Article Per Year (5 Year)
p-Index From 2020 - 2025
1.503
P-Index
This Author published in this journals
All Journal Jurnal Sain Veteriner Majalah Kedokteran Bandung Althea Medical Journal Jurnal Farmasi Klinik Indonesia Global Medical and Health Communication The Indonesian Biomedical Journal Pharmacology and Clinical Pharmacy Research The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Enny Rohmawaty
Departemen Ilmu Kedokteran Dasar, Fakultas Kedokteran, Universitas Padjadjaran, Bandung
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

Published : 22 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 22 Documents
Search

 1   2   3 
Description of Treatment Outcomes among Pulmonary Tuberculosis Patients in Bandung City in 2014 Hamdan, Syafinaz; Rohmawaty, Enny; Lestari, Bony Wiem
Althea Medical Journal Vol 4, No 3 (2017)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (687.584 KB)

Abstract

Background: Pulmonary Tuberculosis (pulmonary TB) is an infectious lung disease which is still a major health problem in the world. In Indonesia, pulmonary TB treatment outcomes are monitored and assessed in Directly Observed Treatment Short Course (DOTS) as an indicator of national TB control program performance. Therefore, the study was conducted to determine the treatment outcomes among pulmonary TB patients in Bandung City.Methods: This cross-sectional study was conducted using secondary data. The sample sizes were 1,598 pulmonary TB patients taken by total sampling with data collected from TB Registration database of Bandung city at Infectious Disease Control Unit, Bandung City Health Office (Unit Kontrol Penyakit Menular, Dinas Kesehatan Kota Bandung) from January to December 2014. The treatment outcomes were classified as successful (cured and treatment completed) and unsuccessful (failed, defaulted, and died).Results: Out of the 1,598 TB patients, most of the respondents were male, aged 15–24 years old and from Public Health Center (Pusat Kesehatan Masyarakat, Puskesmas) and hospital. A total of 1,008 treatments (63.08%) were cured, 292 (18.27%) were completed, 47 (2.94%) were failed, 211 (13.21%) were defaulted, and 40 (2.50%) were died. Total of transferred outpatients were 134 and  not considered as treatment outcome.Conclusions: From the results, it can be concluded that 81.35% and 18.65% were considered as successful and unsuccessful outcome respectively, thus, did not achieve WHO target of 85%. Therefore, DOTS program implemented in Bandung City should be reviewed to improve success rate of the treatment outcome.
Differences of Clinical and Laboratory Presentation in Positive and Negative Acid Fast Bacilli Pulmonary Tuberculosis Patients Muslimah, Amila Hanifan; Soeroto, ArtoYuwono; Rohmawaty, Enny
Althea Medical Journal Vol 3, No 2 (2016)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (138.195 KB)

Abstract

Background: Based on bacteria status, tuberculosis is classified into positive and negative acid fast bacilli. This study was conducted to determine the differences of clinical and laboratory presentation in positive and negative acid fast bacilli pulmonary tuberculosis patients.Methods: This study was an observational analytic study with a cross-sectional approach which used 338 medical records of patients with pulmonary tuberculosis at Direct Observational Treatment Short-course(DOTS) clinic Dr. Hasan Sadikin General Hospital from January to December 2012. Data collected were clinical and laboratory presentation for analytic study. Data about comorbid were collected for descriptive data.Results: From 338 medical records, 223 were medical records of patients with pulmonary tuberculosis and 105 medical records of patients with comorbid. Twenty (18.01%) comorbid were Human Immunodeficiency Virus (HIV). Acid fast bacilli negative was more (121, 51.9%) than acid fast bacilli positive (112, 48.1%). Differences of laboratory presentation were found in hemoglobin count (p=0.037), red blood cell count (p=0.022), and erythrocyte sedimentation rate (p=0.006) and not found in white blood cell count (p=0.073), thrombocyte count (p= 0.766), serum glutamic oxaloacetic transaminase (p=0.169), and serum glutamicpyruvic transaminase (p=0.309). Difference of clinical manifestation was not found in fever (p=1), cough (p=0.608), night sweats (p=0.09), dyspnea (p=0.210), and weight loss (p=0.269).Conclusions: Differences between acid fast bacilli positive and negative are found in hemoglobin, red blood cell, and erythrocyte sedimentation rate laboratory examination. The highest comorbid of pulmonary tuberculosis patient is HIV. [AMJ.2016;3(2):286–5]DOI: 10.15850/amj.v3n2.786
Propolis as an Anti-allergy Based on Decrease in Total Eosinophil Count in Rat Models Nambiar, Rashmika; Rohmawaty, Enny; Lismayanti, Leni
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (493.687 KB)

