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All Journal NUCLEUS: Jurnal Sains dan Teknologi PUBLIKA : Jurnal Ilmu Administrasi Publik Cermin Dunia Kedokteran Folia Medica Indonesiana
Fadhilah, Nur Lailatul
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Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Environmental Science Health Professions Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Social Sciences

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RELATIONSHIP OF NEUTROPHIL LYMPHOCYTE RATIO WITH APPENDICITIS INCIDENCE Review of Appendicitis Patients at Ibnu Sina Hospital, Gresik Regency in 2022-2023 Rahman, Akhmad Setyo; Harijanto, Taufan; Marsetio, Dono; Negara, Agung Kusuma; Fadhilah, Nur Lailatul
NUCLEUS Vol 5 No 02 (2024): NUCLEUS
Publisher : Neolectura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37010/nuc.v5i02.1776

Abstract

This study aims to analyze the relationship between the neutrophil lymphocyte ratio (NLR) and the incidence of acute appendicitis in patients at Ibnu Sina Hospital, Gresik Regency, in the 2022-2023 period. Acute appendicitis is a frequent emergency surgical condition, especially in adolescents and young adults, with the risk of complications such as perforation and peritonitis. NLR, as an indicator of inflammatory response, is considered more practical and economical than CT scans and ultrasounds, which have limited cost, accessibility, and risk of radiation exposure. This study used an observational analytical method with a cross-sectional approach on 51 appendicitis patients who underwent appendectomy. NLR data was obtained through routine blood results, with statistical analysis using SPSS to test the normality and difference in NLR values between uncomplicated appendicitis and appendicitis with complications. There was a significant difference in the mean NLR value between patients with complementary and non-complementary appendicitis, with a p < value of 0.001. The results of the ROC Curve analysis show that NLR has a high prediction value in predicting complementary appendicitis of 97.5%. This study concludes that NLR can be an effective indicator in distinguishing cases of complementary and non-complementary appendicitis and the potential of NLR as an easy and efficient screening tool in the treatment of acute appendicitis, especially in health facilities with limited resources.
THE EFFECT OF ASTAXANTHIN ON TUMOR NECROSIS FACTOR ALPHA (TNF-<i>α</i>) AND INTERLEUKIN 10 (IL-10) EXPRESSION IN UV-B-INDUCED RATS MODEL Rahman, Akhmad Setyo; Budhy, Theresia Indah; Nugraha, Jusak; Fadhilah, Nur Lailatul
Folia Medica Indonesiana Vol. 61, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

The skin, the largest organ in the human body, serves as a protective barrier against external factors. Exposure to UV-B radiation accounts for approximately 90% of skin damage, leading to aging characterized by dryness and wrinkles. Proper nutrition has been associated with skin repair and delayed aging. Astaxanthin, known for its pharmacological properties including anti-cancer, anti-diabetic, anti-inflammatory, and antioxidant activities has garnered attention for its ability to improve damaged skin when administered as a daily supplement. This study investigated the roles of TNF-α and IL-10 as inflammatory markers in skin damage and repair, which remain underexplored. A true experimental randomized posttest-only control group design was employed using 24 male white rats divided into four groups: (1) normal group (N), untreated rats; (2) control group (C), rats administered with olive oil (5 ml/kg BW); (3) treatment group 1 (P1), rats exposed to UV-B and administered with olive oil (5 ml/kg BW); and (4) treatment group 2 (P2), rats exposed to UV-B and administered with astaxanthin (10 mg/kg BW) combined with olive oil (5 ml/kg BW). ANOVA and Games-Howell post-hoc tests revealed significant differences (p < 0.05) among groups, except between the control (C) and normal (N) groups. Astaxanthin (10 mg/kg BW) demonstrated both curative and protective effects by reducing TNF-α expression (pro-inflammatory) and increasing IL-10 expression (anti-inflammatory) in UV-B-induced rats. These findings highlight astaxanthin’s potential as a therapeutic agent for UV-B-induced skin damage.
Karakteristik Pasien Luka Bakar di Rumah Sakit Ibnu Sina, Gresik, Indonesia – 2022–2024: Sebuah Studi Deskriptif Observasional Retrospektif: Penelitian Rahman, Akhmad Setyo; Harijanto, Taufan; Marsetio, Dono; Negara, Agung Kusuma; Fadhilah, Nur Lailatul
Cermin Dunia Kedokteran Vol 53 No 04 (2026): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i04.2032

Abstract

Introduction: Burns are a significant cause of morbidity and mortality, particularly in developing countries with limitations in healthcare systems. This study describes clinical characteristics of burn patients at Ibnu Sina Regional Public Hospital, Gresik Regency, during the2022−2024 period. Methods: A retrospective observational descriptive study on secondary data from medical records of burn patients admitted through the Emergency Department (ED) within the first 24 hours following injury. Results: Out of a total of 64 patients, the majoritywere male and within the productive age group (16−35 years). Most worked as entrepreneurs or factory workers. The most frequent causes of burns were flame exposure and gas explosions, mostly involving 20%−39% of the total body surface area (TBSA). Patients with inhalationtrauma and comorbidities, such as diabetes mellitus or smoking habits, experienced longer hospital stays. Conclusion: Most moderate-tosevere burn injuries in this study occurred among factory workers and entrepreneurs as a result of open flame and gas explosions, indicatingthe need to strengthen occupational safety and burn prevention efforts in the workplace.
Determination of economic growth in Bali province 2004-2023 Fadhilah, Nur Lailatul; Sukadi, Agung Slamet
PUBLIKA : Jurnal Ilmu Administrasi Publik Vol. 12 No. 1 (2026): Publika : Jurnal Ilmu Administrasi Publik
Publisher : UIR Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25299/jiap.2026.26853

Abstract

The purpose of this study is to examine how household consumption, literacy rates, poverty rates, and per capita income affect economic growth in Bali Province. This study uses a macro analysis unit covering 9 regencies/cities in Bali Province during the period 2004-2023, the data used is secondary panel data sourced from official reports of the Central Statistics Agency (BPS). The Panel Data Model was chosen to overcome the potential endogeneity between variables and capture the effect of welfare persistence from year to year across all regencies/cities in Bali. The results of the analysis show that the poverty variable does not have a significant impact on economic growth, meaning that changes in poverty levels do not have a direct impact on Bali's economic growth rate. Economic growth is negatively and significantly influenced by the per capita income variable, as shown in the uneven distribution of income across various regions, economic growth does not always follow the increase in per capita income. Increases consumption Public participation can stimulate regional economic activity, as evidenced by the significant positive impact of household consumption on economic growth. Furthermore, economic growth is positively and significantly influenced by the literacy rate, indicating that increasing literacy rates among the Balinese population is crucial for increasing labor productivity. This confirms that improving the quality of human resources and strengthening people's purchasing power are key factors in driving sustainable economic growth in Bali Province.
Co-Authors Harijanto, Taufan Jusak Nugraha Marsetio, Dono Negara, Agung Kusuma Rahman, Akhmad Setyo Sukadi, Agung Slamet Theresia Indah Budhy Sulisetyawati