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All Journal Jurnal Fitofarmaka Indonesia JFL : Jurnal Farmasi Lampung Jurnal Media Pengabdian Kepada Masyarakat (JM-PKM) Indonesian Journal of Community Empowerment Gotong Royong Galen: Jurnal Ilmu Farmasi dan Kesehatan Journal Health of Indonesian Multicore International Journal of Multidisciplinary (MIJM) Journal Abdimas Paspama Service
M. Wahyu Ariawan
Universitas Tulang Bawang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Aktivitas Iron Chelator Ekstrak Etanol Dan Fraksi Daun Putri Malu (Mimosa pudica L) Terhadap Pasien Thalasemia Menggunakan Metode Fic (Ferrous Ion Chelating) M. Wahyu Ariawan; Ana Indrayati; Supriyadi Supriyadi
Jurnal Fitofarmaka Indonesia Vol 9, No 2 (2022): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i2.838

Abstract

Thalasemia merupakan penyakit genetik yang disebabkan oleh defisiensi rantai globin α dan β yang menyusun hemoglobin. Penelitian ini bertujuan untuk mengetahui adanya kandungan senyawa mimosin dan konsentrasi optimum mimosin pada tanaman Mimosa pudica L sebagai agen pengkhelat besi pada pasien thalasemia secara in-vitro. Penelitian diawali dengan melakukan ekstraksi dan fraksinasi daun putri malu selanjutnya menguji kadar feritin menggunakan uji Ferrous Ion Chelating (FIC). Pengujian dilakukan sebanyak tiga kali. Selanjutnya dihitung kadar feritin dengan ELISA reader. Tahap akhir, yaitu mengukur kadar mimosin. Mimosin dengan konsentrasi 500 ppm memiliki aktivitas pengkhelat besi dengan persentase penurunan kadar feritin sebesar 84,48%.  Fraksi n-heksan dengan  konsentrasi  500 ppm memiliki aktivitas pengkhelat besi dengan penurunan aktivitas feritin sebesar 81,27%.
Aktivitas Gastroprotektif Kombinasi Madu Dan Virgin Coconut Oil (Cocos nucifera) Pada Model Tikus Tukak Lambung Widyastuti, Lita; Herowati, Rina; Ariawan, M Wahyu; Purwidyaningrum, Ika
Jurnal Fitofarmaka Indonesia Vol 11, No 1 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i1.1064

Abstract

Gastric ulcers are damage that occurs to the mucosal tissue, submucosa and the muscle layer of the stomach, this condition is caused by hypersecretion of stomach acid. The substance content of VCO has a gastroprotective effect because it includes flavonoid compounds, phenols, catalase, ascorbic acid, and vitamin E, while VCO includes octanoic acid, δ-Octalactone, dodecanoic acid, δ-Decalactone, acetic acid. The aim of this research is to understand the gastroprotective activity resulting from giving a combination of honey and VCO to aspirin-induced rats. Honey and VCO in single administration include one dose, namely 14 ml/kgBW honey and 10 ml/kgBW VCO, while in combination treatment three doses are given, namely 10.5; 7; 3.5 ml/kgBB honey and 7.5; 5; 2.5 ml/kgBB VCO. Then in the combined treatment, 5 variations of doses were given, namely honey and VCO (7:7.5); (7:5); (7:2.5); (10.5:5); (3.5:5) ml/kgBB. TNFα levels before being induced by aspirin, after being induced by aspirin, after honey and VCO therapy, and macroscopic observations on a single treatment showed that administration of honey and VCO at doses of 10.5 ml/kgBW and 5 ml/kgBW showed a gastroprotective effect compared to other doses. Then, in histopathological testing, doses with gastroprotective effects can restore mucosal cell cohesion which has been previously damaged due to erosion. The combination of honey and VCO showed gastroprotective results at a dose of 10.5 ml/kgBB honey and 5 ml/kgBB VCO.
Asistensi Penyusunan Naskah Proposal Penelitian Dan Pengabdian Masyarakat Dengan Metode Lgd (Leaderless Group Discussion) Di Universtias Kadiri Prasetyawan, Fendy; Saristiana, Yuneka; Dhafin, Anis Akhwan; Mildawati, Ratna; Muslikh, Faisal Akhmal; Ariawan, Wahyu
Gotong Royong Vol. 1 No. 1 (2024)
Publisher : CV. Akira Java Bulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63935/gr.v1i1.16

