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All Journal e-CliniC Jurnal Ilmiah Universitas Batanghari Jambi Medical Scope Journal (MSJ)
Manginstar, Christian
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Penilaian Jaringan Parut Paska Insisi Kulit Menggunakan Patient and Observer Scar Assessment Scales (POSAS): Perbandingan Hasil Penggunaan Monopolar Electrosurgery dan Pisau Bedah Barends, David; Hatibie, Mendy; Manginstar, Christian; Rawung, Rangga; Langi, Fima FL
Medical Scope Journal Vol 2, No 2 (2021): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.2.2.2021.32731

Abstract

Abstract: Scalpel was once considered as the gold standard in surgical incisions. Electrosurgery has been used as a substitute for scalpels but has not been accepted as standard due to burns and injuries. Patient and observer scar assessment scale (POSAS) is a subjective scar assessment of the patient as well as the observer. This study was aimed to compare post-skin-incision scarring of monopolar electrosurgery and scalpel, and evaluate the appropriateness of scar assessments of the observer and the patient by using POSAS. This was a self-controlled trial design. Post-incision scar tissue assessment was carried out simultaneously by the observer and the patient in the third month after the operation was completed. The paired t test or Wilcoxon rank sum test showed that the differences of assessments of either patient or observer or both were not significant (p=0.05). The correlation test between the total POSAS scores of the patient and observer assessments showed a moderate linear relationship (r=0.51; p<0.001). In conclusion, the use of monopolar electrosurgery and scalpel in performing skin incisions resulted in the formation of equally good scar tissues. The POSAS assessments of patient and observer showed a moderate degree of similarity.Keywords: electrocautery, scar tissue, surgery scalpel, patient and observer scar assessment scale (POSAS)  Abstrak: Pisau bedah dahulu dianggap sebagai standar emas dalam insisi pembedahan. Electrosurgery telah digunakan sebagai pengganti pisau bedah namun belum diterima sebagai standar karena luka bakar dan cedera. Patient and observer scar assessment scale (POSAS) merupakan instrumen penilaian jaringan parut yang bersifat subyektif baik dari pasien maupun observer. Penelitian ini bertujuan untuk membandingkan jaringan parut pasca insisi kulit antara monopolar electrosurgery dan pisau bedah serta mengevaluasi kesesuaian penilaian jaringan parut hasil insisi kulit dari dokter pengamat dan pasien saat keduanya meng-gunakan POSAS. Desain penelitian ialah self-controlled trial. Setiap subjek mendapat dua macam perlakuan secara bersamaan: operasi dengan monopolar electrosurgery dan pisau bedah. Penilaian jaringan parut pasca insisi dilakukan bersamaan oleh observer dan pasien pada bulan ketiga setelah operasi selesai. Hasil paired t test atau Wilcoxon rank sum test terhadap penilaian dalam bentuk skor baik dari pasien atau observer ataupun keduanya terhadap perbedaan jaringan parut oleh penggunaan kedua modalitas tidak bermakna (p>0,05). Uji korelasi antara skor total POSAS dari pasien dan observer menunjukkan adanya hubungan linear sedang (r=0,51; p<0,001). Simpulan penelitian ini ialah penggunaan monopolar electrosurgery mau-pun pisau bedah untuk insisi kulit menghasilkan pembentukan jaringan parut yang sama baik. Penggunaan POSAS dalam penilaian jaringan parut memperlihatkan tingkat kesamaan sedang antara pasien dan observer.Kata kunci: electrocautery, jaringan parut, pisah bedah, patient and observer scar assessment scale (POSAS)
Analisis Hubungan Ca 15-3 dan Respon Kemoterapi Neoadjuvan pada Pasien Kanker Payudara Stadium Lanjut Lokal Rusli, Lie V.; Merung, Marselus; Pontoh†, Victor; Manginstar, Christian; Hatibie, Mendy J.; Langi, F. L. Fredrik G.
e-CliniC Vol 9, No 2 (2021): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v9i2.34659