Abstract

Background: Propolis is a natural herb derived from plant resins by bees. Propolis contains flavonoids that act as anti-allergy. The composition of flavonoids in propolis varies according to each region like Brazilian, Chinese, Malaysian and Indonesian propolis due to differences in medicinal plants in that area. The aim of this study is to determine the effect of propolis as an anti-allergy and to determine which is the most effective among propolis of Brazilian, Malaysian and Indonesian origin.Methods: An experimental study was performed on 28 Wistar male rats divided into four groups, Brazilian, Malaysian, Indonesian propolis and a negative control group. The used parameter was decreased in total eosinophil count in ovalbumin induced allergy in rats. Propolis or aquadest as control were given orally 0.25ml once daily.Results: All three groups of propolis showed statistically significant results (p<0.05), in decreasing eosinophil count. However, Malaysian and Brazilian propolis showed much more significant effects compared to that of Indonesian propolis. This could be due to the difference in composition and concentration of flavonoids in Indonesian propolis compared to the Brazilian and Malaysian propolis.Conclusion: Propolis has a significant effect as an anti-allergy. Malaysian and Brazilian propolis are more effective as an anti-allergy compare to Indonesian propolis. Propolis can thus be used as an alternative treatment for allergy. [AMJ.2015;2(1):208–12]
Bixa Orellana L Leaf infusion as an Anti-inflammatory Agent in Carrageenan-induced Wistar Rats Yusuf, Sabrina Munggarani; Rohmawaty, Enny; Nusjirwan, Rama
Althea Medical Journal Vol 1, No 2 (2014)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (712.412 KB)

