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All Journal Jurnal Teknik Kimia USU The Journal of Pure and Applied Chemistry Research Biology, Medicine, & Natural Product Chemistry MPI (Media Pharmaceutica Indonesiana) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA ALCHEMY Jurnal Penelitian Kimia Stability: Journal of Management and Business CARADDE: Jurnal Pengabdian Kepada Masyarakat JPSCR : Journal of Pharmaceutical Science and Clinical Research FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Farmasi Indonesia Jurnal Analis Farmasi Community Empowerment Advance Sustainable Science, Engineering and Technology (ASSET) Bioscientia Medicina : Journal of Biomedicine and Translational Research JAF (Jurnal Analis Farmasi) Pharmademica: Jurnal Kefarmasian dan Gizi SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT El-Mal: Jurnal Kajian Ekonomi & Bisnis Islam SWAGATI: Journal of Community Service SEMINAR NASIONAL SOSIAL, SAINS, PENDIDIKAN, HUMANIORA Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Advance Sustainable Science, Engineering and Technology (ASSET) Berita Biologi
Marlina, Dian
Universitas Setia Budi
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UJI AKTIVITAS ANTIHIPERGLIKEMIK EKSTRAK ETANOL DAUN KETAPANG (Terminalia catappa L) PADA MENCIT PUTIH YANG DIINDUKSI ALOKSAN Jena Hayu Widyasti; Dian Marlina; Avianti Eka Dewi A.P Eka Dewi A.P
Jurnal Farmasi Indonesia Vol 13 No 2 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (470.932 KB) | DOI: 10.31001/jfi.v13i2.283

Abstract

Diabetes mellitus is a chronic disease that caused of decreasing insulin production at Pancreatic β cell or insulin production which not effective. The purpose of this research was proving catappa’s leaves extract (Terminalia catappa L) have an activity to decrease blood glucose levels trough diabetics on effective doses. The prominent goal may achieved was obtaining efficacious natural medicine of anti-diabetes and knowing the effective doses of catappa’s leaves extract (Terminalia catappa L) as anti-diabetes. This Anti-hyperglycemic research is using mice as many as 30 mice. The activity experiment of anti-diabetes was executed to 6 treatment groups, there are Group I (normal control), Group II negative control (alloxan induced 180 mg/kgBW and aquadest), Group III (alloxan induced and catappa’s leaves extract 75 mg/kgBW), Group IV (alloxan induced and catappa’s leaves extract 150 mg / kgBW), Group V (alloxan induced and catappa’s leaves extract 300 mg/kgBW), and Group VI (positive control that given by alloxan induced and glibenclamide 10mg/kgBW). All of the treatment group was given with that treatment for 14 days and were carried measurement of blood glucose levels on days 0, 3, 10, 17. The leaf extract anti-diabetes activities shown by calculating hypoglycemic capacity of each treatment. The result of this research showed that the ethanol extract of catappa’s leaves have anti-hyperglycemic activities on mice that alloxan induced. At the doses of ethanol extract of leaves of catappa 300 mg/kgBW have effectively anti-hyperglycemic activities than doses of 150 mg/kgBW and 75 mg/kgBW that was comparable with positive control group
Antibacterial Activity of Moringa Plants (Moringa oleifera Lam.) to Overcome Antibiotic Resistance: A Systematic Review Novitarini; Jason Merari P.; Dian Marlina
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.591

