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All Journal MPI (Media Pharmaceutica Indonesiana) Jurnal Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI)
Priyanto, Widodo
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Formulasi Orally Disintegrating Tablet (ODT) Furosemide Menggunakan Fast Disintegrant Crospovidone dan Croscarmellose Sodium dengan Metode Kempa Langsung Prastika, Delia Ayu; Rejeki, Endang Sri; Priyanto, Widodo
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p17-27

Abstract

Orally Disintegrating Tablets (ODT) are tablets that disintegrate or break down in less than one minute. Furosemide is a potent diuretic (loop diuretic) used in the treatment of edema associated with hypertension, congestive heart disease, heart failure, liver cirrhosis and kidney disease. Crospovidone is a fast disintegrating agent which is very porous so it can speed up the tablet disintegration time. Croscarmellose sodium is able to absorb water and expand quickly, thereby accelerating the disintegration of the tablet. The aim of this research was to determine the effect of the fast disintegrants crospovidone and croscarmellose sodium on the physical properties and dissolution profile of furosemide ODT, and to find out which fast disintegrant is better in producing good furosemide ODT. This study used seven formulas, namely three formulas with variations of crospovidone 1%, 3% and 5%, three formulas with variations of crosscarmelosse sodium 1%, 3% and 5% and one formula as a control. Furosemide ODT is made by direct compression method. Evaluation of the physical properties of furosemide ODT includes hardness test, brittleness test, and disintegration time test. Tablet dissolution profile testing was carried out in-vitro. The data obtained were analyzed using the one way ANOVA test with a confidence level of 95%. The results showed that the addition of rapid disintegrating crospovidone and croscarmellose sodium at a concentration of 5% was able to influence the hardness, friability and disintegration time of the tablet, as well as increasing the dissolution profile. A better rapid disintegrating agent that produces good furosemide ODT is croscarmellose sodium.
Pengaruh Croscarmellose Sodium Terhadap Mutu Fisik Orally Disintegrating Tablet Glibenklamid Hasil Dispersi Padat Hariyani, Bunga Fitri; Harjanti, Reslely; Priyanto, Widodo
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p154-161

Abstract

Glibenclamide is the second generation of the sulfonylurea group, which is used orally in patients with type 2 diabetes mellitus. Oral tablet preparations are still the main choice because they have the exact size of the usual desired dose, whereas for liquid preparations, patients must measure the medicine themselves. Pediatric and geriatric patients generally often experience difficulties when swallowing tablet or oral medications. So, to overcome this, an ODT preparation was made, the way to consume it is just to put it on the tongue, then the ODT tablet will disintegrate and dissolve in saliva. The aim of this research was to determine the variation of croscarmellose sodium that produces the best physical quality of Glibenclamide ODT tablets. The manufacture of Glibenclamide ODT has been carried out using the mixture method (dissolution-mixing). The solid dispersion that has been used is PEG 4000 and uses various concentrations of Croscarmellose Sodium, namely 0 mg, 2 mg, 4 mg, 6 mg, and 8 mg. The resulting ODT tablets were evaluated using several parameters, namely hardness test, friability test, wetting test, in vitro disintegration time test, and taste response test. The data obtained will be analyzed using one-way ANOVA with a confidence level of 95%. Research results have shown that the use of 4% Croscarmellose Sodium has resulted in the fastest in vitro disintegration (disintegration) time of 4.44 seconds, and the fastest wetting time of 21.67 seconds. The higher the concentration of croscarmellose sodium can produce the best physical quality.
Optimization of Papaya Leaf Extract Cream Using Stearic Acid and Triethanolamine via Simplex Lattice Design Siwi, Andini Prabandaru; Priyanto, Widodo; Novita, Mega; Marlina, Dian
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 1 (2025): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i1.7468

Abstract

Papaya leaves (Carica papaya L.) are known to contain bioactive compounds such as flavonoids, alkaloids, tannins, and saponins, which exhibit antiseptic, anti-inflammatory, antifungal, and antibacterial properties, making them promising for topical pharmaceutical preparations. However, achieving optimal physical characteristics in cream formulations requires careful selection and proportioning of emulsifiers. This study investigates the effect of varying ratios of stearic acid and triethanolamine on the physical properties of creams containing ethanol-extracted papaya leaf extract. The extract was obtained via maceration using 96% ethanol and confirmed to contain active compounds through phytochemical screening and thin-layer chromatography. Eight formulations were developed using a Simplex Lattice Design (SLD) with stearic acid concentrations ranging from 15–17% and triethanolamine from 2–4%. Physical evaluations included tests for pH, viscosity, adhesion, and spreadability. All formulations met standard of cream quality requirements, but the optimal formula was identified at 15.20% stearic acid and 3.79% triethanolamine, offering the most desirable physical characteristics. This formulation strategy demonstrates the potential for producing effective and stable papaya leaf creams, with implications for natural-based dermatological product development. Submitted: 05-05-2025, Revised: 18-06-2025, Accepted: 25-06-2025, Published regularly: June 2025
Formulasi Dan Uji Aktivitas Tabir Surya Gel Kitosan Menggunakan Karbopol 940 Dan Hpmc K100 Sebagai Gelling Agent Ahmad Fahrezi, Mukhlis; Nopiyanti, Vivin; Priyanto, Widodo
Jurnal Farmasi (Journal of Pharmacy) Vol. 10 No. 1 (2021): Jurnal Farmasi (Journal of Pharmacy), April 2021
Publisher : Jurnal Farmasi (Journal of Pharmacy)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ultraviolet (UV) radiation can penetrate the epidermis layer of the skin so that it can irritate and damage skin tissue. Chitosan containing chitin compounds has the potential to provide protection against ultraviolet (UV) exposure. This study aims to determine the activity of chitosan gel sunscreen seen from the SPF value, the influence of the use of variations in concentration in a combination of carbopol and HPMC as a gelling agent on the activity of chitosan gel sunscreens, concentration variations in the combination of carbopol and HPMC which are able to provide good physical properties and gel stability. The variation of concentration in the combination of carbopol and HPMC as a gelling agent was made into 3 formulas, F1 (100% carbopol: 0% HPMC), F2 (50% carbopol: 50% HPMC), F3 (0% carbopol: 100% HPMC). Chitosan gel sunscreen activity test was carried out with the SPF (Sun Protection Factor) test using UV-VIS spectrophotometry. The SPF value price is calculated using the mansyur method. SPF test results were statistically analyzed using One Way ANOVA. SPF test results from variations in concentration in a combination of carbopol and HPMC as a gelling agent, F1 (9,091348), F2 (5,419107), F3 (6,437869). SPF test results that were statistically analyzed using One Way ANOVA showed that all the data tested were significantly different from the most active formula, F1 (100% carbopol: 0% HPMC) with the SPF value price 9,091348.
Co-Authors Ahmad Fahrezi, Mukhlis Endang Sri Rejeki Hariyani, Bunga Fitri Marlina, Dian Mega Novita Prastika, Delia Ayu Reslely Harjanti Siwi, Andini Prabandaru Vivin Nopiyanti