Abstract

The assistance program for drafting research and community service proposals using the Leaderless Group Discussion (LGD) method at Universitas Kadiri aims to enhance the capacity of lecturers and students in producing high-quality and relevant proposals. The LGD method allows each participant to actively engage in discussions without a dominant leader, fostering involvement and constructive collaboration. The program includes preparation, workshop implementation, proposal evaluation, and follow-up stages. Results indicate significant improvements in problem formulation clarity, methodological accuracy, and proposal consistency. Additionally, active participant involvement and the development of collaborative skills were achieved, strengthening an inclusive discussion culture within the academic environment. Evaluations show that the LGD method effectively enhances academic and professional quality, despite challenges in ensuring deep understanding of topics and methodologies. With support from the Universitas Kadiri's Center for Educational Development and Quality Assurance (LP3M) team, this program successfully met its objectives and provides a strong foundation for similar future activities. The outcomes of this program are expected to contribute to improving the quality of innovative and impactful research and community service.
AKTIVITAS ANTIHIPERURISEMIA KOMBINASI EKSTRAK DAUN KERSEN (MUNTINGIA CALABURA L.) DAN DAUN SIRSAK (ANNONA MURICATA L.) TERHADAP TIKUS PUTIH JANTAN: ANTIHYPERURICEMIA ACTIVITY OF EXTRACT COMBINATION OF KERSEN LEAF (MUNTINGIA CALABURA L.) AND SOURSOP LEAF (ANNONA MURICATA L.) ON MALE WHITE RATS Susanti, Laila; Samsuar; Ariawan, M Wahyu; Widiyastuti, Asih; Isbiyantoro; Widodo, Subur
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1908

Abstract

Kersen (Muntingia calabura L.) and soursop (Annona muricata L.) have many properties to cure several diseases, including antihiperurisemia, which is a disorder of purine metabolism in which patients experience increased uric acid levels. This study aimed to examine the antihiperuricemia effect of a combination of kersen leaf extract and soursop in male rats orally. Extraction was carried out by maceration using 70% ethanol. This research is a laboratory experimental study using male white mice as test animals. Data were processed in the form of ANOVA and LSD (Least Significant Difference) test results to compare between groups P0 (normal control), PI (negative control), P2 (Allopurinol 9 mg/Kg BW), P3 (410 and 3.5 mg/Kg BW), P4 (410 and 7 mg/Kg BW), P5 (410 and 10.5 mg/Kg BW), P6 (610 and 3.5 mg/Kg BW), P7 (610 and 7 mg/Kg BW), P8 (610 and 10.5 mg/Kg BW), P9 (910 and 3.5 mg/Kg BW), P10 (910 and 7 mg/Kg BW) ), P11 (910 and 10.5 mg/Kg BW). Giving the test material starting on the 8th to 14th day. On the 15th day blood was taken by slaughtering to measure uric acid levels using a UV-Vis spectrophotometer. On examination of uric acid levels, the administration of beef liver can significantly increase uric acid levels in male rats. and the administration of kersen leaf extract and soursop leaves can significantly reduce uric acid levels in male rats. The administration of kersen leaf extract and soursop leaves for 7 days at doses of 910 and 10.5 mg/Kg BW most effectively reduced uric acid levels in hyperuricemic mice.   Keywords: Hyperuricemia, kersen leaves extract, soursop leaves extract  
FORMULATION AND ANTIBACTERIAL ACTIVITY OF MOUTHWASH COMBINATION OF GUAVA LEAF (Psidium guajava L.) AND BASIL LEAF (Ocinum basilicum L.) EXTRACT AGAINST Streptococcus mutans : FORMULASI SEDIAAN MOUTHWASH KOMBINASI EKSTRAK DAUN JAMBU BIJI (Psidium guajava L.) DAN DAUN KEMANGI (Ocinum basilicum L.) TERHADAP AKTIVITAS BAKTERI Streptococcus mutans Samsuar, Samsuar; Ariawan, M Wahyu; Pratiwi, Inda; Widodo, Subur; Susanti, Laila; Luthfiyah, Yosi
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2427