Abstract

Background: One of the characteristics of inflammation is swelling or edema. Inflammation can be treated with traditional medicine, such as Bixa orellana L. Bixa orellana L leaf  contains flavonoid and tannin responsible for its anti-inflammatory effect. This study was conducted to analyse the ability of Bixa orellana L leaf infusion (BOLI) to suppress paw edema in carrageenan-induced Wistar rats.Methods: This study was conducted in the Animal Laboratory of Department of Pharmacology and Therapy Faculty of Medicine Universitas Padjadjaran in October 2012. Bixa orellana L leaves were procured from Lembang, Bandung, and were botanically identified at the Herbarium of Universitas Padjadjaran, Jatinangor. Thirty female Wistar rats were randomly divided into five groups. Group 1 was given 5 mL aquades as a control, three groups received BOLI with 0,09 g; 0,18 g; and 0,36 g dosage respectively; and group 5 was given 0,9 mg diclofenac. At 1 hour after treatment, all rats were induced by carrageenan injection subcutaneously. Paw edema changes were quantified at 0, 1, 2, 3, 4, 5, 6, and 24 hour afterwards. Data were analysed using Kruskal-Wallis and Mann-Whitney testResults: Based on paw edema inhibition percentage, 0.18 g of BOLI was shown most effective (16.97%) compared to 0.09 g (10.96%) and 0.36 g (7.50%). Interestingly, no significant differences of anti-inflammatory effect were observed between groups that were treated with 0,18 g of BOLI and diclofenac (p > 0,005).Conclusions: The BOLI can suppress inflammation comparable to diclofenac. The effective dosage is 0.18 g/200 g BW/day.[AMJ.2014;1(1):7–12]Keywords: anti-inflammatory, Bixa orellana L leaf, paw edema Infusa Daun Kesumba (Bixa Orellana L) sebagai Anti Inflamasi pada Tikus Wistar yang Diinduksi Carrageenan Latar Belakang: Salah satu ciri khas dari peradangan atau inflamasi adalah adanya pembengkakan atau edema. Peradangan dapat diobati  dengan obat tradisional, seperti Kesumba (Bixa orellana). Daun Kesumba diketahui mengandung flavonoid dan tanin yang berfungsi sebagai anti-inflamasi. Penelitian ini dilakukan untuk menganalisis kemampuan infusa daun kesumba (Bixa orellana) (BOLI) dalam mengurangi edema tungkai pada kaki tikus Wistar yang diinduksi Carrageenan.Metode: Penelitian ini dilakukan di Laboratorium Hewan Departemen Farmakologi dan Terapi di Rumah Sakit Umum Dr. Hasan Sadikin Bandung pada bulan Oktober 2012. Daun Kesumba (Bixa Orellana) diperoleh dari Lembang, Bandung, dan diidentifikasi botani di Herbarium Universitas Padjadjaran, Jatinangor. Tiga puluh tikus Wistar betina secara acak dibagi menjadi lima kelompok. Kelompok kontrol negatif diberi 5 mL aquades, tiga kelompok menerima BOLI dengan 0,09 g; 0,18 g; dan masing-masing 0,36 g dosis; sedangkan kelompok kontrol positif diberikan 0,9 mg diklofenak. Pada 1 jam setelah pengobatan, semua tikus diinduksi oleh subkutan injeksi karagenan. Perubahan edema (Paw) yang diukur pada 0, 1, 2, 3, 4, 5, 6, dan 24 jam sesudahnya. Data dianalisis denganmenggunakanKruskal-Wallis dan uji Mann-Whitney.Hasil: Berdasarkan persentase pengurangan edema tungkai, kelompok 0,18g BOLI terlihat paling efektif (16,9%) dibandingkan dengan 0,09 g (10,9%) dan 0,36 g (7,5%). Tidak ada perbedaan yang signifikan dari efek anti-inflamasi yang diamati antara kelompok-kelompok yang diobati dengan 0,18 g BOLI dan diklofenak (p> 0.005).Simpulan: Infusa Daun Kesumba (Bixaorellana) dapat menekan peradangan sama baiknya dengan diklofenak. Dosis efektif adalah 0,18 g /200 g BB / hari.Kata kunci: anti-inflamasi, daun kesumba (Bixaorellana), edema tungkai DOI: 10.15850/amj.v1n2.347
Hypertension Treatment and Control in Older Adult at Tanjung Sari Primary Health Care Fauziah, Rahmi; Rohmawaty, Enny; Dwipa, Lazuardhi
Althea Medical Journal Vol 3, No 1 (2016)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Hypertension is considered as a major health problem in Indonesia, especially in older adult population because of its prevalence increases by age. Treatment strategy and control management of hypertension in Public Health Center (Pusat Kesehatan Masyarakat, Puskesmas) as primary health care should be enhanced to overcome this issue. This study aimed to describe the pattern of antihypertensive agent in older adults.Methods: This was a descriptive study with total sampling method for data collection. Data were collected from medical record of older adult patients with diagnosis of hypertension at Puskesmas Tanjung Sari from January to December 2013. The variables observed were gender, number of visits, the degree of hypertension, types of antihypertensive drug, combinations of antihypertensive drugs, and blood pressure control.Results: The number of older adults with hypertension was 180 people. Some of which, 120 women (66.7%) participated, 152 (84.4%) had hypertension stage 2, 100 (55.6%) had just one visit, and 80 (44.4%) had more than one visit. Among 80 participants with more than one visit, 8 had achieved target blood pressure. There were 166 participants (92.2%) who received single antihypertensive agent (captopril was given the most), and 14 participants (7.8%) who received the combination of two antihypertensive agent (combination of captopril and HCT (hydrochlorothiazide)) were given the most).Conclusions: More than 75% of older adult with hypertension have stage 2 hypertension and are treated by single antihypertensive agent. Ninety percent of the patient have uncontrolled blood pressure. [AMJ.2016;3(1):17–21] DOI: 10.15850/amj.v3n1.699
POTENSI QUERCETIN-3-O-GLUCOSIDE (Q3G) DAN QUERCETIN-4-O-GLUCOSIDE (Q4G) DARI DAUN MIMBA (AZADIRACHTA INDICA A.JUSS) TERHADAP AMBILAN GLUKOSA Rohmawaty, Enny; Yunivita, Vycke
Majalah Kedokteran Bandung Vol 48, No 4 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (201.819 KB) | DOI: 10.15395/mkb.v48n4.913

