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All Journal Jurnal Fitofarmaka Indonesia Jurnal Farmasi
Widyastuti, Lita
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Aktivitas Gastroprotektif Kombinasi Madu Dan Virgin Coconut Oil (Cocos nucifera) Pada Model Tikus Tukak Lambung Widyastuti, Lita; Herowati, Rina; Ariawan, M Wahyu; Purwidyaningrum, Ika
Jurnal Fitofarmaka Indonesia Vol 11, No 1 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i1.1064

Abstract

Gastric ulcers are damage that occurs to the mucosal tissue, submucosa and the muscle layer of the stomach, this condition is caused by hypersecretion of stomach acid. The substance content of VCO has a gastroprotective effect because it includes flavonoid compounds, phenols, catalase, ascorbic acid, and vitamin E, while VCO includes octanoic acid, δ-Octalactone, dodecanoic acid, δ-Decalactone, acetic acid. The aim of this research is to understand the gastroprotective activity resulting from giving a combination of honey and VCO to aspirin-induced rats. Honey and VCO in single administration include one dose, namely 14 ml/kgBW honey and 10 ml/kgBW VCO, while in combination treatment three doses are given, namely 10.5; 7; 3.5 ml/kgBB honey and 7.5; 5; 2.5 ml/kgBB VCO. Then in the combined treatment, 5 variations of doses were given, namely honey and VCO (7:7.5); (7:5); (7:2.5); (10.5:5); (3.5:5) ml/kgBB. TNFα levels before being induced by aspirin, after being induced by aspirin, after honey and VCO therapy, and macroscopic observations on a single treatment showed that administration of honey and VCO at doses of 10.5 ml/kgBW and 5 ml/kgBW showed a gastroprotective effect compared to other doses. Then, in histopathological testing, doses with gastroprotective effects can restore mucosal cell cohesion which has been previously damaged due to erosion. The combination of honey and VCO showed gastroprotective results at a dose of 10.5 ml/kgBB honey and 5 ml/kgBB VCO.
Pengaruh Pemberian Sediaan Creambath Ekstrak Daun Kembang Sepatu (Hibiscus Rosa-Sinensis) pada Pertumbuhan Rambut Kelinci (New Zealand) Widyastuti, Lita; Ningsih, Dwi; Aisiyah, Siti
Jurnal Farmasi (Journal of Pharmacy) Vol. 8 No. 1 (2019): Jurnal Farmasi (Journal of Pharmacy), October 2019
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Hibiscus rosa-sinensis is contains flavonoids, saponins and polyphenols that play a role in accelerating the growth of hair.This research aims to know the influence of the variation of concentration of ethanol extracts of hibiscus leaves in preparation creambath against rabbit hair growth. Of ethanol extracts of hibiscus leaves are obtained with the method remaseration using ethanol 70%. Creambath preparation made in 4 formula with the concentration of the extract of hibiscus in 10%, 15%, 20% and a negative control. Applied to the backs of rabbits that had been shaved and then given the preparations-2 times a day for 15 days. To test the activity of rabbit hair growth by measuring the length of the hair and rabbit hair, weight and physical test performed which include odor, color, pH, spread power, power protection, the ability to say, type, viscosity and stability of creams, creambath. Physical quality test data, weight, and hair is analyzed with the Saphiro-Wilk, then using ANOVA and Post Hoc Tests. The results showed that preparations creambath hibiscus leaves ethanol extract with a concentration of 10%, 15%, and 20% have good physical stability. The higher the concentration of the extract in preparations creambath hair growth activity differences produce rabbits. The results views of the parameter weights and lengths of hair, but not yet as effective as comparison control formula that delivers results-effective against the growth of rabbit hair creambath is with a concentration of 20%.
Co-Authors Dwi Ningsih, Dwi Ika Purwidyaningrum M. Wahyu Ariawan Siti Aisiyah