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All Journal Media Kesehatan Masyarakat Indonesia CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Pharmaceutical Sciences and Research (PSR)
Wijono, Heru
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Health Professions Medicine & Pharmacology Nursing Public Health

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Profil Penggunaan Antibiotik Profilaksis pada Pasien Bedah di Salah Satu RS Swata Kota Surabaya Octavianty, Clara; Yulia, Rika; Herawati, Fauna; Wijono, Heru
MEDIA KESEHATAN MASYARAKAT INDONESIA Vol 20, No 3 (2021): MKMI
Publisher : Fakultas Kesehatan Masyarakat, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/mkmi.20.3.168-172

Abstract

Latar belakang: Masalah resistensi bakteri terhadap antibiotik telah menjadi masalah internasional, jika tidak segera ditangani maka dapat merugikan masyarakat di seluruh dunia dari segi kesehatan dan ekonomi Data Antimicrobial Resistant in Indonesia (AMRIN) memperkirakan pada tahun 2018 kematian akibat Antimicrobial Resistant (AMR) sekitar 700.000 jiwa dan diperkirakan juga pada tahun 2050, AMR menyebabkan kematian 10 juta jiwa/tahun. Penelitian ini bertujuan untuk mengetahui profil kuantitas penggunaan antibiotik berdasarkan metode DDD/100 patient-days dan profil Infeksi Daerah Operasi (IDO) pada pasien bedah di salah satu RS Swasta Kota Surabaya periode Januari-Juni 2019.Metode: Penelitian ini menggunakan desain penelitian deskriptif dengan pengambilan data secara retrospektif terhadap data rekam medik sampel penelitian. Subyek penelitian adalah pasien bedah periode Januari-Juni 2019 yang memenuhi kriteria inklusi yaitu sebanyak 241 sampel penelitian, lalu dihitung dengan menggunakan metode DDD/100 patient-days.Hasil: Hasil yang diperoleh dari penelitian ini yaitu kuantitas penggunaan antibiotik periode Januari-Juni 2019 didominasi oleh antibiotik ceftriaxone (J01DD04) dengan nilai total DDD/100 patient-days pada pre operasi yaitu 17,95, on operasi 23,57, dan post operasi 23,22.Simpulan: Konsumsi antibiotik terbanyak pada pre, on, dan post bedah didapatkan pada antibiotik ceftriaxone.Kata kunci: Kuantitas antibiotik, pasien bedah, antibiotik profilaksis ABSTRACT Title: Usage Profile Prophylactic Antibiotics in Surgery Patient in A Private Hospital in SurabayaBackground: The problem of bacterial resistance to antibiotics has become an international problem, if it does not act immediately it can harm people around the world in terms of health and economy. Antimicrobial Resistant in Indonesia (AMRIN) data is estimated that in 2018 the death due to Antimicrobial Resistant (AMR) is around 700,000 people and assumptions too by 2050, AMR causes the death of 10 million people / year. This research aims to determine the quantity of antibiotic usage profiles based on the DDD/100 patient-days method and as well as Surgical Site Infection (SSI) profiles in surgical patients in the Private Hospital in Surabaya in the January-June 2019 period. Then calculate using the DDD/100 patient-days method.Method: This research use descriptive research design method with retrospective data retrieval against medical records as research samples. The research subjects were surgical patients from January to June 2019 who met the inclusion criteria, which were 241 research samples.Result: The results obtained from this research were the quantity of antibiotic used in the January-June 2019 which dominated by the antibiotic ceftriaxone (J01DD04) with a total DDD/100 patient-days value in pre-surgery that was 17,95, ion isurgery 23,57, and post surgery 23,22.Conclusion: The most antibiotic consumption in pre, on, and post surgery was found in ceftriaxone antibiotics.Keywords: Quantity of antibiotics, surgical patients, antibiotics prophylaxis  
Kajian Narrative terhadap Profil Farmakokinetik Antibiotik pada Pasien Kritis: Implikasi terhadap Ketercapaian Target Farmakokinetik-Farmakodinamik Setiawan, Eko; Widyati,; Marpaung, Ferdy Royland; Sukandar, Edy; Susaniwati,; Lukas, Dwi Lily; Wijono, Heru; Warindra, Taufin; Kurniawan, Roni; Wibowo, Tjipto; Hendradi, Wahyu; Costa, Menino Osbert; Aziz, Mohd-Hafiz Abdu; Roberts, Jason
Pharmaceutical Sciences and Research Vol. 6, No. 1
Publisher : UI Scholars Hub