Abstract

Antibiotic resistance This causes the performance of synthetic antibiotics to decrease, so it is necessary to search for natural antibiotics. Moringa plant (Moringa oleifera Lam.) has antibacterial activity proven to inhibit and kill pathogenic bacteria and Multi-Drug Resistance (MDR)article review aims to collect data related to testing the antibacterial activity of Moringa plants as an effort to overcome antibiotic resistance. The method follows the PRISMA-2020 protocol by searching data on PubMed and ScienceDirect media using the keywords: "Antibacterial activity" and "Moringa oleifera". The data selection uses the Rayyan application by considering the inclusion and exclusion criteria that have been set. The final results obtained are 95 data which are experimental journals of the Randomized Control Trial (RCT) type published in 1981-2021. Moringa plants began to be investigated for their activity against MDR bacteria in 2012 and became a sign that research was already in the direction of finding solutions. Antibacterial testing was carried out in vitro (10 studies) and in vivo (1 study). The leaves have been thoroughly tested for their activity against Methicillin-Resistant Staphylococcus aureus (MRSA). The results of in vitro study obtained the range of zone of inhibition, minimum inhibitory concentration, and minimum kill concentration, respectively: 8.3-12 mm; 0.25-20 mg/ml; 0.50-20 mg/ml study in vivo showed that there was the healing of MRSA infection wounds in test animals.
Variations of Tween Surfactant and Propylene Glycol Cosurfactant in Topical Microemulsion Formulation on The Penetration of Ibuprofen Sri Fitrianingsih; Gunawan Pamudji Widodo; Dian Marlina
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 12, No 2 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i2.5785

Abstract

ABSTRACTIbuprofen is a derivative of propionic acid, a class of non-steroidal anti-inflammatory drugs (NSAIDs). Ibuprofen has side effects on the gastrointestinal tract. So that topical use can be a solution to reduce the side effects of oral use because of the release of topical drugs through the stratum corneum which makes it selective in certain places. The preparation chosen was a topical microemulsion because it is more thermodynamically stable and has no effect on the gastrointestinal tract. This study aims to determine the effect of the ratio of surfactant concentrations of various ratios of tween 20:tween 80 and cosurfactant propylene glycol to the penetration rate of ibuprofen across the membrane and to determine the physical characteristics of topical microemulsions. Selection of tween surfactant and propylene glycol cosurfactant because it has high physical stability. This research is an experimental study, namely by making four formulations with various ratios of surfactant and cosurfactant with a difference of 2.5% in each formulation of topical ibuprofen microemulsion with a concentration of 5% ibuprofen using variations of surfactant tween 20 and tween 80, cosurfactant propylene glycol with black cumin oil phase. Evaluation of the preparation by organoleptic test, pH test of the preparation, examination of the type of emulsion, particle size measurement, microemulsion release test in vitro using the Franz diffusion method. The results show that the concentration ratio of surfactant tween 20:tween 80 and cosurfactant propylene glycol can affect particle size, pH and penetration velocity (flux) in Franz diffusion. The results of the study showed that in F1 using surfactant tween 20:tween 80 with a concentration of 71.6% (6:4) had the smallest particle size of 11.5 nm and the largest flux value was 128.45 g.cm-2.H- 1. In conclusion, variations in surfactant and cosurfactant concentrations can affect the pH of the preparation, particle size, penetration speed (flux). The results obtained that the cumulative percent and penetration speed of all formulas had significant differences (p0.05).
MENGELOLA RISIKO PADA MANAJEMEN RANTAI PASOKAN (MRP) DI INDUSTRI FARMASI Haryo Kusumo; Achmad Solechan; Dian Marlina
Stability: Journal of Management and Business Vol 5, No 2 (2022): December
Publisher : Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/sta.v5i2.12554