Abstract

Daun mimba (Azadirachta indica A.Juss) yang berasal dari BPT Situbondo memiliki zat aktif quercetin-3-O-glucoside (Q3G) dan quercetin-4-O-glucoside (Q4G) yang diketahui mempunyai kemampuan menghambat ambilan glukosa melalui membran usus halus. Penelitian ini bertujuan mengetahui potensi isolat dan dosis optimal Q3G dan Q4G dari daun mimba terhadap ambilan glukosa melalui membran usus halus tikus putih (Rattus rattus novergicus). Zat aktif Q3G dan Q4G dari daun mimba diisolasi secara kualitatif dengan metode Kromatografi Lapis Tipis (KLT). Penelitian ini dilakukan di beberapa tempat, antara lain: Laboratorium Kimia Organik FMIPA Unpad, Laboratorium Biokimia FK Unpad, serta Laboratorium Farmakologi dan Terapi FK Unpad. Penelitian dilakukan pada bulan Juni?Desember 2011. Penelitian laboratorium eksperimental dengan rancangan acak lengkap dilakukan terhadap 30 ekor tikus putih yang dibagi dalam 5 kelompok. Kelompok kontrol diberi larutan glukosa 3,0 x 10-3M, dan 4 kelompok perlakuan diberi larutan glukosa berturut-turut Q3G 1 mg/kgBB, Q3G 2 mg/kgBB, Q4G 1 mg/kgBB, dan Q4G 2 mg/kgBB menggunakan alat perfusi in situ. Kadar ambilan glukosa diamati setiap 15 menit selama 1 jam. Data dianalisis menggunakan one-way ANOVA dan tes Duncan dengan taraf kepercayaan 95% (?=0,05). Hasil penelitian menunjukkan sebanyak 53,1 mg isolat Q3G dan 14,4 mg Q4G diperoleh dari daun mimba BPT Situbondo sebanyak 1 kg. Isolat Q3G 1 mg/kgBB, Q4G 1 mg/kgBB, dan Q4G 2 mg/kgBB berbeda secara bermakna dalam menghambat ambilan glukosa melalui membran usus halus tikus dibanding dengan kontrol pada menit ke-45 (p<0,05). Simpulan, isolat Q3G dan Q4G dari daun mimba dapat menghambat ambilan glukosa melalui membran usus halus tikus putih. [MKB. 2016;48(4):222?7]Kata kunci: Ambilan glukosa, daun mimba, Q3G, Q4GPotential Influence of Quercetin-3-O-Glucoside (Q3g) and Quercetin-4-O-Glucoside (Q4g) from Mimba Leaves (Azadirachta indica a.juss) on Glucose UptakeAbstractMimba leaves (Azadirachta indica A.Juss), which was obtained from Brigade Proteksi Tanaman (BPT) Situbundo in this study, contain active compounds of quercetin-3-O-glucoside (Q3G) and quercetin-4?-O-glucoside (Q4G). These compounds were isolated using the Thin Layer Chromatography (TLC). From previous studies, Q3G and Q4G are known to inhibit the glucose uptake from intestinal membrane. This study was conducted to understand the potential influence of Q3G and Q4G isolated from mimba leaves in inhibiting glucose uptake in rat?s intestinal membrane (Rattus rattus norvegicus). This experimental study employed 30 male rats that met the inclusion criteria that were divided into 5 groups (n=6). Group I was the control group and only received glucose solution 3,0 x 10-3 M. Group II, III, IV, and V received glucose solution with Q3G 1 mg/kgBW, Q3G 2 mg/kgBW, Q4G 1 mg/kgBW, and Q4G 1 2 mg/kgBW, respectively. The inhibitory potentials of Q3G and Q4G on glucose uptake was measured every 15 minutes for one hour using in situ perfusion equipment. Data were analyzed using One-way ANOVA and Duncan test with a significance level 95% (?=0.05). From 1 kg fresh mimba leaves, 60.1 mg Q3G and 14.4 mg Q4G were isolated. This study showed that Q3G 1 mg/kgBW, Q4G 1 mg/kgBW, and Q4G 2 mg/kgBW significantly inhibited glucose uptake from rat intestinal membrane compared to negative control at 45th minute (p<0.05). Therefore, Q3G and Q4G isolated from mimba leaves have significantly inhibit glucose uptake from rat?s intestinal membrane (Rattus rattus norvegicus). [MKB. 2016;48(4):222?7]Key words: Glucose uptake, mimba leaves, Q3G, Q4G
Peningkatan Kadar Hemoglobin dengan Pemberian Ekstrak Daun Salam (Syzygium Polyanthum (Wight) Walp) pada Tikus Model Anemia Defisiensi Besi Adyani, Kartika; Anwar, Anita D.; Rohmawaty, Enny
Majalah Kedokteran Bandung Vol 50, No 3 (2018)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (26.792 KB) | DOI: 10.15395/mkb.v50n3.1390

