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All Journal Media Kesehatan Masyarakat Indonesia CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Pharmaceutical Sciences and Research (PSR) Jurnal Kesehatan Masyarakat
Wijono, Heru
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Education Health Professions Medicine & Pharmacology Nursing Public Health

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Profil Penggunaan Antibiotik Profilaksis pada Pasien Bedah di Salah Satu RS Swata Kota Surabaya Octavianty, Clara; Yulia, Rika; Herawati, Fauna; Wijono, Heru
MEDIA KESEHATAN MASYARAKAT INDONESIA Vol 20, No 3 (2021): MKMI
Publisher : Fakultas Kesehatan Masyarakat, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/mkmi.20.3.168-172

Abstract

Latar belakang: Masalah resistensi bakteri terhadap antibiotik telah menjadi masalah internasional, jika tidak segera ditangani maka dapat merugikan masyarakat di seluruh dunia dari segi kesehatan dan ekonomi Data Antimicrobial Resistant in Indonesia (AMRIN) memperkirakan pada tahun 2018 kematian akibat Antimicrobial Resistant (AMR) sekitar 700.000 jiwa dan diperkirakan juga pada tahun 2050, AMR menyebabkan kematian 10 juta jiwa/tahun. Penelitian ini bertujuan untuk mengetahui profil kuantitas penggunaan antibiotik berdasarkan metode DDD/100 patient-days dan profil Infeksi Daerah Operasi (IDO) pada pasien bedah di salah satu RS Swasta Kota Surabaya periode Januari-Juni 2019.Metode: Penelitian ini menggunakan desain penelitian deskriptif dengan pengambilan data secara retrospektif terhadap data rekam medik sampel penelitian. Subyek penelitian adalah pasien bedah periode Januari-Juni 2019 yang memenuhi kriteria inklusi yaitu sebanyak 241 sampel penelitian, lalu dihitung dengan menggunakan metode DDD/100 patient-days.Hasil: Hasil yang diperoleh dari penelitian ini yaitu kuantitas penggunaan antibiotik periode Januari-Juni 2019 didominasi oleh antibiotik ceftriaxone (J01DD04) dengan nilai total DDD/100 patient-days pada pre operasi yaitu 17,95, on operasi 23,57, dan post operasi 23,22.Simpulan: Konsumsi antibiotik terbanyak pada pre, on, dan post bedah didapatkan pada antibiotik ceftriaxone.Kata kunci: Kuantitas antibiotik, pasien bedah, antibiotik profilaksis ABSTRACT Title: Usage Profile Prophylactic Antibiotics in Surgery Patient in A Private Hospital in SurabayaBackground: The problem of bacterial resistance to antibiotics has become an international problem, if it does not act immediately it can harm people around the world in terms of health and economy. Antimicrobial Resistant in Indonesia (AMRIN) data is estimated that in 2018 the death due to Antimicrobial Resistant (AMR) is around 700,000 people and assumptions too by 2050, AMR causes the death of 10 million people / year. This research aims to determine the quantity of antibiotic usage profiles based on the DDD/100 patient-days method and as well as Surgical Site Infection (SSI) profiles in surgical patients in the Private Hospital in Surabaya in the January-June 2019 period. Then calculate using the DDD/100 patient-days method.Method: This research use descriptive research design method with retrospective data retrieval against medical records as research samples. The research subjects were surgical patients from January to June 2019 who met the inclusion criteria, which were 241 research samples.Result: The results obtained from this research were the quantity of antibiotic used in the January-June 2019 which dominated by the antibiotic ceftriaxone (J01DD04) with a total DDD/100 patient-days value in pre-surgery that was 17,95, ion isurgery 23,57, and post surgery 23,22.Conclusion: The most antibiotic consumption in pre, on, and post surgery was found in ceftriaxone antibiotics.Keywords: Quantity of antibiotics, surgical patients, antibiotics prophylaxis  
Kajian Narrative terhadap Profil Farmakokinetik Antibiotik pada Pasien Kritis: Implikasi terhadap Ketercapaian Target Farmakokinetik-Farmakodinamik Setiawan, Eko; Widyati,; Marpaung, Ferdy Royland; Sukandar, Edy; Susaniwati,; Lukas, Dwi Lily; Wijono, Heru; Warindra, Taufin; Kurniawan, Roni; Wibowo, Tjipto; Hendradi, Wahyu; Costa, Menino Osbert; Aziz, Mohd-Hafiz Abdu; Roberts, Jason
Pharmaceutical Sciences and Research Vol. 6, No. 1
Publisher : UI Scholars Hub