Abstract

Manajemen risiko dalam manajemen rantai pasokan adalah salah satu hal yang paling penting diperhatikan disebabkan karena dapat mempengaruhi kinerja perusahaan. Riset ini bertujuan untuk mengetahui manajemen risiko pada rantai pasokan di industri farmasi. Teknik dalam analisis data pada penelitian ini menggunakan studi literatur review. Hasil penelitian menunjukkan dalam rantai pasok, kinerja perusahaan farmasi sebagai pemain utama memiliki dampak penting pada manajemen rantai pasokan efisiensi. Identifikasi risiko dan pencegahan pada perusahaan farmasi tidak hanya dapat berfokus pada optimalisasi proses, peningkatan produktivitas dan meminimalkan risiko, akan tetapi juga prioritas perusahaan untuk memenuhi manajemen rantai pasokan yang meliputi aksesibilitas obat, kualitas obat dan sistem distribusi obat. Untuk riset mendatang perlu dilakukan kajian masalah yang dihadapi perusahaan farmasi dalam aspek strategi, aspek keuangan, aspek logistik, aspek politik, aspek pasar dan masalah peraturan terkait risiko pasokan produk farmasi serta perlu pula kajian terkait implementasi terintegrasi pada rantai pasok produk farmasi yang konsisten dan berkelanjutan.
Potensi Inkompatibilitas Terapeutik Penggunaan Kortikosteroid pada Resep Anak Racikan di Klinik ‘X’ Sukoharjo Nur Anggreini Dwi Sasangka; Avianti Eka Dewi Aditya Purwaningsih; Dian Marlina
Seminar Nasional Penelitian dan Pengabdian Kepada Masyarakat 2021: Prosiding Seminar Nasional Penelitian dan Pengabdian Kepada Masyarakat (SNPPKM 2021)
Publisher : Universitas Harapan Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (525.874 KB)

Abstract

Penulisan resep racikan masih banyak ditemukan dibeberapa fasilitas kesehatan di Indonesia. Peracikan obat umumnya menjadi solusi terhadap keterbatasan formula obat untuk anak. Inkompatibilitas merupakan suatu kejadian obat yang tidak tercampurkan secara fisika maupun kimia dan berakibat pada hilangnya potensi, meningkatnya toksisitas atau efek samping yang lain. Inkompatibilitas adalah reaksi yang tidak diinginkan yang terjadi antara obat dengan larutan, wadah atau dengan obat lainnya. Dua jenis inkompatibilitas yang berkaitan dengan peracikan adalah inkompatibilitas fisik dan kimia. pada pustaka lain dibagi menjadi inkompatibilitas fisika, kimia, dan teraupetik. Penelitian yang dilakukan merupakan penelitian observasional yang dilakukan di klinik utama “x” di Sukoharjo pada bulan Juli hingga desember 2020. Dalam penelitian ini terlihat bahwa pasien laki-laki paling banyak mendapatkan resep kortikosteroid 49,5% (n=113) dan sebanyak 24,7% (n=113) untuk perempuan yang mendapatkan resep kortikosteroid. Resep dengan racikan kortkisteroid Dexamethason yang memiliki inkompatibilitas terapeutik sebanyak 1 dengan obat asam mefenamat sebanyak 12 resep, sedangkan untuk methylprednison ditemukan sebanyak 4 obat kombinasi yaitu dengan vitamin C sebanyak 4 resep, Amoxicillin sebanyak 1 resep, Antasida sebanyak 1 resep dan As.mefenamat sebanyak 12 resep.
The Effect of Storage Conditions on the Absorption Profile of 2% Lydocaine Hydrochloridum Injection by UV-Vis Spectrophotometry Dian Marlina; Sephia Febriyanti; Arsyeni Destra Anarchy Arsyandi; Nur Anggreini Dwi Sasangka
Advance Sustainable Science Engineering and Technology Vol 5, No 1 (2023): November-April
Publisher : Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/asset.v5i1.14937

Abstract

Lidocaine HCl injection is a sterile product that is easily contaminated when opened. The temperature and humidity in the injection storage conditions also affect the quality of the drug when viewed from the UV-Vis spectrophotometric absorption value. The aimed of this study is to find out how the effect of storage conditions on the absorption profile of 2% lydocaine HCl injection by UV-Vis spectrophotometry. The study used 27 ampoules of 2% lidocaine HCl injection and was qualitatively analyzed using UV-Vis spectrophotometry. The study lasted for 14 days by first storing the injections in storage conditions at room temperature (25-27℃), cold temperatures (5-10℃), and exposed to Ultraviolet light (380 nm). Based on the results of laboratory tests, the most suitable storage condition used for storing lidocaine HCl injection was cold storage (5-10℃) because there was no shift in the maximum wavelength as occurred during the 14th day of UV exposure storage.
Handmade batik with tuberose motifs as creative home industry idea Mega Novita; Febrian Murti Dewanto; Aris Trijaka Harjanta; Bambang Agus Herlambang; Dian Marlina; Desi Purwaningsih; Haryo Kusumo
Community Empowerment Vol 8 No 8 (2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.8772