Abstract

Defisiensi zat besi merupakan penyebab utama anemia di negara berkembang. Kadar hemoglobin darah digunakan sebagai penanda anemia defisiensi besi. Indonesia kaya bahan makanan tinggi zat besi namun belum diketahui kemanfaatannya seperti daun salam (Syzygium polyanthum (Wight) Walp). Tujuan penelitian ialah mengetahui peningkatan kadar hemoglobin pada tikus model anemia defisiensi besi sesudah pemberian ekstrak daun salam. Penelitian eksperimental laboratorium dengan rancang acak lengkap dilakukan di Laboratorium Farmakologi dan Terapi Fakultas Kedokteran Unpad periode 4 Mei–19 Juni 2018. Sebanyak 20 ekor tikus Wistar betina berumur 7 minggu diinduksi menggunakan alumunium sulfat 67,5 mg/kg BB secara intramuskuler selama 7 hari, dan dibagi menjadi 5 kelompok perlakuan, yaitu K1 (tanpa perlakuan) K2 (tablet tambah darah 5,4 mg), P1 (ekstrak daun salam 2,2 mg), P2 (ekstrak daun salam 4,4 mg), P3 (ekstrak daun salam 6,6 mg). Kadar hemoglobin diukur menggunakan auto hematology analyzer sysmex. Uji LSD menunjukkan rerata kadar hemoglobin setelah perlakuan pada kelompok perlakuan berbeda signifikan dibanding dengan kelompok kontrol negatif (p<0,05) dan tidak berbeda signifikan dibanding dengan kelompok kontrol positif (p>0,05). Analisis uji median menunjukkan peningkatan kadar hemoglobin berbeda signifikan pada K2, P1, P2, dan P3 (p<0,05). Disimpulkan, ekstrak daun salam meningkatkan kadar hemoglobin pada tikus model anemia defisiensi besi. Increasing Hemoglobin Level Using Bay Leaf (Syzygium Polyanthum (Wight) Walp) Extraction in Rats Models with Iron-Deficiency AnemiaIron deficiency is a major cause of anemia in developing countries. Blood hemoglobin level is used as a marker of iron-deficiency anemia. Iron-rich foods that are not widely known can easily be found in Indonesia, including bay leaf. The aim of this study was to determine the increase in hemoglobin level after the administration of bay leaf extract in rat models with iron-deficiency anemia. This experimental study used completely randomized sampling technique and was performed at Pharmacology and Therapy Laboratory, Faculty of Medicine, Universitas Padjadjaran, from 4 May to 19 June 2018. Twenty 7-week-old female Wistar rats were induced intramuscularly by 67,5 mg/kg BW alumunum sulfate for 7 days and were divided into 5 groups: K1 (without treatment), K2 (5.4 mg of ferrous sulphate), P1 (2.2 mg bayleaf extract), P2 (4.4 mg  bay leaf extract), P3 (6.6 mg bay leaf extract). Hemoglobin levels were measured using Auto Hematology Analyzer Sysmex. Results froom LSD test showed that the average hemoglobin levels after treatment in treatment groups were significantly different from that of the negative control group (p<0.05) and there was no  significant difference when compared to the positive control group (p>0.05). The median analysis test showed that there were significant differences in the increase of hemoglobin levels among K2, P1, P2, and P3 (p<0.05). It is concluded that bay leaf simplicia increases the hemoglobin level in rat model with iron-deficiency anemia.
Propolis as an Anti-allergy Based on Decrease in Total Eosinophil Count in Rat Models Rashmika Nambiar; Enny Rohmawaty; Leni Lismayanti
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (493.687 KB)