Abstract

Dental caries is basically caused by cariogenic bacteria, including Streptococcus mutans, which are found in the oral cavity, especially dental plaque. To treat dental caries, antiseptics packaged in the form of mouthwash use unnatural active ingredients which often cause side effects. Therefore, it is necessary to carry out preventive measures to reduce side effects by using waste from guava leaves and basil leaves. This research purpose were to making mouthwash formulation with the active ingredients guava leaf extract and basil leaf extract and determine the antibacterial activity of mouthwash formulation. The method used is the diffusion method, a combination of concentrations of guava leaf extract and basil leaves, namely F1(0%+20%), F2(5%+15%), F3(10%+10%), F4( 15%+ 5.0%), F5(20%+0%), F6(15%+15%). In this study, the variable measured in this study was the diameter of the inhibition zone formed by the combination of extracts. Data analysis was tested using One Way Anova. The significant value obtained was 0.00 ≤ 0.05, indicating a significant difference from the formulation containing a combination of extracts. The results of this research showed that the largest inhibitory zone was at F5 with the largest average value of 15.07mm which had a strong inhibitory response. This research can be concluded that the mouthwash formulation of extracts meets the physical requirements and can inhibit S. mutans. Keywords :  Guava, basil, mouthwash, S. mutans
Unveiling the Mysteries of Pharmacoreincarnation: A Study on the Spiritual and Metaphysical Dimensions of Using Psychoactive Drugs for Accessing Past Life Memories Fendy Prasetyawan; Nanda Ardianto; Yuneka Saristiana; Wahyu Ariawan; Faisal Akhmal Muslikh; Yunita Dian Permatasari
Journal Health of Indonesian Vol. 1 No. 02 (2023): Journal Health of Indonesian, July 2023
Publisher : Paspama Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The research delves into the multifaceted realm of psychoactive drugs, spirituality, and the exploration of past life memories, known as "pharmacoreincarnation." Psychoactive substances like psilocybin, LSD, and DMT have gained attention for their profound alterations in consciousness and subjective experiences, often described as mystical or spiritual. Belief in reincarnation persists globally, fueled by anecdotal testimonials and cultural traditions. The study aims to explore pharmacoreincarnation through a comprehensive literature review and interdisciplinary perspective. Academic databases such as PubMed, PsycINFO, Scopus, and Google Scholar will be utilized to access relevant articles published in English within the last two decades. Thematic analysis will identify recurring themes and patterns across the literature, synthesizing findings to develop a coherent understanding of pharmacoreincarnation. The methodology involves systematic literature search, screening, and review processes to extract pertinent information aligned with the research objective. The synthesized findings will be organized into logical sections within the literature review, ensuring clarity and rigor. Peer review and revision will validate the quality and accuracy of the review before finalization. The study anticipates contributing significantly to knowledge on pharmacoreincarnation and its implications for consciousness studies, spirituality, and therapeutic practices. By embracing an interdisciplinary approach, it aims to unravel the underlying mechanisms of such experiences and their broader implications for personal identity and reality.
Prediction of Sinensetin from Kumis Kucing (Orthosiphon aristatus) as Aspulvinone Dimethylallyltransferase Inhibitor for Anticancer Agent Prasetyawan, Fendy; Arifin, Chandra; Astutik, Widhi; Rohmah, Eka Hayati; Kadir, Mujtahid Bin Abd; Ariawan, M Wahyu; Marhenta, Yogi Bhakti; Mildawati, Ratna; Saristiana, Yuneka; Rofiq, Abd
Multicore International Journal of Multidisciplinary (MIJM) Vol. 1 No. 1 (2025): May
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mijm.v1.i1.3

Abstract

Sinensetin, a polymethoxylated flavone found in Orthosiphon aristatus (commonly known as Kumis Kucing), was evaluated in silico for its potential inhibitory activity against Aspulvinone Dimethylallyltransferase, an enzyme implicated in cancer-related biosynthetic pathways. The SMILES structure of sinensetin was retrieved from PubChem and analyzed using the PASS online prediction tool (www.way2drug.com). The results showed a high probability of activity (Pa = 0.865) and a very low probability of inactivity (Pi = 0.016), indicating that sinensetin is likely to act as a potent inhibitor of the enzyme. These findings suggest that sinensetin could be a promising anticancer agent candidate by targeting Aspulvinone Dimethylallyltransferase. Further studies are recommended to validate this prediction through molecular docking and biological assays.
Prediction of Augenol in Cinnamon (Cinnamomum burmannii) Boiled as a Carminative to Overcome Floating Stomach Rika Wahyu Pujiastini; Fendy Prasetyawan; Yuneka Saristiana; M. Wahyu Ariawan; Muhammad Nurul Fadel; Emma Jayanti Besan
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 1 No. 1 (2025): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v1i1.2