Abstract

Batik tulis is a rich cultural heritage of Indonesia, encompassing traditional values and artistic expressions. However, in some regions, there has been a decline in interest and skills in batik tulis making, along with the threat of plagiarism of local batik motifs. Therefore, efforts are needed to develop creative innovations in batik tulis production and ensure the sustainability of local batik traditions. Desa Doplang faces challenges in enhancing the skills of its residents in creating batik tulis with the motif of Polyanthes Tuberosa L., preserving the authenticity and originality of batik motifs, and improving economic well-being through increased production and sales of batik tulis. The Community Engagement Program (PKM) is designed to address these challenges through intensive mentoring, quality control, and efforts to prevent plagiarism. Through technical and creative training, the residents of Desa Doplang have acquired the skills required to produce batik tulis with the motif of Polyanthes Tuberosa L. Mentoring is provided at every stage of production, including the application of wax, dyeing, and the final boiling process. Feedback and constructive advice are given to improve the quality and authenticity of the batik tulis produced. Quality control measures are implemented to ensure that each batik tulis product meets the established quality standards. Additionally, through socialization and education, awareness regarding the importance of authenticity and originality of batik motifs is heightened. The program utilizes a community development, empowerment, and engagement approach. As a result, the program has successfully enhanced the skills of the residents of Desa Doplang in batik tulis production, increased cultural appreciation, and improved economic well-being through enhanced production and sales of batik tulis. The quality of the batik tulis produced has shown continuous improvement alongside the enhancement of skills. Moreover, the program has successfully preserved the local tradition of batik making and strengthened the position of batik tulis with the motif of Polyanthes Tuberosa L. as the flagship product of Desa Doplang. Another positive impact is the increase in the residents' income through the sale of batik tulis at better prices.
Inovasi Pengolahan Hasil Pertanian Bunga Sedap Malam berbasis Destilasi Sederhana Minyak Atsiri Mega Novita; Rifki Hermana; Senowarsito Senowarsito; Sutomo Sutomo; Dian Marlina; Haryo Kusumo
CARADDE: Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 2 (2023): Desember
Publisher : Ilin Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31960/caradde.v6i2.1965