Abstract

Background: Propolis is a natural herb derived from plant resins by bees. Propolis contains flavonoids that act as anti-allergy. The composition of flavonoids in propolis varies according to each region like Brazilian, Chinese, Malaysian and Indonesian propolis due to differences in medicinal plants in that area. The aim of this study is to determine the effect of propolis as an anti-allergy and to determine which is the most effective among propolis of Brazilian, Malaysian and Indonesian origin.Methods: An experimental study was performed on 28 Wistar male rats divided into four groups, Brazilian, Malaysian, Indonesian propolis and a negative control group. The used parameter was decreased in total eosinophil count in ovalbumin induced allergy in rats. Propolis or aquadest as control were given orally 0.25ml once daily.Results: All three groups of propolis showed statistically significant results (p<0.05), in decreasing eosinophil count. However, Malaysian and Brazilian propolis showed much more significant effects compared to that of Indonesian propolis. This could be due to the difference in composition and concentration of flavonoids in Indonesian propolis compared to the Brazilian and Malaysian propolis.Conclusion: Propolis has a significant effect as an anti-allergy. Malaysian and Brazilian propolis are more effective as an anti-allergy compare to Indonesian propolis. Propolis can thus be used as an alternative treatment for allergy. [AMJ.2015;2(1):208–12]
Bixa Orellana L Leaf infusion as an Anti-inflammatory Agent in Carrageenan-induced Wistar Rats Sabrina Munggarani Yusuf; Enny Rohmawaty; Rama Nusjirwan
Althea Medical Journal Vol 1, No 2 (2014)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (712.412 KB)

Abstract

Background: One of the characteristics of inflammation is swelling or edema. Inflammation can be treated with traditional medicine, such as Bixa orellana L. Bixa orellana L leaf  contains flavonoid and tannin responsible for its anti-inflammatory effect. This study was conducted to analyse the ability of Bixa orellana L leaf infusion (BOLI) to suppress paw edema in carrageenan-induced Wistar rats.Methods: This study was conducted in the Animal Laboratory of Department of Pharmacology and Therapy Faculty of Medicine Universitas Padjadjaran in October 2012. Bixa orellana L leaves were procured from Lembang, Bandung, and were botanically identified at the Herbarium of Universitas Padjadjaran, Jatinangor. Thirty female Wistar rats were randomly divided into five groups. Group 1 was given 5 mL aquades as a control, three groups received BOLI with 0,09 g; 0,18 g; and 0,36 g dosage respectively; and group 5 was given 0,9 mg diclofenac. At 1 hour after treatment, all rats were induced by carrageenan injection subcutaneously. Paw edema changes were quantified at 0, 1, 2, 3, 4, 5, 6, and 24 hour afterwards. Data were analysed using Kruskal-Wallis and Mann-Whitney testResults: Based on paw edema inhibition percentage, 0.18 g of BOLI was shown most effective (16.97%) compared to 0.09 g (10.96%) and 0.36 g (7.50%). Interestingly, no significant differences of anti-inflammatory effect were observed between groups that were treated with 0,18 g of BOLI and diclofenac (p > 0,005).Conclusions: The BOLI can suppress inflammation comparable to diclofenac. The effective dosage is 0.18 g/200 g BW/day.[AMJ.2014;1(1):7–12]Keywords: anti-inflammatory, Bixa orellana L leaf, paw edema Infusa Daun Kesumba (Bixa Orellana L) sebagai Anti Inflamasi pada Tikus Wistar yang Diinduksi Carrageenan Latar Belakang: Salah satu ciri khas dari peradangan atau inflamasi adalah adanya pembengkakan atau edema. Peradangan dapat diobati  dengan obat tradisional, seperti Kesumba (Bixa orellana). Daun Kesumba diketahui mengandung flavonoid dan tanin yang berfungsi sebagai anti-inflamasi. Penelitian ini dilakukan untuk menganalisis kemampuan infusa daun kesumba (Bixa orellana) (BOLI) dalam mengurangi edema tungkai pada kaki tikus Wistar yang diinduksi Carrageenan.Metode: Penelitian ini dilakukan di Laboratorium Hewan Departemen Farmakologi dan Terapi di Rumah Sakit Umum Dr. Hasan Sadikin Bandung pada bulan Oktober 2012. Daun Kesumba (Bixa Orellana) diperoleh dari Lembang, Bandung, dan diidentifikasi botani di Herbarium Universitas Padjadjaran, Jatinangor. Tiga puluh tikus Wistar betina secara acak dibagi menjadi lima kelompok. Kelompok kontrol negatif diberi 5 mL aquades, tiga kelompok menerima BOLI dengan 0,09 g; 0,18 g; dan masing-masing 0,36 g dosis; sedangkan kelompok kontrol positif diberikan 0,9 mg diklofenak. Pada 1 jam setelah pengobatan, semua tikus diinduksi oleh subkutan injeksi karagenan. Perubahan edema (Paw) yang diukur pada 0, 1, 2, 3, 4, 5, 6, dan 24 jam sesudahnya. Data dianalisis denganmenggunakanKruskal-Wallis dan uji Mann-Whitney.Hasil: Berdasarkan persentase pengurangan edema tungkai, kelompok 0,18g BOLI terlihat paling efektif (16,9%) dibandingkan dengan 0,09 g (10,9%) dan 0,36 g (7,5%). Tidak ada perbedaan yang signifikan dari efek anti-inflamasi yang diamati antara kelompok-kelompok yang diobati dengan 0,18 g BOLI dan diklofenak (p> 0.005).Simpulan: Infusa Daun Kesumba (Bixaorellana) dapat menekan peradangan sama baiknya dengan diklofenak. Dosis efektif adalah 0,18 g /200 g BB / hari.Kata kunci: anti-inflamasi, daun kesumba (Bixaorellana), edema tungkai DOI: 10.15850/amj.v1n2.347
Knowledge, Attitude, and Behavior Regarding Homosexualilty among New Students in Universitas Padjadjaran Ade Nea; Rudi Wisaksana; Enny Rohmawaty
Althea Medical Journal Vol 5, No 4 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (370.688 KB) | DOI: 10.15850/amj.v5n4.1519

