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All Journal MDJ (Makassar Dental Journal) Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal)
Helena Jelita
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Dentistry Health Professions Medicine & Pharmacology

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Journal : MDJ (Makassar Dental Journal)

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Effectiveness of neem leaf extract (Azadirachta Indica A. Juss) against C.albicans on acrylic resin plates: Efektivitas ekstrak daun mimba (Azadirachta Indica A. Juss) terhadap C.albicans pada plat resin akrilik Helena Jelita; Sintha Nugrahini
Makassar Dental Journal Vol. 10 No. 1 (2021): Volume 10 Issue 1 April 2021
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v10i1.381

Abstract

Denture stomatitis, the main cause of which is Candida species, especially C.albicans, is an inflammation of the oral mucosa of removable denture users which can be associated with reactions to oral biofilms, denture materials, or trauma due to dentur-es. The use of chemicals as denture cleaners can increase the roughness of the base surface, so that herbal ingredients can be used as alternative denture cleaners. Neem leaves (Azadirachta Indica A. Juss) contain active ingredients that can kill bacte-ria and fungi, in the form of azadirachtin, salannin, meliantriol, and nimbin as well as tannin compounds, saponins, flavonoids and terpenoids which have antifungal mechanisms. This research was aimed to determine the effectiveness of neem leaf extract against C.albicans on acrylic resin denture plates. The sample of this posttest only control group design study consisted of 24 acrylic resin plates contaminated with C.albicans suspension. After that, the samples were immersed in 4 groups of disinfectant solutions, namely 5% EDM, 10% EDM, aquadest and Polident® for 30 minutes. The number of C.albicans colonies was tested by Kruskal Wallis and U Mann Whitney. The results showed that the mean C.albicans colony in the EDM 5%, 10% EDM, aquadest and Polident® groups were 21.50 CFU/mL, 15.50 CFU/mL, 27.50 CFU/mL, 6.50 CFU/mL respectively. Neem leaf extract significantly decreased the number of C.albicans colonies (p <0.005). It was concluded that the higher the EDM con-centration, the greater its ability to reduce the number of C.albicans colonies.
Co-Authors Astri Widiarti ASTRID TERESA Dian Mutiasari Erald Giovanny Hasiholan Simatupang Indria Augustina Natalia Sri Martani Netanya Gloria Nugrahini, Sintha Reza Kurnia Rahmawati Sanggap Indra Sitompul Syamsul Arifin