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Abstract

The severity of diseases, the complexity of treatment, and the use of medical devices in the intensive care unit (ICU) may change the pharmacokinetics (PK) profile of antibiotics among critically ill patients.This narrative review aims to explain the PK profile of critically ill patients compared to other group of patients and to describe the pharmacokinetic-pharmacidynamic (PK-PD) target attainment among this group of patients. Only articles published less than 10 years ago were included in this narrative review. Evidences have indicated that critically ill patients have relatively larger volume distribution (Vd) of hydrophilic antibiotics compared to patients with stable conditions. The fluid shifting to interstitial space, hypoalbuminemia, and aggressive fluid treatment may contribute to the increase value of Vd in critically ill patients. The clearance (CL) of hydrophilic antibiotics in critically ill patients is highly determined by dynamic changing of renal function compared to patients in other wards. The phenomenon of augmented renal clearance and the use of high intensity of renal replacement therapy can increase the CL of hydrophilic antibiotics. The different PK profile of antibiotics may lead to the failure of attaining the PK-PD target if the dose of antibiotics is not adjusted according to such differences
Pengaruh Persepsi Masyarakat Terhadap Covid-19 Dan Perilaku Penerapan Protokol Kesehatan Berdasarkan Health Belief Model Putri, Stevani Dinda; Wijono, Heru; Boengas, Sawitri
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 3 No. 3 (2023): Februari
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v3i3.129

Abstract

COVID-19 is a disease caused by SARS CoV-2, which causes many deaths. The government launched the 5M health protocol to reduce morbidity and mortality from COVID-19. Awareness of implementing health protocols is influenced by various factors besides knowledge. Theory Health Belief Model (HBM) focuses on individual perceptions and beliefs about the COVID-19 which includes which perceived susceptibility, perceived severity, perceived benefits, and perceived barriers, can be used in predicting public awareness in carrying out the behavior of implementing the COVID-19 health protocol. This study aims to determine the relationship between perceived vulnerability, perceived severity, perceived benefits and perceived obstacles with adherence to implementing the COVID-19 health protocol. This research is an analytic observational study, the data was taken by cross-sectional use google form. Correlation test was performed with Rank Spearman test use SPSS version 25. Results: There were 40 respondents, 21 (53.5%) female, 19 (47.5%) male, 17 to 70 yo. There is a significant relationship between perceived severity (p = 0.003), perceived benefits (p = 0.000) and perceived barriers (p = 0.004) to the behavior of implementing health protocols, but no relations was found between perceived susceptibility (p =0.216) and behavior of implementing protocols health. Perceived severity, perceived benefits, and perceived barriers are related to the behavior of implementing health protocols
The Chemotherapy Use and Adverse Effects of Patients with Lung Cancer at Regional General Hospital in Surabaya, Indonesia Yulia, Rika; Kirtishanti, Aguslina; Wijono, Heru; Setiawan, Eko; Presley, Bobby; Go, Tjie Kok; Mayani, Ni Putu Irma; Febriani, Anna; Jaya, Halim Priyahau; Herawati, Fauna
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Abstract

In Indonesia, lung cancer is the leading cause of death related to cancer, according to Global Cancer Observatory. Chemotherapy is the most common treatment since it works systemically and can prevent cancer cells from spreading to other organs. Cytotoxicity of chemotherapy can also put patients at high risk of experiencing adverse effects. This study aimed to evaluate the congruity of chemotherapy use with treatment recommendations and the profile of adverse effects, not only acute but also delayed adverse drug reactions. This prospective observational study involved 41 adult patients with lung cancer who received chemotherapy. Data is collected through patients’ medical records, brief patient interviews, and analyzed descriptively. The majority of the patients received first-line chemotherapy (87.80%). Pemetrexed-cisplatin (39.02%) and pemetrexed-carboplatin (19.51%) are the most common first-line therapy, followed by docetaxel (12,20%) as the second-line chemotherapy commonly used by patients. The chemotherapy regimens used in patients were 100% appropriate based on treatment guidelines. 61.11% and 60% of patients experience adverse effects with the first and second line of chemotherapy, respectively. Anemia (63,89%) was the most common delayed adverse effect in the first-line chemotherapy and hair loss (60%) was the most common one in the second-line chemotherapy. The platinum-based chemotherapy is a standard treatment for lung cancer, but its tolerability limits its uses. These findings showed chemotherapy-related adverse effects that need to be considered in choosing the best choice of therapy to optimize the treatment. Therefore, prophylaxis therapy to manage chemotherapy-related adverse effects may be considered in patients with chemotherapy.
Co-Authors Aguslina Kirtishanti Aziz, Mohd-Hafiz Abdu Bobby Presley, Bobby Boengas, Sawitri Costa, Menino Osbert Eko Setiawan Febriani, Anna Go, Tjie Kok Hendradi, Wahyu Herawati, Fauna Jaya, Halim Priyahau Lukas, Dwi Lily Marpaung, Ferdy Royland Mayani, Ni Putu Irma Octavianty, Clara Putri, Stevani Dinda Rika Yulia Roberts, Jason RR. Ella Evrita Hestiandari Sukandar, Edy Susaniwati, Warindra, Taufin Wibowo, Tjipto Widyati,