Abstract

Desa Doplang merupakan satuan wilayah pemerintahan yang berada di Kecamatan Bawen Kabupaten Semarang Jawa Tengah Indonesia. Desa ini memiliki lahan bunga sedap malam (Polianthes tuberosa) seluas 3 hektar yang di andalkan oleh warga sebagai sumber penghasilan. Sayangnya, masyarakat Desa Doplang belum mampu untuk meningkatkan nilai tambah potensi bunga sedap malam yang mereka miliki. Bunga sedap malam yang sudah siap panen biasanya diambil oleh tengkulak dan dijual dalam bentuk mentah. Hal ini sering merugikan petani karena harga ditentukan oleh tengkulak secara sepihak. Oleh karena itu, Program Kemitraan Masyarakat (PKM) inovasi pengolahan hasil pertanian bunga sedap malam berbasis destilasi sederhana minyak atsiri dilaksanakan. Beberapa produk olahan bunga sedap malam seperti minyak wangi, minyak telon, dan hand sanitizer dari bunga sedap malam diajarkan kepada warga Desa Doplang. Harapan dari kegiatan ini adalah meningkatnya ketrampilan warga untuk melakukan inovasi dan diversivikasi produk berbasis bunga sedap malam. Hal ini akan secara langsung meningkatkan nilai jual hasil pertaniannya.
PERAN MEDIA PAPAN PERKALIAN PINTAR (PAPERPI) TERHADAP KETERAMPILAN BELAJAR MATEMATIKA SISWA DI SDN 01 MANISREJO Tia Tri Kuswanti; Fauzatul Ma’rufah; Dian Marlina
SEMINAR NASIONAL SOSIAL, SAINS, PENDIDIKAN, HUMANIORA (SENASSDRA) Vol 2, No 2 (2023): Implementasi kurikulum merdeka menuju transformasi pendidikan dalam mempersiapka
Publisher : SEMINAR NASIONAL SOSIAL, SAINS, PENDIDIKAN, HUMANIORA (SENASSDRA)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penelitian ini merupakan penelitian kuantitatif dengan model the nonequivalent pretest-posttest control. Yang melatarbelakangi penelitian ini adalah siswa kelas 2 merasa kesulitan dan belum memahami materi perkalian, selain itu guru tidak kreatif dalam penggunaan media dan kemampuandalam penyusunan media belajar belum memadai. Tujuan Penelitian ini untuk mengetahui pengaruh hasil belajar matematika antara siswa kelas 2 SDN 01 Manisrejo yang belajar menggunakan media papan perkalian pintar terhadap siswa yang mendapatkan pembelajaran konvensional dengan menggunakan metode eksperimen semu. Pada penelitian ini teknik pengumpulan data yang digunakan adalah tes serta dokumentasi, sedangkan teknik untuk menganalisis data menggunakan metode deskriptif dan uji prasyarat hipotesis. Hasil penelitian membuktikan bahwa posttest siswa kelas eksperimen dan kelas control adalah (3,10 ≥ 2,01), yang berarti (H2) diterima sedangkan (H0) ditolak. Dengan demikian penulis menyimpulkan bahwa terdapat pengaruh penggunaan media papan cerdas perkalian untuk hasil belajar matematika siswa kelas 2 di SDN 01 MANISREJO.
Analisis Kualitas Kimia dan Fisika Sediaan Pulveres Antibiotika dan Kortikosteroid di Klinik "X" Kota Sukoharjo: Analysis of Chemical and Physical Quality of Pulveres Antibiotic and Corticosteorid Conditions Clinic in Sukoharjo Nur Anggreini Dwi Sasangka; Avianti Eka Dewi Aditya Purwaningsih; Dian Marlina
Jurnal Sains dan Kesehatan Vol. 5 No. SE-1 (2023): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5iSE-1.2059