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Abstract

The severity of diseases, the complexity of treatment, and the use of medical devices in the intensive care unit (ICU) may change the pharmacokinetics (PK) profile of antibiotics among critically ill patients.This narrative review aims to explain the PK profile of critically ill patients compared to other group of patients and to describe the pharmacokinetic-pharmacidynamic (PK-PD) target attainment among this group of patients. Only articles published less than 10 years ago were included in this narrative review. Evidences have indicated that critically ill patients have relatively larger volume distribution (Vd) of hydrophilic antibiotics compared to patients with stable conditions. The fluid shifting to interstitial space, hypoalbuminemia, and aggressive fluid treatment may contribute to the increase value of Vd in critically ill patients. The clearance (CL) of hydrophilic antibiotics in critically ill patients is highly determined by dynamic changing of renal function compared to patients in other wards. The phenomenon of augmented renal clearance and the use of high intensity of renal replacement therapy can increase the CL of hydrophilic antibiotics. The different PK profile of antibiotics may lead to the failure of attaining the PK-PD target if the dose of antibiotics is not adjusted according to such differences
Pengaruh Persepsi Masyarakat Terhadap Covid-19 Dan Perilaku Penerapan Protokol Kesehatan Berdasarkan Health Belief Model Putri, Stevani Dinda; Wijono, Heru; Boengas, Sawitri
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 3 No. 3 (2023): Februari
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v3i3.129

Abstract

COVID-19 is a disease caused by SARS CoV-2, which causes many deaths. The government launched the 5M health protocol to reduce morbidity and mortality from COVID-19. Awareness of implementing health protocols is influenced by various factors besides knowledge. Theory Health Belief Model (HBM) focuses on individual perceptions and beliefs about the COVID-19 which includes which perceived susceptibility, perceived severity, perceived benefits, and perceived barriers, can be used in predicting public awareness in carrying out the behavior of implementing the COVID-19 health protocol. This study aims to determine the relationship between perceived vulnerability, perceived severity, perceived benefits and perceived obstacles with adherence to implementing the COVID-19 health protocol. This research is an analytic observational study, the data was taken by cross-sectional use google form. Correlation test was performed with Rank Spearman test use SPSS version 25. Results: There were 40 respondents, 21 (53.5%) female, 19 (47.5%) male, 17 to 70 yo. There is a significant relationship between perceived severity (p = 0.003), perceived benefits (p = 0.000) and perceived barriers (p = 0.004) to the behavior of implementing health protocols, but no relations was found between perceived susceptibility (p =0.216) and behavior of implementing protocols health. Perceived severity, perceived benefits, and perceived barriers are related to the behavior of implementing health protocols
Demographic Factors and BMI on Declined Lung Function and Vitamin D Levels in Active Smokers Laksono, Pandu; Lorensia, Amelia; Wijono, Heru
Jurnal Kesehatan Masyarakat Vol. 21 No. 1 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v21i1.4547

Abstract

Cigarettes are one of the causes of health problems in the world. Smoking has been known to have a direct impact on reducing lung function. Smoking increases the risk of vitamin D deficiency. Vitamin D is a vital nutrient as a lung immunomodulator. Deficient levels will cause problems with lung health, especially in active smokers. This cross-sectional research using multivariate path analysis and the SEM-PLS method has three objectives. The direct influence of three independent variables, including obesity, smoking, and demographics. Regarding vitamin D status and lung function, analyzing the direct effect of vitamin D on lung function, and thirdly, analyzing the indirect one of the three independent variables on lung function through vitamin D levels. This research took time from October 2023 to January 2024 and involved 47 active smoker respondents whose vitamin D level status and lung function were measured. There was a significant direct effect of obesity level on vitamin D levels in the active smoker population (p<0.05;f-square=2.889). While demographic factors (p>0.05;f-square=0.030) and smoking frequency (p>0.05;f-square=0.003) did not have a direct significant effect. Demographic factors, obesity, and smoking frequency don’t have significant direct effect on lung function in active smokers (p>0.05).
Co-Authors Amelia Lorensia Aziz, Mohd-Hafiz Abdu Boengas, Sawitri Costa, Menino Osbert Eko Setiawan Hendradi, Wahyu Herawati, Fauna Lukas, Dwi Lily Marpaung, Ferdy Royland Octavianty, Clara Pandu Laksono, Pandu Putri, Stevani Dinda Rika Yulia Roberts, Jason RR. Ella Evrita Hestiandari Sukandar, Edy Susaniwati, Warindra, Taufin Wibowo, Tjipto Widyati,