Abstract

Abstract: Neoadjuvant chemotherapy is one of the therapeutic modalities used in the management of locally advanced breast cancer. Therapeutic response can be objectively assessed with RECIST and Ca 15-3 could be used to monitor response to breast cancer (BC) treatment. This study was aimed to prove the relationship between Ca 15-3 and response to neoadjuvant chemotherapy in locally advanced BC. The study was carried out at the Departement of Surgery Prof. Dr. R. D. Kandou Hospital Manado using a single-arm pre-post trial. Each patient would be performed Ca 15-3 test and clinical assessment (RECIST) pre and post chemotherapy for two sessions. There were 11 BC patients with invasive ductal carcinoma.  The average age was 60 years old and the majority had anemia and lymphocytopenia. There was a decrease in Ca 15-3 in each patient by a baseline of 21.8 U/mL pre-treatment and a decrease in the lesion size by 30.3 mm using RECIST. The results showed that changes in RECIST and Ca 15-3 level were correlated with each unit change in RECIST was associated with a decrease in Ca 15-3 level by 0.03 units (p=0.019). In conclusion, there was a decrease in Ca 15-3 level in response to chemotherapy, followed by a decrease in RECIST. There was a relationship between Ca 15-3 level and chemotherapy response assessed with RECIST after the second chemotherapy.Keywords: Ca 15-3, chemotherapy response, neoadjuvant chemotherapy, RECIST, breast cancer  Abstrak: Kemoterapi neoadjuvan masih merupakan pilihan utama terapi untuk kanker payudara (KPD) stadium lanjut local. Respon suatu kemoterapi dapat dinilai secara objektif dengan RECIST dan Ca 15-3 dapat digunakan untuk memantau respon terhadap pengobatan KPD. Penelitian ini bertujuan untuk membuktikan hubungan antara Ca 15-3 dengan respon kemoterapi neoadjuvan RECIST pada pasien KPD stadium lanjut lokal. Penelitian dilaksanakan di Bagian Bedah RSUP Prof. Dr. R. D. Kandou, Manado dengan menggunakan single-arm pre-post trial. Setiap individu yang terlibat akan diperiksa kadar Ca 15-3, serta penilaian RECIST sebelum dan sesudah mereka menerima kemoterapi selama dua sesi. Hasil penelitian mendapatkan 11 pasien KPD dengan karsinoma duktal invasif. Rerata usia 60 tahun, umumnya dengan anemia dan limfositopenia. Terdapat penurunan Ca 15-3 pada tiap pasien sebesar awal 21,8 U/mL pra pengobatan dan penurunan lesi 30,3 mm saat dinilai menurut RECIST. Didapatkan bahwa perubahan RECIST dan Ca 15-3 memiliki keterkaitan dengan setiap unit perubahan RECIST berhubungan dengan penurunan kadar Ca 15-3 sebesar 0,03 unit (p=0,019). Simpulan penelitian ini ialah terdapat hubungan antara kadar Ca 15-3 dengan respon kemoterapi setelah kemoterapi siklus ke dua.Kata kunci: Ca 15-3; respon kemoterapi; neoadjuvan kemoterapi; RECIST; kanker payudara
Small Lymphocytic Lymphoma Presenting as Breast Mass: A Rare Case Report Manginstar, Christian; Merung, Marselus A.; Saleh, Denny; Merung, Marcella
e-CliniC Vol. 12 No. 2 (2024): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v12i2.46852

Abstract

Abstract: Primary breast lymphoma is rare and it accounts for around 0.5% of malignant breast neoplasms. Small lymphocytic lymphoma (SLL) is a subtype of non-Hodgkin lymphoma originating from a B-cell lineage. This report presents a case of primary SLL of the breast with lung metastasis that had excellent clinical response. We reported a 67-year-old female complained a right breast mass that suddenly appeared after she got massage on her right left arm. The mass was swollen and painless with no systemic complications. The specimen was submitted to histopathology department and it revealed small diffuse lymphocytic lymphoma. Chest X-ray showed a lung metastasis. The patient was then treated with CHOP regimens (Cyclophosphamid, Doxorubicin, Vincristin, and Prednison) and the clinical result was excellent. The side effects of the medication were minimal. In conclusion, primary breast lymphocytic lymphoma is rare and this case highlights the differential diagnosis for a painless breast mass. The treatment must be individualized and multimodal, with chemotherapy being the most accepted treatment. Keywords: breast lymphoma; breast mass; malignancy
Effect of Propolis Trigona Sp on Expression of TNF-α in Superficial Dermal Burns through In Vivo Test Siwabessy, Melfrits R.; Manginstar, Christian; Merung, Marselus A.; Langi, Fredrik G. L.
e-CliniC Vol. 12 No. 2 (2024): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v12i2.51816

