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All Journal Current Research on Biosciences and Biotechnology Nusantara Hasana Journal
Elfahmi
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Economics, Econometrics & Finance Education Materials Science & Nanotechnology Medicine & Pharmacology Nursing

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Development of an efficient and eco-friendly method for mitragynine enrichment Febriandi, Rizal; Rizaldy, Defri; Ishak, Sumail Sidik Ode; Elfahmi
Current Research on Biosciences and Biotechnology Vol. 7 No. 1 (2025)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/crbb.2025.7.1/362C71GB

Abstract

Kratom (Mitragyna speciosa) is rich in mitragynine, a bioactive alkaloid with antinociceptive, sedative, and antimicrobial activities, and potential benefits for alleviating alcohol dependence. This study aimed to develop a safe, environmentally friendly, cost-effective, and efficient method for enriching mitragynine using macroporous resins. Extraction was performed via maceration with 70% ethanol, and the performance of macroporous resins (PAD610 and PAD900) was evaluated in terms of adsorption and desorption characteristics using UPLC-MS/MS. The results showed that the adsorption and desorption processes followed a pseudo-second-order kinetic model, indicating that mitragynine adsorption is influenced by coexisting compounds in the extract. Isothermal adsorption analysis demonstrated good agreement with the Freundlich model, with R2 values of 0.9973 for PAD610 and 0.9905 for PAD900, suggesting multilayer adsorption on heterogeneous surfaces. Under optimized conditions, macroporous resin enrichment effectively increased mitragynine content, yielding 753 mg for PAD900 and 303 mg/g for PAD610. Additionally, a flow rate of 3 BV/hour was identified as optimal for large-scale applications. This study demonstrates that macroporous resins provide an efficient and scalable approach for mitragynine enrichment from M. speciosa extract, offering a promising method for the preparation of high-purity bioactive compounds.
PROFIL PNEUMONIA PADA PASIEN RAWAT INAP PARU RSUP M. DJAMIL Nilas Warlem; Abdullah, Dessy; Elfahmi; Soufni Morawati; Yanti Fitri Yasa; Jenny Tri yuspitasari; Rifaldo Yudistira
Nusantara Hasana Journal Vol. 3 No. 11 (2024): Nusantara Hasana Journal, April 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v3i11.1113

Abstract

Pneumonia is an inflammation that affects the lung parenchyma, which can be caused by microorganisms, aspiration of gastric juices, foreign bodies and hypersensitivity reactions. The crude fatality rate (CFR) of pneumonia was quite high, namely 7.6%. In 2013, pneumonia increased was found 5878 cases with a prevalence of 3.1% in West Sumatra. Objective of this research to determine the profile of pneumonia in lung patients RSUP M. Djamil Padang. The type and design of this study is a retrospective observational descriptive study. This study using 54 samples with simple random sampling technique. Univariate data analysis and data processing using the computerized SPSS program version 25.0. Most of the patients with pneumonia were 56-65 years old, namely 17 people (32.7%), the most gender was male, namely 27 people (51.9%), the most occupation was IRT, namely 21 people (40.4 %), the most comorbidities were absent, namely 16 people (30.8%), the highest levels of leukocytes were abnormal, namely 45 people (86.5%), the most used drugs were the kinolone group, namely 34 people (65.4 %), the most germs were chlamydia pneumonia, namely 29 people (55.8%), the most length of treatment was daily, namely 34 people (65.4%). Most age is 56-65 years old, most sex is male, most occupation is IRT, most comorbidities are absent, most leukocyte levels are abnormal, most drugs used are kinolones, most bacteria are Chlamydia pneumonia , the most length of treatment is daily.
Co-Authors Abdullah, Dessy Defri Rizaldy Febriandi, Rizal Ishak, Sumail Sidik Ode Jenny Tri yuspitasari Nilas Warlem Rifaldo Yudistira Soufni Morawati Yanti Fitri Yasa