Abstract

Background: Homosexualilty has raised a controversy in the society, which commonly has a negative attitude towards homosexual. It is important to develop knowledge and attitude about homosexuality in new students as agents of change. This study aimed to identify the knowledge, attitude, and behavior of new undergraduate students in Universitas Padjadjaran about homosexual.Methods: This was a descriptive quantitative cross-sectional study using primary data obtained from questionnaires, distributed not randomly to new undergraduate students of 2016/2017 academic year in Universitas Padjadjaran (n=122) from October to November 2016. Questions asked were demographic data, knowledge and attitude towards homosexualilty, and homosexual behavior.Results: Respondents had a good knowledge (18%; n=22), average (66.4%; n=81) and low knowledge (15.6%; n=19) about homosexuality and the majority (55.7%; n=68) of respondents had a negative attitude towards homosexuality. A heterosexual behavior had been showed in 92.6% (n=113) respondents, and 7.4% (n=9) had a heterosexual dominant behavior.Conclusions: In our new undergraduate students’ community, the majority has average knowledge, however, with a negative attitude towards about homosexuality. The role of new students as agents of change is to educate the community to prevent potential health issues. The developing of knowledge, attitude, and behavior towards homosexual through a holistic education from health workers should be promoted. 
Co-Authors Achadiyani Ade Nea Ade Zuhrotun Adyani, Kartika Amila Hanifan Muslimah Anita D. Anwar Arto Yuwono Soeroto Astrid Feinisa Khairani Bashari, Muhammad H. Bashari, Muhammad Hasan Bony Wiem Lestari Bony Wiem Lestari, Bony Wiem Cynthia Noviyanti Devani, Mochamad Dewi, Sumartini Elsa P. Pratiwi Hamdan, Syafinaz Hardisiswo Soedjana Hesti Lina Wiraswati Iceu D. Kulsum Iceu Dimas Kulsum Jose Arimathea Khairinisa, Miski A. Lazuardhi Dwipa Leni Lismayanti Muhammad Begawan Bestari Muslimah, Amila Hanifan Nenny Agustanti Nur Atik Pangastuti, Miranti Permana, Shenny S.S Putri Halleyana Adrikni Rahman Putri, Aufa A.D Rahmi Fauziah Rahmi Fauziah, Rahmi Rama Nusjirwan Ramadhan, Putra Rashmika Nambiar Rashmika Nambiar, Rashmika Resti Santika Rini Hendriani Ronny Lesmana Rosdianto, Aziiz M. Rosdianto, Aziiz Mardanarian Rudi Wisaksana Sabrina Munggarani Yusuf Sabrina Munggarani Yusuf Saragih, Winda A. M. Savira Ekawardhani Sharon Noor Alya Sudrajat, Ratu Z.A.P Sukmayani, Jasmine Y. Sumardi, Aklila Qurrota Aini Syafinaz Hamdan Usman, Hermin A. Wahyuni, Indah S. Widad Aghnia Shalannandia Wijaya, Muhammad Palar Yoga Windhu Wardhana Yunivita, Vycke Yusuf, Muchamad R.A