<![CDATA[Latar belakang: Pestisida golongan organofosfat bersifat menghambat aktivitas enzim kolinesterase di dalam tubuh. Pekerja yang bertugas untuk melakukan penyemprotan pestisida memiliki risiko yang sangat tinggi terkena dampak negatif dari pajanan pestisida. Penelitian ini bertujuan untuk mengetahui faktor risiko penurunan kadar enzim kolinesterase tenaga sprayer di perkebunan kelapa sawit PT. X Kabupaten Musi Banyuasin.Metode: Penelitian ini menggunakan pendekatan kuantitatif dengan menggunakan rancangan penelitian cross sectional. Sampel pada penelitian ini yaitu sebanyak 113 orang. Pengukuran data dilakukan dengan menggunakan kuesioner dan pemeriksaan kadar enzim kolinesterase.Hasil: Hasil penelitian menunjukkan bahwa terdapat 3,5% tenaga sprayer yang mengalami penurunan kadar kolinesterase. Dari hasil analisis bivariat diketahui adanya hubungan antara penggunaan Alat Pelindung Diri (APD) (p-value = 0,046) dengan penurunan kadar enzim kolinesterase tenaga sprayer. Melalui analisis multivariate diketahui bahwa penggunaan APD merupakan faktor yang paling berhubungan dengan penurunan kadar enzim kolinesterase setelah dikontrol dengan variabel arah angin.Simpulan: Dapat disimpulkan bahwa penggunaan APD berhubungan erat dengan penurunan kadar enzim kolinesterase sehingga disarankan melengkapi APD yang digunakan saat bekerja dan perlu adanya edukasi yang diberikan kepada tenaga sprayer mengenai faktor keracunan pestisida. ABSTRACT Title: The Decrease of Cholinesterase Enzyme Level in Pesticide Sprayers in Palm Oil PlantationBackground: Organophosphate pesticides are inhibiting the activity of the cholinesterase enzyme in human body. Workers in charge of pesticide spraying have a very high risk of being negatively affected by pesticide exposure. This study aims to determine the risk factors for cholinesterase enzyme decline in pesticide sprayers of PT. X Musi Banyuasin Regency.Method: This study used a quantitative approach using a cross sectional study design. The sample in this study were 113 pesticide sprayers. Data measurements were performed using a questionnaire and examination of cholinesterase enzyme levels. Result The results showed that there was 3.5% pesticide sprayers that has decreased cholinesterase enzyme level. From the results of bivariate analysis it is determined that there is a correlation between the use of Personal Protective Equipment (PPE) (p-value = 0.046) and declining cholinesterase enzyme level in pesticide sprayers. Through multivariate analysis it is determined that the use of PPE is the most related factor in the decrease of cholinesterase enzyme after being controlled with wind direction variables..Conclusion: It can be concluded that the use of PPE is closely related to the decrease cholinesterase enzyme in pesticide sprayers so it is recommended for the company to provide PPE at work and to educate the sprayers about factors in pesticide poisoning.  ]]>