Abstract

Abstract: Burn is caused by exposure to high-temperature substances such as hot, solid liquids or gases such as smoke, steam, engines, stoves, radiators and objects that emit heat energy. In severe burns, there is an excessive neutrophil inflammatory response that triggers SIRS, where there is an excessive increase in pro-inflammatory mediators such as TNFα and IL-6. Propolis contains a number of compounds, such as flavonoids, CAPE, phenol compounds, arginine, ferulic acid and albumin which play a good role in healing burns. This study aimed to find out the effect of propolis on TNF-α expression through in-vivo testing in cases of superficial dermal burns. This was an experimental and laboratory study to assess the bioactive compounds contained in Trigona Sp propolis. Descriptive analysis was performed on the bioactive composition of Trigona Sp propolis and experimental effectiveness of propolis on TNF-α expression in superficial dermal burns. The study was conducted at the laboratory of experimental animals "Alike Quality System", Manado. The results showed that the group treated with propolis had smaller burn areas compared to the groups treated with 1% silver sulfadiazine or with 0.9% NaCl. Granulation had been formed throughout all wounds, however, macroscopically, burns with propolis treatment showed reddish wound appearance while treated wounds with 1% silver sulfadiazine and 0.9% NaCl were darker in color and had thicker crust formation. The one-way ANOVA test showed no significant difference between propolis and 1% silver sulfadiazine on TNF-α expression in dermal superficial burns (p=0.666) meanwhile the effect of propolis compared with NaCl 0.9% on TNF-α expression in dermal superficial burns, showed significant differences (p=0.006 and p=0.040). In conclusion, administration of propolis can reduce the expression of TNF-α in superficial dermal burn. Keywords: propolis; Trigona sp; burns; in vivo study
Malignant Phyllodes Tumor of The Breast: A Rare Case Report Manginstar, Christian; Paat, Rigel Kent; Moksidy, Reynaldy Cliftianto
Jurnal Ilmiah Universitas Batanghari Jambi Vol 25, No 2 (2025): Juli
Publisher : Universitas Batanghari Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33087/jiubj.v25i2.6043

Abstract

Tumor phyllodes (PT) adalah neoplasma payudara fibroepitel langka, yang merupakan kurang dari 1% dari semua keganasan payudara. Tumor phyllodes (PT) diklasifikasikan menjadi jinak, borderline, atau ganas berdasarkan karakteristik histologis. Tumor phyllodes (PT) ganas sering muncul sebagai massa yang tumbuh cepat dan tidak menimbulkan rasa sakit yang dapat menyebabkan perubahan kulit yang terlihat. Penelitian ini mengangkat kasus pada seorang wanita berusia 46 tahun menunjukkan massa yang menyakitkan dan tumbuh cepat di payudara kanan, berukuran sekitar 20×20cm, dengan ulserasi kulit dan perdarahan. Temuan ultrasonografi dan histologis menunjukkan bahwa wanita tersebut sebagai pasien terkena tumor phyllodes ganas. Pasien tersebut harus menjalani mastektomi radikal, termasuk pengangkatan tumor, jaringan payudara, dan kelenjar getah bening yang terkena, sambil mempertahankan struktur anatomi yang kritis. Tumor phyllodes (PT) ganas adalah tumor agresif yang membutuhkan eksisi luas untuk mencapai kontrol lokal yang optimal. Kasus ini menyoroti tantangan mendiagnosis dan mengelola PT besar dan menggarisbawahi pentingnya evaluasi histologis menyeluruh. Peran terapi adjuvan seperti radioterapi dan kemoterapi masih belum pasti tetapi dapat dipertimbangkan dalam kasus tertentu.
Co-Authors Barends, David Langi, Fredrik G. L. Marselus A. Merung, Marselus A. Marselus Merung, Marselus Mendy Hatibie Merung, Marcella Moksidy, Reynaldy Cliftianto Paat, Rigel Kent Pontoh†, Victor Rawung, Rangga Rusli, Lie V. Saleh, Denny Siwabessy, Melfrits R.