Abstract

Flatulence (meteorismus) is a common condition caused by excess gas accumulation in the digestive tract. One alternative traditional treatment to overcome this condition is the use of herbal plants, such as cinnamon (Cinnamomum burmannii). This study aims to predict the potential of eugenol, an active compound in cinnamon, as a carminative agent using an in silico approach. Data were obtained from PubChem and analyzed using PASS Online to predict its pharmacological activity. The results of the analysis showed that eugenol has a probability of activity as a carminative of 0.941 and a probability of inactivity of 0.001, indicating high potential in helping to relieve flatulence. Thus, eugenol in cinnamon has the potential as an alternative natural treatment to overcome digestive disorders, especially bloating.
SOSIALISASI TENTANG PEMAHAMAN Vaksin Covid-19 DI WILAYAH KELURAHAN JEBRES SOLO Ariawan, M. Wahyu; Koernia, Lilik Wahidah; Widiyastuti, Asih; Prasetyawan, Fendy
MAJU : Indonesian Journal of Community Empowerment Vol. 1 No. 4 (2024): MAJU : Indonesian Journal of Community Empowerment, JULI 2024
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/ep0gst51

Abstract

The results of a vaccine acceptance survey conducted by the Ministry of Health together with ITAGI (Indonesian Technical Advisory Group on Immunization) with support from UNICEF and WHO in September 2020 showed that the majority of the public (74 percent) already knew about the government's plans to carry out COVID-19 vaccination. As many as 65 percent are willing to be vaccinated, around 27 percent are still hesitant. And only a small percentage or around 8 percent said they refused because they were worried about the safety, effectiveness and halalness of the vaccine. The survey results also show that those who have information about COVID-19 vaccination are more likely to accept COVID-19 vaccination. This shows the importance of ensuring that all people have access to accurate information about handling COVID-19, including about COVID-19 vaccination. (Ministry of Health, 2021) The problem that arises now is that there is a lot of hoax news circulating through social media that is widely spread to the public. So it can lead public opinion to be afraid and not want to be vaccinated. This socialization was held with the theme "Socialization of Understanding Vaccines in the Jebres Solo Region" to provide education to the public, especially in the Jebres Solo Region, what vaccines are, the benefits of using vaccines for the body in this pandemic condition, the dangers they cause and so on
Socialization of the Level of Public Awareness and Knowledge about the Benefits of Kombucha Tea in Overcoming Sleep Paralysis During the COVID-19 Pandemic Yuneka Saristiana; Fendy Prasetyawan; Chadra Arifin; Widhi Astutik; Wahyu Ariawan; Achmad Wahdi
Abdimas Paspama Vol. 2 No. 1 (2023): Abdimas Paspama, December 2023
Publisher : Abdimas Paspama

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The COVID-19 pandemic has profoundly impacted global public health, prompting a heightened focus on both physical and mental well-being worldwide. In this uncertain landscape, sleep paralysis has emerged as a notable health concern, characterized by the inability to move or speak upon waking or falling asleep, often accompanied by distressing hallucinations. With stress levels on the rise during the pandemic, cases of sleep paralysis have shown an upward trend. Conversely, probiotic beverages like kombucha tea have garnered attention for their potential health benefits, including digestive improvement, enhanced energy levels, and better sleep quality. Despite these benefits, public awareness regarding kombucha tea's efficacy in addressing sleep paralysis remains limited.To address this knowledge gap, a community service program has been developed to educate the public about kombucha tea's potential in managing sleep paralysis amidst the COVID-19 pandemic. The program involves collaboration with local communities, health institutions, and experts in mental health and nutrition. Scheduled for January 2021, the program will be executed across various locations, engaging community members and fostering dialogue on sleep health and nutrition. Preliminary results indicate a significant improvement in public understanding of sleep paralysis and kombucha tea benefits post-program. Participants exhibited heightened awareness of symptoms, causes, and treatment options for sleep paralysis, as well as a better grasp of kombucha tea's health advantages. Practical workshops on kombucha tea preparation garnered considerable interest, signaling a potential shift towards healthier lifestyle choices among participants.
Co-Authors Achmad Wahdi Ana Indrayati Anis Akhwan Dhafin Astutik, Widhi Chadra Arifin Chandra Arifin Emma Jayanti Besan Faisal Akhmal Muslikh Fendy Prasetyawan Ika Purwidyaningrum Isbiyantoro Kadir, Mujtahid Bin Abd Koernia, Lilik Wahidah Luthfiyah, Yosi Marhenta, Yogi Bhakti Mildawati, Ratna Muhammad Nurul Fadel Nanda Ardianto Pratiwi, Inda Rika Wahyu Pujiastini Rofiq, Abd Rohmah, Eka Hayati Samsuar Samsuar, Samsuar Supriyadi Supriyadi Susanti, Laila Widhi Astutik Widiyastuti, Asih Widodo, Subur Widyastuti, Lita Yuneka Saristiana Yunita Dian Permatasari