug that, in long-term use, causes nephrotoxicity due to oxidative stress and increases total cholesterol and triglycerides in animal models. Angelica keiskei (Miq.) Koidz., (A. keiskei) or Japanese celery ashitaba, has been reported for its antioxidant and nephroprotective activity. This study aims to determine the activity of A. keiskei sap on total cholesterol levels of cisplatin-induced Wistar rats. The sap of A. keiskeiwas freeze-dried until a yield of 3.62% w/v was obtained. The fat content in A. keiskei sap powder was obtained at 7.36%. A total of 60 g of A. keiskei sap powder was macerated with 96% ethanol solvent (1:10) for 5 x 24 h until the ethanol extract of A. keiskei sap (ASEE) of 82.08% w/w was obtained. The pharmacology activity was conducted on male Wistar rats, which were divided into 5 groups, namely normal (treated with CMC Na 0.3%), negative (nephrotoxicity induced with cisplatin 5 mg/kg BW), positive (nephrotoxicity induced with cisplatin 5 mg/kg BW and treated with quercetin 20 mg/kg BW), and two test groups which were nephrotoxicity induced with cisplatin 5 mg/kg body weight and treated with ASEE 1000 mg/kg BW, and ASEE 1500 mg/ kg BW. It was found that neither dose of ASEE altered the total cholesterol levels in cisplatin-induced male Wistar rats and could maintain the cholesterol levels in the normal range.
Co-Authors Afidika, Janifa Az-Zahra, Farhah Diamantha, Sagung D. A. Elaine, Angela A. Fatimah, Syifa Ika WAHYUNI Jutti Levita Rahmani, Almeira E. Rosdianto, Aziiz M. Sitinjak, Bernap D. P.