Abstract

Pharmacists have one of the tasks, namely dispensing non-sterile preparations by making pulveres preparations. Making pulveres preparation cannot be separated from the risk of medication errors caused by incompatibility. This study aims to determine the incompatibility of antibiotic pulveres preparations with corticosteroids. This study is experimental, the sample used is a mixture of antibiotics and corticosteroids in the form of pulveres. The antibiotics used were amoxicillin, cefixim, and cefadroxil, while the corticosteroids used were dexamethasone and methylprednisolone. The research was conducted in the Setia Budi University laboratory, by looking at organoleptic, moisture test, and active substance content test using UV spectrophotometer instrument. The data obtained were analysed descriptively and displayed in the form of tables and percentages. This study was based on the prescription of children's pulveres preparations at clinic X in Sukoharjo, which mostly prescribed antibiotics with corticosteroids. Experiments were carried out in accordance with the literature test and it was found that there was no organoleptic change when the tablet preparation was crushed. Moisture test results showed that amoxicillin has hygroscopic properties that cause the powder to become moist. Amoxicillin pulveres with corticosteroids have high moisture content. The cefixime pulveres with or without cortocisteroid combination also had high moisture content. The allowable moisture content is < 5%. The test results showed that there was a difference in absorbance values between antibiotics in single form and a combination of antibiotics and corticosteroids Keywords: antibiotic, incompatibility, corticosteroid, pulveres Abstrak Farmasis memiliki salah tugas yaitu dispensing sediaan non steril dengan membuat sediaan pulveres. Pembuatan sediaan pulveres tidak lepas dari risiko medication error yang disebabkan adanya inkompatibilitas. Penelitian bertujuan mengetahui inkompatibilitas sediaan pulveres antibiotika dengan kortikosteroid. Penelitian ini merupakan eksperimental, sampel yang digunakan adalah campuran antibiotika dan kortikosteroid dalam bentuk pulveres. Antibiotika yang digunakan yaitu amoksisilin, sefixim, dan sefadroksil, sedangkan kortikosteroid yang digunakan yaitu dexametason dan metilprednisolon. Penelitian dilakukan dilaboratorium Universitas Setia Budi, dengan melihat organoleptis, uji kelembaban, dan uji kadar zat aktif dengan menggunakan instrument spektofotometer UV. Data yang didapatkan dianalisis secara deskriptif dan ditampilkan dalam bentuk tabel dan persentase. Penelitian ini berdasarkan peresepan sediaan pulveres anak di klinik X di Sukoharjo yang sebagian besar resep antibiotika dengan kortikosteroid. Eksperimen dilakukan sesuai dengan uji literature dan didapatkan tidak ada perubahan secara organoleptik ketika sediaan tablet digerus. Hasil uji kelembaban menunjukkan bahwa amoksisilin memiliki sifat higroskopis yang menyebabkan serbuk menjadi lembab. Pulveres amoksisilin dengan kortikosteroid memiliki kadar kelembapan yang tinggi. Pulveres sefiksim dengan atau tanpa kombinasi kortokisteroid juga memiliki kadar kelembapan tinggi. Kadar kelembapan yang diperbolehkan yaitu < 5%. Hasil uji menunjukkan adanya perbedaan nilai absorbansi antara antibiotik dalam bentuk tunggal dengan kombinasi antibiotika dan kortikosteroid. Kata Kunci: antibiotika, inkompatibilitas, kortikosteroid, pulveres
Co-Authors Achmad Solechan Amanda Kusumaning Astari Amanda, Nathasya Gracya Ana Indrayati Anggraini, Natasya Dila Putri Aris Tri Jaka Harjanta, Aris Tri Arsyeni Destra Anarchy Arsyandi aurelia zahra Avianti Eka Dewi A.P Eka Dewi A.P Bambang Agus Herlambang, Bambang Desi Purwaningsih Dwinata Rahayuningsih Emmellia Yunitha Fauzatul Ma’rufah Febrian Murti Dewanto Fitrianingsih, Sri Ghani Nurfiana Fadma Sari Gunawan Pamudji Widodo Haryo Kusumo Haryo Kusumo Ira Juliani Anwar Iswandi Iswandi Iswandi Iswandi Jason Merari Peranginangin Kusumo, Haryo Mega Novita Mega Novita Muhamad Ansory, Hery Nabilah Nauli Jehan Nilawati, Anita Novitarini Nur Anggreini Dwi Sasangka Nur Anggreini Dwi Sasangka Nurfiana Rachmawati Pramukantoro, Ganet Eko Priyanto, Widodo Purwaningsih, Avianti Eka Dewi Aditya Puspitasari, Ismi Putri, Annisa Ayu Widya Putri, Cinthiya Ekwinta Reny Pratiwi Rifki Hermana Ruddat Ilaina Rahmah Ryan Werytama Saputra Sato, Harumi Senowarsito, Senowarsito Sephia Febriyanti Setiawan, Anang Kuncoro Rachmad Siti Aisiyah Siwi, Andini Prabandaru Sri Fitrianingsih Supriyono Supriyono Sutomo Sutomo Takad Bagas Aji Prasetyo Tia Tri Kuswanti Titik Sunarni Vinola Herawaty Vivin Nopiyanti Widiastuti Setyaningsih Wulandari, Destik